Objective – Amniotic Band Syndrome is a rare birth defect caused by strands of the amniotic sac that tangle around the baby’s body, causing injury. Amniotic Band Syndrome is not seen very often, but should be considered in every newborn with congenital anomalies. It can be diagnosed prenatally by ultrasound and is seen after birth. A team of specialists, a plastic surgeon, an orthopedic surgeon, a physiatrist, a psychologist and others should be included in the treatment and follow-up of children with Amniotic Band Syndrome, with an individual approach to every case. Case Report – The first patient, who was six years old, had malformations of the left hand, rudimentary fingers II and IV, missing finger III with circulatory ring, and clinodactyly of finger V. The second patient, eight months old, had the following malformations: syndactyly and circulatory ring on fingers II, III and IV of the left hand, and lymphedema; circulatory ring and lymphedema of the left lower leg, visible proximal parts of all five fingers; on the right foot syndactyly of toes I, II and III, a circular groove on toe IV, and lymphedema. Conclusion – Our cases have unique clinical presentations and therefore required reports. In such cases, the primary care pediatrician brings together a multidisciplinary team and provides further follow-up through rehabilitation and psychological treatment.