Acute PCP Research Articles

Outpatient treatment issues and strategies for acute and chronic PCP abusers.

Outpatient treatment issues and strategies for acute and chronic PCP abusers.

Pharmacokinetic bases for the diagnosis and treatment of acute PCP intoxication.

(1980). Pharmacokinetic Bases for the Diagnosis and Treatment of Acute PCP Intoxication. Journal of Psychedelic Drugs: Vol. 12, PCP: Problems and Prevention. Selected Proceedings of the National PCP Conference 1979+K2, pp. 253-258.

Tolerance to the behavioral effects of phencyclidine: the importance of behavioral and pharmacological variables.

The effects of phencyclidine (PCP) on the behavior of rats responding to a fixed-interval 1 min schedule of water delivery were determined before, during, and after a period of daily PCP injections. The effects of acute PCP on overall response rate were biphasic: low doses increased and high doses decreased rates. In addition, PCP produced a dose-related decrease in quarter-life and high doses of PCP decreased the number of reinforcers delivered. During the daily injection regimen roughly a two-fold tolerance developed to the effects of 8.0 mg/kg PCP on response rate in animals receiving either presession or post-session injections of this dose, emphasizing the predominance of pharmacological variables in PCP tolerance. However, slight differences between these groups in tolerance development and in the rate of tolerance loss demonstrate that behavioral variables can influence tolerance to the behavioral effects of PCP.

Effects of pentachlorophenol on enzymes involved in energy metabolism in the liver of the eel

1. 1. The effects of PCP in vivo and in vitro on the activity profiles of hexokinase, glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, pyruvate kinase, lactate dehydrogenase, fumarase and cytochrome oxidase in the liver of the eel were investigated. 2. 2. In vivo the activities of pyruvate kinase and lactate dehydrogenase decreased after acute PCP poisoning. On the other hand, the activities of hexokinase, glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, fumarase and cytochrome oxidase showed increased activity. 3. 3. After a recovery period of 30 days in uncontaminated water the PCP-treated eels showed higher activity levels for all the investigated enzymes compared to the controls. 4. 4. Comparison of enzyme activity ratios in vivo suggest a shift between different metabolic pathways. 5. 5. In vitro PCP inhibits all the investigated enzymes. 6. 6. The concentration of soluble protein increased significantly after the eels had been treated with PCP.