Abstract
1. 1. The effects of PCP in vivo and in vitro on the activity profiles of hexokinase, glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, pyruvate kinase, lactate dehydrogenase, fumarase and cytochrome oxidase in the liver of the eel were investigated. 2. 2. In vivo the activities of pyruvate kinase and lactate dehydrogenase decreased after acute PCP poisoning. On the other hand, the activities of hexokinase, glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, fumarase and cytochrome oxidase showed increased activity. 3. 3. After a recovery period of 30 days in uncontaminated water the PCP-treated eels showed higher activity levels for all the investigated enzymes compared to the controls. 4. 4. Comparison of enzyme activity ratios in vivo suggest a shift between different metabolic pathways. 5. 5. In vitro PCP inhibits all the investigated enzymes. 6. 6. The concentration of soluble protein increased significantly after the eels had been treated with PCP.
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