Amount Of Polyethylene Glycol Research Articles

Microstructural modifications of polyethylene glycol powder binder in the processing of sintered alpha alumina under different conditions of preparation

In this study, amounts of polyethylene glycol (PEG) plasticizer which used in the forming and sintering α-alumina ceramics of the sample are optimized. PEG as a conventional binder is used for the preparation of alumina-based materials. The main aim of this work was to investigate the effect of different contents of PEG and sintering conditions on the critical quality of produced alumina including microstructure, porosity, compressibility, and mechanical properties. Also, the influence of compression pressure (from 3500 to 5000 bar) on the green density of the produced alumina pellets was evaluated while the binder contents are varied from 1 to 5 wt%. The analysis results showed that the addition of PEG to the alumina powder enhances the green density of the produced disks until a maximum value. Over the maximum point, the density did not further change with increasing PEG content. This high green density leads to a high sintered density of the alumina disks. The results show that the formulation containing more than 4 wt% of PEG causes both lower sintered and green density. The fabricated alumina pellets were then compared to those without additives in terms of mechanical strength, and it was indicated that the density of fabricated pellets enhanced by rising the compaction pressure greater than 3500 bar.

Influence of gelation step for preparing PEG–SiO2 shape-stabilized phase change materials by sol–gel method

An in situ shape-stabilized phase change material (ssPCM) from polyethylene glycol (PEG) has been produced by sol–gel method. The inorganic matrix was in situ formed from tetraethyl orthosilicate (TEOS), controlling the condensation rate in a second alkaline step using NaOH. ssPCMs having a latent heat up to 113.8 J/g were synthetized using a sol with a molar ratio H2O:EtOH:H2SO4:PEG1000:TEOS of 2:0.34:0.021:0.50:1 and an equivalent ratio NaOH/H2SO4 of 1.15 for promoting the gel step. The presence of high-density hydrogen bonds between silanol groups and the ether oxygen atoms of PEG and the existence of latent heat allowed to confirm that the PEG worked in two ways. It either forms the PEG–SiO2 matrix or adsorbs onto the surface of the previous polymeric matrix, losing or conserving its latent heat, respectively. The addition of NaOH allowed to change the functionality of the silicon matrix which strongly affected the water content, the thermal stability, and the amount of active PEG in the ssPCMs, leading to an optimal neutralization condition when an equivalent ratio NaOH/H2SO4 of 1.15 was used. The obtained ssPCM has an appropriate range of operative temperatures, a high latent heat in the range of common thermoregulating materials, and a proper thermal reliability.

Determination of the release of PEG and HPMC from nelfilcon A daily disposable contact lenses using a novel in vitro eye model

The traditional method to measure release of components from CLs is a vial containing a static volume of PBS (phosphate buffered saline). However, this model does not simulate physiologically relevant tear volume and natural tear flow, air exposure, and mechanical rubbing. These factors can significantly impact release kinetics. We have developed an in vitro eye model (OcuFlow) that simulates these parameters. The aim of the study was to measure the release of PEG (polyethylene glycol), and HPMC (hydroxypropyl methylcellulose) from a daily disposable hydrogel contact lens material (nelfilcon A; Dailies AquaComfort PLUS; DACP;) over 24 hrs using the OcuFlow platform. The elution of PEG and HPMC from DACP lenses was analyzed using LCMS (liquid chromatography mass spectrometry). The release of all wetting agents from the lenses followed a burst release pattern, which occurred within the first 1.5 hrs (P < 0.05). The release of PEG was greater than that of HPMC (P < 0.05). The amount of PEG and HPMC released at any given time was less than 1% of the amount in the blister pack solution. Our results suggest that HPMC and PEG are rapidly released from the CL.

Quality-by-design model in optimization of PEG-PLGA nano micelles for targeted cancer therapy

Poly (D,L-Lactic-co-Glycolic acid) (PLGA) is a biodegradable and biocompatible polymer approved by FDA for clinical uses. Surface functionalization of self-assembly micelles made of PLGA with Poly-Ethylene Glycol (PEG) improves its stability and half-life in blood circulation via inhibiting adsorption of proteins on the surface and consequently decreasing opsonisation rate. The purpose of present study was to optimize PEG amount absorbed on PLGA (PEGabsPLGA) micelles by application of quality by design approach. Based on risk assessment, effect of three variables including PLGA concentration, PEG concentration and molecular weight (MW) of PLGA were studied. Central composite design was implemented for design of experimentation with 26 runs. The PEGabsPLGA nano drug delivery system (NDDS), produced by o/w method, was optimized according to particle size, polydispersity index (PDI) and zeta potential values. Validation of the model was successfully performed with three representative formulations from the design space. As a result, 43.79 mg of PLGA with MW of 30,000–60,000 was incorporated with 12.61 mg of PEG to obtain a 69 nm NDDS (predicted 67.72 nm) with the PDI value equal to 0.124 (predicted 0.112). The results successfully led to the preparation of the most stable nanoparticles which were stable at room temperature for six months.

Reduced mass transport resistance in polymer electrolyte membrane fuel cell by polyethylene glycol addition to catalyst ink

Abstract Effects of Polyethylene glycol (PEG) addition to cathode catalyst ink were investigated by changing the addition amount of PEG. Performance of the polymer electrolyte membrane fuel cells (PEMFCs) increased and then decreased at the higher current density than 1.5 A/cm2 as the amount of PEG addition increased. However, durability was not changed by the addition of PEG to the catalyst ink. Three different molecular weights of PEG were compared for PEG additives to cathode catalyst ink. Performance at high current density region increased and then decreased as PEG molecular weight increases from 200 to 10000. Increased performance by addition of PEG was attributed from reduced mass transport resistance. However, addition of large molecular weight PEG to catalyst ink reduced the performance because it lowered ionomer conductivity in the catalyst layer and then reduced proton transport resistance. Increased pore size in the catalyst layer and increased hydrophilicity on the electrode were also analyzed by addition of PEG to catalyst ink.

Noncovalent Pyrene-Polyethylene Glycol Coatings of Carbon Nanotubes Achieve in Vitro Biocompatibility.

Single-walled carbon nanotubes (SWNTs) have become increasingly exploited in biological applications, such as imaging and drug delivery. The application of SWNTs in biological settings requires the surface chemistry to remain through the low solubility in aqueous media. In this research, a facile approach for the preparation of a polyethylene glycol (PEG)-coated SWNT-based nanocarrier was reported. We focused on the effect of PEG chain length and SWNT size on the cytotoxicity of PEG-coated SWNTs as a superior drug delivery nanovector. First, all-atom molecular dynamics (MD) simulations were employed to explore the stability and behavior of SWNT/pyrene-PEG (SWNT/Pyr-PEG) structures at a molecular level that is not attainable with experiments. The MD studies revealed that (i) π-π stacking interactions between the pyrene bearing PEG molecules and SWNTs are maintained in bulky situations, regardless of PEG molecular weight or SWNT size; (ii) pyrene molecules diffuse over the SWNT surface without detaching; and (iii) both short and long dynamic Pyr-PEG chains have the capability of effectively coating the SWNT surface. In light of the simulations, noncovalent (π-π stacking) assemblies of SWNT/Pyr-PEG with different molecular weights of PEG ( Mw = 2000, 5000, and 12000) were successfully fabricated and characterized. For longer PEG chains, more effective coating of SWNTs was obtained, resulting in more biocompatible SWNT/Pyr-PEG nanomaterials. The number of SWNTs coated by Pyr-PEG was highly dependent on the length of pyrene bearing PEG polymers. Moreover, the short SWNTs showed a higher amount of PEG coating with respect to the long SWNTs. Cell viability results demonstrated a dose-dependent cytotoxicity of coated SWNTs. Short SWNTs coated with longer PEG chains have low cytotoxicity to be used in in vivo studies.

Development of fast-release piroxicam/polyethylene glycol capsules by solid dispersion and curing using full factorial design

Purpose: To develop fast-release piroxicam (PRX) capsules by solid dispersion with polyethylene glycol (PEG) using melting and curing in a heated coating pan.Methods: A full factorial design was conducted to investigate the main and interaction effects of molecular weight (4000 - 8000 Da) and amount (10 - 30 mg PEG to 10 mg PRX) on the dissolution rate of PRX. Temperature (50 - 70 °C) and duration of the curing process (15 - 45 min) were also systematically selected by factorial design.Results: The molecular weight and amount of PEG significantly impacted on the dissolution rate of PRX (p = 0.04 and 0.01, respectively), while temperature and duration of the curing process were not significant effects (p = 0.10 and 0.17, respectively). Based on the results, a fast dissolution rate and burst release of PRX was obtained from capsules formulated by PRX/PEG 8000 (1:3 weight ratio) as a solid dispersion compared to the physical mixture and free drug. Furthermore, this capsule was in the acceptance range for the labeled amount, weight variation and disintegration time.Conclusion: PRX/PEG melted solid dispersion capsule may be a suitable immediate release drug delivery system with improved dissolution rate and increased drug absorption.Keywords: Capsules, Solid dispersion, Piroxicam, Polyethylene glycol, Fast release, Full factorial design

Optimization study of polyethylene glycol and solvent system for gas permeation membranes

Cellulose acetate (CA) membranes blended with Polyethylene glycol (PEG) in acetone–water solvent system were synthesized by using solution-casting method that resulted in the formation of flexible, white membranes. Different molecular weight (MW) grades of PEG (including MW 1000, 10,000 and 20,000 g/mol) were used. Cast membranes were tested for tensile strength and permeability at different loading of PEG MW 10,000 and 20,000 g/mol. Excellent flexible membranes were produced in acetone–water solvent system in the presence of PEG, which were otherwise brittle. Surface structure and morphology were analysed using scanning electron microscopy. The presence of different functional groups was confirmed using Fourier transform infra-red spectroscopy and the mechanical characteristics were studied by tensile testing. The introduction of PEG caused an increase in permeability of the membranes. The increase in permeability is due to the opening up of pores as the membrane becomes more flexible, when the plasticizer is added. The permeability continues to increase with the addition of PEG. Moreover, the resulting membranes are not only more flexible, but also have largely improved tensile strength as compared to the CA membranes without PEG. This improved tensile strength can also be attributed to the improved flexibility of the membrane. A trade-off is reached between tensile strength and permeability as increasing amount of PEG improves tensile strength but the resulting membrane becomes too permeable to be used for gas separation. Moreover, using PEG of higher MW resulted in porous membranes, even at low amounts of PEG. Therefore, we concluded that CA membrane with less amount of low-MW PEG (i.e. 5% PEG of MW 1000 g/mol) must be used to optimize both permeability and tensile strength of the membrane.

Study on Dispersion Stability of SiC Slurry and Its Membrane Properties

Silicon carbide (SiC) slurry with a low concentration was prepared, which was milled for 3 hours by mixing SiC powder with a certain amount of polyethylene glycol (PEG), tetramethyl ammonium hydroxide (TMAH), carboxymethyl cellulose sodium (CMC-Na), distilled water, and ethonal. The influence of the pH value on the Zeta potential and the additional components on the dispersion stability of the slurry were analyzed. The influence of various factors on slurry was studied by orthogonal experiment. The results showed that solid content had the greatest influence on viscosity and stability of slurry. After the slurry was coated on the surface of porous SiC ceramics and sintered at high temperature to form a SiC membrane, the micro-structure of SiC membrane and its pore size were characterized. The result showed that the pore size distribution of SiC membrane was narrow, and the average pore diameter was about 1µm. Meanwhile, the resultant grains tend to be round, uniform, single phase. Based on the above, we could know that the slurry has a good membrane-forming properties.

Citric acid crosslinked carboxymethylcellulose-poly(ethylene glycol) hydrogel films for delivery of poorly soluble drugs

In present work, carboxymethylcellulose (CMC) - polyethylene glycol (PEG) hydrogel films were prepared using citric acid as a non-toxic crosslinking agent, for the controlled delivery of model hydrophobic drug (ketoconazole). The carboxyl content of the hydrogel films were determined by acid-base titration. The films were characterized by solid state 13C NMR, ATR-FTIR, TGA and DSC, and evaluated for swelling behavior, drug loading, drug release, hemocompatibility, in vitro cytotoxicity and implantation test. An increase in the amount of PEG caused increase in the carboxyl content and swellability of the hydrogel films. The solid state 13C NMR, ATR-FTIR and thermal analysis confirmed the formation of ester crosslinks in between CMC and PEG in the hydrogel films. The release of KTZ was found to be retarded due to presence of grafted PEG in the hydrogel films. The hydrogel films exhibited excellent hemocompatibility and cytocompatibility. Implantation test revealed that the hydrogel films caused minimum inflammation. From the overall results, citric acid crosslinked CMC-PEG hydrogel films were found to be suitable for enhanced loading and controlled release of the poorly soluble drugs.

Novel superhydrophilic and hydrophobic nanostructured agar-like zirconia thin films: manipulating of morphology with PEG/CTAB

In this paper, a thorough study is dedicated to the manipulating of nanostructured zirconia thin films prepared by a sol–gel process with the focus on the wetting properties. It is observed that by engineering the amount of cetyltrimethylammonium bromide [[N(CH3)3] Br] (CTAB) and polyethylene glycol (PEG) in zirconium chloride precursor solution, the novel agar-like morphology with random orientation can be grown. Different morphologies are observed by changing the amount of PEG in the solution. All the prepared samples in this method show tetragonal phase after annealing at 500 °C for 1 h. The crystallite sizes have a direct correlation with the ratio of lattice parameters. The optical band gap is estimated by Kubelka–Munk method. Modified ZrO2 thin films at an optimum ratio of PEG to CTAB annealed at 500 °C and present water contact angle lower than 3° (without UV illumination) which indicates their superhydrophilic properties. The analytical results of SEM images of samples annealed at 500 °C are also reported. Spreading and wicking of liquid through the nanochannels which are formed in the vacant spaces between nanorods lead to superior wetting property. Annealing temperature also strongly affects the wettability of agar-like zirconia thin films. Agar-like ZrO2 thin films are obtained with superhydrophilic behavior by annealing at 500 °C. Similar agar-like morphology is also observed with hydrophobic character by annealing at 200 °C. The introduced preparation method in this paper provides an easy route to fabricate superhydrophilic agar-like ZrO2 thin films without further processing.

Use of polyethylene glycol to improve the utilisation of leguminous leaf meals in pigs: A review

The use of leguminous leaf meal as feed ingredients for pigs needs to be intensified and improved. Leguminous trees and shrubs are valuable sources of protein, amino acids, and dietary fibre for pigs. Leguminous leaf meals are abundant in the tropical regions and their use as alternate protein-rich feed ingredients for pigs is promising. In tropics, climate change and vegetation management practices have certainly increased the availability of shrub legumes compared to grasses. There is, therefore, a need to resort on harnessing abundant and cheap feed resources to cope with environmental changes and rise of feed prices. Leguminous leaf meals are invaluable feed ingredients for pigs because of their relatively high crude protein and they are highly available. The leguminous leaves also thrive in, and tolerate, adverse climatic and soil conditions. However, their utilisation is limited by presence of polyphenolic compounds, particularly condensed tannins that inhibit their efficient use by pigs. Other challenges for the utilisation of legume-based leaf meal diets are the presence of thorns and high fibre content. If leguminous leaf meals are included in the diet beyond optimum levels, polyphenolic compounds can suppress appetite, promote feed refusal, reduce digestibility, and can induce toxicity in pigs. This warrants investigation on the use of tannin-binding agents (TBA) to improve nutrient utilisation of leguminous leaf meal-containing diets fed to pigs. The inclusion level of polyethylene glycol (PEG) in livestock diets has a huge potential to neutralise negative effects of undesirable polyphenolic compounds. Therefore, the current review aimed to assess the potential of PEG to inactivate tannin and amount of PEG to include for optimum pig performance.Keywords: Leguminous leaf meals, performance, pigs, polyethylene glycol, polyphenolic compounds

Surface Tension of Aqueous Amoxicillin + Peg Systems

This work presents a study on the interfacial activity of amoxicillin in aqueous systems containing polyethylene glycol (PEG). The results showed that aqueous systems containing different amounts of PEG and amoxicillin reach promptly the chemical equilibrium, displaying a small variation in surface tension over the time. However, the PEG concentration increasing causes a surface tension reduction, which indicates increasing the surface-active component amount on the interface. It was not identified the occurrence of critical micelle concentration for the amoxicillin within the concentration range of this study. Data must be useful for design and operation of processes involving the amoxicillin extraction in two phase aqueous systems containing polyethylene glycol.

Preparation and characterization of modified polyphenylsulfone membranes with hydrophilic property for filtration of aqueous media

In the present research, the low water flux of polyphenylsulfone membranes was addressed, and a novel improvement in their water permeation and fouling resistance was achieved using polyethylene glycol (PEG) as the hydrophilic additive. Scanning electron microscopy and field emission scanning electron microscopy, atomic force microscopy, attenuated total reflection Fourier‐transform infrared spectroscopy, thermogravimetric analysis, and tensile test were applied for the investigation of membrane morphology, surface topography, surface chemical structure, thermal stability, and mechanical properties, respectively. Moreover, the relative hydrophilicity/hydrophobicity of the membranes was assessed via determination of membrane water uptake capacity and water contact angle. The membrane performance was studied and compared by determination of pure water flux and filtration of canned beans production wastewater as well as bovine serum albumin solution. The filtration results indicated a remarkable pure water flux and 100% turbidity rejection provided by the polyphenylsulfone/PEG 20 000 membrane. In addition, it was confirmed that the amount of residual PEG within the membrane was increased with increasing PEG molecular weight and concentration.

Fabrication of Mesoporous Titania Nanoparticles with Controlled Porosity and Connectivity for Studying the Photovoltaic Properties in Perovskite Solar Cells

AbstractMesoporous titania (TiO2) nanoparticles (NPs) were synthesized by treating prehydrolyzed titanium precursors with polyethylene glycol (PEG). By varying the amount of PEG, their different physical properties were tuned appropriately in terms of surface area, pore size/volume, and electrical conductivity. By increasing the amount of PEG in TiO2, the surface area and pore volume of mesoporous TiO2 increased, and no direct correlation with the photovoltaic performance of perovskite solar cells was observed. In comparison, the pore size of mesoporous TiO2 first increased greatly before quickly decreasing, and a similar trend was also observed for electrical conductivity. These implied that the interparticle interaction became much stronger with an optimum amount of PEG added to form mesoporous TiO2 NPs. With an optimum molar ratio of PEG/Ti precursor at 0.75, greatly improved conductivity of mesoporous TiO2 NPs with interconnection as compared to that prepared in the absence of PEG, which was used as an electron transport layer, improved the power conversion efficiency of perovskite solar cells by ≈36%. Their greatly reduced photoluminescence after incorporating the perovskite also revealed a difference in the electron‐injection properties from the perovskite into mesoporous TiO2. This strategy highlights a versatile tool to tune mesoporous structures to achieve a cooperative effect for studying photovoltaic properties in perovskite solar cells.

Involvement of Tumor Lymphatic System in Translocation of Intratumorally Injected Liposomes.

The tumor microenvironment is one of the key factors contributing to the efficiency of drug delivery to a tumor. It has been reported that lymphangiogenesis is induced in certain tumors. Because the lymphatic system functions as a drainage one, it is possible that tumor lymphatic vessels alter not only the tumor microenvironment, but also the distribution of drug nanocarriers accumulated in the tumor tissue. Herein, we aimed to elucidate the involvement of the tumor lymphatic system in the translocation of intratumoral liposomes to regional lymph nodes by using vascular endothelial growth factor (VEGF)-C-overexpressing B16F10 tumor-bearing mice (B16/VEGF-C). When the amount of polyethylene glycol (PEG)-modified liposomes in lymph nodes (cervical, brachial, axillary, and inguinal lymph nodes) was measured after the radiolabeled liposomes had been intratumorally injected into B16/VEGF-C-bearing mice or wild-type B16-bearing mice, the accumulation of liposomes in the axillary and inguinal lymph nodes was significantly higher on the tumor-implanted side of B16/VEGF-C-bearing mice than on that of the B16-bearing ones. On the other hand, the accumulation of liposomes in these lymph nodes on the control side (no implantation) of either type of tumor-bearing mice was very low; and no difference could be observed between the 2 sides. Furthermore, the intratumoral distribution of liposomes was observed to be located near the lymphatic vessels. These results indicate that the tumor lymphatic system contributed to the extrusion of a portion of PEG-modified liposomes from the tumor tissue, suggesting that tumor lymphangiogenesis would be one of the key factors to determine the intratumoral distribution of liposomes and their subsequent fate.

FORMULATION DEVELOPMENT AND EVALUATION OF GASTRO-RETENTIVE DOSAGE FORM OF ATAZANAVIR SULPHATE

Objective: To improve dissolution properties of atazanavir sulphate by preparing gastro-retentive granules by solid dispersion method and development of RP-HPLC method for estimation of this drug.Methods: Estimation of atazanavir sulphate was done using high performance liquid chromatography (HPLC) on inertsil column (5 µm, 250x4, 6 mm) with a mobile phase consists of methanol: water (91:9 v/v), at 0.5 ml/min flow rate and 249 nm UV detection. The method was validated as per ICH guidelines. Selection of the carrier for gastro-retentive formulation was based on phase solubility study of the drug. Solid dispersions of gastro-retentive granules of different composition of drug and carrier, were prepared by the kneading, heating and solvent evaporation. A 32factorial design was applied to optimize the gastro-retentive formulation. The amounts of polyethylene glycol 6000 (PEG 6000) (X1) and hydroxypropyl methyl cellulose (HPMC) (X2) were selected as independent variables and in vitro-release at 5, 9 h and total floating time was selected as dependent variables. Results: HPLC method was found to be linear in a concentration range of 10-60 μg/ml of the drug (r2= 0.999). The low value of % RSD in precision study indicates reproducibility of the method. The low value of LOD and LOQ suggests the sensitivity of the method. The solubility enhancement study of drug with various carriers followed descending order of solubility [Gelucire 44/14&gt;PEG 6000&gt;polyvinyl pyrrilidone (PVP)]. Highest % cumulative release was observed for the heating method at drug polymer (PEG 6000) ratio 1:5. Hence, this ratio has been selected for preparation of solid dispersion. From comparison of dissolution profile of formulated batches, formulation F4 [containing PEG6000 (1.6 g) and HPMC (200 mg)] showed promising dissolution parameters with desired floating properties.Conclusion: Results obtained by validation studies suggested that the developed HPLC method is simple, accurate, precise and can be used for routine analysis of atazanavir sulphate formulation. Results of evaluation of prepared batches indicate that batch F4 is a promising formulation for gastro-retentive dosage form of drug.

Parametric Study of the Effect of the Suspension Composition on the Electrophoretic Deposition of Alumina

Electrophoretic deposition (EDP) is gaining increasing attention both in science and industry because this method has allowed the formation of thin films or multilayer films of controlled thickness and morphology. The method enables the formation of films on substrates of complex geometry that suits for various applications.&#x0D; This work is a study the effect of polyethylene glycol as a binder-suspension agent, the amount the solid loading (alumina particles), and the effect of the toluene as a dielectric liquid, on the pH of suspension, the final thickness and green density of the deposed parts.&#x0D; It has been shown that a certain amount of polyethylene glycol when added to ethanol or ethanol-30%toluene has given good results for both the green density and the thickness.

Modulatory effect of high molecular weight polyethylene glycols on drug release from ibuprofen matrix tablets

The work aim at investigating the channeling or modulatory effects of polyethylene glycol (PEG) (MW 4000 and 6000) on drug release from ibuprofen sustained release formulation. Different batches of ibuprofen matrix granules and tablet were prepared by melt granulation using different concentrations of carnauba wax and PEG at different ratios. The granule flow properties and various tablets parameters were evaluated using standard procedures. Drug release kinetics and mechanisms from the tablets were investigated as well as DSC and FTIR drug-excipients compatibility. The granules showed increasingly close packing with increase in the amounts of PEG incorporated. All the tablets did not meet compendial specifications with regard to crushing strength and friability. The release rate and extent of release were found to be influenced by the amount of PEG used as well as the carnauba wax concentration. PEG combination of equal amounts produced the highest release of 91 % in the formulation prepared with 12.20 %w/w of carnauba wax while a 1:2 combination in tablets prepared with 24.40 %w/w of carnauba wax gave a maximum drug release of 83 %. Drug release kinetic and mechanism were most consistent with the Higuchi model hence the release was diffusion mediated. DSC and FTIR studies showed no interactions between ibuprofen and the excipients. Carnauba wax-PEG system can be used successfully as a matrix former to sustain the release of ibuprofen for over 6 h. The studies indicate that the proper balance between a matrix former and a channeling agent can produce a desired drug dissolution profile.Keywords: carnauba wax, PEG, granulation, release modifier, ibuprofen, tablets

Synthesis of Al2O3 with tunable pore size for efficient formaldehyde oxidation degradation performance

Alumina aerogel is of great interest for many potential applications because of high surface areas, intrinsic acid, and excellent mechanical properties. Different particle and pore size distribution can show superior performance in some applications, and therefore, the realization of the regulation of alumina particle and pore size has important industrialization significance. Herein, we demonstrate a simple method to prepare alumina aerogels with high surface areas and tunable pore size using sol–gel method with adding polyethylene glycol (PEG). And PEG is used as not only complexing agent to change the size of alumina aerogel particles and enhance the three-dimensional interconnected network structure, but also phase separation agent to promote the formation of macroporous. By changing the molecular mass of PEG and the amount of PEG of the same molecular mass, tunable pore size can be easily achieved. Owing to their high surface area and the three-dimensional network structure for promoting the transport of material into mesoporous where reactions take place, Al2O3 with centered pore size distribution was demonstrated to have excellent catalytic performance. In particular, the prepared Al2O3 adding 0.03 molar ratio of PEG-8000 exhibits the excellent catalytic activity for formaldehyde.