Active Role Research Articles

From Synthesis to Mechanisms: In-Depth Exploration of the Dual-Atom Catalytic Mechanisms Toward Oxygen Electrocatalysis.

Dual-atom catalysts (DACs) hold a higher metal atom loading and provide greater flexibility in terms of the structural characteristics of their active sites in comparison to single-atom catalysts. Consequently, DACs hold great promise for achieving improved catalytic performance. This article aims to provide a focused overview of the latest advancements in DACs, covering their synthesis and mechanisms in reversible oxygen electrocatalysis, which plays a key role in sustainable energy conversion and storage technologies. The discussion starts by highlighting the structures of DACs and the differences in diatomic coordination induced by various substrates. Subsequently, the state-of-the-art fabrication strategies of DACs for oxygen electrocatalysis are discussed from several different perspectives. It particularly highlights the challenges of increasing the diatomic loading capacity. More importantly, the main focus of this overview is to investigate the correlation between the configuration and activity in DACs in order to gain a deeper understanding of their active roles in oxygen electrocatalysis. This will be achieved through density functional theory calculations and sophisticated in situ characterization technologies. The aim is to provide guidelines for optimizing and upgrading DACs in oxygen electrocatalysis. Additionally, the overview discusses the current challenges and future prospects in this rapidly evolving area of research.

Application of the AlphaFold2 Protein Prediction Algorithm Based on Artificial Intelligence

As the expression products of genes and macromolecules in living organisms, proteins are the main material basis of life activities. They exist widely in various cells and have various functions such as catalysis, cell signaling and structural support, playing a key role in life activities and functional execution. At the same time, the study of protein can better grasp the life activities from the molecular level, and has important practical significance for disease management, new drug development and crop improvement. Due to advances in high-throughput sequencing technology, protein sequence data has grown exponentially. The protein function prediction problem can be seen as a multi-label binary classification problem by extracting the features of a given protein and mapping them to the protein function label space. A variety of data sources can be mined to obtain protein function prediction features, such as protein sequence, protein structure, protein family, protein interaction network, etc. The initial steps are classical sequence-based methods, such as BLAST, which calculate the similarity between protein sequences and transmit annotations between proteins whose similarity scores exceed a specific threshold. This method has great limitations for protein function prediction without sequence similarity. Therefore, this paper analyzes the development prospect of bioanalysis and artificial intelligence through the application status and realization path of AlphaFold2 protein prediction algorithm based on artificial intelligence.

Anti-PD-1 therapy triggers Tfh cell-dependent IL-4 release to boost CD8 T cell responses in tumor-draining lymph nodes.

Anti-PD-1 therapy targets intratumoral CD8+ T cells to promote clinical responses in cancer patients. Recent evidence suggests an additional activity in the periphery, but the underlying mechanism is unclear. Here, we show that anti-PD-1 mAb enhances CD8+ T cell responses in tumor-draining lymph nodes by stimulating cytokine production in follicular helper T cells (Tfh). In two different models, anti-PD-1 mAb increased the activation and proliferation of tumor-specific T cells in lymph nodes. Surprisingly, anti-PD-1 mAb did not primarily target CD8+ T cells but instead stimulated IL-4 production by Tfh cells, the major population bound by anti-PD-1 mAb. Blocking IL-4 or inhibiting the Tfh master transcription factor BCL6 abrogated anti-PD-1 mAb activity in lymph nodes while injection of IL-4 complexes was sufficient to recapitulate anti-PD-1 mAb activity. A similar mechanism was observed in a vaccine model. Finally, nivolumab also boosted human Tfh cells in humanized mice. We propose that Tfh cells and IL-4 play a key role in the peripheral activity of anti-PD-1 mAb.

The genesis of the Baguamiao orogenic gold deposit linked to multistage ore-forming processes in Triassic tectonic transition of South Qinling, China

The Baguamiao gold deposit represents one of the largest Triassic orogenic gold deposits in the South Qinling metallogenic belt of central China. Here we investigate Ar-Ar dating of sericite and muscovite, fluid inclusion of quartz, the trace element and sulfur isotopic composition of pyrite from different mineralization stage in the Baguamiao gold deposit to gain insights into the ore genesis. The Ar-Ar dating results yield 40Ar/39Ar plateau ages of 217.5 ± 2.1 Ma, 209.2 ± 0.2 Ma and 208.8 ± 0.2 Ma, indicating a two-stage gold mineralization during the tectonic transition from the early metamorphic deformation (at ca. 218 Ma) to the late extension (ca. 209 Ma) in the post-collision environment. Fluid inclusion, trace element and sulfur isotopic analyses reveal that the two stages gold mineralization show different sources. The early mineralization period developed CO2-rich inclusions with medium temperature (317–413 °C) and medium–low salinity (4.62–18.81 wt% NaCleqv.), and is characterized by formation of Py1 and Py2 with depleted Au, Cu, Pb, Zn, Ag, Te and Bi. The sulfur isotope data of Py1 and Py2 are between 3.6 ∼ 10.5 ‰, suggesting that the sulfur source was mainly derived from the surrounding rock (Xinghongpu Group). The late mineralization period developed medium–high temperature (321–453 °C), medium–high salinity (3.3–19.62 wt% NaCleqv.) CO2-rich inclusions and high-temperature and high-salinity daughter crystal inclusions, and is characterized by formation of Py3 and Py4 with obviously higher arsenic and metal contents, such as Au, As, Cu, Pb, Zn, Ag, Cr, Ti, Mn, Sb. The δ34S values of Py3 and Py4 are 8.3 ∼ 18.8 ‰, suggesting a mixed fluid of the Xinghongpu Group and Gudaoling Group with deep magmatic-hydrothermal fluids. We propose that the two periods of gold mineralization in the Baguamiao deposit, in response to the collision assembly of Qinling Orogenic Belt, preserve evidence for diverse metal sources with the early mineralization period sourced from the metamorphism of the upper crust (Xinghongpu Group) in the compressional stage (ca. 218 Ma), and the late mineralization period characterized by the contribution of the Xinghongpu Group, Gudaoling Group and deep magmatic-hydrothermal fluids in a post-collisional extensional setting (ca. 209 Ma). The role of metamorphism and magmatic activity during the Triassic Qinling orogenic processes is considered to be important in the remobilization, transport and enrichment of sulfur, arsenic and gold (and potentially other trace elements) from the earlier formed seafloor exhalation sequence.

Application of wetPf2 Data for Investigating Characteristics of Temperature and Humidity of Air Masses over Paracel and Spratly Islands

This article uses data from the second-generation Constellation Observing System for Meteorology, Ionosphere, and Climate (COSMIC-2) satellites (wetPf2) to study the temperature and humidity properties of the air masses over Paracel and Spratly Islands in the Vietnam East Sea (South China Sea). The satellite observational data were validated with the radiosonde data from three stations in Vietnam: Hanoi, Danang, and Ho Chi Minh City. Subsequently, the wetPf2 data are used to analyze the characteristics of temperature and relative humidity variations of the air masses over the Paracel and Spratly regions. Results show that the mean error of the satellite observational data for temperature ranges from −0.06°C to −0.02°C, with standard deviations ranging from 0.73°C to 1.04°C. The mean error of relative humidity fluctuates between 11.6% and 12.5%, with standard deviations ranging from 15.1% to 19.1%. The values are reasonable and comparable to those in previous studies. Seasonal variations of temperature and humidity show that the air mass over the Paracel Islands exhibits a larger annual temperature with an annual variation of approximately 5.0°C, significantly higher than the value of 2.2°C in the air mass over the Spratly Islands. The difference may be due to the greater influence of continental and seasonal wind systems in the northern region. Within both air masses, the annual temperature variation in the boundary layer is much larger than that in the free atmosphere. Annual relative humidity variation is higher in summer and autumn than in winter and spring. The significant changes in the relative humidity with height during winter and no significant change of the relative humidity with height during summer may be related to the important role of strong convective activity carrying moist air upward to higher atmospheric levels during the summer time.

Set in Stone: Human–Horse Relations as Embodied in Shaped Stone Balls

AbstractThe enigmatic presence of uniquely shaped, spherical stones attracted the attention of archaeologists at Oldowan sites in Africa as early as a century ago. Shaped stone balls (SSBs) are among the oldest implements used by humans. For nearly 2 million years, they accompanied ancient humans as a stable cultural anchor throughout the Lower Paleolithic period and beyond. These tools reflect techno-cultural processes and Lower Paleolithic human perceptions of their relationships with the non-human animal world. Nonetheless, the few techno-functional studies focussing on these items have only scraped the surface of their research potential. In this paper, I will explore evidence suggesting that SSBs embody the relations of ancient humans with a particular animal—the horse—and propose that they might have played an active role in the social and cosmological realms of Lower Paleolithic (LP) ontology. Several previous studies indicate that they were shaped through a meticulous process. Traces of use and organic residues of marrow/fat associate them with bone-breaking activities. Furthermore, a comprehensive contextual analysis points to a correlation, observed at various sites, between SSBs and large herbivores, specifically horses. This correlation supports the premise that early humans relied on SSBs to extract calories from horses and points to a possible link between the simultaneous disappearance of large horses and SSBs from the Levantine landscape at the end of the LP. The role of horses in Paleolithic diet and culture is well reflected in the archaeological record. Following recent anthropological views, I advocate that SSBs played an important role in the human–horse alignment, embodying within them the world of perceptions and relationships of ancient humans with this non-human animal who shared their habitat.

To vanlige digitaliseringsfloker

Når verden endrer seg gir det offentlige virksomheter både muligheter og utfordringer, men også endrede rammebetingelser. For holde seg relevant må de organisere seg slik at de er i takt med brukernes endrede behov og forventninger. Teamorganisering er den mest dynamiske organisasjonsformen vi kjenner. Mange norske virksomheter velger nettopp å bevege seg mot en teambasert organisering for å holde seg relevant for målgruppene og levere verdi. Denne overgangen er et hamskifte, ikke to graders kursendring som preges ofte av noen digitaliseringsfloker. Artikkelen presenterer to typiske floker: målsetting og lederens rolle og ansvar. Abstract in English In an ever-evolving world, public organizations are confronted with continuous shifts in their operating environment. This presents a spectrum of opportunities and challenges. To maintain relevance in this dynamic landscape, it is imperative that these organizations continuously focus on organizational form to meet the evolving needs and expectations of their users. To our knowledge, team organization is the most dynamic organizational form. Recently, aiming to stay relevant and capitalize on the benefits of digitalization has become a strategic choice for many organizations. This move towards team-based structure is not merely an adjustment but a fundamental transformation, essential for harnessing digitalization's full potential. This transition often encounters two "digitalization tangles”: goal setting, and the roles and responsibilities of leaders. Goals must be tailored to the team organization and cannot follow the traditional matrix organization structure. When goals are set along the axes of expertise and delivery, they create competing objectives, which makes it difficult for teams and individuals to prioritize in their daily work. Leadership in a team-based organization requires a paradigm shift. Leaders must pivot from traditional task-focused management to fostering value creation and team success. This necessitates a nuanced understanding and execution of leadership roles, balancing clear direction and goal setting with the autonomy of task execution. Some leaders struggle in this new context, veering towards either absenteeism or micromanagement, both of which hinder the efficacy of team organization. Successful public organizations that leverage the advantages of digitalization through team organization overcome these challenges. They establish clear, non-conflicting goals, and leaders play an active role in facilitating team success, embracing the evolution of their roles with a learning mindset and commitment. Our experience suggests that thriving in a team organization differs fundamentally from traditional matrix or domain-based forms of organizing. It requires a rethinking of fundamental business aspects, including goal setting and leadership roles.

Mendeteksi Ancaman Kecanduan Gadget pada Anak Usia Dini

This article examines providing information for parents in detecting gadget addiction in young children from the start before young children become addicted to gadgets. This study was motivated by the fact that many aged children have gadget addiction disorders such as sleep disorders, aggressive nature, difficulty understanding learning, hunched body posture, reduced brain growth and development, strange behavior, irritability, and unwillingness to socialize. This study discusses 4 (four) discussions, namely (1) factors causing gadget addiction in early childhood, (2) the threat of gadget addiction in early childhood, (3) how to detect the threat of gadget addiction in early childhood, (4 ) The role of parents in preventing gadget addiction in early childhood. Based on the results of the analysis in this paper, it can be concluded that gadget addiction in early childhood is a serious problem that has various negative impacts. Several factors that cause gadget addiction include inappropriate parenting, neuroscientific factors, gadget technology designs that create dependency, and the influence of the surrounding environment. Parents play a key role in preventing gadget addiction by limiting the time they use gadgets, choosing appropriate applications, monitoring gadget use, and being good role models. Parents also need to detect signs of gadget addiction in their children, including changes in behavior, and physical, emotional, social, and academic performance. With the active role of parents, the negative impact of gadget addiction in young children can be minimized.

Ecotourism Development Strategy of Lhok Batee Jeumpa Reservoir, Bireuen Regency

Bireuen Regency has natural tourism that has the potential to be an ecotourism area, namely the Lhok Batee Reservoir, which is located in Seuneubok Lhong Village, Jeumpa District. This study aims to calculate the carrying capacity of tourist areas, analyze stakeholders based on their influence and importance, and formulate ecotourism development strategies at Lhok Batee Reservoir. The research method uses a survey approach through direct observation in the field with interviews with 50 respondents. The results showed that the carrying capacity of the area was 1,008 people per day. The analysis shows that two classifications of stakeholders play a role in the management of the area and the development of reservoir ecotourism, namely bystanders (Marine Fisheries Food Service; Public Works and Spatial Planning Service; Youth, Sports, and Tourism Service; Environmental Observation Group) and players (Village Government; Regional Development Planning Agency; Environment and Forestry Service). The results of the study formulated an ecotourism development strategy at Lhok Batee Reservoir to increase natural resource conservation efforts, develop the potential of natural resources owned by Lhok Batee Reservoir, develop ecotourism activities while maintaining biodiversity, involve the community to play an active role in tourism activities at Lhok Batee Reservoir, and optimize cooperation programs with stakeholders in marketing Lhok Batee Reservoir ecotourism and in providing environmental training

Prevention of Vascular Contributions to Cognitive Impairment and Dementia: The Role of Physical Activity and Exercise.

Vascular contributions to cognitive impairment and dementia, specifically cerebral small vessel disease (CSVD), are the second most common cause of dementia. Currently, there are no specific pharmacological treatments for CSVD, and the use of conventional antidementia drugs is not recommended. Exercise has the potential to prevent and mitigate CSVD-related brain damage and improve cognitive function. Mechanistic pathways underlying the neurocognitive benefits of exercise include the control of vascular risk factors, improving endothelial function, and upregulating exerkines. Notably, the therapeutic efficacy of exercise may vary by exercise type (ie, aerobic versus resistance training) and biological sex; thus, studies designed specifically to examine these moderating factors within a CSVD context are needed. Furthermore, future research should prioritize resistance training interventions, given their tremendous therapeutic potential. Addressing these knowledge gaps will help us refine exercise recommendations to maximize their therapeutic impact in the prevention and mitigation of CSVD.

The Neural Correlates of Creativity and Innovation in Various Domains and Contexts in Germany

Purpose: The aim of the study was to investigate the neural correlates of creativity and innovation in various domains and contexts.
 Methodology: This study adopted a desk methodology. A desk study research design is commonly known as secondary data collection. This is basically collecting data from existing resources preferably because of its low cost advantage as compared to a field research. Our current study looked into already published studies and reports as the data was easily accessed through online journals and libraries.
 Findings: Neuroscientific studies reveal that creativity and innovation engage diverse brain networks, including those governing divergent thinking and cognitive flexibility. These processes show consistent neural activation patterns across different domains, suggesting a universal basis for creativity regardless of context. Environmental factors, like novelty exposure and social interactions, also play significant roles in shaping neural activity underlying creative thinking.
 Unique Contribution to Theory, Practice and Policy: Conceptual blending theory, network theory of creativity & four-stage model of creativity may be used to anchor future studies on the neural correlates of creativity and innovation in various domains and contexts. Practical implications of understanding the neural correlates of creativity and innovation can inform the design of interventions and training programs aimed at fostering creative thinking skills. Policymakers can leverage insights from research on the neural correlates of creativity to inform decision-making processes related to education, workforce development, and innovation policy.

Transient Receptor Potential Ankyrin 1-dependent Activation of Extracellular Signal-regulated Kinase 2 in the Cerebral Cortices Contributes to Cortical Spreading Depolarization

Extracellular signal-regulated kinase (ERK) are serine/threonine-selective proteins and ERK1/2 can be phosphorylated in peripheral and central brain regions after cortical spreading depolarization (CSD) and calcitonin gene-related peptide; However, it remains unclear about whether and how ERK activity modulates CSD that correlates to migraine aura. Here, we determined the role of ERK in regulating CSD and explored the underlying mechanism involving transient receptor potential ankyrin 1 (TRPA1), a stress-sensing cation channel. CSD was recorded using intrinsic optical imaging in mouse brain slices, and electrophysiology in rats. Phosphorylated ERK (pERK1/2) and interleukin-1β (IL-1β) protein levels were detected using Western blot or enzyme-linked immunosorbent assay, respectively. IL-1β mRNA level was detected using qPCR. The results showed that an ERK inhibitor, SCH77298, markedly prolonged CSD latency and reduced propagation rate in mouse brain slices. Corresponding to this, CSD induction increased levels of cytosolic pERK1/2 in ipsilateral cerebral cortices of rats, the elevation of which correlated to the level of IL-1β mRNA. Mechanistic analysis showed that pre-treatment of an anti-TRPA1 antibody reduced the cytosolic pERK2 level but not pERK1 following CSD in cerebral cortices of rats and this level of pERK2 correlated with that of cerebral cortical IL-1β protein. Furthermore, an ERK activator, AES16-2M, but not its scrambled control, reversed the prolonged CSD latency by a TRPA1 inhibitor, HC-030031, in mouse brain slices. These data revealed a crucial role of ERK activity in regulating CSD, and elevation of pERK and IL-1β production induced by CSD is predominantly TRPA1 channel-dependent, thereby contributing to migraine pathogenesis.

Role of tungsten disulfide quantum dots in specific protein-protein interactions at air-water interface.

The intriguing network of antibody-antigen (Ab-Ag) interactions is highly governed by environmental perturbations and the nature of biomolecular interaction. Protein-protein interactions (PPIs) have potential applications in developing protein-adsorption-based sensors and nano-scale materials. Therefore, characterizing PPIs in the presence of a nanomaterial at the molecular level becomes imperative. The present work involves the investigation of antiferritin-ferritin (Ab-Ag) protein interactions under the influence of tungsten disulfide quantum dots (WS2 QDs). Isothermal calorimetry and contact angle measurements validated the strong influence of WS2 QDs on Ab-Ag interactions. The interfacial signatures of nano-bio-interactions were evaluated using sum frequency generation vibration spectroscopy (SFG-VS) at the air-water interface. Our SFG results reveal a variation in the tilt angle of methyl groups by ∼12° ± 2° for the Ab-Ag system in the presence of WS2 QDs. The results illustrated an enhanced ordering of water molecules in the presence of QDs, which underpins the active role of interfacial water molecules during nano-bio-interactions. We have also witnessed a differential impact of QDs on Ab-Ag by raising the concentration of the Ab-Ag combination, which showcased an increased inter-molecular interaction among the Ab and Ag molecules and a minimal influence on the methyl tilt angle. These findings suggest the formation of stronger and ordered Ab-Ag complexes upon introducing WS2 QDs in the aqueous medium and signify the potentiality of WS2 QDs relevant to protein-based sensing assays.

Overview of Cyanide Poisoning in Cattle from Sorghum halepense and S. bicolor Cultivars in Northwest Italy.

Sorghum plants naturally produce dhurrin, a cyanogenic glycoside that may be hydrolysed to cyanide, resulting in often-lethal toxicoses. Ruminants are particularly sensitive to cyanogenic glycosides due to the active role of rumen microbiota in dhurrin hydrolysis. This work provides an overview of a poisoning outbreak that occurred in 5 farms in Northwest Italy in August 2022; a total of 66 cows died, and many others developed acute toxicosis after being fed on either cultivated (Sorghum bicolor) or wild Sorghum (Sorghum halepense). Clinical signs were recorded, and all cows received antidotal/supportive therapy. Dead animals were subjected to necropsy, and dhurrin content was determined in Sorghum specimens using an LC-MS/MS method. Rapid onset, severe respiratory distress, recumbency and convulsions were the main clinical features; bright red blood, a bitter almond smell and lung emphysema were consistently observed on necropsy. The combined i.v. and oral administration of sodium thiosulphate resulted in a rapid improvement of clinical signs. Dhurrin concentrations corresponding to cyanide levels higher than the tolerated threshold of 200 mg/kg were detected in sorghum specimens from 4 out of 5 involved farms; thereafter, such levels declined, reaching tolerable concentrations in September-October. Feeding cattle with wild or cultivated Sorghum as green fodder is a common practice in Northern Italy, especially in summer. However, care should be taken in case of adverse climatic conditions, such as severe drought and tropical temperatures (characterising summer 2022), which are reported to increase dhurrin synthesis and storage.

Assessment of muscle endocrine function and inflammatory signalling in male school children following a physical activity programme

Regular and planned physical activity can diminish the risk of numerous illnesses. However, school children and teenagers often exercise intermittently and for brief periods, restricting potential benefits. Furthermore, previous studies mainly focused on body composition, without providing molecular mechanisms elucidating the role of physical activity in muscle tissue and inflammatory signalling. The objective of this study was to determine the effect of a vigorous physical activity intervention on endocrine muscle function and cytokine output in children. 103 boys were divided into two groups: control (n=51, did not perform additional physical activity) and exercise (n=52, performed vigorous physical activity). Body composition measurements, endocrine muscle function and inflammatory signalling biomarkers were assessed at enrolment and after 6 months of intervention. No statistical significance was found for fractalkine, oncostatin, EGF, TNF-α and eotaxin. However, LIF, FBAP3, IL-6, FGF21 and IL-15 increased in the exercise group at the end of the protocol, though myostatin got decreased. In contrast, IFN-γ was increased in the exercise group at the beginning and end of the exercise protocol, IL-10 was also increased in this group, IL-1α decreased in the exercise group before and after the exercise protocol, and IP-10 and MCP-1 also decreased in the exercise group. It can be affirmed that a physical activity programme for boys was shown to produce changes in body composition (decreased fat mass, increased lean mass) and in markers of endocrine muscle function and cytokine release. It is possible that these changes, if sustained, could reduce the risk of chronic disease.

Isomorphic Insertion of Ce(III)/Ce(IV) Centers into Layered Double Hydroxide as a Heterogeneous Multifunctional Catalyst for Efficient Meerwein-Ponndorf-Verley Reduction.

The development of highly active acid-base catalysts for transfer hydrogenations of biomass derived carbonyl compounds is a pressing challenge. Solid frustrated Lewis pairs (FLP) catalysis is possibly a solution, but the development of this concept is still at a very early stage. Herein, stable, phase-pure, crystalline hydrotalcite-like compounds were synthesized by incorporating cerium cations into layered double hydroxide (MgAlCe-LDH). Besides the insertion of well-isolated cerium centers surrounded by hydroxyl groups, the formation of hydroxyl vacancies near the aluminum centers, which were formed by the insertion of cerium centers into the layered double hydroxides (LDH) lattice, was also identified. Depending on the initial cerium concentration, LDHs with different Ce(III)/Ce(IV) ratios were produced, which had Lewis acidic and basic characters, respectively. However, the acid-base character of these LDHs was related to the actual Ce(III)/Ce(IV) molar ratios, resulting in significant differences in their catalytic performance. The as-prepared structures enabled varying degrees of transfer hydrogenation (Meerwein-Ponndorf-Verley MPV reduction) of biomass-derived carbonyl compounds to the corresponding alcohols without the collapse of the original lamellar structure of the LDH. The catalytic markers through the test reactions were changed as a function of the amount of Ce(III) centers, indicating the active role of Ce(III)-OH units. However, the cooperative interplay between the active sites of Ce(III)-containing specimens and the hydroxyl vacancies was necessary to maximize catalytic efficiency, pointing out that Ce-containing LDH is a potentially commercial solid FLP catalysts. Furthermore, the crucial role of the surface hydroxyl groups in the MPV reactions and the negative impact of the interlamellar water molecules on the catalytic activity of MgAlCe-LDH were demonstrated. These solid FLP-like catalysts exhibited excellent catalytic performance (cyclohexanol yield of 45%; furfuryl alcohol yield of 51%), which is competitive to the benchmark Sn- and Zr-containing zeolite catalysts, under mild reaction conditions, especially at low temperature (T = 65 °C).

'It sort of broke me': A thematic analysis of the psychological experiences and coping strategies employed by Australian fire-affected farmers.

People exposed to bushfires are known to be at heightened risk of experiencing mental health challenges. When farms are impacted, farmers often risk losing not only their homes but also their businesses, containing their livestock, infrastructure and identities. To understand the psychological experiences of farmers who have been exposed to fires on their farms and identify the coping strategies they already employ to recover and prepare psychologically for future bushfires. In-depth, semi-structured interviews were conducted face-to-face or via Zoom. Thematic analysis was used to analyse the data, using a descriptive, essentialist approach. Sixteen farmers and/or their spouses (50% female; median age of 50.8 years), who owned and/or played an active role in the operation of a farming or pastoral enterprise and had been affected by a farm fire within the last 20 years, participated. Participants resided in inner regional, outer regional and remote South Australia and New South Wales. Seven overarching themes and 22 subthemes resulted: (1) intense emotions in the aftermath, (2) long-term psychological challenges, (3) deliberate focus on organising, prioritising and completing recovery-focused tasks, (4) importance of seeking and/or accessing support to rebuild, (5) adopting a positive attitude and outlook, (6) (dis)engaging from/with community and social connection and (7) various strategies employed to self-regulate emotions. This study demonstrates the unique set of psychological challenges Australian farmers experience in the wake of a farm fire and the coping strategies they report using to help them manage. Findings will inform the development of contextually and culturally appropriate bushfire recovery and preparedness initiatives that are tailored to meet the unique needs of farmers and build upon their existing strengths.

Parent-child associations of sleep quality: is physical activity a confounder? The EPI-FAMILY health study

IntroductionThe incidence of sleep deprivation has increased in pediatric populations, however, the relationship with physical activity (PA) remains uncertain and lacks evidence. Although some studies have shown that parents' lifestyle habits can influence this process, one point that requires further clarification in the literature is whether parents' sleep quality is linked to that of their children and whether parents' physical activity could play an important role in these possible relationships. ObjectivesTo investigate the relationship of sleep quality between parents and children and verify the role of physical activity in this association. MethodsThis is a cross-sectional study. Sleep quality was assessed using the Mini Sleep Questionnaire. The amount of sleep was estimated by the number of hours slept. PA domains (occupational activities, leisure, and active commuting) were assessed using the Baecke questionnaire, while moderate to vigorous PA (MVPA) was assessed with an accelerometer. Socioeconomic status was obtained through a questionnaire. The relationship of sleep quality between parents and children was carried out using hierarchical models with Binary Logistic Regression, where the factors were inserted one by one (1. unadjusted model; 2. sociodemographic variables; 3. children's PA; 4. parents’ PA). ResultsThe study sample consisted of 102 children and adolescents (6–17 years), 92 mothers, and 69 fathers. Poor sleep quality of mothers was associated with their children's sleep quality (OR = 3.95; 95%CI = 1.33–11.38; P = 0.013). After inserting mothers' PA intensity into the final model, the associations remained significant (OR = 8.05; 1.33–48.59; P = 0.023). No relationship was observed between poor sleep quality of fathers and their children's sleep quality. ConclusionThe relationship between poor sleep quality of mothers and that of their children remained significant, regardless of confounding variables.

5-6세기 고구려의 몽촌토성 점유 양상에 관한 연구

This paper aims to examine the processs of regeneration of Mongchontoseong by Goguryeo, following Baekje’s relocation of its capital to Ungjin. Drawing upon the artifacts from 1980s excavation and the recent fieldwork findings, this study explores the spatial and temporal reorganization in the Mongchontoseong after 5th century AD. The spatial distribution of the pottery from the southern part of the inner Mongchontoseong site was first explored. Goguryeo strategically reused places previously built by Baekje, including storage, ponds, and pits, and also altered the built environment. The features, iron weapons, farming tools, and pottery type also reveal the diverse aspects of the long-term occupation of Goguryeo, taking the roles of domestic housing, rituals, agricultural activities, and storage. The radiocarbon dating results from the pits and roadways show Goguryeo’s active engagement in infrastructure reconstruction from the late 5th century to the middle of the 6th century, predating the reoccupation by the allied forces of Baekje and Silla in 550 AD. The material evidence reveals Goguryeo’s prolonged regeneration of the site for the southward expansion, as sociopolitical strategies in the context of warfare in the Korean Peninsula during 5-6th century AD.

Preparation and Application of Apatite-TiO2 Composite Opacifier: Preventing Titanium Glaze Yellowing through Pre-Combination.

In order to enhance the degree of binding reaction of TiO2 in titanium-containing ceramic glazes and prevent the reaction of its transformation into rutile to eliminate the yellowing phenomenon of the glaze surface, an apatite-TiO2 composite opacifier (ATO) was prepared through the mechanical grinding of hydroxyapatite and anatase TiO2. The properties, opacification mechanism, and yellowing inhibition of the prepared ceramic glazes were studied. The results show that the ATO is characterized by a uniform coating of TiO2 on the surface of the apatite and the formation of close chemical bonding between the apatite and TiO2. The ceramic glaze surface when using an ATO has a white appearance and excellent opacification performance. When an ATO was used, the L*, a*, and b* values of the glaze were 89.99, -0.85, and 3.37, respectively, which were comparable to those of a ZrSiO4 glaze (L*, a*, and b* were 88.24, -0.02, and 2.29, respectively). The opacification of the glaze was slightly lower than that of the TiO2 glaze (L* value was 92.13), but the appearance changed from yellow to the white of the TiO2 glaze (b* value was 9.18). The ceramic glaze layer when using an ATO mainly consists of titanite, glass phase, and a small amount of quartz, and the opacification mechanism is the crystallization of the generated titanite. ATOs can play an active role in solving the critical problem that arises when TiO2 replaces ZrSiO4 as an opacifier.