Phytochemical Composition, In Vitro Antioxidant, and Anticancer Activities of Cold Pressed Oil from Sesame (Sesamum indicum L.) from the Kingdom of Saudi Arabia

Abstract

Sesame seed oil (SSO) has long been used in many complementary and alternative medicine systems to treat a variety of maladies and ailments. SSO was obtained by cold pressing Sesamum indicum L. (sesame) seeds. Sesamum indicum L. (sesame) oil’s chemical constituents identified with GC-MS. Using the DDPH and MTT assays, respectively, the antioxidant and anticancer activities were investigated. phytosterols, (β-sitosterol, Campesterol, and Stigmasterol), lignans such as sesamin, fatty acids such as Oleic Acid, Esters of fatty acid, such as Hexadecanoic acid, methyl ester, Linoleic acid ethyl ester, flavonoids such as 3′,4′,7Trimethylquercetin, 6,8-di-c-a-glucosylluteolin, the carboxylic ester glycidyl oleate, alcoholic compounds, 1-heptatriacotanol, were the active chemical compounds detected in Sesamum indicum L. (sesame) oil. SSO has a high tocopherol profile. SSO showed antioxidant properties with DDPH radical scavenging of 63.1% relative to standard beta hydroxyl butyrate (BHT). The anticancer effects of SSO against Ovarian carcinoma (A-2780) cell line with IC50 = 1.68 ± 0.3 μg/mL. Sesamum indicum L. (sesame) oil’s chemical constituents identified with GC-MS showed antioxidant and anticancer properties.