Age Involution Research Articles

URACHAL ANOMALIES IN CHILDREN (ANALYSIS OF MEDICAL LITERATURE AND OWN OBSERVATIONS)

Currently, a significant number of publications have been accumulated on the disorders of urinary duct, urachus involution. However, the world literature data on the timing of obliteration and the frequency of urachal anomalies vary significantly, which makes it difficult to assess the risk of complications. There is also no consensus on the tactics of management of these patients. This paper analyzes 62 medical sources on the issues of urinary duct involution, disorders of its obliteration, clinical manifestations of urethral complications and treatment of related conditions. The article also presents data of our own observations of 37 patients with various urachal pathology over a ten-year observation period, including 21 (56.76%) children had umbilical fistulas, 14 (37.84%) children - urachal cysts, 2 (5.4%) patients - bladder diverticula. The data of diagnosis and treatment of children with this pathology are presented.Purpose: analysis of medical sources and own data on the diagnosis and treatment of urinary duct pathology in children, highlighting important and practically significant recommendations on problematic issues of this pathology.Conclusions.1. Urachus is an embryonic formation that connects the bladder with the allantois. According to pathological and anatomical studies, impaired obliteration of the urinary duct occurs in approximately 30% of cases.2. The presence of discharge from the umbilicus, recurrent omphalitis, the presence of a tumor-like mass of the anterior abdominal wall, symptoms of urinary tract infection should be indications for targeted examination for possible urethral pathology.3. The main methods of diagnosing the pathology of the urinary duct are ultrasound and fistulography.4. Data on the age involution of urachus, which occurs in the postnatal period, determine the need to choose the treatment tactics in childhood.

Гистологические особенности ряда органов куньих и их патологические изменения при неэкссудативном перитоните

The article presents the histological features of some organs of weasel family. Also described the pathological changes during nonexudative form of peritonitis of weasel family. The studies were carried out at the Department of General Pathology named after V. M. Koropov of Moscow State Academy of Veterinary Medicine and Biotechnology – MBA named after K. I. Scriabin. The objects of investigation were predatory animals weasel family both healthy and with sings of peritonitis. There are 21 sables, 11 mink cellular content and 15 domestic ferrets. In the study complex methodological approach was used, including classical anatomical preparation, post mortem and histological examination. It has been established, that abdominal wall weasel has three puffs. There are muscle layer, a layer of dense connective tissue and serous membrane. The muscle layer is showing striated muscle tissue with endomysium layers. In the endomysia of muscle febers of abdominal wall of the weasel there are mast cell. Serous membrane is represented by mesothelium, which has typical structure of single – layered squamous epithelium. Large oil seal showing of fat cells with connective tissue layers, including lymphatic capillaries, vessels and nerve trunks. In a large oil seal single mast cell concentrated around the vessels and in the connective tissue of the omentum observed clusters of mast cells. Essential features of the structural organization of the stomach walls and intestinal canal are not found, but revealed a large number of goblet cells in the mucous membrane of the colon and small intestine and mycocytes in mucous membrane of stomach. The liver has a typical structure, lobilarity is weakly expressed. Liver beams are shortned, hepatocytes fit snugly together, sinusoid capillaries are broad. In morphological organization of organs of immune defense weasel significant features are not found. In the spleen was observed a lot of white pulp. In the cortical layer of lymph node was founded a large number of follicles. Thymus has sings age involution. Kidney and lungs weasel has not significant features. Predatory animals weasel family had predominantly nonexudative form of peritonitis. Under the nonexudative peritonitis form was observed sings of acute inflammation of many organs like as system inflammatory response syndrom.

Morphological reconstruction of the urinary bladder in the process of age involution

Objective - study of morphological rearrangements of the bladder and its vascular system in elderly and senile people.Material and methods. Autopsy material in the form of pieces of the bladder wall from 25 men aged 60-80 years was studied using a number of histological, morphometric and statistical techniques. As a control, we used material from 10 persons aged 20-30 years who died as a result of injuries.Results. It was shown that in men in the process of aging in the extraorganic arteries, atherosclerotic changes are revealed, leading to a narrowing of the lumen. In the intraorgan arteries, thickening of the media, hyperelastosis and hyalinosis are observed, which also lead to a reduction in blood flow and are markers of arterial hypertension. A reflection of the adaptation to hemodynamic disorders is the formation of the so-called "closing arteries" with a powerful intimate layer. Over time, in the media of the arteries, as well as in the intima of the "closing vessels", sclerosis grows. The veins of the bladder lose a powerful smooth muscle layer in the wall, undergo sclerosis, which leads to difficulty in blood outflow, aggravating chronic hypoxia. Remodeling of the vascular bed of the bladder leads to detrusor atrophy and degenerative-dysregenerative changes in the urothelium.Conclusion. In the vascular bed of the urinary bladder in elderly and senile men, atherosclerotic and angiotonic changes characteristic of arterial hypertension progress, followed by the development of detrusor atrophy and impaired urothelium regeneration.

MORPHOLOGICAL FEATURES OF AGE-RELATED INVOLUTION OF THE THYMUS DURING PARASITIC INVASION BY OPISTHORCHIS FELINEUS (RIVOLTA, 1884)

Тhymus (thymic, thymus gland) provides antigen-independent differentiation of lymphocytes, providing processes of cellular and humoral immunity in peripheral immune organs. After the onset of puberty, age-related involution of the organ occurs. Changes of thymus in parasitic invasions are found in the literature only for some types of pathogens, mainly of cestodosis group. No data on the influence of trematodes including Opisthorchis felineus (Rivolta, 1884) on thymus and its involution were found. Morphological study of the thymus was conducted at the invasion of Opisthorchis felineus (Rivolta, 1884) 1 month after infestation, in an invasive dose of 50 metacercariae. Microslides were studied by light and immersion microscopy, descriptive and comparative morphology. The design of the experiment divided the animals into two groups: the observation group consisted of invaded animals (Oryctolagus cuniculus) (n=10) and the control group (n=10). The results obtained were characterized by pronounced morphological signs of age involution in Opisthorchis felineus (Rivolta, 1884) infestation, compared to the control, including a decrease in the volume of the medulla, replacement of the fatty tissue by lobules, an increase in the number of Hassall's corpuscle. These changes characterize earlier aging of the organ in case of parasitic disease.

Protectoral action of molsidomin ATP combination in chronic stress in young and old rats

Adaptive reactions to chronic stress, reaching a certain intensity, can become harmful and be involved in any pathological process. Therefore, the search for new ways to increase the adaptive capacity reduced with age and the body's resistance to the negative effects of chronic stress remains relevant. The aim of the study was to experimentally study the age-related protective properties of the combination of molsidomine and ATP in chronic mild stress. The experiments were performed on young (6 months) and old (26 months) Wistar rats exposed to stressors that changed periodically at random for 8 weeks. During the 6-8th week of the experiment, against the background of stress, the animals were sublingually administered a pharmacological combination based on molsidomine - 2 mg / kg, ATP - 10 mg / kg. It was found that the adaptive reactions of young and old animals to chronic stress have qualitative and quantitative differences. Chronic stress in old rats caused changes in behavior and psycho-emotional state, deterioration of cognitive function, changes in lipoperoxidation. On the part of the immune system in old rats, against the background of a pronounced age involution of lymphoid organs, no significant changes in thymus mass and cellularity were observed during chronic stress, while the mass and cellularity of the spleen increased. The combination of molsidomine and ATP prevented post-stress changes in animal behavior, reduced anxiety, normalized social activity, restored the lost ability to recognize, improved cognitive function. The drug contributed to the preservation of the function of immunocompetent organs in young animals and to a lesser extent showed a protective effect in older animals against the background of involutional changes caused by both aging and chronic stress. The combination of molsidomine and ATP had an antioxidant effect. Thus, in chronic mild stress, older animals showed a different response from young animals to both stress and the administration of molsidomine with ATP. The applied pharmacological combination can be considered as a promising stress-protective agent that has a complex effect on various pathogenetic links of chronic stress due to its neuro- and immunomodulatory, energy-saving, antioxidant properties. Keywords: aging, chronic stress, anxiety, social activity, cellularity of the thymus and spleen, lipid peroxidation, combination of molsidomine and ATP, pharmacological action.

Influence of probiotics on histostructure of the bursa of Fabricius in broiler chickens

The article deals with the data on the influence of probiotic preparation BPS-44 and 2% yeast Saccharomyces cerеvisiae on the histostructure of tissues of the cloacal sac (bursa of Fabricius) of broiler chickens. The conducted histological researches have shown that in chickens of the control group at the end of the experiment in the cloacal sac were revealed intraepithelial microcystic cavities, but in the medullary substance of the lymph nodes, necrotic changes are recorded and glandular structures are formed, indicating an insufficient level of lymphopoiesis. The use of these probiotic preparations to broilers from the experimental groups during the period of their growth in the ration caused a normalizing effect on the morphostructure of the cloacal sac and, in particular, on the action of 2% yeast Saccharomyces cerеvisiae. It is evidenced by the absence of the formation of microscystic cavities in the epithelial layer of the cloacal sac (signs of slowing down the processes of age involution). In this case, the lymph nodes are numerical, the division into cortical and medullar substance is clear, they were densely populated with lymphoid elements, indicating the possibility of forming an adequate immune response in the poultry of this group.

MORPHOFUNCTIONAL EVALUATION OF THYMUS IN PEKIN DUCK DURING DIETARY INCORPORATION OF ORGANIC SELENIUM FEED ADDITIVE DAFS-25k

The histological study results of the thymus structure of Pekin ducks during administration of DAFS-25k feed additive are presented. It has been established that the thymus is a morphologically mature and actively functioning organ in one-day-old Pekin ducklings. With age an increase in the size of thymus lobules was observed in ducklings in the control and experimental groups but under the influence of selenium the cortical area increased more intensively. 45-day-old ducklings in the experimental group demonstrated a reliable increase in the ventricular-brain ratio mainly due to the expansion of the cortical area. The surface of the cortical substance did not change in intact ducklings, the tendency of extension in the surface of the brain substance was observed, which at that age is a sign of an accidental involution associated with the onset of a plumage change from juvenile down to primary feathers. Under the influence of selenium in the thymus of the ducklings of the experimental group the processes of accidental involution are leveled, the processes of synthesis of thymopoietins and proliferation of thymocytes are more active. Up to age of 75 days there is active proliferation of thymocytes in the thymus of ducklings of both groups; however reliably higher parameters of ventricularbrain ratio under the influence of selenium were observed in the experimental group, there was a clear boundary between them, as well as significantly higher quantity and size parameters of Hassal’s corpuscles were noted. From the age of 90 days signs of age involution in the organ were observed, and in the experimental group these processes were going more physiologically in accordance with the age of the birds. Introduction of the organic and selenium additive DAFS-25k in the diet of ducklings at a dose of 1.3 mg/kg of feed promoted the increase of the functional activity of the thymus that leveled the development of accidental involution and optimization of age involution.

Histometric Symptoms of Age-Sensitive Changes of Bone Tissue

This study presents the results of complex histomorphometric research of the features of age-related dynamics of bone tissue. We used as study material samples of the distal epiphysis and diaphysis of the left tibia from 348 male corpses aging from 0 to 90 years. The group of microosteometric features that have the strongest correlation with age is established in different age groups; their quantitative characteristics are given here. It has been clarified that the trends of age-related changes in the structural components of bone tissue correspond to the basic patterns of growth, remodeling, and depend on the species and their localization. Conceptual positions of age involution of bone tissue are proposed in this study.

AGE-RELATED INVOLUTION OF THE SYMPATHETIC NERVOUS SYSTEM, SUDDEN CARDIAC DEATH AND FEATURES OF DIAGNOSIS OF MYOCARDIAL

Neurological nature of major cardiac diseases is attributed to elevated social tension. The established phenomena of early age involution of the sympathetic part of the vegetative nervous system due to Cannon's law make it possible to study the mechanism of sudden cardiac death and to search for diagnostic methods for its prevention. One of such methods is time-frequency spectral analysis of the heart rate variability at the early phases of orthostatic tests. The radionuclide diagnostic method has revealed new data on correlation between blood capillaries and sympathetic nervous plexus under myocardial infarction.

ВОЗРАСТНЫЕ ИЗМЕНЕНИЯ КОГНИТИВНЫХ ФУНКЦИЙ У ПОЖИЛЫХ ЛЮДЕЙ

The paper considers the age-specific involution of cognitive processes in the elderly: thinking, short-term visual memory, and the voluntary attention stability. The relevance of the study is associated with the aging population of the country. Skilled intellectual workers when reaching the retirement, at the discretion of the employers, become eliminated from the active working life. At the same time, their experience turns out frequently to be much-in-demand. The psychological issue is the determination of cognitive resource allowing them to prolong their working efficiency. The empirical study is carried out on the total sample of 322 people at the ages from 18 to 89; they include 144 males and 178 females with higher and secondary education who still work now. Using the age section methods, the authors studied the productivity of the superior mental functions at different age periods during natural aging without pathological changes. The authors used the well-known valid and reliable psychodiagnostic methodologies. The data obtained are presented in the diagrams reflecting the changes in productivity of cognitive processes (Y) depending on the age (X). The authors determined the gender shift in the trends and the nature of age involution of cognitive functions and established that the cognitive processes regress, according to T. Ribot’s law, follows in the order inverted to their genesis. Using the partial sample of 70 people with the higher education and 70 people with the secondary education working at the ages of 60–85, the authors carried out the correlation and factor analyses and detected the psychosocial factors influencing the retention of the efficient mental activity in the elderly. Family support, mental activity, and person’s education are the main factors. It is empirically proved that the cognitive functions regress of the intellectual workers proceeds less intensively and settles down at the age period of 65–70. In the elderly, the prior regular intellectual activity in the spheres of “man – man” and “man – sign” professions influences positively the retention of mental operations. The education of nonintellectual workers has just the latent inhibitory effect on the cognitive functions regress.

ФУНКЦІОНУВАННЯ ІМУННОЇ СИСТЕМИ ПЕРЕПЕЛІВ В РІЗНІ ПЕРІОДИ ПОСТНАТАЛЬНОГО ОНТОГЕНЕЗУ

In the article are given results concerning main morphometric characteristics of immunogenesis organs in “Pharaon” breed of quails of industrial raising during different periods of postnatal ontogenesis. It is established that highest numeric values of relative mass index and thymus, Fabricius bursa, spleen of quail species «Pharaoh» in 5 days age. It was found that the vast mass of the thymus quail increased to 33 days of life, Fabricius bursa – up to 53 days of life and spleen – up to 240 days of life. It was established that with the egg (53 and 75 day life) and 240–day old quail in the relative weight and thymus index decreased five times (p < 0,01 – 0,001) seminary Fabricius bursa – three times (p < 0,05 – 0,01). It was investigated that the relative reduction of mass and spleen index in three quails from 20 to 240 days of life. The data indicate a change of immunological reactivity quail in different age periods, especially in the productive oviparous period and the beginning age involution of the thymus, Fabricius bursa. The possible reduction of the seminary index below 1.0 in quails from 75 to 240 days of life may indicate suppression of B–immunity, that reduce the formation of B – lymphocytes. The reduction of the relative weight and spleen index quail tripled from 20 to 240 days of life on the background of declining same period of the thymus and Fabricius bursa may indicate a compensatory reduction of the organism poultry.

ОПТИМІЗАЦІЯ ТРУДОВОЇ ДІЯЛЬНОСТІ ЛЮДИНИ В УМОВАХ ВПЛИВУ ВІКОВОЇ ІНВОЛЮЦІЇ

Implementation of the proposed scheme of person's employment rights optimization under the impact of age involution will help solving the problem of prevention of accelerated professional aging of man.

Особливості морфофункціонального стану органів імуногенезу перепелів у постнатальному онтогенезі

In the article are given results concerning main morphometric characteristics of immunogenesis organs in “Pharaon” breed of quails of industrial raising during different periods of postnatal ontogenesis. There were published many works, devoted to investigation of immune system of quails as to their age and there was revealed an early stage of physiological immaturity (1-10 days after they are out) the stage of physiological hyperplasia of immune system organs (1,5-2,5 months after they are out) and the stage of age (accidental) involution (in 2,5 months after they are out). The aim of the investigation was to clarify the physiological and morphological changes in central and peripheral organs of immune system of “Pharaon” breed of quails of industrial raising during postnatal ontogenesis. To achieve the goal there were slaughtered quails in every age period and selected for investigations the thymus, Fabrytsius bursa, spleen. According to obtained results it was stated that 20 days old quails possessed the thymus mass as much as 0,36 ± 0,061 gr, and its index was on the average 4,10 ± 0,10. Absolute and comparative mass of bursa was 0,09 ± 0,021 gr and 0,12 ± 0,015 per cent and index was 1,19 ± 0,13. Absolute spleen mass (weight) was 0,08 ± 0,022 gr, whereas index was 1,04 ± 0,05. 33 days old quails possessed the absolute thymus weight as much as 0,83 ± 0,052 gr, two times larger (p < 0,001), compared with 20 days old birds. But, comparative weight and thymus index were 0,44 ± 0,115 per cent and 4,37 ± 0,11; obtained results were almost the same as with 20 days old quails absolute mass of bursa in 33 days old quails reached 0,23 ± 0,045 gr, two times larger (p < 0,005) compared with 20 days old birds, but comparative weight and index were almost the same as at the beginning of the experiment. Absolute weight of the spleen became larger (up to 0,14 ± 0,013 gr) but its comparative weight and index became smaller up to 0,08 ± 0,015 per cent and 0,74 ± 0,08, compared with 20 days old quails. Absolute mass and thymus index of 53 days old quails were 0,11 ± 0,073 gr and 0,33 ± 0,18 respectively, three times smaller (p < 0,005 – 0,001) compared with 20 days old quails. The absolute bursa weight was 0,38 ± 0,066 gr three times larger (p < 0,01) compared with 20 days old quails. Absolute spleen mass was increasing up to 0,27 ± 0,071 gr, three times larger (p < 0,005) compared with 20 days old quails, but comparative mass and index of the spleen were the same as at the beginning of the experiment. Absolute weight and thymus index of 75 days old quails were 0,10 ± 0,024 gr and 0,38 ± 0,15, three times smaller (p < 0,01 – 0,001) compared with 20 days old quails. Absolute bursa mass was 0,14 ± 0,070 gr a little bit more, compared with 20 days old quails, but comparative mass and bursa index were increasing up to 0,05 ± 0,013 per cent and 0,45 ± 0,09 (p < 0,05 – 0,01) respectively. Absolute spleen mass was larger compared with 20 days old birds and was 0,15 ± 0,010 gr, but comparative mass and spleen mass were reducing up to 0,06 ± 0, 011 per cent and 0,57 ± 0,12 (p < 0,05 – 0,01) respectively. Obtained results point out at real lowering of comparative mass and index of the thymus in 53 days old and 75 days old quails, which confirms the change of specific imunomorphological reactions, the material substrate of immune answer is the thymus and also the beginning of it age involution. Reduction of bursa and spleen index lower than 1,0 may emphasize the depression of B-link immunity that is reduction of B-lymphocytes formation in 75 days old quails. Reduction of comparative spleen mass on the basis of reduction of the same thymus index and Fabrytsius bursa of 75 days old quails may stress on lowering of compensatory body abilities.

Comparative assessment of aging rates in population from different cities

437 people (214 men and 223 women) at the age of 50-90 years old, residents of different cities of Russia and Pridnestrovie (Moscow, Barnaul, Tiraspol) have been examined. Using a complex of morphofunctional characteristics, parameters of the biological age have been analyzed, and groups with delayed, moderate and accelerated aging rates have been outlined. Regional peculiarities in distribution of incidence of different variants of aging rates have been revealed. In Moscow men and women, the delayed variant of development of age involution changes is the most widespread. In Tiraspol women, compared to the Moscow group, incidence of people with accelerated aging rates is 2 times higher, which can be stipulated by influence of a complex of biosocial factors.

Why occurrence of arterial hypertension with age becomes frequent?

Research objective: to study a table salt (PS) role in arterial hypertension (AH) increase with age.Material and methods. Examined 583 patients essential hypertension 1-2-th degree aged 25 to 59 years and 350 practically healthy persons - monitoring group. They investigated the threshold taste sensitivity to the PS (TTSPS) was determined daily urinary excretion of sodium ions with urine with the subsequent recalculation on the programme of the substation, which was received by the person with food in grams on the eve of research.Results. It appeared that in increase of AG accruing with age plays an undoubted role increase in consumption of PS. Thus the increase in consumption of PS is carried out involuntarily and is connected with decrease in sensitivity of the flavoring analyzer to Na. It, in turn, can be caused both age involution of the flavoring analyzer, and decrease in its sensitivity in connection with big consumption of PS.Conclusion. With age at sick AG of action for restriction of consumption of PS have to amplify only. It is possible to believe that at advanced and senile age in treatment of sick AG diuretics start playing rather big role.

DYNAMICS AND CONJUGATION OF AGE INVOLUTION OF SOME COMPONENTS OF MALE REPRODUCTIVE FUNCTION

It was studied parameters of sexual activity and quality of spermatogenesis in male rats at the age of 4–4.5, 10, 18 and 20–21 months. It was found that the age involution of sexual activity manifested by changes in the qualitative composition of the group initially sexually active males (decrease in the proportion of animals that are capable of ejaculation and the beginning of the next series of couples), as well as changing the sexual behavior pattern (strengthening of court behavior, weakening of the copulatory behavior and slowing of the postejaculatory recovery). It was identified nonlinear character of age changes in spermatogenesis as the best semen parameters in animals 10 months of age compared with younger and older males. It was suggested that asynchrony of the age involution of the different components of the male reproductive function has adaptive sense.

Почему с возрастом учащается встречаемость артериальной гипертензии?

Research objective: to study a table salt (PS) role in arterial hypertension (AH) increase with age.Material and methods. Examined 583 patients essential hypertension 1-2-th degree aged 25 to 59 years and 350 practically healthy persons - monitoring group. They investigated the threshold taste sensitivity to the PS (TTSPS) was determined daily urinary excretion of sodium ions with urine with the subsequent recalculation on the programme of the substation, which was received by the person with food in grams on the eve of research.Results. It appeared that in increase of AG accruing with age plays an undoubted role increase in consumption of PS. Thus the increase in consumption of PS is carried out involuntarily and is connected with decrease in sensitivity of the flavoring analyzer to Na. It, in turn, can be caused both age involution of the flavoring analyzer, and decrease in its sensitivity in connection with big consumption of PS.Conclusion. With age at sick AG of action for restriction of consumption of PS have to amplify only. It is possible to believe that at advanced and senile age in treatment of sick AG diuretics start playing rather big role.

Immunohistochemical characteristics age transformation of the cell phone mastoid brain people of different sex

Age-related changes in the structure of the human brain mamillary bodies were found in different age and sex. In elderly and senile age there is a decrease of GFAP-immunopositive cells. This process leads to an involutive transformations of neurons in the appropriate age. From 45 years of age in the mamillary bodies NSE-immunopositive cells are located around blood vessels in both sexes. Such an arrangement may be due to age-related changes in hemodynamics this structure. Reducing the number of MBP-immunopositive fibers in the elderly explains violation of synaptic connections both within the mamillary bodies and beyond. The observed changes in the expression of selected neuronal markers indicate age involution of mamillary bodies in both sexes.

Age features of the modular condition of blood in persons of senile age during physiological aging

The study of the peculiarities of blood aggregation in the elderly with physiological aging is of particular interest. A significant contribution to the development of an age involution decrease in endothelium function occurs (which reduces the synthesis of prostacyclin and decreases the antiaggregatory activity of the vascular wall), as well as failure of the diastolic dysfunction of the left ventricle, increases in the rigidity of the vascular wall, and remodeling of the microvasculature. The complex estimation of blood aggregation and identification of features of interaction of individual factors in elderly patients has important clinical implications.

Mammographic Density and Lobular Involution in Older Women with Abnormal Breast Imaging.

Abstract Mammographic density has been established as an independent risk factor for breast cancer, and there is data to suggest that the degree of lobular involution in the breast tissue may also function as an independent risk factor for the disease. The present study was designed to investigate the relationship between mammographic density and lobular involution in a population of mature women undergoing open biopsy for non-palpable breast lesions.A total of 199 women over the age of 60 who underwent breast biopsy with image-guided localization in 2008 at NYU Langone Medical Center formed the study population. Variables of interest included age, breast density, degree of involution, use of hormone replacement therapy (HRT) and biopsy histology (invasive ductal and lobular carcinoma and intraductal carcinoma vs. benign). Breast density was categorized according to BI-RADS classification as less dense (predominantly fatty and scattered fibroglandular elements) vs more dense (heterogeneously dense and extrememely dense). Degree of involution was classified as none (0%), partial (1-74%) and complete (&amp;gt;75%). All specimens were reviewed by a single pathologist who used the criteria of Hartmann, et al in evaluating degree of involution. Statistical analysis was performed using Pearson's Chi-square test and logistic regression analyses.In agreement with our previously presented data, we found an inverse relationship between breast density and age (p=0.02). In our cohort of women over 60 with abnormal breast imaging, we found a trend toward an inverse relationship between age and degree of lobular involution, but this did not achieve statistical significance. 129 of our patients had biopsies yielding malignant histology. There was no significant relationship between degree of lobular involution and biopsy histology. Use of HRT did not correlate with breast density in our cohort. There was no discernable relationship between degree of involution and history of prior or current HRT use.Association of lobular involution with age, density, histology, and HRT INVOLUTION TOTALP-VALUE NONEPARTIALCOMPLETEN (%) AGE (YRS) 60-696337617 (9%)0.18270-797202959 (29%) 80-894618123 (62%) DENSITY Less Dense143477125 (63%)0.177More Dense3254674 (37%) HISTOLOGY Benign5194670 (35%)0.690Malignant124077129 (65%) HRT Never11246398 (70%)0.774Ever3112741 (30%) Our study reinforces the general observation that breast density decreases with age. Our data do not permit us to comment on the validity of lobular involution as a risk factor for breast cancer. However, the degree of lobular involution did not predict malignant histology in our cohort. There was a trend toward an inverse relationship between mammographic density and lobular involution. This observation suggests that other factors such as stromal features may be responsible for the increased mammographic density in these older patients. Further study is warranted to better understand the significance of lobular involution and its relationship with mammographic density in all age groups of women undergoing breast cancer screening. Citation Information: Cancer Res 2009;69(24 Suppl):Abstract nr 6072.