Adenocarcinoma Of Fallopian Tube Research Articles

What Would We Miss if HR-HPV Testing Was Used for Primary Cervical Cancer Screening

Introduction: The US Food and Drug Administration (FDA) recently approved use of the Cobas HPV test (Roche Molecular System, Pleasanton CA) for primary cervical cancer screening in women 25 years or older. False-negative high risk (HR) human papillomavirus (HPV) results can become clinically relevant when used independent of cytology for primary screening. This study investigates the occurrence and significance of abnormal cytology and negative HR HPV testing with the Cobas HPV system in ThinPrep (Hologic, Bedford MA) and SurePath (BD, Burlington NC) preparations. Materials and Methods: All liquid-based Pap tests with negative HR HPV co-testing performed using the Cobas HPV system in women 25 years or older between August 2012 and July 2013 were retrieved. Pathologic follow-up was evaluated when available. Results: A total of 24,384 liquid-based Pap tests with negative HR HPV co-testing from women 25 years or older were evaluated. Overall, abnormal cytology (ASCUS or above) was noted in 1,015 cases (4.2%) as outlined in Table 1. Follow-up was available in 603 (59.4%) women: 150 (24.9%) were found to have significant uterine lesions (CIN 1+), including 9 (1.5%) with CIN 2+ squamous lesions, 3 endometrial simple hyperplasias, 4 (0.6%) endometrial adenocarcinomas, and 1 fallopian tube adenocarcinoma. All 5 women who on follow up were found to have uterine adenocarcinoma were asymptomatic. In addition, of 838 (5.1%) women aged 40 or older with endometrial cells noted by cytology, 4 (0.5%) were diagnosed with endometrial adenocarcinoma on subsequent follow-up. Conclusions: Using CIN 2+ as the cutoff, 1.5% of women would have a significant HPV-related uterine lesion that would have gone undetected if HR HPV testing was used alone as the primary screening test. Therefore, while HR HPV testing is sensitive in detecting HPV-related precancerous and cancerous lesions, a small percentage of non-HPV related uterine malignancies would go undetected.

A case of bilateral primary fallopian tube carcinoma

Abstract A 60 years old postmenopausal woman was presented with complaints of intermittent watery discharge from vagina, and of cramping pain at the lower abdomen. On pelvic examination, blood tinged watery discharge was seen coming out of os. But, ultrasonography revealed bilateral adenexal masses and pyometra. The serum CA-125 level in blood was raised. Cervical smear showed inflammatory changes, but endometrial histopathology was negative for malignant cells. Suspecting ovarian malignancy, laparotomy was done that revealed the bilateral tubal growth with normal ovaries; the right adenexal mass was of the size (6.8×4.8) cm while, the left adenexal mass was the size of (4.2×2.6) cm. Histopathology study revealed bilateral serous cyst adenocarcinoma of fallopian tubes. The case of bilateral primary fallopian tube carcinoma was presented here for its rarity.

Proteomic analyses of serous and endometrioid epithelial ovarian cancers – Cases studies – Molecular insights of a possible histological etiology of serous ovarian cancer

Epithelial ovarian carcinogenesis may occur de novo on the surface of ovarian mesothelial epithelial cells or from cells originating in other organs. Foreign Müllerian cell intrusion into the ovarian environment has been hypothesized to explain the latter scenario. In this study, MALDI MS profiling technology was used to provide molecular insights regarding these potentially different mechanisms. Using MALDI MS profiling, the molecular disease signatures were established in their anatomical context. MALDI MS profiling was used on serous and endometrioid cancer biopsies to investigate cases of epithelial ovarian cancer. We then applied bioinformatic methods and identification strategies on the LC-MS/MS analyses of extracts from digested formalin-fixed, paraffin-embedded tissues. Extracts from selected regions (i.e. serous ovarian adenocarcinoma, fallopian tube serous adenocarcinoma, endometrioid ovarian cancer, benign endometrium, and benign ovarian tissues) were performed, and peptide digests were subjected to LC-MS/MS analysis. Comparison of the proteins identified from benign endometrium or three ovarian cancer types (i.e. serous ovarian adenocarcinoma, endometrioid ovarian adenocarcinoma, and serous fallopian tube adenocarcinoma) provided new evidence of a possible correlation between the fallopian tubes and serous ovarian adenocarcinoma. Here, we propose a workflow consisting of the comparison of multiple tissues in their anatomical context in an individual patient. The present study provides new insights into the molecular similarities between these two tissues and an assessment of highly specific markers for an individualized patient diagnosis and care.

Malignant mixed mullerian tumor of endometrium coexisting with bilateral papillary serous adenocarcinoma of fallopian tube: a rare case report.

Malignant mixed mullerian tumor of the female genital tract is a rare neoplasm of uncertain histogenesis. Malignant mixed mullerian tumors are uterine neoplasms which are composed of a mixture of malignant epithelial and mesenchymal elements. Primary adenocarcinoma of the fallopian tube is a rare tumor of the female genital tract accounting for only 0.3–1.1 % of all gynecological malignancies. Bilateral involvement occurs in 20 % carcinomas. A rare case of Malignant mixed mullerian tumor of endometrial polyp with associated bilateral fallopian tube papillary adenocarcinoma is being reported.

細胞診異常の約 2 年後に診断しえた卵管類内膜腺癌の 1 例

細胞診異常の約 2 年後に診断しえた卵管類内膜腺癌の 1 例

A Case Report Of Fallopian Tubal Carcinoma

Primary adenocarcinoma of fallopian tube is one of the rarest gynaecological malignancies. Its incidence is under estimated because advanced tumors usually spread to ovaries are often wrongly diagnosed as ovarian tumor. We are presenting this rare case of Primary Fallopian Tubal Carcinoma(PFTC).

Primary and bilateral tubal carcinoma is associated with long‐standing granulomatous inflammation and primary infertility: A case report

We report a case of bilateral and primary tubal carcinoma associated with granulomatous inflammation and long-standing primary infertility. A 38-year-old woman with a 17-year history of primary infertility presented with lower abdominal pain and granulomatous inflammation in the endometrial biopsy. Bilateral adnexal masses measuring 4 and 6 cm in size were detected and the serum cancer antigen 125 level was 141 IU/ml. Laparoscopic surgical exploration and frozen section on the resected tubes revealed bilateral fallopian tube adenocarcinoma and then a staging laparotomy was performed. Histopathological examination showed a primary bilateral Grade 2 tubal serous adenocarcinoma of Stage 1b associated with granulomatous salpingitis. Primary fallopian tube carcinomas in young women are extremely rare gynecological tumors that are infrequently diagnosed prior to surgical exploration and their cause is unknown. A definitive diagnosis could be made on the histopathological examination in our case with the evidence of chronic pelvic inflammation. Our findings suggest that chronic pelvic inflammation may play a role in carcinogenesis in the tubes of infertile women.

Abstract LB-253: Mesenchymal stem cells of fallopian tube cancers are specifically attracted by mature ovulating follicles: implication of fallopian tube origin of serous ovarian carcinoma

Abstract Background: Recent studies of surgical specimens resected from carriers of breast ovarian cancer syndrome have suggested a fallopian tube origin of serous carcinoma of the ovary. We tested the following hypothesis: Cancer initiating cells arising from fallopian tube home to ovulation wound via chemotaxis of follicular fluid. Materials and Methods: Mesenchymal stem cells from fallopian tube cancers (FTC-MSC) and normal fallopian tubes (FT-MSC) were respectively culture-isolated from two patients with FIGO stage 3C serous adenocarcinoma of fallopian tube and three patients with uterine myoma. Tissues were digested with collagenase type I and dispase and cells were grown in anti-oxidant DMEM medium containing 5% fetal bovine serum. Characteristics of stem cells including cell surface markers, colony formation, trans-differentiation and hTERT expression were analyzed. Follicular fluids and cells were procured and cultured from ovulating women receiving in-vitro fertilization program. Chemotaxis and cell migration activities were studied by trans-well migration assay and wound healing assay. Results: The isolated FTC-MSC had a doubling time of around 25h and gave a typical mesenchymal stem cell phenotypes with anchorage independent growth, lack of gap junction communication, positive for CD24, CD44, CD133, CD29, CD90, CD56, CD117 and CD146, negative for CD 34 and CD45, and had high hTERT expression. Capabilities of osteogenic and adipogenic differentiation and chemo-resistence paclitaxol and cisplatin were evident. FTC-MSC but not FT-MSC highly responded to mature, ovulating follicular fluid, and to condition media of cultured follicular cells or ovarian stromas, and much less to those derived from immature follicles, and to conditional media of endometrial, cervical and peritoneal cells in culture. Conclusions: The highly specific chmotaxic effect of mature, ovulating follicles to FTC-MSC supports the hypothesis of fallopian tube origin of serous ovarian carcinoma. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr LB-253.

Primary adenocarcinoma of fallopian tube

Primary adenocarcinoma of fallopian tube

Serous adenocarcinoma of the fallopian tube, associated with verrocous carcinoma of the uterine cervix: a case report of synchronic rare gynecological tumors

BackgroundSynchronous gynecological tumors are rare; it is even rarer to find the rarest of gynecological tumors that of the fallopian tube, together with a histological sub-type as rare as verrucous cervix.Case presentationWe report a synchronic fallopian tube adenocarcinoma and a verrucous cervical cancer. A 85-year-old woman with postmenopausal genital hemorrhage, endometrial biopsy was reported as squamous metaplasia, an exploratory laparotomy was performed finding a tubal tumor diagnosed as adenocarcinoma, a staging procedure was performed. Final staging revealed IB1 cervical carcinoma and IA G3 fallopian tube carcinoma. Adjuvant treatment with chemotherapy was not accepted by the patient. The patient has remained in follow-up, and at 9 months, there has been no documented evidence of recurrent disease.ConclusionReasons for our presentation of this work are: first, due to the rarity of these, and second, because of the usefulness of possessing a case report for establishing a norm for later behavior with respect to treatment of these patients.

Primary fallopian tube adenocarcinoma with brain and lung metastasis

Primary fallopian tube adenocarcinoma with brain and lung metastasis

Occult Malignancy in Patients With Suspected Paraneoplastic Neurologic Syndromes: Value of Positron Emission Tomography in Diagnosis

OBJECTIVE To determine the value of positron emission tomography (PET) in diagnosing occult malignancies in patients with paraneoplastic neurologic syndromes (PNSs) at Mayo Clinic's site in Rochester, MN. PATIENTS AND METHODS We retrospectively reviewed the medical charts of all 107 patients who underwent PET from January 1, 2000, to July 31, 2006, for the indication of suspected PNS. Three patients did not meet inclusion criteria. PET results were considered positive if increased fludeoxyglucose F 18 uptake indicated malignancy (24 patients). Results from computed tomography were interpreted as positive if any suspect lesion was consistent with malignancy (26 patients). RESULTS One hundred four patients with PNS were identified from the PET central database; 73 patients had at least 1 positive result for paraneoplastic antibody, and 31 had antibody-negative PNS. Malignancy was confirmed pathologically in 10 patients, of whom 8 had positive PET results. There were 2 cases of confirmed malignancy (fallopian tube adenocarcinoma and spindle cell uterine carcinoma) for which PET results were negative. Two patients with positive PET results declined biopsy. Computed tomography was able to identify 3 of the 10 malignancies detected. Five cases of malignancy were detected only by PET. All patients with confirmed malignancy had positive results for at least 1 paraneoplastic antibody. One patient with positive results for PNS antibody and negative PET results was diagnosed as having small cell carcinoma on a follow-up PET scan after 27 months. PET had sensitivity, specificity, positive predictive value, and negative predictive value of 80%, 67%, 53%, and 88%, respectively. CONCLUSION PET scan was shown to be more sensitive than computed tomography for detecting occult malignancy (confirmed by positive test results for autoantibody) among patients with suspected PNS. The greatest clinical utility of PET could be in its high negative predictive value. To determine the value of positron emission tomography (PET) in diagnosing occult malignancies in patients with paraneoplastic neurologic syndromes (PNSs) at Mayo Clinic's site in Rochester, MN. We retrospectively reviewed the medical charts of all 107 patients who underwent PET from January 1, 2000, to July 31, 2006, for the indication of suspected PNS. Three patients did not meet inclusion criteria. PET results were considered positive if increased fludeoxyglucose F 18 uptake indicated malignancy (24 patients). Results from computed tomography were interpreted as positive if any suspect lesion was consistent with malignancy (26 patients). One hundred four patients with PNS were identified from the PET central database; 73 patients had at least 1 positive result for paraneoplastic antibody, and 31 had antibody-negative PNS. Malignancy was confirmed pathologically in 10 patients, of whom 8 had positive PET results. There were 2 cases of confirmed malignancy (fallopian tube adenocarcinoma and spindle cell uterine carcinoma) for which PET results were negative. Two patients with positive PET results declined biopsy. Computed tomography was able to identify 3 of the 10 malignancies detected. Five cases of malignancy were detected only by PET. All patients with confirmed malignancy had positive results for at least 1 paraneoplastic antibody. One patient with positive results for PNS antibody and negative PET results was diagnosed as having small cell carcinoma on a follow-up PET scan after 27 months. PET had sensitivity, specificity, positive predictive value, and negative predictive value of 80%, 67%, 53%, and 88%, respectively. PET scan was shown to be more sensitive than computed tomography for detecting occult malignancy (confirmed by positive test results for autoantibody) among patients with suspected PNS. The greatest clinical utility of PET could be in its high negative predictive value.

Occult Malignancy in Patients With Suspected Paraneoplastic Neurologic Syndromes: Value of Positron Emission Tomography in Diagnosis

To determine the value of positron emission tomography (PET) in diagnosing occult malignancies in patients with paraneoplastic neurologic syndromes (PNSs) at Mayo Clinic's site in Rochester, MN. We retrospectively reviewed the medical charts of all 107 patients who underwent PET from January 1, 2000, to July 31, 2006, for the indication of suspected PNS. Three patients did not meet inclusion criteria. PET results were considered positive if increased fludeoxyglucose F 18 uptake indicated malignancy (24 patients). Results from computed tomography were interpreted as positive if any suspect lesion was consistent with malignancy (26 patients). One hundred four patients with PNS were identified from the PET central database; 73 patients had at least 1 positive result for paraneoplastic antibody, and 31 had antibody-negative PNS. Malignancy was confirmed pathologically in 10 patients, of whom 8 had positive PET results. There were 2 cases of confirmed malignancy (fallopian tube adenocarcinoma and spindle cell uterine carcinoma) for which PET results were negative. Two patients with positive PET results declined biopsy. Computed tomography was able to identify 3 of the 10 malignancies detected. Five cases of malignancy were detected only by PET. All patients with confirmed malignancy had positive results for at least 1 paraneoplastic antibody. One patient with positive results for PNS antibody and negative PET results was diagnosed as having small cell carcinoma on a follow-up PET scan after 27 months. PET had sensitivity, specificity, positive predictive value, and negative predictive value of 80%, 67%, 53%, and 88%, respectively. PET scan was shown to be more sensitive than computed tomography for detecting occult malignancy (confirmed by positive test results for autoantibody) among patients with suspected PNS. The greatest clinical utility of PET could be in its high negative predictive value.

The Tyrphostin B42 Inhibits Cell Proliferation and HER-2 Autophosphorylation in Cervical Carcinoma Cell Lines

The HER family receptors have an important role controlling cell growth and differentiation. Although the activity of the HER-2 receptor is strictly controlled in normal cells, its overexpression plays a pivotal role in transformation and tumorigenesis. Constitutive phosphorylation of HER-2 protein has been implicated in conferring uncontrolled growth to mammary cancer cells, and to a lesser extent, with adenocarcinoma of uterus, cervix, fallopian tube, and endometrium. This study addresses the role of HER-2 in cervical carcinoma. Firstly, we demonstrate the presence of HER-2 protein expression by flow cytometry in two new cervical carcinoma cell lines CALO and INBL. Secondly, we use the specific tyrosine kinase inhibitors, Tyrphostins to examine HER-2 regulation by the crystal violet assay. Thirdly, we use western blot analysis to assess the state of HER-2 phosphorylation. The most efficient agent, Tyrphostin B42, known as an inhibitor of epithelial growth factor receptor, arrested cervical carcinoma cell lines growth in vitro at micromolar concentrations within 72 h of application. Tyrphostin B42 inhibited the HER2 signal-regulated kinase pathway, as observed by the reduction in the phosphorylated forms of HER2. The loss of phosphorylated forms of HER2 at early time points after Tyrphostin B42 application was associated with suppression of cell growth. Thus, the inhibition of the proliferation of our cervical carcinoma cell lines by Tyrphostin B42 is associated with inhibition of HER2 protein kinase signal.

Fallopian tube carcinoma

Primary adenocarcinoma of Fallopian tube is a rare gynecological malignancy affecting women in the fifth and sixth decades of their lives. The rarity of this type of carcinoma has prompted reports of individual cases rather than publication of a large series. One such case is reported in a 50-year-old nulliparous post-menopausal female. The age, low fertility index and presentation of the disease are in accordance with previous reports in the literature. The present case also fulfills the diagnostic criteria's applied to this tumor.

P1-087: The role of Positron Emission Tomography (PET) in the evaluation of Paraneoplastic Neurologic Syndrome (PNS)

PNS are a heterogenous group of disorders in patients with malignancy. Often, these are the presenting symptoms of a malignancy, most commonly lung cancers. Auto-antibodies against different neuronal antigens can be detected in the serum, however an underlying malignancy may be difficult to identify. PET using 18-flurodeoxygenase glucose (18-FDG) has been employed to detect occult malignancy. We present the Mayo Clinic experience with PET in diagnosis of occult malignancy. A single center retrospective chart review of all patients, who underwent PET with the diagnosis of suspected or proven paraneoplastic syndrome from January 2000 to October 2006 at Mayo Clinic, Rochester. The PET scan report was considered positive if it showed any foci of increased 18-FDG uptake, as noted by the radiologist. A CT scan was interpreted as positive, if there was presence of a suspicious mass as noted by radiologists. 107 patients were identified form the PET center database, of which 74 patients had at least one positive paraneoplastic antibody. PET was positive in total of 48 patients, 32 of which had antibody positive PNS. Malignancy was detected in 10 patients, of which 9 had a positive PET. There was 1 case of malignancy (fallopian tube adenocarcinoma) with negative PET report .2 patients with positive PET deferred biopsy. CT scan was able to identify only 3 of the 10 malignancies detected. Malignancies diagnosed were small cell carcinomas (N=4), mixed small and large cell (N=1), adenocarcinoma of the lung (N=1), adenocarcinoma of unknown origin (N=1) and thymoma (N=1). Of patients with antibody positive PNS, PET scan had a positive predictive value and negative predictive value of 28% and 97%, respectively. The diagnostic accuracy of PET scan was calculated to be 67%. PET is a useful diagnostic tool in the evaluation of antibody positive PNS patients when standard imaging is non diagnostic.

A Case of Endometrioid Adenocarcinoma of The Fallopian Tube: A Clinically Misleading Type

Carcinoma of the fallopian tube is a rare occurrence. In this paper, the authors report on a case of endometrioid adenocarcinoma of the fallopian tube that was initially misdiagnosed as endometrial carcinoma. The diagnostic dilemma and implications are discussed. (J GYNECOL SURG 23:41)

Sister Mary Joseph’s nodule as the first presenting sign of primary fallopian tube adenocarcinoma

Umbilical metastasis (Sister Mary Joseph's nodule) is often the first sign of intraabdominal and/or pelvic carcinoma. We describe the fourth case reported in the literature of Sister Mary Joseph's nodule originating from fallopian tube carcinoma. In a 54-year-old woman, Sister Mary Joseph's nodule was unexpectedly detected during umbilical hernia repair. Subsequent laparoscopy revealed a 2-cm friable tumor located at the fimbriated end of right fallopian tube and 1-cm peritoneal implant in the pouch of Douglas. Laparoscopic bilateral adnexectomy and resection of the peritoneal implant were performed. Because frozen section examination revealed fallopian tube carcinoma, the procedure was continued with laparotomy including total abdominal hysterectomy, omentectomy, and pelvic lymph node sampling. Final diagnosis was stage IIIB fallopian tube carcinoma. The patient received postoperative adjuvant chemotherapy with single-agent carboplatin and has remained alive and with no evidence of disease. It is concluded that in cases of Sister Mary Joseph's nodule, laparoscopy can be a useful tool in the search of the primary tumor in the abdomen and/or pelvis. Laparoscopy can provide crucial information with respect to the location, size, and feasibility of optimal surgical resection of the intraabdominal and/or pelvic tumors.

Carcinoma tubárico primitivo y polimiositis

We report a case of a primitive fallopian tube carcinoma associated with polymyositis. A 53-year-old woman consulted for pelvic pain, metrorrhagia, and leukorrhea. Physical examination revealed a renitent and mobile mass in the pelvis. Ultrasonography showed a right lateral uterine mass with hydrosalpinx. Pathological examination of the right annexectomy specimen provided the definitive diagnosis. No residual tumor was found at total hysterectomy with bilateral annexectomy. The patient was lost to follow-up for 3 years without complementary treatment and then consulted again for functional disability first of the upper limbs and subsequently of the lower limbs with myalgia, swallowing disorders and left supraclavicular node enlargement resulting from pelvic relapse of the right fallopian tube adenocarcinoma and left supraclavicular metastasis with paraneoplastic polymyositis. The patient was given 6 courses of chemotherapy with radiotherapy (45 Gy) centered on the left clavicular region. The patient showed excellent response to treatment, and remains in complete remission 50 months after diagnosis. The association of fallopian tube carcinoma with polymyositis is exceptional, requiring rapid treatment effective against the cancer and paraneoplastic polymyositis.

Malignant mixed mullerian tumor of primary mesenteric origin

Malignant mixed müllerian tumor (MMMT) is a rare tumor. A literature search revealed very few reports on MMMT, especially those arising in the peritoneum. We recently encountered an MMMT of primary mesenteric origin associated with left fallopian tube cancer. There have been no previous reports about its occurrence in the mesentery. When cases of peritoneal MMMT were reviewed, the disease was found to be associated with synchronous or metachronous gynecologic tumors of müllerian duct origin (ie, ovarian tumors, primary serous carcinoma of the peritoneum, fallopian tube cancer, endometrial cancer, and adenocarcinoma of the cervix) in 12 out of 32 patients (37.5%). Peritoneal MMMT are frequently associated with gynecologic tumors.