The article shows the strategic role of cargo air transport in the economies of the world, related to the maintenance of foreign trade, urgent delivery of goods, their transportation over long distances, and so on. The determining factors of the development of cargo air transport in the global economy are systematized: organizational innovations, information technologies, new forms of cooperation of air carriers and logistics solutions. The contribution of air transport to the formation of cargo turnover in Ukraine is determined. The opposite dynamics of volumes of cargo transportation by air and other types of transport is revealed. The contradiction between the low share of air cargo traffic and their strong absolute and structural growth is quantitatively shown. Air freight is defined by a market of oligopolistic competition due to a limited number of economic entities, the dominance of one large and several medium-sized players, the presence of barriers to entry, which are financial-investment and technical-technological nature. The attractiveness of the air freight market for investments is shown given the predominant positivity of financial results and the growing share of profitable enterprises. The institutional forms of organization of cargo air carriers (classic, combined, hybrid) are generalized, their advantages and disadvantages are defined. The principles of functioning of transport chains and realization of multimodal transportations on the basis of cargo air transport are substantiated. The main information systems of booking and management of air cargo transportation, distribution, pricing, calculations, tracking of luggage by buyers and sellers are characterized. The requirements of the International Air Transport Association for the use of innovative e-freight technologies in aviation are summarized, recommendations for joining the subjects of the domestic air cargo market in terms of electronic document management and simplification of customs procedures are developed. The improvement of economic mechanisms of development of cargo air transport in Ukraine on the basis of special economic zones of port type is offered.