Alimentary Lipemia Research Articles

Ethanol and Alimentary Lipemia

Ethanol and Alimentary Lipemia

Effect of alimentary lipaemia on the glycoproteins and the congo red-binding capacity of albumin in healthy and atherosclerotic individuals.

Effect of Alimentary Lipaemia on the Glyco-proteins and the Congo Red-binding Capacity of Albumin in Healthy and Atherosclerotic Individuals

Arterioselerosis with Reference to Blood Coagulation

It is now generally accepted that lipemia has a close relationship to the pathogenesis of arteriosclerosis, and blood coagulation has been reported to be accelerated by alimentary lipemia. But the precise mechanism of this atherogenic factor of lipemia is not yet clarified. In thromboembolic patients and alimentary lipemia hypercoagulability has been reported to be observed frequently. Thus recently the atherogenic factor of lipemia has been discussed with reference to this hypercoagulability induced by lipemia. In this paper the author reported the effect of alimentary lipemia on blood coagulation factors and the effect of experimentally accelerated blood coagulation on the occurrences of atherosclerosis.

Preservation of Dietary Triglycerides in the Secondary Particles of Alimentary Lipemia*

Preservation of Dietary Triglycerides in the Secondary Particles of Alimentary Lipemia*

The Effect of Heparin Pretreatment on Development and Clearing of Alimentary Lipemia

Ten fasting subjects, who received 50 mg. heparin intravenously 30 minutes before ingestion of a high fat meal, responded with an immediate but brief rise in plasma unesterified fatty acid (UFA) levels. The subsequent lipemia was significantly higher than that which developed in a second comparable group of ten subjects who received the same high fat meal but no pretreatment with heparin. The pretreated subjects also showed reduced lipemia-clearing activity following a second dose of heparin administered 3 hours after the meal.

Fibrinolysis and Alimentary Lipaemia in Whites and Bantus; Their Relationship and Response to Intravenous Heparin

Summary and Conclusion1. Diurnal variation in fibrinolysis is marked in the Whites and almost absent in the Bantu. >2. The difference in fibrinolytic activity beween White and Bantu has been confirmed, but was found to decrease over the course of the morning due to diurnal variation in the White subjects.3. The ingestion of butter fat does not inhibit fibrinolysis to any appreciable extent in either White or Bantu.4. The accelerating effect of heparin on fibrinolysis was found to be present in lipaemic plasma, but appears to be distinct from the fat-clearing effect.

Successive Trials of Induced Alimentary Lipemia

Two successive trials of induced alimentary lipemia were made one week apart in twelve normal subjects. The test meal consisted of ice cream containing 100 gm. fat, 90 gm. carbohydrate and 14 gm. protein. As judged by serum triglyceride levels, responses to successive trials of alimentary lipemia were poorly replicated at two and four hours, but rather consistent at six hours. This early variability limits the usefulness of this procedure for evaluating therapy. All subjects showed varying increases in serum triglyceride levels with a peak mean response of 139 per cent over fasting levels at four hours. Fasting serum triglyceride levels were good predictors of peak levels, being significantly correlated. Optical density rose in a similar fashion, being rather highly correlated with serum triglyceride levels at four and six hours. Mean levels of free fatty acids tended to fall initially, then rose slowly to an increase of 48 per cent over fasting levels by the sixth hour. The variability of successive measurements of fasting serum triglycerides is about three times that of serum cholesterol, a point of practical importance when this measurement is used as a predictor of ischemic heart disease or as a gauge of therapy.

HYPERLIPEMIA AND ARTERIOSCLEROSIS.

TURBIDITY of blood plasma, if marked, is abnormal. Even at the peak of alimentary lipemia the plasma of an average healthy person shows no more than a faint to moderate milkiness. Those who are studying transport of fat in blood therefore look for the unusual person, the so-called good producer of chylomicrons. Although grateful to these subjects for supplying material, one cannot fail to become concerned with the consequences of their talent. Is hyperlipemia a benign abnormality, or does it reflect metabolic faults that will shorten life? Can blood vessels be damaged by an excess of circulating fat? More generally, . . .

The effect of atromid on alimentary lipaemia

Summary In all of 7 patients, there was a reduction in alimentary lipaemia induced by a highfat meal after treatment with Atromid. The coagulability of the blood, as measured by the recalcified plasma clotting time, was unaffected by treatment with Atromid but 6 of the 7 subjects were receiving anticoagulant therapy which is known to mask this effect.

Effect of Alimentary Lipemia on the Thromboplastic Activity of Serum

Effect of Alimentary Lipemia on the Thromboplastic Activity of Serum

Gastric Secretion and Alimentary Lipemia in Ischemic Heart Disease

Gastric Secretion and Alimentary Lipemia in Ischemic Heart Disease

Effect of alimentary lipaemia on plasma fibrinolytic activity.

Effect of alimentary lipaemia on plasma fibrinolytic activity.

The Effect of Fasting Lipid Levels on Alimentary Lipemia

The alimentary lipemia following the ingestion of test meals of constant fat, but varying carbohydrate content, was studied in healthy male subjects. Significant changes occurred only in the serum triglycerides, the free fatty acids and in serum turbidity. When fasting triglyceride levels were under 180 mg. per 100 ml., the degree of lipemia was 50 per cent less with the meal high in carbohydrate content. When fasting serum triglyceride levels were elevated, each meal caused a decrease in triglyceride level. It is concluded that the lipemia following a meal is influenced by the fat and carbohydrate constituents and by the fasting triglyceride level when the meal is ingested.

Demonstration of two kinds of fat particles in alimentary lipemia with polyvinylpyrrolidone gradient columns.

Summary1. A gradient column of polyvinylpyrrolidone in 10% saline sharply divides the fat particles of alimentary lipemic plasma into 2 groups. The particles of both groups float in isotonic saline, density 1.006. 2. During alimentary lipemia the 2 groups differ in rates of appearance and disappearance, and in fatty acid composition. Evidence is presented that one group consists of particles from thoracic duct chyle, and that the other group consists of particles originating elsewhere, possibly the liver.

The significance of blood coagulation in atherosclerosis

The effect of the administration of various fats on blood coagulation properties is considered in relation to their degree of saturation. The influence of fats on fibrinolysis is also discussed. The working hypothesis is put forward that changes in both coagulability and fibrinolytic ability during alimentary hyperlipaemia play a part in initiating atherosclerotic processes by disturbing the equilibrium between fibrin formation and lysis at the vessel wall. L'effet de l'administration de diverses graisses plus ou moins saturées, sur la coagulation du sang est étudié. L'influence des graisses sur la fibrinolyse est aussi discutée. Une hypothése de travail est avancée, selon laquelle les modifications de la coagulabilité et de l'activité fibrinolytique qui surviennent au cours de l'hyperlipémie alimentaire jouent un rôle dans la genése de l'athérosclérose en détruisant l'équilibre qui régit la formation et la lyse de la fibrine sur la paroi vasculaire. Die Verabreichung von verschiedenartigen Fetten führt zu einer Aktivierung der Blutgerinnung, wobei jedoch Unterschiede bestehen je nach dem Grad der Sättigung der in den Fetten enthaltenen Fettsäuren. Weiterhin wird der Einfluss der Fette auf die Fibrinolyse diskutiert. Es wird die Arbeitshypothese aufgestellt, dass der durch die Verabreichung von bestimmten Nahrungsfetten bedingten Änderung der Blutgerinnung und fibrinolytischen Aktivität eine Bedeutung in der Pathogenese der Atherosklerose zukommt. Möglicherweise spielen hierbei Störungen im Gleichgewicht zwischen Fibrinbildung und -abbau an der Gefässinnenwand eine Rolle.

Influence of chlortetracycline and neomycin on digestion and absorption of fat in rats.

Effects of chlortetracycline (CTC) and neomycin on the rate of lipolysis and alimentary lipemia in rats, after the introduction of 1 ml of olive oil or a suspension of 1/10 of the ld50 doses of antibiotics in oil, were determined after 1 and 3 hr. Presence of CTC or neomycin did not affect the rate of gastric emptying. A similar finding was obtained concerning the amount of fat left in the intestine after these periods. In the presence of CTC the lipolysis was significantly inhibited after 1 as well as after 3 hr; alimentary lipemia was slowed down in the 1st hr, and after 3 hr a return to normal levels was achieved. Administration of neomycin did not influence the rate of lipolysis, but was followed by a lower level of alimentary lipemia not only after 1 hr but also after 3 hr.

The effect of heparin on alimentary hyperlipemia two-dimensional electrochromatographic study

The effect of heparin injected during the alimentary hyperlipemia was studied by two-dimensional electrochromatography. The clearing effect of heparin was found to be associated with a considerable disappearance of free serum lipids (neutral fats, chylomicrons, and the α 1 ′-lipid fraction). The last two groups of free lipids showed an increase of the electrophoretic mobility. The lipids of the A-lipoprotein fraction showed also a greater electrophoretic mobility. This prealbumin lipid fraction unexpectedly showed a considerably greater chromatographic effect on filter paper than did proteins. Thus, this lipid does not seem to be associated with the corresponding protein fractions (albumins, α 1-globulins), but to be separated from the protein component by the action of heparin. No visible changes of β- and γ-lipoprotein fractions i.e., lipids firmly bound to protein could be found.

On the Effect of Alimentary Lipemia and a Natural Heparinoid on the Fibrinolytic System of Man

On the Effect of Alimentary Lipemia and a Natural Heparinoid on the Fibrinolytic System of Man

On the Effect of Alimentary Lipemia and a Natural Heparinoid on the Fibrinolytic System of Man

The effect of alimentary lipemia and Ateroid on the fibrinolytic system of blood was studied in 12 patients. The plasminogen (profibrinolysin), proactivator and antiplasmin activities were determined by the clot lysis time-method.Lipemia had an inhibiting effect on the fibrinolytic system. This appeared most distinctly in the antiplasmin determinations. In the. In the pre-therapeutic fat load tests the changes in the antiplasmin activity differed statistically significantly from those observed during therapy. Ateroid seemed to protect the organism against the antiplasmin effect of lipemia.The female fibrinolytic system seemed to react more sensitively than the male.The effect of Ateroid on the fibrinolytic system seems to be first and foremost a nor-malising influence: it appears most distincly in exceptional circumstances and is very distinct if the divergence is due to hyperlipemia.

Studies on the Effect of Alimentary Lipemia on Blood Coagulation (III) : Experimental Studies of the Effect of Alimentary Hyperlipemia on Thrombolysis in Vivo.

In this report the effect of alimentary hyperlipemia on thrombolysis was investigated in vivo when fibrinolytic activity was enhanced experimentally by the injection of streptokinase.