Alternative Systems Of Medicine Research Articles

Ayurvedic Perspective of Abnormal Vaginal Discharge

In the context of wide prevalence and growing incidence of abnormal vaginal discharge throughout the globe and due to the lack of effective and safe therapy in modern science, there is an increasing focus on alternative systems of medicine. Ayurveda is an age-old life science that offers great potential in treating the symptom. The present study was taken up to review the theoretical foundations and empirical evidence of Ayurvedic drugs for this. Apart from consulting the texts in Ayurveda and modern systems, the study got access to internet sources like AYUSH Portal and PubMed, Google Scholar etc. Out of 90 papers identified, forty research papers were selected for review on various aspects of AVD, such as observational studies, clinical studies, review studies. They are reviewed for theoretical background, research techniques adopted, the drugs and methods employed for treatment and the parameters chosen for evaluation of the effects of these drugs. The results show that Ayurveda has both theoretical foundations and empirical evidence of efficacy of Ayurvedic drugs and shows the promise of evolving a polyherbal formulation to address the symptom holistically.

Phytochemical Composition, In Vitro Antioxidant, and Anticancer Activities of Cold Pressed Oil from Sesame (Sesamum indicum L.) from the Kingdom of Saudi Arabia

Sesame seed oil (SSO) has long been used in many complementary and alternative medicine systems to treat a variety of maladies and ailments. SSO was obtained by cold pressing Sesamum indicum L. (sesame) seeds. Sesamum indicum L. (sesame) oil’s chemical constituents identified with GC-MS. Using the DDPH and MTT assays, respectively, the antioxidant and anticancer activities were investigated. phytosterols, (β-sitosterol, Campesterol, and Stigmasterol), lignans such as sesamin, fatty acids such as Oleic Acid, Esters of fatty acid, such as Hexadecanoic acid, methyl ester, Linoleic acid ethyl ester, flavonoids such as 3′,4′,7Trimethylquercetin, 6,8-di-c-a-glucosylluteolin, the carboxylic ester glycidyl oleate, alcoholic compounds, 1-heptatriacotanol, were the active chemical compounds detected in Sesamum indicum L. (sesame) oil. SSO has a high tocopherol profile. SSO showed antioxidant properties with DDPH radical scavenging of 63.1% relative to standard beta hydroxyl butyrate (BHT). The anticancer effects of SSO against Ovarian carcinoma (A-2780) cell line with IC50 = 1.68 ± 0.3 μg/mL. Sesamum indicum L. (sesame) oil’s chemical constituents identified with GC-MS showed antioxidant and anticancer properties.

RECENT ADVANCES IN NANOTECHNOLOGY - BASED DRUG DELIVERY SYSTEMS FOR DELIVERY OF PHYTOCONSTITUENTS WITH SPECIAL EMPHASIS ON PSORIASIS MANAGEMENT

Psoriasis is an inflammatory, autoimmune disorder characterized by thick and silvery lesions of the skin. Beyond its physical dimension, this disease has a significant adverse effect on quality of life and represents a huge social health burden. Based on symptoms, psoriasis may be characterized from mild to severe. A range of therapeutic agents are available to treat the disease, but none is able to provide permanent cure of the disease. The most commonly used medicines for treatment of psoriasis include anti-inflammatory drugs, steroids, biological and immunosuppressants. Though these drugs cure the disease to an extent, they are associated with many contra-indicative manifestations. Hence, an alternative system of medicine could be an excellent approach in the management of this disease, and numerous studies proved that bio-actives derived from natural sources have potential anti-psoriatic activity. Further, the therapeutic actions of these natural products can be enhanced by incorporating them in nano-formulations. The present era of medicine is focusing on implementation of natural product based nanotechnology to overcome the drawbacks of conventional treatment. This review primarily aims to focus on the recent advances in the field of natural product based nanomedicines for the effective management of psoriasis.

IJCM_124A: A cross sectional study to assess the prevalence, pattern and predictors of complementary and alternative medicine use among non – communicable disease patients in the urban field practise area of a Government Medical College, Bengaluru

Background: In the current century, a significant challenge is addressing the escalating global burden of Non-Communicable Diseases. Integrating Alternative and Complementary Medicine into the existing healthcare system is a major initiative to combat this issue. Despite increased access to free healthcare facilities, heightened disease awareness, and widespread exposure through electronic and print media, the popularity of unprescribed alternative medicine persists in India. Objectives: To assess the Prevalence, Patterns, and Predictors of Complementary and Alternative Medicine use among non-communicable disease patients in the urban field practice area of Bangalore Medical College and Research Institute, Bengaluru. Methodology: A cross-sectional study conducted among non-communicable disease patients residing in the urban field practice area of Bangalore Medical College and Research Institute, Bengaluru. A sample size of 250 was determined based on a pilot study and systematic random sampling used for participant recruitment. Data collection utilized a pre-tested structured questionnaire. Data analysed using SPSS 21.0 Results: Among the 250 participants, 55 (22%) used both Allopathic and Alternative medicines, only 11 (20%) exclusively relying on Alternative systems. Ayurveda was the most utilized alternative medicine 15(27.2%), followed by Sidda 8(14.5%). Statistically significant associations were observed between the usage of Alternative medicine and patients’ religion and education. Conclusion: A relatively small percentage of adults exclusively used Alternative systems of medicine in this study. Ayurveda emerged as the predominant alternative medicine, followed by Sidda. The prevalence of alternative medicine was higher among Hindus and participants with education below the primary level. These findings shed light on the complex dynamics of healthcare.

Rural-urban disparity in cancer burden and care: findings from an Indian cancer registry

BackgroundCancer incidence and mortality vary across the globe, with nearly two-thirds of cancer-related deaths occurring in low- and middle-income countries. The rural-urban disparity in socio-demographic, behavioural, and lifestyle-related factors, as well as in access to cancer care, is one of the contributing factors. Population-based cancer registries serve as a measure for understanding the burden of cancer. We aimed to evaluate the rural-urban disparity in cancer burden and care of patients registered by an Indian population-based cancer registry.MethodsThis study collected data from Varanasi, Uttar Pradesh, India, between 2017 and 2019. Sex and site-specific age-standardised rates for incidence and mortality per 100,000 population were calculated. Rural-urban disparities in cancer incidence and mortality were estimated through rate differences and standardised rate ratios (with 95% confidence intervals). Univariable and multivariable regressions were applied to determine any significant differences in socio-demographic and cancer-related variables according to place of residence (rural/urban). Crude and adjusted odds ratios with 95% confidence intervals were calculated.Results6721 cancer patients were registered during the study duration. Urban patients were older and had better literacy and socioeconomic levels, while rural patients had higher odds of having unskilled or semi-skilled professions. Diagnostic and clinical confirmation for cancer was significantly higher in urban patients, while verbal autopsy-based confirmation was higher in rural patients. Rural patients were more likely to receive palliative or alternative systems of medicine, and urban patients had higher chances of treatment completion. Significantly higher incidence and mortality were observed for oral cancer among urban men and for cervical cancer among rural women. Despite the higher incidence of breast cancer in urban women, significantly higher mortality was observed in rural women.ConclusionsLow- and middle-income countries are facing dual challenges for cancer control and prevention. Their urban populations experience unhealthy lifestyles, while their rural populations lack healthcare accessibility. The distinctness in cancer burden and pattern calls for a re-evaluation of cancer control strategies that are tailor-made with an understanding of urban-rural disparities. Context-specific interventional programmes targeting risk-factor modifications, cancer awareness, early detection, and accessibility to diagnosis and care are essential.

Complementary and alternative system of medicine for type 2 diabetes mellitus and its complications: A scoping review

Background This review aims to map the evidence on the effectiveness of Complementary and Alternative Medicine (CAM) for Type 2 Diabetes Mellitus (T2DM) and its associated complications and identify research gaps in key outcomes and CAMs. Methods Our scoping review was informed by Johanna Briggs Institute guidelines. We searched electronic databases from inception to March 2020 and references of included studies. The experimental and non-randomized studies with intervention and control arm were mapped based on the effectiveness of various CAM (Yoga, Ayurveda, Homeopathy, Siddha, Naturopathy, Unani, and Sowa-rigpa) on outcomes among individuals with prediabetes or metabolic syndrome, and T2DM. Results A total of 249 studies were included after screening 3798 citations. Most of the included studies were conducted in India (30.52 %) and Iran (28.51 %). Of the 249 studies, 21 were efficacy, feasibility or pilot interventional studies. Most frequently studied CAM interventions include Ayurveda, and herbal products (58.63 %) followed by Yoga (20.88%). Unani medicines (n = 2 studies), Sowa-Rigpa (n = 1) and Homeopathy (n = 1) were the least studied modalities. With regards to population, 15 studies recruited newly diagnosed T2DM and 59 studies had included T2DM with comorbidity. Sixteen studies included population with mean ages 45-years or younger. Twenty-eight studies included pre-diabetic or metabolic syndrome, 46 studies included T2DM with no oral glycemic drugs, and 116 included T2DM with oral drugs. Blood sugars (fasting and postprandial) were the most measured outcomes. Outcomes such as HbA1c, lipid profiles, anthropometric measures, adverse effects were also assessed. Among complications, ulcer healing in diabetic foot ulcers was a commonly reported. Conclusion Future investments for research in CAM may focus on assessing the quality of existing trials and finding out an optimal dose, frequency, and duration of CAM that is beneficial, both as an alternative and complementary approach (or not) by carrying out a systematic review.

Investigation of The Effect of Metal-based Medicine Arsenicum album on Humoral Immune Response in SRBC-immunized Mice.

In complementary and alternative medicinal systems, the Arsenicum album in ultra-high dilution was used in various therapeutic conditions, considering its effects on the body's immune system, including the COVID-19 pandemic. However, scientific evidence regarding its immunomodulatory effects is insufficient. The current study aimed to investigate the immunomodulatory effects of Arsenicum album in an experimental mouse model. Immunomodulatory activity of potentized dilutions of Arsenicum album i.e., 6C, 30C, 200C in BALB/c mice was evaluated by humoral antibody titer and delayed- type hypersensitivity assays wherein a fixed concentration (0.5 ml of 1× 109 cells/ml) of freshly prepared sheep RBC was administered as a foreign antigen to generate primary and secondary antibodies. Arsenicum album showed significant immunomodulatory activity by increasing primary antibody titer evaluated on day 21 of the treatment in all the dilutions as compared to SRBC and vehicle control group in humoral immune response assay without showing any effect on delayed-type hypersensitivity. The results of this preliminary study indicate that oral administration of Arsenicum album has the potential to augment primary humoral response at all dilutions. Hence, the possibility of using the Arsenicum album could be explored to treat immunological conditions, infections, etc., as an alternative therapy alongwith modern medicines.

Pharmacological Investigation of Anticonvulsant Effect of Artemisia Vulgaris on Pentylenetetrazole-Induced Epileptic Seizures in Zebrafish Experimental Model

Background:: Epilepsy is the most common neurological disorder, characterized by abnormal, unpredictable, and recurrent seizures. In the alternative medicine system, Artemisia vulgaris has been used to treat epileptic symptoms since its inception. However, scientific evidence concerning its effect on the treatment of epileptic seizures is not available. Objective:: The objective of the study is to evaluate the anti-convulsant potential of Artemisia vulgaris in zebrafish experimental models. Methods:: Zebrafish larvae and adult zebrafish were used as experimental models. Briefly, larvae and adult zebrafish were exposed to 0.5% of the test medicine Artemisia vulgaris mother tincture (ϕ) and its potencies (6CH, 30CH), and valproic acid for 1 hour. After 1 hour of exposure, they were exposed to pentylenetetrazole to record different seizure scores from 1 to 5 using ANY maze video tracking software. Results:: Artemisia vulgaris 30CH in zebrafish larvae and Artemisia vulgaris 6CH and 30CH in adult zebrafish delayed the latency score from score 1 to score 5 and were found effective against PTZinduced locomotor activity and seizure duration and intensity. Conclusion:: In conclusion, Artemisia vulgaris (6CH and 30CH) has the potential to be a novel treatment for symptomatic epileptic seizures and could be a potential alternative drug candidate for symptomatic treatment of epilepsy.

Ayurvedic management of Alcohol Use Disorder

Substance use disorders are chronic relapsing disorders, leading to significant impairment in psychosocial functioning. Nicotine and alcohol are most widely consumed psychotropic drugs worldwide. The common use of both increases the risk of noncommunicable diseases to many folds. Conventional therapies have not been able to alter the outcome of these disorders significantly and frequent relapses continue to occur. Hence there is a need to look at complementary and alternate systems of medicine. Ayurveda remains one of the most ancient and yet living traditions practiced widely in India and has a sound philosophical and experiential basis. The planning of an effective adequate management of alcohol use disorder in Ayurveda with the aid of Ahara, Vihara, Achara and Aushadhi depends upon the strength of the disease (Roga) and the stamina of the patient (Rogi). Here is an attempt made to explain a case study of alcohol use disorder with holistic Ayurvedic management.

Prevalence and correlates of multimorbidity among patients attending AYUSH primary care settings in Delhi-National Capital Region, India

IntroductionIndia has a multifaceted healthcare system and recognizes complementary and alternative systems of medicine (AYUSH) that cater to the healthcare needs of people. Multimorbidity requires frequent visits to physicians and long-term use of medications, due to which people tend to prefer AYUSH systems as they provide holistic patient-centered treatment. Hence, we aimed to estimate the prevalence of multimorbidity and assess its correlates among patients attending AYUSH primary care clinics in Delhi.MethodsA cross-sectional study was conducted among 943 patients aged ≥ 18 years attending various AYUSH primary care clinics in Delhi from September 2021 to February 2022, employing a stratified random sampling technique. Descriptive statistics such as frequency and proportion were used to report the prevalence of multimorbidity (two or more chronic conditions in an individual out of the 33 conditions listed as per the Multimorbidity Assessment Questionnaire for Primary Care). A multivariable logistic regression assessed the association between various socio-demographic characteristics and multimorbidity, presented as an adjusted odds ratio (AOR) with a 95% confidence interval (CI).ResultsThe prevalence of diabetes (14.7%) was found to be the highest (out of all included chronic conditions) among the patients attending various AYUSH primary care settings. The overall prevalence of multimorbidity was observed to be around 39.4%. We observed a higher likelihood of having multimorbidity among participants aged ≥ 70 years [AOR: 9.19 (95% CI: 3.75–22.54)], females [AOR: 1.57 (95% CI: 1.04–2.37)], and middle class [AOR: 2.23 (95% CI: 1.45–3.43)].ConclusionMultimorbidity was evidently prevalent across AYUSH primary care settings, which cannot be overlooked. The results suggest behavioral change communication may be aimed at older individuals, females, and the middle class.

Complementary and alternative system of medicine for type 2 diabetes mellitus and its complications: A scoping review

Background This review aims to map the evidence on the effectiveness of Complementary and Alternative Medicine (CAM) for Type 2 Diabetes Mellitus (T2DM) and its associated complications and identify research gaps in key outcomes and CAMs. Methods Our scoping review was informed by Johanna Briggs Institute guidelines. We searched electronic databases from inception to March 2020 and references of included studies. The experimental and non-randomized studies with intervention and control arm were mapped based on the effectiveness of various CAM (Yoga, Ayurveda, Homeopathy, Siddha, Naturopathy, Unani, and Sowa-rigpa) on outcomes among individuals with prediabetes or metabolic syndrome, and T2DM. Results A total of 249 studies were included after screening 3798 citations. Most of the included studies were conducted in India and Iran. Of the 249 studies, 21 were efficacy, feasibility or pilot interventional studies. Most frequently studied CAM interventions include Ayurveda, and herbal products (58.63 %) followed by Yoga (20.88%). Unani medicines (n = 2 studies), Sowa-Rigpa (n = 1) and Homeopathy (n = 1) were the least studied modalities. With regards to population, 15 studies recruited newly diagnosed T2DM and 59 studies had included T2DM with comorbidity. Sixteen studies included population with mean ages 45-years or younger. Twenty-eight studies included pre-diabetic or metabolic syndrome, 46 studies included T2DM with no oral glycemic drugs, and 116 included T2DM with oral drugs. Blood sugars (fasting and postprandial) were the most measured outcomes. Outcomes such as HbA1c, lipid profiles, anthropometric measures, adverse effects were also assessed. Among complications, ulcer healing in diabetic foot ulcers was a commonly reported. Conclusion Future investments for research in CAM may focus on assessing the quality of existing trials and finding out an optimal dose, frequency, and duration of CAM, both as an alternative and complementary approach.

Health-Seeking Behaviour and the use of Artificial Intelligence-based Healthcare Chatbots among Indian Patients

Artificial Intelligence (AI) based healthcare chatbots can scale up healthcare services in terms of diagnosis and treatment. However, the use of such chatbots may differ among the Indian population. This study investigates the influence of health-seeking behaviour and the availability of traditional, complementary and alternative medicine systems on healthcare chatbots. A quantitative study using a survey technique collects data from the Indian population. Items measuring the awareness of chatbot’s attributes and services, trust in the chatbots, health-seeking behaviour, traditional, complementary and alternative medicine, and use of chatbots are adapted from previous scales. A convenience sample is used to collect the data from the urban population. 397 samples were fetched, and statistical analysis was done. Awareness of the chatbot’s attributes and services impacted the trust in the chatbots. Health-seeking behaviour positively impacted the use of chatbots and enhanced the impact of trust of a chatbot on the use of a chatbot. Traditional, complementary and alternative medicine was not included in the chatbot, which negatively impacted the use of chatbots. At the same time, it dampened the impact of trust in chatbots on the use of chatbots. The study was limited to the urban population and a convenience sampling because of the need to use the Internet and a smart device for accessing the chatbots. The results of the study need to be used cautiously. The results can be inferred from the relationships’ existence rather than the impact’s magnitude. The study’s outcome encourages the availability of chatbots due to the health-seeking behaviour of the Indian urban population. The study also highlights the need for creating intelligent agents with knowledge of Traditional, complementary and alternative medicine. The study contributes to the knowledge of using chatbots in the Indian context. When earlier studies focus mainly on the chatbot features or user characteristics in the intention studies, this study looks at the healthcare system and the services unique to India.

Standardisation of Kuvalayaghrta: A Potential Nootropic Supplement

Nootropics are groups of medicines which are known to act as memory enhancers. There is a growing need for such medicines from alternate systems of medicine to prevent or delay memory loss and related disorders. Classical textbooks in Ayurveda describe a group called as Medhya Rasayana, which act as neuro-nutrients. Chathushkuvalaya Rasayana is one such ghee preparation mentioned in Ashtangahrdaya. In it, Kuvalaya, botanically identified in Kerala as Monochoria vaginalis Presl. is the only herbal ingredient. Though Kuvalaya has been considered widely as a memory enhancer, there is scarce published literature regarding standardisation aspects of Kuvalaya ghrta. In this work, we have phytochemically standardized the ingredients of Kuvalayaghrta including its Atomic Absorption spectroscopy, Thin Layer Chromatography (TLC) and High-Performance Thin Layer Chromatography (HPTLC) profiling followed by the preparation of the ghrta(ghee) according to the standard procedure mentioned in Ayurvedic Formulary of India. Kuvalayaghrta was also standardised physicochemically and was found to be safe for internal administration. All the observations obtained in this study can be used for future reference.

The Imperative Need for Research in Ayurveda: Unraveling Ancient Wisdom through Modern Science

Ayurveda, the ancient system of traditional medicine, has been an integral part of various cultures and communities for centuries. With its holistic approach to health and well-being, Ayurveda offers a wealth of ancient wisdom that can potentially address contemporary health challenges. However, to validate and integrate Ayurvedic practices into modern healthcare systems, rigorous scientific research becomes indispensable. Standardization of Ayurvedic treatments is another vital aspect that can be achieved through systematic research. The establishment of standardized procedures ensures consistency in practice across different regions and among practitioners, enhancing the credibility of Ayurveda as a viable alternative or complementary system of medicine. Preserving and documenting Ayurvedic knowledge not only protects the cultural heritage but also enables the transmission of accurate information to future generations of practitioners and researchers. Research in Ayurveda is of utmost importance to unlock the profound potential of this traditional medical system through the lens of modern science. The integration of ancient wisdom and contemporary knowledge will pave the way for a more holistic and inclusive approach to healthcare, benefitting individuals and societies worldwide. This article emphasizes the critical need for research in Ayurveda to bridge the gap between traditional knowledge and modern scientific understanding. By employing modern scientific methods, researchers can validate the efficacy and safety of Ayurvedic treatments and practices, leading to wider acceptance and recognition within the medical community.

Computer Vision Syndrome and Scope of Homoeopathy

The utilization of technology has become a fundamental part of our daily lives. Therefore, regardless of whether one is an adult or a child, there are various motivations for individuals to remain attached to their digital devices. As the utilization of computers and video display terminals in the workplace increases, a growing number of individuals are experiencing symptoms associated with prolonged use of computers. These symptoms encompass visual and eye symptoms, as well as musculoskeletal symptoms, and are collectively referred to as Computer Vision Syndrome (CVS). There are a variety of allopathic treatments available, however, they are limited in their long-term use and associated side effects. Establishing an ergonomically designed work environment is an important factor in reducing the risk of developing CVS symptoms, and alternative treatments may be appropriate depending on the underlying causes of CVS and associated symptoms. Homeopathy is an alternative system of medicine that allow the court to choose the indicated homoeopathic medicine for management of computer vision syndrome. Keywords: Homeopathy, computer vision syndrome (cvs), Digital eyestrain (DES), Video display terminals (VDTs),

Review of the Literature on Usefulness of Homoeopathy in Child and Adolescent Psychiatry

Background: Emotional and behavioural disorders are very common in childhood and adolescence. Homoeopathy is an alternative system of medicine which has a potential role in Child and Adolescent Psychiatry (CAP).
 Objectives: To identify, summarize and disseminate research findings that could assess the role of Homoeopathy in CAP.
 Materials and Methods: Two electronic databases PubMed and Google scholar are searched for publications on childhood behavioural disorders in peer-reviewed, indexed journals. Articles published on Homoeopathy and CAP in the past two decades i.e from 2000 to 2020 are included. An explicit systematic search strategy included web-based key word searches. The collected information has been collated, summarized, and the results are presented in tables and charts according to key themes.
 Results: The research studies varied widely in all aspects such as design, conduct, intervention and outcome reporting. 38 eligible studies are identified on different clinical conditions in CAP. Individual sources of data are critically appraised and findings are discussed in terms of implications for gaps in research.
 Conclusions: There is limited yet convincing evidence for usefulness of Homoeopathy in CAP disorders such as Autism and ADHD. Our review emphasises the paucity of studies in other CAP disorders such as Intellectual disability, Learning disability, Conduct disorder, Childhood depression and Anxiety disorders etc. which is the domain of future research.

AYURVEDIC INSIGHTS: UNDERSTANDING THE PATHOGENESIS AND NATURAL MANAGEMENT OF HYPERTENSION

Hypertension, or high blood pressure, is a prevalent health concern worldwide. As medical advancements con-tinue, alternative systems of medicine like Ayurveda offer valuable insights into understanding and managing this condition. This article provides an in-depth exploration of the intersection between hypertension and Ayur-veda, emphasizing the holistic approach of this ancient healing system. The article begins by elucidating the pathogenesis of hypertension according to Ayurveda's Shat Kriya Kala, which encompasses six stages of disease progression. It delves into how doshic imbalances, particularly Pitta and Vata, accumulate and disrupt the cardi-ovascular system, leading to increased blood pressure. Furthermore, the article offers a comprehensive treatment protocol derived from Ayurvedic principles. Lifestyle modifications, such as regular exercise, balanced routines, stress management, and adequate sleep, play a crucial role in managing hypertension. Dietary recommendations focus on reducing salt intake, incorporating fresh fruits and vegetables, and including healthy fats. Herbal reme-dies like Ashwagandha, Arjuna, and Brahmi, known for their beneficial effects on blood pressure regulation, are discussed. Stress management techniques, including yoga asanas, pranayama, and meditation, are highlighted as effective tools for managing hypertension. Additionally, the article emphasizes the importance of personalized treatment and the role of qualified Ayurvedic practitioners in guiding individuals toward tailored interventions. It also suggests considering therapies like Panchakarma to detoxify the body and restore doshic equilibrium. By embracing Ayurveda's holistic approach, individuals can gain a deeper understanding of hypertension and ex-plore natural methods to restore balance and promote optimal blood pressure levels. Integrating the wisdom of Ayurveda with modern medical knowledge offers a comprehensive and personalized approach to hypertension management, contributing to overall well-being and vitality.

Review of Unimedicine as a Complete System of Alternative Medicine for Physical and Mental Health

This research paper is a compilation of eight different double-blind peer-reviewed original research papers by the author which were published in a reputed journal in past, and this paper integrates all of them into the single unified framework of “Unimedicine”, forming a complete system of alternative medicine for physical and mental health. This paper contains the original text corpus of all those published research papers in a synergistic form without changing the content or meaning, forming the integrated corpus of Unimedicine. This paper is categorized into 4 sections, each section containing two of those eight papers, with duly mentioned reference to each paper. All of those eight research papers which constitute this paper are original intellectual creations of the Author.

Modern Development in Medicinal Plant Cultivation

Over thousands of years, nature has given us better environments for the growth and development of medicinal plants. Plants have been used as medicines since ancient times because people thought they were safe and had benefit. Even now, 80% of the world’s population relies mostly on alternative medicine systems for their primary healthcare needs. Several kinds of secondary metabolites, also known as bioactive plant elements, are found in plants and are what give them their medical value in nature. For the growth of a greater quantity of secondary metabolites from the plants and their by-products, scientific agriculture allows the application of modern technical elements like mutation, polyploidy, and hybridization. Simple approaches are required for the cultivation, gathering, and preservation of medicinal plants in order to maintain their therapeutic potential. Alkaloids, glycosides, tannins, resins, volatile oils, and other bioactive phytochemicals are only a few examples of the phytochemicals that play a major role in the pharmacological actions of medicinal and aromatic plants. The physical environment, including sunshine, temperature, rainfall, and soil type, has a significant impact on the growth and development of medicinal plants as well as the secondary metabolites that result from those processes. The world’s most significant sources of herbal goods are medicinal plants, yet they are vanishing quickly. We stressed the need for sufficient consideration of resource management and conservation techniques for the sustainable use of medicinal plant resources, including in situ and ex situ conservation and growing approaches. We advise applying biotechnological methods (such as tissue culture, micropropagation, synthetic seed technology, and techniques based on molecular markers) to increase production and alter the potency of medicinal plants. The numerous innovations employed in farming methods are described in this article.

Computational analysis of the phytocompounds of Mimusops elengi against spike protein of SARS CoV2 – An Insilico model

The COVID-19 pandemic has been a global health crisis for over three years now, with the virus causing widespread illness and death. The urgent need for safe and effective therapeutic drugs has prompted the exploration of alternative medicine systems such as Ayurveda and Siddha. This study focuses on the potential therapeutic properties of the Ayurvedic plant, Mimusops elengi. In silico techniques were employed to analyze the bioactivity of the plant, including target prediction, gene ontology analysis, OMIM analysis, and molecular docking analysis. The results revealed 36 phytocompounds that interacted with 1431 receptors in the human body, and two compounds - hederagenin and quercetin - showed exceptionally high binding affinities toward their corresponding receptors, IL6 and MMP9. These results provide important insight into the potential therapeutic activity of M. elengi and its compounds in combating COVID-19. However, further research and clinical trials are necessary to validate these findings and develop safe and effective drugs. The study highlights the importance of combining traditional medicine with modern scientific methods to find effective treatments for global health challenges.