Adenocarcinoma Of Fallopian Tube Research Articles

Magnetic resonance imaging in the diagnosis of serous adenocarcinoma of fallopian tubes - description of a clinical observation.

Serous adenocarcinoma of the fallopian tubes is an extremely rare and difficult to diagnose form of the female genital tract malignancies. This pathology is often asymptomatic or accompanied by a nonspecific clinical picture, including serosanguineous vaginal discharge, colicky pain in the lower abdomen and pelvis, and adnexal mass. These symptoms are known in the literature as the Lacko triad and are considered pathognomonic for fallopian tube cancer. However, all of these symptoms occur in less than 15% of patients. The low frequency of occurrence and the absence of pathognomonic clinical picture lead to a high number of diagnostic errors, or to the diagnosis of the disease already in a neglected stage, which significantly worsens the prognosis for the patient. The exact diagnosis at the preoperative stage is established in only 4% of cases. This clinical observation describes a case of serous adenocarcinoma of the fallopian tube with all manifestations of the Lacko triad and MR imaging, which allowed us to suspect the presence of serous adenocarcinoma in the patient at the preoperative stage.

Primary mucinous gland lesions of fallopian tube: a clinicopathological analysis of fourteen cases

Objective: To investigate the clinical and pathological characteristics of primary mucinous gland lesions of the fallopian tubes. Methods: The clinical data, pathomorphological characteristics and immunophenotype of 14 cases of primary mucinous gland lesions of the fallopian tube diagnosed at Obstetrics and Gynecology Hospital of Fudan University from 2015 to 2023 were analyzed retrospectively. In addition, a comprehensive review of relevant literature was conducted. Results: The age of 14 patients ranged from 53 to 83 years, with an average of 65 years. Among them, 13 cases exhibited unilateral involvement while one case showed bilateral presentation. Nine cases were mucinous metaplasia of the fallopian tube, four cases were invasive mucinous adenocarcinoma and one case was mucinous carcinoma in situ. Morphologically, mucinous metaplasia of the fallopian tube was focal, with or without inflammation. The cells of mucinous adenocarcinoma or mucinous carcinoma in situ exhibited characteristics indicative of gastrointestinal differentiation. Immunohistochemical analysis revealed diffuse positive expression of CK7, and negative expression of SATB2. CDX2 demonstrated positive staining in two cases. One case exhibited diffuse and strongly positive mutant expression of p53, whereas the remaining cases displayed wild-type expression. MUC6 showed diffuse or focally positive staining in mucinous gland lesions characterized by gastric differentiation. Some cases of mucinous adenocarcinoma of fallopian tube were subject to AB-PAS staining, resulting in red to purple cytoplasmic staining. Conclusions: Primary mucinous lesions of the fallopian tube are exceedingly uncommon. All cases of mucinous adenocarcinoma of fallopian tubes in this study exhibit the morphology and immunohistochemical characteristics of gastrointestinal differentiation. Mucinous metaplasia of the fallopian tube is a benign lesion of incidental finding, which is closely related to inflammation or gastric differentiation. Mucinous lesions of cervix, ovary and digestive tract are excluded in all patients, confirming the independent existence of mucinous lesions within fallopian tubes.

Metastatic Mullerian adenocarcinoma involving the pancreas initially misdiagnosed as an intraductal papillary mucinous neoplasm (IPMN): A case report, and lessons learned

Abstract Introduction/Objective Metastases to the pancreas from Mullerian primaries are rare and can be confused with primary pancreatic malignancies. Methods/Case Report A 49-year-old woman presented with right lower abdominal pain. She denied any prior history of malignancy but had undergone hysterectomy and bilateral salpingo-oophorectomy for unknown reasons. CT scan revealed an 8.9 cm predominantly cystic mass in the pancreas, highly suspicious of an invasive mucinous neoplasm. EUS-guided FNA of the pancreas showed large, complex papillary fronds of mucinous epithelial cells in a background of abundant extracellular mucin, findings that were interpreted as an intraductal papillary mucinous neoplasm (IPMN) with foci of high-grade dysplasia and possible adenocarcinoma. A subsequent PET/CT scan demonstrated a 3.9 cm hepatic mass and a 3.8 cm perihepatic lesion. FNA of the liver was interpreted as metastatic pancreatic adenocarcinoma. Despite aggressive treatment, her disease progressed. Molecular profiling of her liver tumor demonstrated a pathogenic KRAS G12D mutation and a PDGFRA variant of uncertain significance. Genomic (DNA) and transcriptomic (RNA) analysis indicated a 96% probability that the patient had ovarian or fallopian tube adenocarcinoma and a 4% probability of uterine endometrial adenocarcinoma rather than metastatic pancreatic adenocarcinoma. A panel of immunocytochemical stains was performed on the pancreas and liver FNAs. The tumor cells were strongly positive for CK7, CK19, ER, and WT1, focally positive for PAX8 (nuclear) and P53 (wild-type), and negative for CK20, CDX2, and SATB2. Results (if a Case Study enter NA) NA Conclusion These findings corroborated the molecular analysis suggesting that the patient had metastatic Mullerian adenocarcinoma rather than metastatic pancreatic adenocarcinoma. Her oncologic treatment was adjusted accordingly.

CYSTIC CHANGES IN MEDIASTINAL LYMPH NODES WITH METASTATIC SEROUS FALLOPIAN TUBE CARCINOMA

TOPIC: Disorders of the Mediastinum TYPE: Medical Student/Resident Case Reports INTRODUCTION: Fallopian tube carcinoma is associated with a high rate of distant metastasis, likely due to the lack of florid symptoms. We describe a case of fallopian tube carcinoma, metastatic to mediastinal lymph nodes with cystic changes developing in the lymph nodes. CASE PRESENTATION: Our patient is a 65-year-old female with stage IIIA2 high-grade serous carcinoma of the fallopian tube diagnosed in 2019. She initially presented with lower extremity weakness, thought to be Guillain-Barré syndrome. She underwent MR spine, which was notable for a pelvic mass. PET-CT revealed hypermetabolic appearance of abdominal and mediastinal lymph nodes and a right lung nodule. She underwent surgical debulking of the pelvic mass, wedge resection of the right lung, and extensive lymph node dissection. This was followed by chemotherapy with carboplatin and paclitaxel. Final pathology reported a high-grade serous carcinoma of the fallopian tube. The right lung nodule was noted to be a histoplasma granuloma. She had a good response to the initial management. Approximately two years after initial diagnosis, the patient had rising CA-125 and subsequent imaging revealed new pulmonary nodules with enlarged necrotic appearing mediastinal and retroperitoneal lymph nodes. She was hesitant to start chemotherapy without confirmation of recurrence. She underwent endobronchial ultrasound (EBUS) with bronchoscopy, which confirmed enlarged mediastinal lymph nodes and biopsies were performed. The lymph node at the 4R station was 24mm in size with distinct cystic changes. Fine needle aspiration was performed, and it yielded 3ml of yellow-colored fluid. The final pathology showed high-grade adenocarcinoma of gynecologic origin with cells positive for PAX8, CK-7 and p53. The patient returned to the care of her oncologist to undergo further chemotherapy. DISCUSSION: Fallopian tube carcinoma is an uncommon gynecological malignancy, with very few reported cases of metastasis to the mediastinum. There is a limited understanding of the manifestations of the disease, especially regarding the characteristics of distant metastasis. Our patient had delayed recurrence of this cancer and imaging demonstrated distant metastasis to the mediastinal lymph nodes. We are presenting ultrasound characteristics of mediastinal lymph nodes in metastatic serous fallopian tube cancer with cystic changes and EBUS guided aspiration of fluid. After an extensive literature search, a case with similar findings was not found. CONCLUSIONS: Cystic changes in malignant lymph nodes are uncommon. This case demonstrates the importance of bronchoscopy and EBUS in the investigation of gynecological malignancies which are metastatic to the mediastinum. REFERENCE #1: Zhang B, Liu R, Li T, et al. Anterior mediastinal metastasis of primary fallopian tube adenocarcinoma: a case report. J Cardiothorac Surg. 2020;15(1):77. Published 2020 May 11. doi:10.1186/s13019-020-01111-4 DISCLOSURES: No relevant relationships by Zaid Ansari, source=Web Response No relevant relationships by Sharjeel Israr, source=Web Response No relevant relationships by Ashish Sadolikar, source=Web Response No relevant relationships by Ali Saeed, source=Web Response No relevant relationships by Hursh Sarma, source=Web Response No relevant relationships by Cindrel Tharumia Jagadeesan, source=Web Response

Heat Artifact Mimicking Adenocarcinoma of Fallopian Tube

Heat Artifact Mimicking Adenocarcinoma of Fallopian Tube

Study of spectrum of neoplastic and non-neoplastic lesions in fallopian tube in a tertiary care hospital

Background: Fallopian tubes are affected by a wide spectrum of diseases varying from salpingitis to carcinoma. Most pathological processes involving the fallopian tube are inflammatory and are of clinical significance because they interfere with the function of the fallopian tube and result in infertility. Although fallopian tube is affected by a wide spectrum of diseases, a literature search reveals that there are only occasional studies, documenting histologic changes in the fallopian tube removed for all reasons. This prompts the present study. The aim is to study the gross and microscopic features of the excised fallopian tubes and to study the common and unusual lesions in them and to study the frequency of histological findings and relative frequencies of different findings. Materials and methods: Four hundred and forty-five cases of fallopian tubes that were removed were studied retrospectively, and their histopathological findings documented. Results: The majority of the fallopian tubes had inflammatory changes comprised of acute and chronic salpingitis, salpingitis isthmica nodosa, tuberculous salpingitis, xanthogranulomatous salpingitis, hematosalpinx, and hydrosalpinx. Sixteen cases comprised of ectopic pregnancy. One case of primary fallopian tube adenocarcinoma and two cases of metastatic adenocarcinoma. Conclusion: The majority of the fallopian tubes remain unremarkable in a majority of the surgical pathology specimens, yet the fallopian tube must be subjected to a thorough histopathological examination to evaluate the various pathological lesions.

Serous Adenocarcinoma of Fallopian Tubes: Histological and Immunohistochemical Aspects.

BackgroundAlthough primary cancer of the fallopian tubes is a relatively rare type of tumor in female reproductive organs, its mortality is quite high. It is important to identify molecular and biological markers of this malignancy that determine its specific phenotype.MethodsThe study was carried out on samples received from 71 female patients with primary cancer of the fallopian tubes. The main molecular and biological properties, including hormone status (estrogen receptor [ER], progesterone receptor [PR]), human epidermal growth factor receptor (HER2)/neu expression, proliferative potential (Ki-67), apoptosis (p53, Bcl-2), and pro-angiogenic (vascular endothelial growth factor) quality of serous tumors were studied in comparison with clinical and morphological characteristics.ResultsER and PR expression is accompanied by low grade neoplasia, early clinical disease stage, and absence of lymphogenic metastasis (p < .001). HER2/neu expression is not typical for primary cancer of the fallopian tubes. Ki-67 expression is characterized by an inverse correlation with ER and PR (p < .05) and is associated with lymphogenic metastasis (p < .01). p53+ status correlates with high grade malignancy, tumor progression, metastasis, negative ER/PR (p < .001), and negative Bcl-2 status (p < .05). Positive Bcl-2 status is positively correlated with ER and PR expression and low grade malignancy.ConclusionsComplex morphologic (histological and immunohistochemical) study of postoperative material allows estimation of the degree of malignancy and tumor spread to enable appropriate treatment for each case.

Case report of primary serous adenocarcinoma of fallopian tube - a diagnostic dilemma

Historically, primary fallopian tube carcinoma constitutes 0.3% of all cancers of the female genital tract. But literature suggests that the primary fallopian tube carcinoma may be more common. The true incidence of fallopian tube cancer may be underestimated because of the convention of assigning many of these as ovarian cancer when the site of origin is unclear. The preoperative diagnosis is difficult due to the lack of specific symptoms. Fallopian tube carcinoma clinically behaves like epithelial ovarian cancer and histologically similar to it; thus, the evaluation and treatment are essentially the same. We report here a typical case of primary fallopian tube cancer in a 48 year old female diagnosed as ovarian tumour, preoperatively by radiological imaging but was recognized as fallopian tube carcinoma intraoperatively and was confirmed by histopathology.

A Preliminary Report Requiring Continuation of Research to Confirm Fallopian Tube Adenocarcinoma: A Non-Experimental, Non-Randomized, Cross-Sectional Study.

BackgroundTransvaginal ultrasound has fair characteristics, and pathology is an invasive technique for fallopian tube tumor diagnosis. Magnetic resonance images have better intra- and inter-observer reliabilities for detection of primary fallopian tube malignant tumor(s) than the other diagnostic modalities. The purpose of this study was to investigate parameters of different types of magnetic resonance images for women with fallopian tube adenocarcinoma and to compare these parameters with the FIGO grading system to improve the accuracy of diagnosis and prognosis.Material/MethodsA total of 121 women who had clinically-proven fallopian tube adenocarcinoma were included in this cross-sectional study. A 3.0 T magnetic resonance images system was used for spin-lattice relaxation-weighted (T1WI), spin-spin relaxation-weighted (T2WI), diffusion-weighted, (DWI), and apparent diffusion coefficient (ADC) images. ANOVA following Tukey post hoc tests and Spearman rank correlation were performed at 99% confidence level.ResultsAxial T1WI, axial T2WI, and axial DWI, were provided low, intermediate, and high fluid signal intensity, respectively, for a tumor. Sagittal T1WI showed contrast uptake by the mass with necrosis. Sagittal T2WI showed a solid mass with well-defined walls. Sagittal DWI showed restriction to diffusion. ADC values were significantly higher for FIGO grade 1 women than for FIGO grade 3 women (p<0.0001, q=16.591). The Spearman correlation coefficient was 0.1012 between mean ADC and FIGO grading.ConclusionsWe recommend that magnetic resonance images be included in the FIGO guideline for grading of malignancies in the female genital tract.

Внематочная беременность, ассоциированная с аденокарциномой маточной трубы

Внематочная беременность, ассоциированная с аденокарциномой маточной трубы

Primary Fallopian Tube Adenocarcinoma Discovered with the Vaginal Cytology: A Case Report with Pathological and Immunohistochemical Investigation

Background: Primary fallopian tube cancer is an extremely rare gynecological malignancy. Aim: To discuss, through a case report, the diagnostic process by means of cytology immunohistochemistry. Case Presentation: A 47-year-old Japanese woman, who also had lung cancer, presented with enlarged para-aortic lymph node without any symptoms. Based on the vaginal cytology report suggestive of gynecologic malignant tumor (possibly fallopian tube adenocarcinoma), primary surgery comprised of total abdominal hysterectomy and bilateral salpingo-oophorectomy was performed. Histopathology and immunohistochemistry examinations revealed primary fallopian tube carcinoma with metastasis of para-aortic lymph node. She is free from recurrence and metastases 9 months after the surgery and chemotherapy. Conclusion: Although primary fallopian tube cancer is a rare gynecologic malignancy, vaginal cytology may be useful for detecting fallopian tube carcinoma.

Primary fallopian tube carcinoma: A case of rare malignancy

Primary fallopian tube carcinoma is an extremely uncommon tumor of female genital tract origin with the incidence of 0.1%–1.8% of all genital malignancies. Due to its nonspecific symptomatology and rarity of this neoplasm, correct preoperative diagnosis is made only in 4% of the cases and is usually first recognized by pathologist. Our case was a 39-year-old patient who presented with intermittent vaginal bleeding, lower abdominal pain, and pelvic mass. On physical examination, lower abdominal tenderness was found. Ultrasound examination revealed bilateral hydrosalpinx. The patient underwent total abdominal hysterectomy with bilateral salpingo-oophorectomy. Histopathological examination confirmed features of papillary serous adenocarcinoma of the left fallopian tube. The patient was referred to oncologist for chemotherapy. Six months following initial surgery, the patient is in good condition. This case is being reported due to the scarcity of data published from the Indian population and rarity of this neoplasm.

Bilateral serous papillary adenocarcinoma of fallopian tube: a case report

Primary carcinoma of fallopian tube is rare and accounts for only 0.7-1.5% of all gynecological malignancies. Majority of the patients are postmenopausal with mean age of 61 years. Study present a case of 48-year-old lady, who underwent total abdominal hysterectomy with bilateral salpingo oophorectomy for a clinical diagnosis of fibroid uterus. Histopathological examination revealed, in addition to intramural fibroids, bilateral serous papillary adenocarcinoma of fallopian tube. We present this case due to its rarity.

Primary Fallopian Tube Carcinoma Presenting with Isolated Controlateral Inguinal Lymphadenopathy

Primary fallopian tube carcinoma is a rare tumor accounting for <1% of all female genital tract cancers. Presentation primarily as inguinal lymphadenopathy alone is rare. We report a case of a 57-year postmenopausal woman who presented with seven months history of swelling in the right groin, excised and confirmed to be metastatic adenocarcinoma. CA-125 was elevated with a value of 960 U/ml. An exploratory laparoscopy was done, with total abdominal hysterectomy, omentectomy, and appendicectomy, without lymph node dissection. Uterus, right fallopian tube, and ovaries were normal. The left fallopian tube was distended with a mass of 6x5 cm. Histology of left fallopian tube revealed high-grade adenocarcinoma with malignant peritoneal cytology. Histology of right fallopian tube and other structures was normal. The patient received four cycles of adjuvant carboplatin plus taxol with good biological and radiological response. She was referred to our institute for a second look surgery and lymph node dissection. Two months after the end of chemotherapy, she underwent the second surgery consisting of a pelvic, para-aortic and right inguinal lymphadenectomy with a sample from the left inguinal node. There were two metastatic nodes. The patient received six other cycles of carboplatin plus taxol. At present, she remains well, and CA-125 is normal. Fallopian tube adenocarcinoma rarely presents as metastatic inguinal lymphadenectomy. The management of this malignancy is generally the same as epithelial ovarian cancer.

Primary Adenocarcinoma of the Fallopian Tube: Report of Two Cases

Primary fallopian tube cancer is the rarest cancer of female genital tract. In fact, it represents less than 1% of all the gynaecological and breast cancers. Adenocarcinoma is the most common histological type. This paper revels two cases of primary fallopian tube adenocarcinoma. They are diagnosed in pathology department. There are two patients to 53 years and 62 years respectively, with no significant personal or family history. They are consulted for chronic pelvic pain with pelvic mass. The clinical assessment revealed an abdomino-pelvic mass of hard consistency. We review the epidemiological, clinical, anatomo-pathological, therapeutic and prognosis specificities of this tumor. This cancer occurs in patients in their sixties, in a context of infertility, pauci-parity, chronic tubal infection or a genetic predisposition. The pelvic pain and the perception of a pelvic mass are the most frequent clinical manifestations. Paraclinical examinations (pelvic ultrasound, CT, MRI and serum markers) are not specific and diagnosis is often made peroperatively or postoperatively by anatomo-pathological examination. In fact, the tubal carcinoma is often confused with his ovarian counterpart which have several similarities. The prognosis is relatively dark, but still better than ovarian carcinoma. It mainly depends on the stage of disease and quality of surgical resection.

Incidental Fallopian Tube Adenocarcinoma Managed using Robotic Staging Surgery

Primary fallopian tube carcinoma is an uncommon gynecological malignancy. Management of primary fallopian tube carcinoma using a robotic-assisted approach is also rare. We have described here two cases of adenocarcinoma located in the fallopian tubes that were managed using robotic-assisted staging surgery, followed by subsequent serial chemotherapy. The surgical procedure consisted of a total hysterectomy, bilateral salpingo-oophorectomy, bilateral pelvi lymph node dissection, para-aortic lymph node dissection, appendectomy, omentectomy, peritoneal biopsies, and ascites cytology. After surgery, a test for CA-125 level and a computed tomography (CT) evaluation were conducted every 3 and 6 months, respectively. In Case I, the patient received 6 cycles of chemotherapy consisting of cisplatin and paclitaxel after surgery, and CA-125 level decreased from 55.9 U/mL to 9.5 U/mL over 6 months. At 16 months after surgery, a follow-up CT scan revealed no evidence of local recurrence. In Case II, the patient received 11 cycles of chemotherapy including cisplatin and paclitaxel, and CA-125 level decreased from 52.1 U/mL to 11.1 U/mL over 12 months. At 20 months after surgery, a follow-up CT scan revealed no evidence of local recurrence. In conclusion, robotic-assisted staging surgery is a feasible approach for treating incidentally located tumors in the fallopian tubes.

New concept in serous adenocarcinoma of fallopian tube

输卵管癌在传统上被认为主要是继发癌,原发性输卵管癌的发病率很低,在女性生殖道肿瘤中居次要地位.近年研究显示,输卵管伞端存在与浆液性腺癌有关的系列病变,尤其是早期癌与前驱病变,表明输卵管伞端是多数盆腔浆液性腺癌的起源地,从而在很大程度上颠覆了人们以往对输卵管癌的认识,有关输卵管癌的定义、病变谱系、临床与病理形态等重要概念均需更新.为此,我们对有关输卵管癌的新的研究进展介绍如下。

Spinal Metastases from a Primary Fallopian Tube Serous Adenocarcinoma: A Case Report

Study Design Case report. Objective This case exemplifies the importance of a high index of suspicion when dealing with intractable pain and neurologic symptoms in patients with a history of cancer. Fallopian tube cancer is relatively uncommon, accounting for less than 0.2% of all female malignancies. Because of a low index of suspicion, it is often detected at an advanced stage. From an orthopedic perspective, osseous metastasis from primary fallopian tube malignancies is rare with only a few documented cases in the medical literature. Methods This case report documents a 68-year-old woman who developed back pain and leg weakness after undergoing surgical resection with adjuvant therapy of a primary fallopian tube adenocarcinoma. Her hospital course and follow-up are documented. Results Imaging revealed a compression fracture in the L1 vertebral body that when a biopsy confirmed a soft tissue diagnosis of a high-grade serous papillary adenocarcinoma of fallopian tube origin. The patient underwent a surgical decompression, posterior stabilization, and tumor debulking with postoperative resolution of her symptoms. Conclusions This is the first reported case of a spine metastasis from a fallopian tube serous carcinoma in a living patient. This case documents the diagnosis of a pathologic vertebral fracture due to metastasis of an atypical cancer.

A rare primary malignant tumor of fallopian tube

Primary adenocarcinoma of fallopian tube is one of the rarest and accounts for about 1% of all gynecological malignancies. We are presenting this rare case of the primary fallopian tubal carcinoma. A 60-year-old female patient with para 2 visited the Gynecologic and Obstetric Department with the complaints of white discharge and abdominal pain since 4 months duration. Radiological study suggested hydrometra with polypoidal growth in the left adnexa suggestive of malignant lesion. The patient und

Incidental Fallopian Tube Adenocarcinoma Managed with Robotic Staging Surgery

Incidental Fallopian Tube Adenocarcinoma Managed with Robotic Staging Surgery