Active Role Research Articles

Clean and Healthy Living Behavior Education to improve the knowledge of Elementary School Students


 Clean and healthy living behavior is the main foundation for maintaining individual health and preventing the spread of disease. Education about clean and healthy living behaviors can be done in various ways, such as through counseling, campaigns, the development of educational materials, collaboration with health centers, training, the active role of schools, the use of social media, exemplary examples, and measurement and evaluation. Educational materials that are arranged in an attractive and easy-to-understand manner are the main instruments in this effort. Collaboration with medical personnel, involving health centers, and the active role of schools are recognized as important supporting factors. The use of social media is also integrated as an effective means of reaching a wider audience. By combining these approaches, it is hoped that people can better understand and adopt clean and healthy living behaviors in their daily lives. Evaluation of the effectiveness of educational programs needs to be done to ensure their success and impact on community knowledge and behavior.

Revealing the Hidden Role of Radical Scavengers: Unraveling the Key to Tailoring the Formation of the hcp PdHx Phase in Graphene Liquid Cells

AbstractRadiation chemistry enables the synthesis of colloidal nanoparticles without chemical reducing agents, yielding metal nanoparticles via simple and direct processes. Aliphatic alcohols are widely used to promote the formation of nanoparticles in radiolytic synthesis by inhibiting the reoxidation of these metal nanoparticles by scavenging hydroxyl radicals. However, the role of the scavenger has been limited to simply accelerating the formation of the nanoparticles without altering their nature. Herein, the role of radical scavengers is investigated in determining the type of metal nanoparticles formed, with the scavenger concentration playing a crucial role. It is found that the addition of isopropyl alcohol controls the formation of hexagonal close‐packed (hcp) palladium hydride (PdHx) nanoparticles that are previously synthesized for the first time via radiation chemistry by increasing the concentrations of hydrated electrons and hydrogen radicals. This discovery reveals a more active role for radical scavengers in radiolytic syntheses, and this strategy can be used for the cost‐effective mass production of hcp PdHx nanoparticles.

Unstructured linker regions play a role in the differential splicing activities of paralogous RNA binding proteins PTBP1 and PTBP2

RNA Binding Proteins regulate, in part, alternative pre-mRNA splicing and, in turn, gene expression patterns. Polypyrimidine tract binding proteins PTBP1 and PTBP2 are paralogous RNA binding proteins sharing 74% amino acid sequence identity. Both proteins contain four structured RNA-recognition motifs (RRMs) connected by linker regions and an N-terminal region. Despite their similarities, the paralogs have distinct tissue-specific expression patterns and can regulate discrete sets of target exons. How two highly structurally similar proteins can exert different splicing outcomes is not well understood. Previous studies revealed that PTBP2 is post-translationally phosphorylated in the unstructured N-terminal, Linker 1, and Linker 2 regions that share less sequence identity with PTBP1 signifying a role for these regions in dictating the paralogs distinct splicing activities. To this end, we conducted bioinformatics analysis to determine evolutionary conservation of RRMs vs linker regions in PTBP1 and PTBP2 across species. To determine the role of PTBP2 unstructured regions in splicing activity, we created hybrid PTBP1-PTBP2 constructs that had counterpart PTBP1 regions swapped to an otherwise PTBP2 protein and assayed on differentially regulated exons. We also conducted molecular dynamics studies to investigate how negative charges introduced by phosphorylation in PTBP2 unstructured regions can alter their physical properties. Collectively, results from our studies reveal an important role for PTBP2 unstructured regions and suggest a role for phosphorylation in the differential splicing activities of the paralogs on certain regulated exons.

The Impact of Martin Luther’s Religious Reform on the Conversion of New Chinese Immigrants to Christianity

Abstract Through a study of the M Church in Bangkok, this research paper explores the influence of Martin Luther’s Reformation spirit of freedom of religion on the conversion of new Chinese immigrants to Christianity. With the increase in the number of Chinese who have emigrated overseas since the reform and opening up, Christianity has become increasingly popular among new Chinese immigrants, and the concept of freedom of religion advocated by Martin Luther’s Reformation has played an active role in this process. This study first, introduces the background of Martin Luther’s Reformation and his advocacy of religious freedom. Then, the literature related to Martin Luther’s Reformation, the Christian faith of new immigrants in China, and the Christian faith of Chinese in Thailand is reviewed. Then, through field research, the history and current situation of the new Chinese immigrants’ participation in the M Church in Bangkok are analyzed, and the transmutation of their beliefs in this chapel is discussed. Through interviews and surveys, the paper further analyzes the reasons for the conversion of Chinese new immigrants to Christianity. The study shows that the concept of religious freedom advocated by Martin Luther’s Reformation has played a positive role in the conversion of Chinese new immigrants to Christianity. However, Chinese new immigrants face many difficulties and challenges in the process of converting to Christianity, such as understanding and identifying with the faith and understanding the cultural differences between China and the West. Therefore, this paper argues that the concept of religious freedom advocated by Martin Luther’s Reformation has played an important role in the conversion of new Chinese immigrants to Christianity, but this process also needs to be combined with the integration and development of traditional Chinese culture.

Women's experiences with opting out of cervical cancer screening and the role of the nurse in the women's decision-making process.

To explore Danish women's experiences with opting out of cervical cancer screening and the role of the nurse in the women's decision-making process. A qualitative study using semi-structured, individual interviews with a phenomenological-hermeneutic approach. Interviews were conducted with 13 women with experience in opting out of cervical cancer screening. Women were recruited through a public flyer and interviewed virtually or by phone. The interviews were analysed using the theory of interpretation from Paul Ricoeur and consisted of three levels: naïve reading, structural analysis, and critical discussion and analysis. The present study adheres to the COREQ guidelines. The women experience various personal causes for opting out of cervical cancer screening, such as low accessibility of screening appointments, discomfort during the smear test, fear of being sick, and insufficient information about the relevance of screening to the individual woman. The perceived disadvantages of screening outweighed their perceived advantages. The women's experiences did not include the role of the nurse in the procedures and knowledge sharing related to cervical cancer screening. However, nurses were described as having good communicative and relational qualifications relevant to being involved in cervical cancer screening. It was challenging for the women to weigh the advantages and disadvantages of cervical cancer screening and thus to make an informed decision about participation. They expressed a need for more information on which to base their decision. This places nurses in a much needed, yet unexplored, role of identifying and lowering potential personal barriers that may outweigh the women's perceived benefits of participating in screening. Nurses should play a more active role in cervical cancer screening such as improving general knowledge and facilitating two-way communication about its relevance. The present study adheres to the Consolidated Criteria for Reporting Qualitative Research (COREQ) guidelines. No patient or public contribution.

Examining Knowledge Management and the Culture Change Movement in Long-Term Care: A Study of High-Medicaid-Census Nursing Homes.

High-quality nursing home (NH) care has long been a challenge within the United States. For decades, policymakers at the state and federal levels have adopted and implemented regulations to target critical components of NH care outcomes. Simultaneously, our delivery system continues to change the role of NHs in patient care. For example, more acute patients are cared for in NHs, and the Center for Medicare and Medicaid Services (CMS) has implemented value payment programs targeting NH settings. As a part of these growing pressures from the broader healthcare delivery system, the culture-change movement has emerged among NHs over the past two decades, prompting NHs to embody more person-centered care as well as promote settings which resemble someone's home, as opposed to institutionalized healthcare settings. Researchers have linked culture change to high-quality outcomes and the ability to adapt and respond to the ever-changing pressures brought on by changes in our regulatory and delivery system. Making enduring culture change within organizations has long been a challenge and focus in NHs. Despite research suggesting that culture-change initiatives that promote greater resident-centered care are associated with several desirable patient outcomes, their adoption and implementation by NHs are resource intensive, and research has shown that NHs with high percentages of low-income residents are especially challenged to adopt these initiatives. This chapter takes a novel approach to examine factors that impact the adoption of culture-change initiatives by assessing knowledge management and the role of knowledge management activities in promoting the adoption of innovative care delivery models among under-resourced NHs throughout the United States. Using primary data from a survey of NH administrators, we conducted logistic regression models to assess the relationship between knowledge management and the adoption of a culture-change initiative as well as whether these relationships were moderated by leadership and staffing stability. Our study found that NHs were more likely to adopt a culture-change initiative when they had more robust knowledge management activities. Moreover, knowledge management activities were particularly effective at promoting adoption in NHs that struggle with leadership and nursing staff instability. Our findings support the notion that knowledge management activities can help NHs acquire and mobilize informational resources to support the adoption of care delivery innovations, thus highlighting opportunities to more effectively target efforts to stimulate the adoption and spread of these initiatives.

Lipid droplets provide metabolic flexibility for cancer progression.

A hallmark of cancer cells is their remarkable ability to efficiently adapt to favorable and hostile environments. Due to a unique metabolic flexibility, tumor cells can grow even in the absence of extracellular nutrients or in stressful scenarios. To achieve this, cancer cells need large amounts of lipids to build membranes, synthesize lipid-derived molecules, and generate metabolic energy in the absence of other nutrients. Tumor cells potentiate strategies to obtain lipids from other cells, metabolic pathways to synthesize new lipids, and mechanisms for efficient storage, mobilization, and utilization of these lipids. Lipid droplets (LDs) are the organelles that collect and supply lipids in eukaryotes and it is increasingly recognized that the accumulation ofLDs is a new hallmark of cancer cells. Furthermore, an active role of LD proteins in processes underlying tumorigenesis has been proposed. Here, by focusing on three major classes of LD-resident proteins (perilipins, lipases, and acyl-CoA synthetases), we provide an overview of the contribution of LDs to cancer progression and discuss the role of LD proteins during the proliferation, invasion, metastasis, apoptosis, and stemness of cancer cells.

How Game Ecology Drives Player Choices in Strategy Video Games: An Environmental Determinism Perspective

Background Recent years have witnessed increasing attention on the study of game ecology, the virtual environments, and underlying mechanics within games. Yet, these studies often focus on the active role that players have in changing game ecology, while overlooking the reciprocal influence between game ecology and players. Methods This study investigates the potential impact of game ecology on player choices from an environmental determinism perspective—the development of humanity is shaped by the physical environment. This new perspective is substantiated by a case study of two strategy games, Sid Meier's Civilization VI and Humankind, using an immersive-participatory method to analyze their game mechanics. Results This study identifies four major forms of game mechanics that use game ecology to influence player choices: spatial constraints, movement modifiers, uncommon events, and dynamic indexes. Discussion This study discusses how the identified game mechanics reflect environmental determinism and contrast with the conventional ideology of cultural determinism. Additionally, environmental determinism in video games, derived from a broader social background, is constantly evolving into new forms. Conclusion This study introduces a new perspective of environmental determinism for analyzing the interaction between game ecology and players. This approach has the potential to offer valuable insights into guiding future game design and research endeavors.

Comparing the gut microbiota of Sichuan golden monkeys across multiple captive and wild settings: roles of anthropogenic activities and host factors

BackgroundCaptivity and artificial food provision are common conservation strategies for the endangered golden snub-nosed monkey (Rhinopithecus roxellana). Anthropogenic activities have been reported to impact the fitness of R. roxellana by altering their gut microbiota, a crucial indicator of animal health. Nevertheless, the degree of divergence in gut microbiota between different anthropogenically-disturbed (AD) R. roxellana and their counterparts in the wild has yet to be elucidated. Here, we conducted a comparative analysis of the gut microbiota across nine populations of R. roxellana spanning China, which included seven captive populations, one wild population, and another wild population subject to artificial food provision.ResultsBoth captivity and food provision significantly altered the gut microbiota. AD populations exhibited common variations, such as increased Bacteroidetes and decreased Firmicutes (e.g., Ruminococcus), Actinobacteria (e.g., Parvibacter), Verrucomicrobia (e.g., Akkermansia), and Tenericutes. Additionally, a reduced Firmicutes/Bacteroidetes ratiosuggested diminished capacity for complex carbohydrate degradation in captive individuals. The results of microbial functional prediction suggested that AD populations displayed heightened microbial genes linked to vitamin and amino acid metabolism, alongside decreased genes associated antibiotics biosynthesis (e.g., penicillin, cephalosporin, macrolides, and clavulanic acid) and secondary metabolite degradation (e.g., naphthalene and atrazine). These microbial alterations implied potential disparities in the health status between AD and wild individuals. AD populations exhibited varying degrees of microbial changes compared to the wild group, implying that the extent of these variations might serve as a metric for assessing the health status of AD populations. Furthermore, utilizing the individual information of captive individuals, we identified associations between variations in the gut microbiota of R. roxellana and host age, as well as pedigree. Older individuals exhibited higher microbial diversity, while a closer genetic relatedness reflected a more similar gut microbiota.ConclusionsOur aim was to assess how anthropogenic activities and host factors influence the gut microbiota of R. roxellana. Anthropogenic activities led to consistent changes in gut microbial diversity and function, while host age and genetic relatedness contributed to interindividual variations in the gut microbiota. These findings may contribute to the establishment of health assessment standards and the optimization of breeding conditions for captive R. roxellana populations.

Electrical and chemical modulation of homogeneous and heterogeneous human-iPSCs-derived neuronal networks on high density arrays.

The delicate "Excitatory/Inhibitory balance" between neurons holds significance in neurodegenerative and neurodevelopmental diseases. With the ultimate goal of creating a faithful in vitro model of the human brain, in this study, we investigated the critical factor of heterogeneity, focusing on the interplay between excitatory glutamatergic (E) and inhibitory GABAergic (I) neurons in neural networks. We used high-density Micro-Electrode Arrays (MEA) with 2304 recording electrodes to investigate two neuronal culture configurations: 100% glutamatergic (100E) and 75% glutamatergic / 25% GABAergic (75E25I) neurons. This allowed us to comprehensively characterize the spontaneous electrophysiological activity exhibited by mature cultures at 56 Days in vitro, a time point in which the GABA shift has already occurred. We explored the impact of heterogeneity also through electrical stimulation, revealing that the 100E configuration responded reliably, while the 75E25I required more parameter tuning for improved responses. Chemical stimulation with BIC showed an increase in terms of firing and bursting activity only in the 75E25I condition, while APV and CNQX induced significant alterations on both dynamics and functional connectivity. Our findings advance understanding of diverse neuron interactions and their role in network activity, offering insights for potential therapeutic interventions in neurological conditions. Overall, this work contributes to the development of a valuable human-based in vitro system for studying physiological and pathological conditions, emphasizing the pivotal role of neuron diversity in neural network dynamics.

Inhibition of Cpeb3 ribozyme elevates CPEB3 protein expression and polyadenylation of its target mRNAs and enhances object location memory.

A self-cleaving ribozyme that maps to an intron of the cytoplasmic polyadenylation element-binding protein 3 (Cpeb3) gene is thought to play a role in human episodic memory, but the underlying mechanisms mediating this effect are not known. We tested the activity of the murine sequence and found that the ribozyme's self-scission half-life matches the time it takes an RNA polymerase to reach the immediate downstream exon, suggesting that the ribozyme-dependent intron cleavage is tuned to co-transcriptional splicing of the Cpeb3 mRNA. Our studies also reveal that the murine ribozyme modulates maturation of its harboring mRNA in both cultured cortical neurons and the hippocampus: inhibition of the ribozyme using an antisense oligonucleotide leads to increased CPEB3 protein expression, which enhances polyadenylation and translation of localized plasticity-related target mRNAs, and subsequently strengthens hippocampal-dependent long-term memory. These findings reveal a previously unknown role for self-cleaving ribozyme activity in regulating experience-induced co-transcriptional and local translational processes required for learning and memory.

Domestic or export: What is basic at the NUTS 2 regional level? A spatial endogenous regional growth model applied in the EU

AbstractA common statement found in regional policy reports is that regional growth is an “export or die” issue. However, the succession of disruptions in the international supply chain has highlighted the crucial roles of domestic activities, local markets and short supply chains, turning the environmental and resilience challenge present in growth policy into a “domestic or die” issue. Recent regional growth theories have seriously questioned export activity as the only way in which to drive regional growth and have highlighted the crucial role of the domestic sector. However, no empirical study has assessed the roles of the domestic and export sectors in growth during this troubled economic period, despite the usefulness of this information for nonbiased policy decisions. Using a spatial endogenous regional growth model as a framework, we investigate the role of the domestic sector during the 1999–2014 period for 263 European Union (EU) Nomenclature of Territorial Units for Statistics (NUTS) regions. The results stress the importance of domestic productivity for regional growth during this period, which is characterized by three economic shocks, thereby elucidating the importance of domestic productivity for competitiveness and resilience issues.

MrERF039 transcription factor plays an active role in the cold response of Medicago ruthenica as a sugar molecular switch.

Cold stress severely restricts plant development, causing significant agricultural losses. We found a critical transcription factor network in Medicago ruthenica was involved in plant adaptation to low-temperature. APETALA2/ethylene responsive factor (AP2/ERF) transcription factor MrERF039 was transcriptionally induced by cold stress in M. ruthenica. Overexpression of MrERF039 significantly increased the glucose and maltose content, thereby improving the tolerance of M. ruthenica. MrERF039 could bind to the DRE cis-acting element in the MrCAS15A promoter. Additionally, the methyl group of the 14th amino acid in MrERF039 was required for binding. Transcriptome analysis showed that MrERF039 acted as a sugar molecular switch, regulating numerous sugar transporters and sugar metabolism-related genes. In addition, we found that MrERF039 could directly regulate β-amylase gene, UDP glycosyltransferase gene, and C2H2 zinc finger protein gene expression. In conclusion, these findings suggest that high expression of MrERF039 can significantly improve the cold tolerance of M. ruthenica root tissues during cold acclimation. Our results provide a new theoretical basis and candidate genes for breeding new legume forage varieties with high resistance.

Community empowerment in improving health status


 Community empowerment is an important approach to improving health at various social, economic, and cultural levels. This approach emphasizes the active role of communities in managing and improving their own well-being, including aspects of physical, mental, and social health. Community empowerment involves the process of developing the knowledge, skills, and capacity of individuals and groups to understand and overcome health problems. This can include health education, the promotion of healthy lifestyles, strengthening access to health services, and building community-friendly health infrastructure. Through collaboration between governments, non-governmental organizations, and the private sector, community empowerment can be an effective means to improve the accessibility and quality of health services, as well as to reduce health disparities among different groups of people. The implementation of community empowerment programs has shown a significant impact on increasing health knowledge, improving healthy living behaviors, and reducing preventable disease and mortality. The development of strategies and policies that support community empowerment is an important step in achieving sustainable development goals in the health sector

DEVELOPMENT OF OBSTACLE BYPASSING METHOD OF ECO-AGROROBOT

In this paper, the movement of a laboratory model of a wheeled eco-acrorobot equipped with photovoltaic panels and performing agricultural work is investigated. Having an active role of eco-agrorobot within the framework of the smart village project the linear movement, maneuverability and capability to bypass the obstacles encountered during the movement of the eco-acrorobot are being investigated. The eco-agrorobot is powered by solar panels installed on it. Eco-agrorobot is supposed to be driven by two asynchronous electric motors controlled by a frequency converter installed on front gears. The rear wheels are "royal" (passive) type and do not create traction force. The movement of the eco-agrorobot is controlled by the software. The eco-agrorobot performs agricultural work by moving along a predetermined trajectory in the field previously set to its memory. The ability of the eco-agrorobot to bypass the obstacles encountered during its movement is achieved via two leading wheels controlled by obstacle detectors installed on the robot. The algorithm of maneuvering and bypassing obstacles by the eco-agrorobot was developed, the calculation of the parameters of the solar panels and the selection of other devices were applied. In the presented laboratory model of the eco-agrorobot, the linear movement and maneuverability of the eco-agrorobot is achieved via two DC motors controlled by four ultrasonic sensors installed on the robot. The robot's trajectory is determined by processing the incoming signals through the Arduino microprocessor. Keywords: frequency control, regulated electric drive, wheeled robot, ultrasonic sensor, solar panel, smart village.

Assessing needs of children for childcare at Allama Iqbal Open University

The present study aimed to assess the children needs for childcare at daycare centre of Allama Iqbal Open University Islamabad. Childcare is an important area for research as it directly affects the life of working women in an organization. The University has a daycare centre to facilitate those female employees having kids. It is situated in the main campus of the university. The mothers usually place their offspring in the daycare due to the need to work. The mothers visit daycare centre during duty hours and during break. The present study assessed the working conditions of the daycare centre and suggest some possible interventions for quality provisions and facilities at the daycare centre. It was a need assessment survey. The population of the study included mothers, daycare workers, ayas and members of the management committee of the daycare centre of AIOU. Data was collected through interview, checklists and observations of the care workers with children. It was a need assessment study. A checklist was used to record existing facilities at daycare. While, an interview was conducted regarding awareness, opinion and vision of the mothers and caregivers. Results indicated that the day care centre was equipped with necessary facilities. However, some of the facilities need to provided/upgraded. The study recommended active role of the parents in affairs of the daycare centre.

Association of Visceral Obesity Indices With Incident Diabetic Retinopathy in Patients With Diabetes: Prospective Cohort Study.

Visceral adipose tissue plays an active role in the pathogenesis of type 2 diabetes and vascular dysfunction. The lipid accumulation product (LAP), visceral adiposity index (VAI), and Chinese VAI (CVAI) have been proposed as simple and validated surrogate indices for measuring visceral adipose tissue. However, the evidence from prospective studies on the associations between these novel indices of visceral obesity and diabetic retinopathy (DR) remains scant. This study aimed to investigate the longitudinal associations of LAP, VAI, and CVAI with incident DR in Chinese patients with diabetes. This was a prospective cohort study conducted in Guangzhou in southern China. We collected baseline data between November 2017 and July 2020, while on-site follow-up visits were conducted annually until January 2022. The study participants consisted of 1403 patients with a clinical diagnosis of diabetes, referred from primary care, who were free of DR at baseline. The LAP, VAI, and CVAI levels were calculated by sex-specific equations based on anthropometric and biochemical parameters. DR was assessed using 7-field color stereoscopic fundus photographs and graded according to the modified Airlie House Classification scheme. Time-dependent Cox proportional hazard models were constructed to estimate the hazard ratios with 95% CIs. Restricted cubic spline curves were fitted to examine the dose-response relationship between the 3 indices of visceral obesity and new-onset DR. Subgroup analyses were performed to investigate the potential effect modifiers. The mean age of study participants was 64.5 (SD 7.6) years, and over half (816/1403, 58.2%) were female. During a median follow-up of 2.13 years, 406 DR events were observed. A 1-SD increment in LAP, VAI, or CVAI was consistently associated with increased risk for new-onset DR, with a multivariable‑adjusted hazard ratio of 1.24 (95% CI 1.09-1.41; P=.001), 1.22 (95% CI 1.09-1.36; P<.001), and 1.48 (95% CI 1.19-1.85; P=.001), respectively. Similar patterns were observed across tertiles in LAP (P for trend=.001), VAI (P for trend<.001), and CVAI (P for trend=.009). Patients in the highest tertile of LAP, VAI, and CVAI had an 84%, 86%, and 82% higher hazard of DR, respectively, compared to those in the lowest tertile. A nonlinear dose-response relationship with incident DR was noted for LAP and VAI (both P for nonlinearity<.05), but not for CVAI (P for nonlinearity=.51). We did not detect the presence of effect modification by age, sex, duration of diabetes, BMI, or comorbidity (all P for interaction>.10). Visceral obesity, as measured by LAP, VAI, or CVAI, is independently associated with increased risk for new-onset DR in Chinese patients with diabetes. Our findings may suggest the necessity of incorporating regular monitoring of visceral obesity indices into routine clinical practice to enhance population-based prevention for DR.

Depressive symptom trajectory of older adults with diabetes: exploring the role of physical activities using latent growth modeling

Objectives The literature highlights the role of physical activities in reducing depression, primarily in clinical samples and international longitudinal studies on older adults with diabetes. Based on Andersen’s Behavioral Model, this study aims to describe the trajectory of depressive symptoms in this population and examine whether physical activities are associated with this trajectory. Methods This study used a longitudinal survey design, utilizing three waves of data from the Health and Retirement Study. The respondents were adults aged 50 or older (N = 4,278) with diabetes. After conducting descriptive analyses, latent growth modeling was performed including unconditional and conditional models. Results The overall trajectory of depressive symptoms in adults with diabetes decreased over a 4-year period. Physical activities were significantly associated with the variance in the intercept of the trajectory (p < .05), but not associated with the variance in the slope (p > .05). Additionally, this study identified factors significantly associated with the variance in the intercept (e.g. age, gender, race, marriage, education, income, self-reported health) or the slope (e.g. race, marriage, education, self-reported health) of the depressive symptom trajectory (p < .05). Conclusion The findings underscore the importance of implementing targeted interventions to encourage and promote physical activities among older adults with diabetes, recognizing the potential benefits for managing their mental health.

Digitalization of Trade in Russia by Means of Using Marketplaces

Digitalization of trade through marketplaces is actively being introduced into the daily lives of citizens of many countries, this process began to develop especially actively during the quarantine measures during the pandemic in 2020–2021. E-commerce is most active in Asian countries. For example, China has switched to commodity marketplace platforms by 90 percent. To a certain extent, this made it possible to avoid the collapse of the food and commodity markets in 2020–2021. Having proved very popular among the population, this method of sales has fi rmly established itself in the commodity market. In this article, the authors examined what marketplaces are and what types of marketplaces exist in the global space. They also proposed the author’s classification of marketplaces. In addition, the authors presented practical examples of successful cases of Russian marketplaces in the context of the dynamics of economic development and digitalization of trade, as well as current trends and challenges in the fi eld of e-commerce; opportunities and risks of further development of domestic marketplaces and their role in international export activities. At the end of the study, the authors examined the options for using artificial intelligence in electronic commerce.

Which intellectual activities are related to cognitive reserve? Introduction and testing a three-dimensional model.

A common belief among people and some researchers is that keeping yourself mentally active may decrease the risk of dementia. Over the past years, despite widespread efforts to identify proxies for protecting cognitive reserve against age-related changes, it is still not clear what type of intellectual activity would be beneficial for cognitive reserve. To fill this gap, we propose a three-dimensional model of intellectual activity. According to this conceptual model, intellectual activities could be distinguished based on their locations in a three-dimensions space, including; (1) Activation:activevs.passive, (2) Novelty:novelvs. familiar, and (3) Productivity:productivevs.receptive. We assumed that the activities that are categorized as more active, novel, and productive could be considered as a cognitive reserve proxy. To test this hypothesis, a sample of 237 participants older than 50 years (Mage = 58.76 ± 6.66; 63.7% women) was recruited to take part in the study. Episodic, semantic and working memory were assessed with computerized battery tests (Sepidar) and a self-report questionnaire was used to assess intellectual activities. Activities were categorized in terms of; (1) passive, familiar, and receptive activities (radio/watching TV), (2) active,familiar, and receptive activities (solving crosswords), (3) active,novel, and receptive activities (reading), and (4) active,novel, and productive activities (writing). The results indicated that writing moderates the effect of age on episodic and semantic memory. Reading only moderates the effect of age on semantic memory, and radio/watching TV and solving crosswords do not play a role in moderation analysis. Our finding suggests that intellectual activities have different moderating effects on the relationships between age and memory performance. Individuals with high levels of participation in novel and productive activities over the life course are less likely to clinically demonstrate cognitive impairments. Our results support the potential benefit of the three-dimensional model to provide a better insight into the complex role of intellectual activities in cognitive reserve, particularly for older adults. Further research is needed to evaluate the efficacy and the benefits of the model.