Adiponectin Levels In Women Research Articles

Association between anthropometric markers of adiposity, adipokines and vitamin D levels

Inverse association between serum levels of vitamin D and obesity has been pointed out in several studies. Our aim was to identify to the associations between vitamin D levels and a large panel of anthropometric markers and adipokines. Cross-sectional study including 6485 participants. Anthropometric markers included body mass index (BMI), % body fat, waist, waist-to-hip (WHR), waist-to-height (WHtR), conicity index, body roundness index (BRI) and a body shape index (ABSI). 55.7% of women and 60.1% of men presented with vitamin D deficiency. Vitamin D levels were negatively associated with most anthropometric markers, with correlation coefficients ranging between −0.017 (ABSI) and −0.192 (BMI) in women and between −0.026 (weight) and −0.130 (% body fat) in men. Vitamin D levels were inversely associated with leptin levels in both sexes and positively associated with adiponectin levels in women only. The likelihood of vitamin D deficiency increased with increasing adiposity levels, except for ABSI (women) and BMI (men). Total body fat, rather than localized or unevenly distributed body fat, is the adiposity marker most associated with decreased vitamin D levels. Monitoring vitamin D levels in people with overweight/obesity is essential.

Association of Adiponectin Levels with Polycystic Ovarian Syndrome

Objective: To measure the levels of adiponectin in women with PCOS having high body mass index. Methodology: A cross-sectional study including 96 study participants was conducted in Services Hospital, Lahore in December 2020 out of 96 study participants 48 were enrolled as cases having polycystic ovarian syndrome compared with 48 healthy women as controls. Detailed information about age, duration of menstrual cycle, body mass index (BMI), and clinical features like obesity, infertility, acne and hairs on face were noted. A total 5ml venous blood was collected by using aseptic techniques and then centrifuged immediately; serum was separated and stored at -20 °C after proper labeling. Samples were analyzed for estimation of serum adiponectin by using enzyme linked immunosorbent assay. Statistical analysis was carried out by statistical package for social sciences (SPSS) 21. The p-value < 0.05 was considered to be statistically significant. Results: In this study level of adiponectin was decreased in PCOS women as compared to healthy women. Mean ± SD of adiponectin in PCOS women was 2.08±0.70µg/ml which was lower than in control group 9.71±5.35µg/ml. Median/Inter Quaitel Range of PCOS women was 2.00/0.78 which is lower in comparison with the Median/IQR of adiponectin in healthy women 8.60/9.63, p-value of adiponectin was significant (p = 0.00). Conclusion: Adiponectin is important variable present in circulation. Its levels are changed in response to disease process as occurs in PCOS.

Association of Serum Adipokines and Resting Energy Expenditure in Patients With Chronic Kidney Disease

Background and AimMetabolic disorders are prevalent in patients with chronic kidney disease (CKD) and may lead to protein energy wasting (PEW). Adipokines improve connections between PEW and energy metabolism. We aimed to determine the relationship between adipokine levels and resting energy expenditure (REE) in patients with CKD.MethodsA total of 208 patients in non-dialyzed CKD stages 3–5 were enrolled in this cross-sectional study. Serum adipokines (leptin, adiponectin, and interleukin 6 (IL-6) were measured using enzyme-linked immunosorbent assay. Patient's REE was measured using indirect calorimetry. Fat mass (FM) and lean tissue mass (LTM) were measured using multiple-frequency bioimpedance analysis. Spearman correlation analyses and multivariate linear regression models were used to assess the association between serum adipokines and REE.ResultsThe mean age was 52.7 ± 14.6 years, and 26.9, 26.4, and 46.7% of our participants had CKD stages 3, 4, and 5, respectively. The median values of serum adiponectin, leptin, and IL-6 were 470.4 (range, 291.1–802.2), 238.1 (range, 187.9–418.4), and 4.0 (range, 2.4–9.5) pg/mL, respectively. The male participants had significantly lower FM% (P = 0.001) and lower leptin levels (P < 0.001) than the female participants. After adjusting for age, diabetes, high-sensitivity C-reactive protein, intact parathyroid hormone, LTM, and FM, multiple linear regression analysis revealed that serum leptin levels were significantly positively associated with REE in men rather than in women (P < 0.05). Serum adiponectin levels were inversely associated with REE in men, but this association disappeared while FM was additionally adjusted. Adiponectin levels in women were not correlated with REE (P > 0.05). IL-6 was not significantly associated with REE in either men or women.ConclusionsA sex-specific relationship between serum adipokines (leptin and adiponectin) and REE was observed in patients with CKD stages 3–5, which was partly confounded by FM.

The Effect of Regular Physical Activity in Water with and without Ginger Supplementation on Adiponectin Levels in Women with Breast Cancer

The aim of this study was to determine the effect of regular physical activity in water with and without ginger supplementation on adiponectin levels in women with breast cancer. The population of the study, 98 women with a mean age of breast cancer patients (48±8.5), weight (76±9)kg and fat mass (8.41±4) formed that voluntarily participated in this study that 40 people of them were selected as sample. subjects were randomly divided into four groups (Group 1: placebo, Group 2: Selected exercises in water placebo, Group 3 and Group 4 supplementation Ginger: Ginger supplements selected exercises in water) were divided into groups of ginger supplements and exercise The Water Department ginger supplements daily for 6 weeks orally 4 capsules (750mg) were used. Programs supplement group ginger exercise and water exercise group placebo juice containing a combination of increased intensity and distance training, with 50% to 75% heart rate reserve for 60 to 75 minutes in a pool with a width of 15 meters and a depth of 4m, 4 times a week 6 weeks was performed. Fasting blood samples were collected at pre-test and post-test. The result of the study All findings using the statistical software in SPSS23 and evaluated p&lt;0.05. Ginger supplements or exercise in water increase adiponectin was compared to baseline. However, the exercise group in water exercise with ginger showed a much better effect on the inflammatory marker adiponectin and blood, than the exercise group in water with placebo or the ginger group alone. The findings show that a protective effect of non-pharmacological strategies such as exercise in water and plant anti-inflammatory agents such as ginger has been detected in inflammatory and metabolic responses in obese women with breast cancer.

The Effects of Synbiotic Supplementation on Serum Anti-Inflammatory Factors in the Survivors of Breast Cancer with Lymphedema following a Low Calorie Diet: A Randomized, Double-Blind, Clinical Trial

Background and Aim Breast cancer-related lymphedema (BCRL) is a treatment-related inflammatory complication in breast cancer survivors (BCSs). This study was aimed to evaluate the effect of synbiotic supplementation on serum concentrations of IL-10, TGF-β, VEGF, adiponectin, and edema volume among overweight or obese BCSs with lymphedema following a low-calorie diet (LCD). Method In a randomized double-blind, controlled clinical trial, 88 obese and overweight BCSs women were randomized to synbiotic supplement (n = 44) or placebo (n = 44) groups and both groups followed an LCD for 10 weeks. Pre- and post-intervention comparisons were made regarding the anti-inflammatory markers which included IL-10, TGF-β, VEGF, adiponectin, edema volume, and anthropometric measurements. Also, the same factors were analyzed to find inter-group disparities. Results There were no significant differences among participants in the baseline, except for IL-10 and adiponectin. Post-intervention, no significant differences were observed regarding the anti-inflammatory markers, including IL-10, VEGF, adiponectin, and TGF-β between the groups. After 10 weeks of intervention edema volume significantly decreased in the synbiotic group; additionally, anthropometric measurements (body weight, BMI, body fat percent, and WC) decreased in both groups significantly (P < 0.001 and P < 0.005; respectively). Conclusion Synbiotic supplementation coupled with an LCD in a 10-week intervention had beneficial effects on increasing the serum TGF-β, IL-10, and adiponectin levels in women with BCRL. It also reduced arm lymphedema volume. Therefore, synbiotic supplementation can be effective in improving health status in BCRL patients.

Assessment of serum adiponectin levels in women with polycystic ovary syndrome

Background and Aim: Serum adiponectin levels were found to be altered in women with polycysticovary syndrome (PCOS) due to the increased adiposity commonly observed in them. Accordingly,earlier studies have reported decreased adiponectin levels in PCOS women. the present study wasconducted to measure serum adiponectin levels in women with PCOS and to evaluate its associationwith the biochemical parameters studied.Material and Methods: The present study included 50women of reproductive age attending the department of Gynecology, tertiary care institute of Indiaand diagnosed with polycystic ovary syndrome based on Rotterdam criteria. Fifty age-matchedhealthy women were recruited as controls. t. Adiponectin levels were measured along withmeasurement of fasting blood glucose, lipid profile using commercial kits and insulin resistance(HOMA-IR) was calculated. Results: Both the study groups were matched concerning age, however,PCOS women were obese when compared to healthy women (p&lt;0.001). Serum total cholesterol andtriglyceride levels were significantly higher (p≤0.05) and serum adiponectin concentration wassignificantly lower in PCOS women when compared to controls (p≤0.05). HDL cholesterol, fastinginsulin and HOMA-IR were similar between cases and controls. Adiponectin did not show significantassociation with any of the parameters studied (Table 2). Conclusion: Serum adiponectin levels aresignificantly lower in women with polycystic ovary syndrome compared to healthy women. Thehyperandrogenemia which is one of the characteristic features of PCOS leads to a state of adipositywhich can further cause a decrease in adiponectin levels.

C-Reactive Protein,Homocysteine, Leptin, and Adiponectin Levels in Women with Polycystic Ovary Syndrome

Background and Aim: We aimed to compare the levels of clinical, biochemical, hormonal, and metabolic parameters as well as serum CRP,homocysteine, leptin, and adiponectin in cases with PCOS and control group to investigate whether they play a role in the etiology of the syndrome. Materials and Methods: The present study included a total of 160 subjects, 90 subjects were diagnosed with PCOS (n = 90) and 70 subjects served as control group (n = 70). Serum CRP, homocysteine, leptin, and adiponectin levels were analyzed for each subject.

C-Reactive Protein, Fibrinogen, Leptin, and Adiponectin Levels in Women with Polycystic Ovary Syndrome.

We aimed to compare the levels of clinical, biochemical, hormonal, and metabolic parameters as well as serum CRP, fibrinogen, leptin, and adiponectin in cases with PCOS and control group to investigate whether they play a role in the etiology of the syndrome. The present study included a total of 90 subjects, 45 subjects were diagnosed with PCOS (n = 45) and 45 subjects served as control group (n = 45). Serum CRP, fibrinogen, leptin, and adiponectin levels were analyzed for each subject. Serum CRP, fibrinogen, and leptin were found to be higher (statistically significant) in the group with PCOS as compared to the control group (p < 0.05). Serum Adiponectin was higher in the control group (statistically significantly) as compared with the patients in the PCOS group (p < 0.05). CRP and fibrinogen (cardiac risk factor markers) increase in women with PCOS. The levels of leptin which affects metabolism increase, whereas the levels of adiponectin decrease.

Serum Adiponectin in women with polycystic ovary syndrome of different body mass index

Background: Polycystic ovary syndrome is an extremely common disorder in women of the reproductive age that is associated with a disturbance of reproductive, endocrine, and metabolic functions. The pathophysiology of PCOS appears to be multifactorial and polygenic. Adiponectin seems to play an important role in the pathogenesis of PCOS, especially in obese women. Objectives: To (1) measure serum adiponectin levels in women with PCOS of different body mass index; and (2) assess possible relation between adiponectin level and the hormonal changes of the disease. Setting: Baghdad Teaching Hospital. Duration of study one year from 2018 to 2019.Methods: 80 women were included in this study, 40 women were suffering from PCOS (study group), and the remainder 40 were healthy women served as a control group. BMI is calculated, then each group subdivided into 2 groups: overweight with BMI≥25Kg/m2 and the normal weight with BMI

Study of serum adiponectin levels in women with polycystic ovary syndrome

Study of serum adiponectin levels in women with polycystic ovary syndrome - IJOGR- Print ISSN No: - 2394-2746 Online ISSN No:- 2394-2754 Article DOI No:- 10.18231/j.ijogr.2019.065, Indian Journal of Obstetrics and Gynecology Research-Indian J Obstet Gynecol Res

The effects of high intensity-interval training on vaspin, adiponectin and leptin levels in women with polycystic ovary syndrome

Aim We aimed to investigate the metabolic effects of HIIT exercise on PCOS patients and how it affects adiponectin, vaspin and leptin. Material and methods Twenty women with PCOS were included in the study and were divided into two groups. HIIT program was applied for 10 PCOS and Medium Intensity Continuous Training (MICT) program was applied for other 10 PCOS. At the beginning and at the end of the study, total cholesterol, low-density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), triglyceride(TG), insulin, Adiponectin, Leptin, Vaspin levels of both PCOS groups were evaluated. Results When PCOS patients by performed HIIT exercise for 12 weeks, we found that the levels of leptin and vaspin did not change while adiponectin levels increased. Moreover serum levels of insulin, TG, total cholesterol, LDL-C decreased but levels of HDL-C increased. Conclusion HIIT increased in the adiponectin levels in women with PCOS and provided more weight loss.

DHA supplementation in women with pregestational obesity does not affect the offspring´s adiposity neither at birth nor at 4 months of age.

Maternal pregestational obesity is a well-known risk factor for offspring obesity, metabolic syndrome, cardiovascular disease and type 2 diabetes. The mechanisms by which maternal obesity can induce alterations in fetal and later neonatal metabolism are not fully elucidated due to its complexity and multifactorial causes. Two adipokines, leptin and adiponectin, are involved in fetal and postnatal growth trajectories, and both are altered in women with pregestational obesity. The placenta synthesizes leptin, which goes mainly to the maternal circulation and in lesser amount to the developing fetus. Maternal pregestational obesity and hyperleptinemia are associated with placental dysfunction and changes in nutrient transporters which directly affect fetal growth and development. By the other side, the embryo can produce its own leptin from early in development, which is associated to fetal weight and adiposity. Adiponectin, an insulin-sensitizing adipokine, is downregulated in maternal obesity. High molecular weight (HMW) adiponectin is the most abundant form and with most biological actions. In maternal obesity lower total and HMW adiponectin levels have been described in the mother, paralleled with high levels in the umbilical cord. Several studies have found that cord blood adiponectin levels are related with postnatal growth trajectories, and it has been suggested that low adiponectin levels in women with pregestational obesity enhance placental insulin sensitivity and activation of placental amino acid transport systems, supporting fetal overgrowth. The possible mechanisms by which maternal pregestational obesity, focusing in the actions of leptin and adiponectin, affects the fetal development and postnatal growth trajectories in their offspring are discussed.

Serum visfatin and adiponectin – markers in women with polycystic ovarian syndrome

Aim: Polycystic ovary syndrome (PCOS) is a leading cause of female infertility. Adipose tissue releases various adipokines, including visfatin and adiponectin, which have influence on insulin resistance (IR).Objective: To determine serum insulin levels, IR, serum visfatin and adiponectin levels in PCOS subjects.Materials and methods: Case-control study on 100 diagnosed PCOS patients (50 obese and 50 non-obese) and 100 control subjects (50 obese and 50 non obese). Investigations included serum measurement of insulin, visfatin and adiponectin using an enzyme-linked immunosorbant assay and Sinbe magnum technique.Results: There were higher levels of serum fasting glucose levels, serum insulin levels, IR and visfatin levels and lower levels of adiponectin in women with PCOS irrespective of body mass index, compared to their respective controls with a p value of < 0.001.Conclusion: The study suggests that serum visfatin levels positively correlate and serum adiponectin levels negatively correlate to insulin and IR in women with PCOS irrespective of obesity. Hence they can serve as markers in women with PCOS.

Supplementation with omega-3 fatty acids and plasma adiponectin in women with polycystic ovary syndrome

ObjectiveTo study plasma adiponectin levels in women diagnosed with polycystic ovary syndrome given omega-3 fatty acid supplements. Patients and methodsA study was conducted in 195 women diagnosed with polycystic ovary syndrome treated with omega-3 fatty acids for 12 weeks (n=97; group A) and control women given placebo (n=98, group B). General characteristics, metabolism, lipid profile, and hormone and adiponectin levels were compared. ResultsThere were no significant differences between the two groups in general characteristics. No significant differences were also found in hormone, blood glucose, and HOMA levels between the groups. Women in study groups A and B showed no statistically significant differences in total calorie, carbohydrate, protein, and total fat intake between the baseline and final values. Decreased total cholesterol, low-density lipoprotein, and triglyceride levels were found in group A women (p<0.0001). Mean of adiponectin levels also showed a statistically significant increase after treatment (p<0.0001). There were no statistically significant differences in the mean values of the different variables in group B women. ConclusionOmega-3 fatty acid supplementation for 12 weeks caused a significant increase in plasma adiponectin levels in women with polycystic ovary syndrome.

Suplementación de ácidos grasos omega-3 y adiponectina plasmática en mujeres con síndrome de ovarios poliquísticos

ObjectiveTo study plasma adiponectin levels in women diagnosed with polycystic ovary syndrome given omega-3 fatty acid supplements. Patients and methodsA study was conducted in 195 women diagnosed with polycystic ovary syndrome treated with omega-3 fatty acids for 12weeks (n=97; groupA) and control women given placebo (n=98, groupB). General characteristics, metabolism, lipid profile, and hormone and adiponectin levels were compared. ResultsThere were no significant differences between the two groups in general characteristics. No significant differences were also found in hormone, blood glucose, and HOMA levels between the groups. Women in study groupsA andB showed no statistically significant differences in total calorie, carbohydrate, protein, and total fat intake between the baseline and final values. Decreased total cholesterol, low-density lipoprotein, and triglyceride levels were found in groupA women (P<.0001). Mean of adiponectin levels also showed a statistically significant increase after treatment (P<.0001). There were no statistically significant differences in the mean values of the different variables in groupB women. ConclusionOmega-3 fatty acid supplementation for 12weeks caused a significant increase in plasma adiponectin levels in women with polycystic ovary syndrome.

High-molecular-weight adiponectin is inversely associated with sympathetic activity in polycystic ovary syndrome

To examine the role of high-molecular-weight (HMW) adiponectin and its relationship to sympathetic activity in women with polycystic ovary syndrome (PCOS). Cross sectional study using biobanked samples. Not applicable. Premenopausal women with PCOS (n = 46, Rotterdam diagnostic criteria) and without PCOS (n = 22). None. High-molecular-weight adiponectin levels with secondary outcomes of sympathetic activity and leptin levels. The high-molecular-weight adiponectin level was lower in women with PCOS (median 2.2 [interquartile range (IQR)2.3] μg/mL) than in controls (median 3 [IQR2.5] μg/mL) (age and BMI adjusted), and it correlated inversely with the values measured for homeostatic model of assessment of insulin resistance (HOMA-IR), fasting insulin, triglycerides, and free androgen index and positively with sex hormone-binding globulin (SHBG) and high-density lipoprotein cholesterol in all participants and in the PCOS group. In the PCOS group, sympathetic activity (burst frequency) was statistically significantly higher than in controls (median 26 [IQR11] vs. median 22 [IQR14], respectively) and correlated inversely with HMW adiponectin (r = -0.230). The leptin levels were similar between the women with PCOS and controls and did not statistically significantly correlate with HMW adiponectin or sympathetic activity. On multiple regression analysis, burst frequency and SHBG explained 40% of the HMW adiponectin variability (B = -0.7; 95% CI -1.2 to -0.2; and B = 0.01; 95% CI 0.004-0.01) in PCOS. Alongside insulin resistance, increased sympathetic activity is associated with and may modulate HMW adiponectin levels in women with PCOS.

Adiponectin levels in serum of women with pre-eclampsia

Background and aim The aim of this study was to investigate the association between serum adiponectin levels and some clinical and hormonal parameters in cases of pre-eclampsia.Patients and methods This cross-sectional controlled observational study was carried out on 75 pregnant women recruited from antenatal outpatient clinic and obstetric departments of Benha University Hospital. The women were subdivided into three subgroups: 25 normal pregnant women, 25 pregnant women with mild pre-eclampsia, and 25 pregnant women with severe pre-eclampsia. All studied groups were subjected to complete history taking, clinical examination, and routine laboratory investigations, for example, complete blood count, Rh, random blood sugar, serum uric acid and proteinuria, serum adiponectin, progesterone, and estradiol levels.Results Serum adiponectin levels in women with pre-eclampsia were significantly higher than in normal pregnant women, and the increase was more marked in cases of severe pre-eclampsia. There was a significant positive correlation between adiponectin levels and arterial blood pressure in all groups. However, there was no correlation between serum adiponectin and estradiol and progesterone levels. The results support the theory that adiponectin might be part of a feedback mechanism for improving insulin sensitivity and cardiovascular health in patients with pre-eclampsia.Conclusion It has been concluded from the study that plasma adiponectin level is increased in pre-eclampsia. It can be taken independently or along with other parameters as a marker for severity of pre-eclampsia, hence, avoiding risk effects of pre-eclampsia to mother and fetus. Serum adiponectin assay increases sensitivity for prediction of pre-eclampsia.

Adiponectin Level in Women with Breast Cancer

Introduction: Adiponectin is one of the plasma protein derived from adipose tissue which has a positive effect on the metabolism of fat and lipid, resulting from its own receptors. Increase in body mass index (BMI) has a direct relationship with life length. Obesity has effects on secretion of some hormones related to adipokines. Adiponectin is an adipokine having an opposite relationship with insulin resistance and breast cancer. There is also an association between breast cancer incidence and obesity. Adiponectin level decreases in women affected by breast cancer and knowing this fact can help treat and prevent the cancer by giving adiponectin supplements. The present study compared the adiponectin levels in women affected by breast cancer and healthy females as a control group. Material and Method: In this study, 80 women with breast cancer and 80 healthy females as controls were selected and adiponectin level was compared between them. Result: Breast cancer group had higher BMI mean (28.77 ± 6.05) and lower adiponectin level in comparison to control group (p= 0.0001). Conclusion: Considering our findings, breast cancer risk is higher in women with higher BMI. Therefore, informing women in this regard could have a great effect on preventing this wide-spread disease. Taking adiponectin supplements as pills or injection could be a preventing step for breast cancer, which needs to be further cultivated in future studies.

The Role of Serum Adiponectin Levels in Women with Polycystic Ovarian Syndrome

Background: Adiponectin is a recently identified adipocyte-derived collagen-like protein. In humans, adiponectin levels were found to be decreased in obese, compared to normal individuals, whereas high adiponectin levels are independently associated with increased insulin sensitivity. The specific role of adiponectin in these metabolic conditions is not clear: it may have a causative role, or it could be regulated by insulin and serve as a marker for insulin resistance. Adiponectin levels hold great promise for use in clinical applications as a potent indicator of underlying metabolic complications. Aim of the work: The present study was aimed to evaluate the link between adiponectin and polycystic ovarian syndrome (PCOS) and the potential use of adiponectin as a biomarker for PCOS. Patients and methods: The study included 84 female patients presenting to the Reproductive and Infertility Clinics at Ain Shams University Maternity Hospital, starting from June 2016 till January 2017. They were divided into four groups based on the diagnosis of polycystic ovarian syndrome (PCOS); Cases were selected as: Group I non-obese PCOS group (n = 21), Group II obese PCOS group (n = 21). Controls were selected as: Group III non-obese control group (n = 21) and Group IV obese control group (n = 21). All the Control subjects had normal, regular menstruation, normal ovarian findings on ultrasound, and normal luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels. None displayed hirsutism. PCOS subjects were enrolled when they had satisfied two of the three following inclusion criteria: 1. Oligomenorrhea or amenorrhea. 2. Clinical or biochemical hyperandrogenism. 3. Ultrasonographic polycystic ovarian morphology. Serum adiponectin, metabolic and hormonal parameters were compared in PCOS patients with BMI matched controls. Measurement of plasma adiponectin levels done by Enzyme Immunoassay kit in Ain Shams University Maternity Hospital lab. Results: Serum adiponectin level was significantly lower among cases than controls (p value < 0.001). No significant difference was found between cases and controls regarding their hormonal profile except for testosterone and insulin levels which were significantly higher among cases (p value <0.001). As regard insulin resistance, there was a significant difference where cases were higher than control (p value <0.001). Conclusion: It could be concluded that PCOS was found to correlate with low adiponectin levels, independently of BMI. The relationships between adiponectin and insulin resistance and sensitivity, metabolic syndrome, and BMI in women with PCOS suggest that adiponectin potentially could serve as a marker for disease risk and provide opportunity for earlier intervention if knowledge is successfully translated from laboratory to clinical practice.

Beneficial Health Effect of Aquarobics (Role of Adiponectin on Women with Obesity)

Background the effects of exercise on adiponectin levels have been reported to be variable. Obesity is associated with adipose tissue inflammation and increased risk of infection. The prevalence of obesity increased in premenopausal women both in developed countries and developing countries, including Indonesia. The purpose of the study to investigate the effect of aquarobics exercise on adiponectin levels in women with obesity. Methods of the research, experimental randomized pretest-posttest control group design performed in twenty four women with obesity (Obese II BMI> 30kg/m2) aged 45-50 years, who were divided into 2 groups, aquarobic exercise group, twice days for 8 weeks (n=12), aquarobic intensity 75%HRmax, and control group (n=12). Percentage of body fat, BMI, adiponectin levels, blood glucose and lipids profile were measured before and after exercise. Data were analyzed using repeated measures and while Pearson’s correlations were performed to identify possible relationship among the assessed variables. Results of the study, the percentage of body fat was higher in aquarobic exercises than control group (p<0.05). Decreased of BMI on the aquarobic exercises group compared to controls (p<0.05) and adiponectin levels in the aquarobic exercise group increase significantly (p<0.05). Conclusion: Aquarobic exercise is effective to decreased body weight and increase adiponectin levels.