Aid Future Research Research Articles

Green Lean Six Sigma in the food industry: a systematic literature review

PurposeThe current paper aims to discuss the implementation of Green Lean Six Sigma (GLSS) in the food industry to improve sustainable practices. The focus is more specifically on dairy processors to ascertain the current state of the literature and aid future research direction.Design/methodology/approachUtilising a systematic literature review (SLR), the paper addresses various terms and different written forms in the literature. The study characterises the current deployment of GLSS in the food industry and explains the reported benefits of this approach.FindingsGLSS, a concept that has yet to be fully explored in the food industry, as in other sectors, holds significant potential to enhance the food industry’s sustainability practices. The dairy sector, a subsector of the food industry known for its high greenhouse gas emissions, is a prime candidate for the application of GLSS. In instances where it has been applied, GLSS has demonstrated its effectiveness in improving sustainability, reducing waste, lowering greenhouse gas emissions and minimising water usage. However, the specific tools used and the model for GLSS implementation are areas that require further study, as they have the potential to revolutionise food industry operations and reduce their environmental impacts.Practical implicationsBenchmarking of this research by the food industry sector and by academics can aid understanding of the practical application of GLSS tools and aid implementation of these practices to evolve the dairy processing sector in the next decade as sustainability champions in the sector.Originality/valueThis study extensively analyses GLSS in the food industry, with a particular focus on dairy processors.

Panoptic-PartFormer++: A Unified and Decoupled View for Panoptic Part Segmentation.

Panoptic Part Segmentation (PPS) unifies panoptic and part segmentation into one task. Previous works utilize separate approaches to handle things, stuff, and part predictions without shared computation and task association. We aim to unify these tasks at the architectural level, designing the first end-to-end unified framework, Panoptic-PartFormer. Moreover, we find the previous metric PartPQ biases to PQ. To handle both issues, we first design a meta-architecture that decouples part features and things/stuff features, respectively. We model things, stuff, and parts as object queries and directly learn to optimize all three forms of prediction as a unified mask prediction and classification problem. We term our model as Panoptic-PartFormer. Second, we propose a new metric Part-Whole Quality (PWQ), better to measure this task from pixel-region and part-whole perspectives. It also decouples the errors for part segmentation and panoptic segmentation. Third, inspired by Mask2Former, based on our meta-architecture, we propose Panoptic-PartFormer++ and design a new part-whole cross-attention scheme to boost part segmentation qualities further. We design a new part-whole interaction method using masked cross attention. Finally, extensive ablation studies and analysis demonstrate the effectiveness of both Panoptic-PartFormer and Panoptic-PartFormer++. Compared with previous Panoptic-PartFormer, our Panoptic-PartFormer++ achieves 2% PartPQ and 3% PWQ improvements on the Cityscapes PPS dataset and 5% PartPQ on the Pascal Context PPS dataset. On both datasets, Panoptic-PartFormer++ achieves new state-of-the-art results. Our models can serve as a strong baseline and aid future research in PPS. The source code and trained models will be available athttps://github.com/lxtGH/Panoptic-PartFormer.

Progressive Ataxia with Palatal Tremor: A Case Series (P9-11.006)

<h3>Objective:</h3> This case series adds to the limited literature about progressive ataxia with palatal tremor (PAPT) by describing clinical findings and the approach to diagnostic testing in six cases of PAPT. <h3>Background:</h3> PAPT is a rare clinical syndrome characterized by symptomatic palatal tremor and progressive cerebellar ataxia. Imaging typically shows bilateral hypertrophic olivary degeneration (HOD). Though published work based on autopsy cases suggests a novel tauopathy as a possible etiology of sporadic PAPT, the syndrome can arise from a variety of vascular, traumatic, autoimmune, or genetic causes. Despite its many possible underlying etiologies, the published literature provides little guidance on a systematic approach to diagnostic testing. <h3>Design/Methods:</h3> We retrospectively reviewed the charts of patients evaluated at the Ataxia Center at Massachusetts General Hospital between 2010–with clinical findings consistent with PAPT. Data were collected about disease presentation, disease progression, imaging findings and diagnostic testing. <h3>Results:</h3> Six patients with PAPT were identified. Average age of symptom onset was 61, range 54–65. Presenting symptoms were gait imbalance in three, and dysarthria, dysphagia, and throat tremor, respectively, in the rest. All developed palatal tremor (patient 6 with ear clicks), appendicular ataxia, and ataxic eye movements throughout their course. All patients had evidence of bilateral HOD on brain MRI. PAPT was attributed to cavernous malformations in patient 2 and multicompartmental hemorrhage in patient 4. The causes in the remainder are unknown. Diagnostic testing varied. Four patients (inclusive of patients 2 and 4) underwent whole exome sequencing, two underwent cerebrospinal fluid analysis (both non-inflammatory), four had celiac testing, and one was tested broadly for neuronal autoantibodies. <h3>Conclusions:</h3> PAPT is a clinical syndrome with a variety of etiologies. As in our study, literature suggests that diagnostic evaluation often varies. Systematic evaluation is important to find underlying causes and aid future research to better identify and study patients with idiopathic PAPT. <b>Disclosure:</b> Dr. Wruble has nothing to disclose. Dr. Gupta has received personal compensation in the range of $100,000-$499,999 for serving as a Consultant for Biogen. The institution of Dr. Gupta has received research support from Biogen. Dr. Schmahmann has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Medavante. Dr. Schmahmann has stock in Cadent. The institution of Dr. Schmahmann has received research support from National Ataxia Foundation. The institution of Dr. Schmahmann has received research support from Biohaven. Dr. Schmahmann has received intellectual property interests from a discovery or technology relating to health care. Dr. Schmahmann has received publishing royalties from a publication relating to health care. Dr. Schmahmann has received publishing royalties from a publication relating to health care. Dr. Schmahmann has received publishing royalties from a publication relating to health care. The institution of Dr. Balaban has received research support from Biogen.

Bringing light onto the Raunkiæran shortfall: A comprehensive review of traits used in functional animal ecology.

Trait-based approaches elucidate the mechanisms underlying biodiversity response to, or effects on, the environment. Nevertheless, the Raunkiæran shortfall-the dearth of knowledge on species traits and their functionality-presents a challenge in the application of these approaches. We conducted a systematic review to investigate the trends and gaps in trait-based animal ecology in terms of taxonomic resolution, trait selection, ecosystem type, and geographical region. In addition, we suggest a set of crucial steps to guide trait selection and aid future research to conduct within and cross-taxon comparisons. We identified 1655 articles using virtually all animal groups published from 1999 to 2020. Studies were concentrated in vertebrates, terrestrial habitats, the Palearctic realm, and mostly investigated trophic and habitat dimensions. Additionally, they focused on response traits (79.4%) and largely ignored intraspecific variation (94.6%). Almost 36% of the data sets did not provide the rationale behind the selection of morphological traits. The main limitations of trait-based animal ecology were the use of trait averages and a rare inclusion of intraspecific variability. Nearly one-fifth of the studies based only on response traits conclude that trait diversity impacts ecosystem processes or services without justifying the connection between them or measuring them. We propose a guide for standardizing trait collection that includes the following: (i) determining the type of trait and the mechanism linking the trait to the environment, ecosystem, or the correlation between the environment, trait, and ecosystem, (ii) using a "periodic table of niches" to select the appropriate niche dimension to support a mechanistic trait selection, and (iii) selecting the relevant traits for each retained niche dimension. By addressing these gaps, trait-based animal ecology can become more predictive. This implies that future research will likely focus on collaborating to understand how environmental changes impact animals and their capacity to provide ecosystem services and goods.

Mapping the literature on Digital and Technological Solutions in nursing: a scoping review protocol.

Digital and technological solutions (DTS) might have an impact on people's personal and professional lives. These types of solutions, according to studies, have the potential to revolutionize and improve the quality and long-term sustainability of healthcare activities, with nurses playing a significant role. Although DTS appears to be intimately linked to the future of nursing, technology must be utilized as an active rather than passive tool. Nonetheless, understanding DTS appears to be difficult, and a scoping study can provide a thorough overview of such a complicated topic. As a result, the scoping study on this topic will map all of the important aspects of DTS and synthesize studies on the nursing workforce, as well as analyze and clarify knowledge gaps and aid future research and development. This article presents the study protocol. The Joanna Briggs Institute (JBI) scoping review methodology will be used for the proposed scoping review. It will include both quantitative and qualitative scientific research as well as grey literature on DTS in nursing. Only English-language works will be considered for inclusion. Two independent reviewers will take part in an iterative process of evaluating literature, choosing papers, and extracting data. Disagreements among reviewers will be resolved through debate until a consensus is reached or through consultation with the study team if necessary. Results will be presented using descriptive statistics, diagrammatic or tabular displayed information, and narrative summaries, as specified in the JBI guidelines. This scoping review protocol explained why it is important to describe the literature on embracing DTS in the nursing field, how to approach the research process, and what the study's key implications will be. The protocol itself may be helpful to increase transparency in the research process, attract interested researchers to work with the group that developed the protocol and offer a practical methodological benchmark for researchers interested in performing scoping reviews by serving as an example of a scoping review protocol.

Brain Imaging Changes in Patients Recovered From COVID-19: A Narrative Review.

The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has caused several outbreaks of highly contagious respiratory diseases worldwide. The respiratory symptoms of Coronavirus Disease-19 (COVID-19) have been closely monitored and studied, while the central nervous system (CNS) and peripheral system (PNS) lesions induced by COVID-19 have not received much attention. Currently, patients with COVID-19-associated encephalopathy present with dizziness, headache, anxiety and depression, stroke, epileptic seizures, the Guillain-Barre syndrome (GBS), and demyelinating disease. The exact pathologic basis for these neurological symptoms is currently not known. Rapid mutation of the SARS-CoV-2 genome leads to the appearance of SARS-CoV-2 variants of concern (VOCs), which have higher infectivity and virulence. Therefore, this narrative review will focus on the imaging assessment of COVID-19 and its VOC. There has been an increase in technologies, such as [18F]fluorodeoxyglucose positron emission tomography (18F-FDG-PET) and functional magnetic resonance imaging (fMRI), that have been used to observe changes in brain microstructure over time in patients with COVID-19 recovery. Medical imaging and pathological approaches aimed at exploring the associations between COVID-19 and its VOC, with cranial nerve and abnormal nerve discharge will shed light on the rehabilitation process of brain microstructural changes related to SARS-CoV-2, and aid future research in our understanding of the treatment and prognosis of COVID-19 encephalopathy.

Translation of a Brazilian educational booklet concerning hydrocephalus into Spanish as spoken in Spain

PurposeA booklet for children with hydrocephalus and their parents was presented. This study translated the Brazilian version of the booklet “Laura's diary: knowing hydrocephalus and its treatment” into Spanish as spoken in Spain. MethodologyThis methodological study conducted in Spain (Universidad de Santiago de Compostela) and Brazil (Botucatu Medical School) undertook the following translation steps: translation, using two Brazilian translators fluent in Spanish; synthesis, involving a Spanish nurse with experience in education; and back-translation, using a Brazilian translator and nurse fluent in Spanish. FindingsThe two versions of the initial translation were similar, with few amendments necessary during the consensus meeting between the researchers to achieve synthesis of the translations. The two versions of the back-translation were very similar to the original. ConclusionA free Spanish booklet was presented to minimize the negative effects of surgery, empower families, and aid future research between Brazil and Spain. Mismanagement of a disease can affect a child's quality of life. Communication is essential for health education to help ensure greater participation of patients and families in care plans.

Mapping Croplands in the Granary of the Tibetan Plateau Using All Available Landsat Imagery, A Phenology-Based Approach, and Google Earth Engine

The Tibetan Plateau (TP), known as “The Roof of World”, has expansive alpine grasslands and is a hotspot for climate change studies. However, cropland expansion and increasing anthropogenic activities have been poorly documented, let alone the effects of agricultural activities on food security and environmental change in the TP. The existing cropland mapping products do not depict the spatiotemporal characteristics of the TP due to low accuracies and inconsistent cropland distribution, which is affected by complicated topography and impedes our understanding of cropland expansion and its associated environmental impacts. One of the biggest challenges of cropland mapping in the TP is the diverse crop phenology across a wide range of elevations. To decrease the classification errors due to elevational differences in crop phenology, we developed two pixel- and phenology-based algorithms to map croplands using Landsat imagery and the Google Earth Engine platform along the Brahmaputra River and its two tributaries (BRTT) in the Tibet Autonomous Region, also known as the granary of TP, in 2015–2019. Our first phenology-based cropland mapping algorithm (PCM1) used different thresholds of land surface water index (LSWI) by considering varied crop phenology along different elevations. The second algorithm (PCM2) further offsets the phenological discrepancy along elevational gradients by considering the length and peak of the growing season. We found that PCM2 had a higher accuracy with fewer images compared with PCM1. The number of images for PCM2 was 279 less than PCM1, and the Matthews correlation coefficient for PCM2 was 0.036 higher than PCM1. We also found that the cropland area in BRTT was estimated to be 1979 ± 52 km2 in the late 2010s. Croplands were mainly distributed in the BRTT basins with elevations of 3800–4000 m asl. Our phenology-based methods were effective for mapping croplands in mountainous areas. The spatially explicit information on cropland area and distribution in the TP aid future research into the effects of cropland expansion on food security and environmental change in the TP.

A Review of Corporate Purpose: An Approach to Actioning the Sustainable Development Goals (SDGs)

This journal article explores Corporate Purpose as an approach to action the Sustainable Development Goals (SDGs). It achieves this objective by presenting a review of existing literature on Corporate Purpose and SDGs from the disciplines of business ethics, management studies, economics and psychology. The review showcases contributions exploring whether and how Corporate Purpose-led strategy facilitates the operationalization of the SDGs and proposes an emerging research agenda. This article employed an inductive approach methodology through grounded theory to develop a critical analysis of scientific evidence-based work for theory construction on Corporate Purpose. One of the major findings of this review is that to achieve the SDGs companies need to shift found from the “business as usual” approach, which perceives sustainability as an externality, to incorporating sustainability factors in the company’s underlying purpose. The article also (1) identifies trends in research outputs and reveals five major antecedents of the phenomenon (drivers to purpose), (2) identifies key gaps within the existing literature, (3) distinguishes three current approaches to Corporate Purpose and (4) elaborates on current theories of Corporate Purpose and SDGs linkages to identify opportunities and aid future research. In summary, this article unpacks Corporate Purpose mechanisms to action the SDGs and stimulates academic discussion of business transformational approaches to long-standing sustainability challenges.

Conceptualizing Resilience: Impacts of Adverse Stressor Severity, Chronicity, and Relevance

Guidance on frameworks for physical resilience, resistance and reserve are underdeveloped. We examined different “physical resilience” characterizations within n=6,538 Atherosclerosis Risk in Communities Study participants (median age: 75 years), followed for 5+ years. Fifteen illustrative clinical, lifestyle and social stressors, each having varying levels of severity, chronicity and relevance, were paired with six functional outcome measure trajectories. Contrasts were made against four fundamental comparator groups (including those without stressors). Particular pairings of stressors and functional measures substantially impacted resilience classifications and related determinants. For example, 5-year recurring robustness (0/5 frailty indicators) was only 12% for participants after Heart Failure (HF), versus 47% with no HF event; relative-risk: RR=0.26 (95%CI: 0.15,0.44). Conversely, recurring robustness was 43% after reporting low social support versus 51% with adequate support; RR=0.87(0.73,1.02). We highlight major components that impacted resilience determinations and outline a broad conceptual framework to help optimize physical resilience assessment and aid future research. Part of a symposium sponsored by Epidemiology of Aging Interest Group.

Value of the International Classification of Diseases code for identifying children with biliary atresia.

Background Although identifying cases in large administrative databases may aid future research studies, previous reports demonstrated that the use of the International Classification of Diseases, Tenth Revision (ICD-10) code alone for diagnosis leads to disease misclassification.Purpose We aimed to assess the value of the ICD-10 diagnostic code for identifying potential children with biliary atresia.Methods Patients aged <18 years assigned the ICD-10 code of biliary atresia (Q44.2) between January 1996 and December 2016 at a quaternary care teaching hospital were identified. We also reviewed patients with other diagnoses of code-defined cirrhosis to identify more potential cases of biliary atresia. A proposed diagnostic algorithm was used to define ICD-10 code accuracy, sensitivity, and specificity.Results We reviewed the medical records of 155 patients with ICD-10 code Q44.2 and 69 patients with other codes for biliary cirrhosis (K74.4, K74.5, K74.6). The accuracy for identifying definite/probable/possible biliary atresia cases was 80%, while the sensitivity was 88% (95% confidence interval [CI], 82%–93%). Three independent predictors were associated with algorithm-defined definite/probable/possible cases of biliary atresia: ICD-10 code Q44.2 (odds ratio [OR], 2.90; 95% CI, 1.09–7.71), history of pale stool (OR, 2.78; 95% CI, 1.18–6.60), and a presumed diagnosis of biliary atresia prior to referral to our hospital (OR, 17.49; 95% CI, 7.01–43.64). A significant interaction was noted between ICD-10 code Q44.2 and a history of pale stool (P<0.05). The area under the curve was 0.87 (95% CI, 0.84–0.89).Conclusion ICD-10 code Q44.2 has an acceptable value for diagnosing biliary atresia. Incorporating clinical data improves the case identification. The use of this proposed diagnostic algorithm to examine data from administrative databases may facilitate appropriate health care allocation and aid future research investigations.

Translation of a Brazilian educational booklet concerning hydrocephalus into Spanish as spoken in Spain

PurposeA booklet for children with hydrocephalus and their parents was presented. This study translated the Brazilian version of the booklet “Laura's diary: knowing hydrocephalus and its treatment” into Spanish as spoken in Spain. MethodologyThis methodological study conducted in Spain (Universidad de Santiago de Compostela) and Brazil (Botucatu Medical School) undertook the following translation steps: translation, using two Brazilian translators fluent in Spanish; synthesis, involving a Spanish nurse with experience in education; and back-translation, using a Brazilian translator and nurse fluent in Spanish. FindingsThe two versions of the initial translation were similar, with few amendments necessary during the consensus meeting between the researchers to achieve synthesis of the translations. The two versions of the back-translation were very similar to the original. ConclusionA free Spanish booklet was presented to minimize the negative effects of surgery, empower families, and aid future research between Brazil and Spain. Mismanagement of a disease can affect a child's quality of life. Communication is essential for health education to help ensure greater participation of patients and families in care plans.

Patent Aggregation Redefinition and Taxonomy of Its Activities Useful for Competition Law

Patent aggregation, or the monetisation of patents without selling patent-implementing products, is a rising practice in the electrical engineering industry. However, the complexity and distance of this phenomenon from traditional patent exercises prevent a clear assessment of its impact on innovation. On the one hand, patent aggregation may spur innovation by determining efficiencies in licensing or litigation and by conveying liquidity to inventors. On the other hand, patent aggregation might also unduly tax technological developments by enforcing otherwise dormant patents. Since the relationship between patent aggregation and innovation is uncertain, it is unsettled whether EU competition law can remedy anti-innovative patent aggregation instances. Building on existing economics and legal scholarship, this paper contributes to the competition law understanding of patent aggregation providing both a definition and a taxonomy of its identifiable activities. Accordingly, patent aggregation is redefined as any activity where electrical engineering patents, patent applications, or their commercialisations rights, aggregated under common ownership or control through direct prosecution or transfer, are then used for non-manufacturing purposes. As such, patent aggregation activities are divided into two prongs. The first one refers to the means of aggregating patents, whereas the second one comprises the non-manufacturing exploitations of aggregated patents. The crossing of the two prongs of activities determines the taxonomy of patent aggregation. The redefinition and taxonomy aid future research to evaluate the effects of patent aggregation on innovation, and, therefore, its treatment under competition law.

Light-Controlled Fruit Pigmentation and Flavor Volatiles in Tomato and Bell Pepper.

Light is a major environmental factor affecting the regulation of secondary metabolites, such as pigments and flavor. The Solanaceae plant family has diverse patterns of fruit metabolisms that serve as suitable models to understand the molecular basis of its regulation across species. To investigate light-dependent regulation for fruit pigmentation and volatile flavors, major fruit pigments, their biosynthetic gene expression, and volatiles were analyzed in covered fruits of tomato and bell pepper. Immature covered fruits were found to be ivory in color and no chlorophyll was detected in both plants. The total carotenoid content was found to be reduced in ripe tomato and bell pepper under cover. Naringenin chalcone decreased more than 7-fold in ripe tomato and total flavonoids decreased about 10-fold in immature and ripe pepper fruit under light deficiency. Light positively impacts fruit pigmentation in tomato and bell pepper by regulating gene expression in carotenoid and flavonoid biosynthesis, especially phytoene synthase and chalcone synthase, respectively. Nineteen volatile flavors were detected, and seven of these exhibited light-dependent regulations for both ripe tomato and pepper. This study will help in improving fruit quality and aid future research works to understand the molecular mechanisms regulating the influence of light-dependency on pigments and flavor volatiles.

An open-source web service for creating quadrilateral grids based on the rHEALPix Discrete Global Grid System

ABSTRACT The foundation of modern Digital Earth frameworks is the Discrete Global Grid System (DGGS). To standardize the DGGS model, the Open Geospatial Consortium (OGC) recently created the DGGS Specification, which also aims to increase usability and interoperability between DGGSs. To support these demands and aid future research, open implementations are necessary. However, several OGC conformant DGGSs are not available for researchers to use. This has motivated us to develop an open-source web service that allows users to create quadrilateral grids based on the rHEALPix DGGS. In this paper, we describe the implementation of the web service, including issues and limitations, and demonstrate how discrete global grids and regional grids can be created. Lastly, we present examples that show how vector data sets can be modeled and integrated at different levels of resolution – a key benefit of the DGGS model.

A Typology of UK Energy Service Brands Based on Size, Licencing and Source of Energy

The UK’s retail energy market is very dynamic. The number of suppliers is changing with some companies leaving the market and some entering. Having a full picture of the players within the sector may be considered daunting. While acknowledging the limitations in getting a definite list of company, this paper presents a typology of UK Energy Service Brands based on their sizes, licencing arrangement and their source of energy. It is anticipated that this will makes two key contributions to the literature. First, it extends the understanding of energy brands in the United Kingdom and secondly, aid future research and theoretical framework development in the UK energy sector.

Establishing normal values for pediatric nighttime sleep measured by actigraphy: a systematic review and meta-analysis.

Despite the widespread use of actigraphy in pediatric sleep studies, there are currently no age-related normative data. To systematically review the literature, calculate pooled mean estimates of actigraphy-derived pediatric nighttime sleep variables and to examine the magnitude of change with age. A systematic search was performed across eight databases of studies that included at least one actigraphy sleep variable from healthy children aged 0-18 years. Data suitable for meta-analysis were confined to ages 3-18 years with seven actigraphy variables analyzed using random effects meta-analysis and meta-regression performed using age as a covariate. In total, 1334 articles did not meet inclusion criteria; 87 had data suitable for review and 79 were suitable for meta-analysis. Pooled mean estimates for overnight sleep duration declined from 9.68 hours (3-5 years age band) to 8.98, 8.85, 8.05, and 7.4 for age bands 6-8, 9-11, 12-14, and 15-18 years, respectively. For continuous data, the best-fit (R2 = 0.74) equation for hours over the 0-18 years age range was 9.02 - 1.04 × [(age/10)^2 - 0.83]. There was a significant curvilinear association between both sleep onset and offset with age (p < .001). Sleep latency was stable at 19.4 min per night. There were significant differences among the older age groups between weekday and weekend/nonschool days (18 studies). Total sleep time in 15-18 years old was 56 min longer, and sleep onset and offset almost 1 and 2 hours later, respectively, on weekend or nonschool days. These normative values have potential application to assist the interpretation of actigraphy measures from nighttime recordings across the pediatric age range, and aid future research.

PBHMDA: Path-Based Human Microbe-Disease Association Prediction.

With the advance of sequencing technology and microbiology, the microorganisms have been found to be closely related to various important human diseases. The increasing identification of human microbe-disease associations offers important insights into the underlying disease mechanism understanding from the perspective of human microbes, which are greatly helpful for investigating pathogenesis, promoting early diagnosis and improving precision medicine. However, the current knowledge in this domain is still limited and far from complete. Here, we present the computational model of Path-Based Human Microbe-Disease Association prediction (PBHMDA) based on the integration of known microbe-disease associations and the Gaussian interaction profile kernel similarity for microbes and diseases. A special depth-first search algorithm was implemented to traverse all possible paths between microbes and diseases for inferring the most possible disease-related microbes. As a result, PBHMDA obtained a reliable prediction performance with AUCs (The area under ROC curve) of 0.9169 and 0.8767 in the frameworks of both global and local leave-one-out cross validations, respectively. Based on 5-fold cross validation, average AUCs of 0.9082 ± 0.0061 further demonstrated the efficiency of the proposed model. For the case studies of liver cirrhosis, type 1 diabetes, and asthma, 9, 7, and 9 out of predicted microbes in the top 10 have been confirmed by previously published experimental literatures, respectively. We have publicly released the prioritized microbe-disease associations, which may help to select the most potential pairs for further guiding the experimental confirmation. In conclusion, PBHMDA may have potential to boost the discovery of novel microbe-disease associations and aid future research efforts toward microbe involvement in human disease mechanism. The code and data of PBHMDA is freely available at http://www.escience.cn/system/file?fileId=85214.

Do anthropometric measures accurately reflect body composition in preterm infants?

Recent literature suggests that neonatal adiposity is predictive of later metabolic health, while neonatal lean mass is predictive of later cognitive function amongst preterm infants. Anthropometric indices that accurately reflect neonatal body composition could improve clinical care and aid future research, but their validity has not been systematically tested in preterm infants. To determine the weight/length indices that best reflect neonatal body composition in preterm infants. Weight and length were measured, and body composition (fat-free mass (FFM), fat mass (FM) and percent body fat (%BF)) was assessed using air-displacement plethysmography within 72 h of birth in 218 preterm infants. The best weight/length proxy for FFM, FM and %BF were those with the highest proportion variance explained (R2 ) and lowest root mean square error (RMSE) in linear regression models. Among all of the weight/length indices tested, weight/length2 was the best proxy for %BF, but nonetheless exhibited very low variance explained (R2 = 0.27) and high prediction error (RMSE = 3.5% fat). Body weight unadjusted for length was strongly associated with FFM (R2 = 0.97). No weight/length index accurately reflected %BF. Weight/length indices are not appropriate for assessment of relative adiposity in preterm infants near birth. What's known on this subject: Compared with term infants, preterm infants have increased fat mass and diminished fat-free mass upon hospital discharge. Early adiposity predicts later metabolic health, while early lean mass is predictive of later neurodevelopmental outcomes. Optimal anthropometric proxies for preterm body composition at birth are not established. Weight is an adequate surrogate for lean mass at birth in preterm infants. There are no weight/length indices that accurately reflect neonatal adiposity at birth.

A Retrospective Review of the Sleep Characteristics in Patients with Chronic Fatigue Syndrome and Fibromyalgia

This study characterizes findings on sleep testing and Human Leukocyte Antigen (HLA) markers in a group of patients with fibromyalgia (FM) and chronic fatigue syndrome (CFS). One hundred eighteen patients seen in a general neurology practice over 5 years meeting standard clinical criteria for FM or CFS were analyzed retrospectively. Cases of untreated sleep apnea or restless legs syndrome were excluded prior to inclusion in this study. Ninety-two patients had multiple sleep latency testing (MSLT). Seventy-three (80%) were abnormal by standard criteria. Of 57 females having positive MSLTs, 22 (39%) had one or more periods of sleep onset rapid eye movement (SOREM), and 5 of 16 (31%) males with positive MSLTs had one or more SOREM. Highly fragmented sleep, as previously described in FM, was seen but not analyzed quantitatively. HLA DQB1*0602 was obtained in 74 patients, and positive in 32 (43%), P < 0.0001 compared with published values in 228 populations. In our patients, who presented with neuromuscular fatigue or generalized pain, we found a sleep disorder characterized by objective hypersomnia. Some patients had characteristics of narcolepsy. Objective assessment by sleep studies can assist the diagnostic process, aid future research, and provide rationale for treatment.