Abstract
Background and Aim: Serum adiponectin levels were found to be altered in women with polycysticovary syndrome (PCOS) due to the increased adiposity commonly observed in them. Accordingly,earlier studies have reported decreased adiponectin levels in PCOS women. the present study wasconducted to measure serum adiponectin levels in women with PCOS and to evaluate its associationwith the biochemical parameters studied.Material and Methods: The present study included 50women of reproductive age attending the department of Gynecology, tertiary care institute of Indiaand diagnosed with polycystic ovary syndrome based on Rotterdam criteria. Fifty age-matchedhealthy women were recruited as controls. t. Adiponectin levels were measured along withmeasurement of fasting blood glucose, lipid profile using commercial kits and insulin resistance(HOMA-IR) was calculated. Results: Both the study groups were matched concerning age, however,PCOS women were obese when compared to healthy women (p<0.001). Serum total cholesterol andtriglyceride levels were significantly higher (p≤0.05) and serum adiponectin concentration wassignificantly lower in PCOS women when compared to controls (p≤0.05). HDL cholesterol, fastinginsulin and HOMA-IR were similar between cases and controls. Adiponectin did not show significantassociation with any of the parameters studied (Table 2). Conclusion: Serum adiponectin levels aresignificantly lower in women with polycystic ovary syndrome compared to healthy women. Thehyperandrogenemia which is one of the characteristic features of PCOS leads to a state of adipositywhich can further cause a decrease in adiponectin levels.
Highlights
Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder affecting reproductiveage women worldwide. [1]
Material and Methods: The present study included 50 women of reproductive age attending the department of Gynecology, tertiary care institute of India and diagnosed with polycystic ovary syndrome based on Rotterdam criteria
Serum adiponectin levels are significantly lower in women with polycystic ovary syndrome compared to healthy women
Summary
Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder affecting reproductiveage women worldwide. [1]. Serum adiponectin levels were found to be altered in women with PCOS due to the increased adiposity commonly observed in them. The altered adiponectin levels are proposed to contribute to the endocrine and metabolic disturbances observed in PCOS women. The glucose oxidase-peroxidase (GOD-POD) method was used for the measurement of fasting blood sugar, total cholesterol and triglycerides were determined by enzymatic endpoint colourimetric methods and high-density lipoprotein cholesterol was estimated by selective inhibition method. All these parameters were analyzed using commercial kits on Beckman. Confidence level and level of significance were set at 95% and 5% respectively
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