Active Region Research Articles

The MODEST catalog of depth-dependent spatially coupled inversions of sunspots observed by Hinode/SOT-SP

We present a catalog that contains depth-dependent information about the atmospheric conditions inside sunspot groups of all types. The catalog, which we named MODEST, is currently composed of observations of individual active regions with sunspots and covers all types of features observed in the solar photosphere. We used the SPINOR-2D code to perform spatially coupled inversions of the Stokes profiles observed by Hinode/SOT-SP at high spatial resolution. SPINOR-2D accounts for the unavoidable degradation of the spatial information due to the point spread function of the telescope. The sunspot sample focuses on complex sunspot groups, but simple sunspots are also part of the catalog for completeness. Sunspots were observed from 2006 to 2019, covering parts of solar cycles 23 and 24. The catalog is a living resource as with time more sunspot groups will be included.

Impact of far-side structures observed by Solar Orbiter on coronal and heliospheric wind simulations

Solar Orbiter is a new space observatory that provides unique capabilities to understand the heliosphere. In particular, it has made several observations of the far-side of the Sun and therefore provides unique information that can greatly improve space weather monitoring. In this study, we aim to quantify how the far-side data will affect simulations of the corona and the interplanetary medium, especially in the context of space weather forecasting. To do so, we focused on a time period with a single sunspot emerging on the far-side in February 2021. We used two different input magnetic maps for our models: one that includes the far-side active region and one that does not. We used three different coronal models typical of space weather modeling: a semi-empirical model (potential field source surface or PFSS) and two different magnetohydrodynamic models (Wind Predict and Wind Predict-AW). We compared all the models with both remote sensing and in situ observations in order to quantify the impact of the far-side active region on each solution. We find that the inclusion of the far-side active region in the various models has a small local impact due to the limited amount of flux of the sunspot (at most 8<!PCT!> of the total map flux), which leads, for example, to coronal hole changes of around 7<!PCT!> for all models. Interestingly, there is a more global impact on the magnetic structure seen in the current sheet, with clear changes for example in the coronal hole boundaries visible in extreme ultra-violet (EUV) on the western limb, which is opposite to the active region and the limb most likely to be connected to Earth. For the Wind Predict-AW model, we demonstrate that the inclusion of the far-side data improves both the structure of the streamers and the connectivity to the spacecraft. In conclusion, the inclusion of a single far-side active region may have a small local effect with respect to the total magnetic flux, but it has global effects on the magnetic structure, and thus it must be taken into account to accurately describe the Sun-Earth connection. The flattening of the heliospheric current sheet for all models reveals that it causes an increase of the source surface height, which in return affects the open and closed magnetic field line distributions.

The Emerging Stellar Complex in Mon R2: Membership and Optical Variability Classification

Monoceros R2 (Mon R2) is one of the closest large active star-forming regions. This extremely young and partially embedded region provides an excellent laboratory for studying star formation and the early evolution of young stellar objects (YSOs). In this paper, we conduct an optical study of the greater Mon R2 region. Beginning with 1690 previously identified candidate YSOs, we used 496 sources with good proper motions and parallaxes from Gaia Data Release (DR) 3 to determine the astrometric properties for likely members of Mon R2. We then used both astrometric and photometric (isochronal and variability) criteria to determine that 308 of these stars are highly probable members. Using the same criteria, we considered a broad area search around Mon R2 in Gaia DR3 and separated candidate members from field stars. In total, we selected 651 likely new cluster members that had been missed in the previous X-ray and infrared excess selection techniques used in the past to establish cluster membership. Revised astrometric properties of the cluster were found using the combined sample of ∼959 highly probable member stars. For the literature plus the new candidate member list, optical light curves were compiled from the Zwicky Transient Facility. For 470 identified variable sources, we attempted classification based on the flux asymmetry (M) and quasiperiodicity (Q) metrics. We find that Mon R2 is dominated by quasiperiodic symmetric variables, with aperiodic sources also a significant population. A few tens of large-amplitude variables are identified that may be of interest for further study.

Chromospheric and coronal heating in an active region plage by dissipation of currents from braiding

AbstractThe question of what heats the outer solar atmosphere remains one of the longstanding mysteries in astrophysics. Statistical studies of Sun-like stars reveal a correlation between global chromospheric and coronal emissions, constraining theoretical models of potential heating mechanisms. However, spatially resolved observations of the Sun have surprisingly failed to show a similar correlation on small spatial scales. Here we use unique coordinated observations of the chromosphere (from the IRIS satellite) and the low corona (from the Hi-C 2.1 sounding rocket), and machine-learning-based inversion techniques, to show a strong correlation on spatial scales of a few hundred kilometres between heating in the chromosphere and emission in the upper transition region in strong magnetic field regions (‘plage’). Our observations are compatible with an advanced three-dimensional magnetohydrodynamic simulation in which the dissipation of current sheets caused by magnetic field braiding is responsible for heating the plasma simultaneously to chromospheric and coronal temperatures. Our results provide deep insight into the nature of the heating mechanism in solar active regions.

Impedance and Dielectric Analysis of Nickel Ferrites: Revealing the Role of the Constant Phase Element and Yttrium Doping

This paper presents the analysis of electrical and dielectric properties of the yttrium-doped nickel ferrite nano-powders synthesized using the co-precipitation method. Impedance and dielectric measurements have been carried out as a function of frequency at different temperatures from 200 to 25 °C in the range of 0.1 kHz–1 MHz. In order to investigate the conduction mechanism and highlight the role of yttrium doping in different concentrations, impedance spectroscopy was employed. The obtained data were analyzed in terms of equivalent circuits made of resistor and capacitor components describing the contributions from different electrical active regions in a material. Further, this study highlights the importance of a single constant phase element (CPE) in the description of dispersion behavior of the impedance response of the investigated samples in the given frequency range. The use of this technique enabled the characterization of grain and grain boundaries contribution in overall conductivity mechanism. The dielectric dispersion nature of all investigated materials is reflected in this study. Very high values of the real part of permittivity at low frequencies are assigned to space-charge polarization. The dependence of the real part of dielectric permittivity values of the yttrium content was also discussed. Doping with yttrium in different concentrations that reflects in different electric and dielectric responses is concluded in this study. The greatest change is noticed for the sample with the minimum dopant content for a x = 0.05 atomic percent share of yttrium. To reveal the potential role of more than one ion contribution to the overall relaxation process in investigated compounds, a modified Debye’s equation was utilized.

Investigation of Displacements in Tunnel-Constructed Liquefiable Soils with Numerical Analysis

The rise in industrialization and population has led to an increase in the economic significance of existing urban areas, and thus the utilization of underground space has become quite remarkable It is an undeniable fact that in seismically active regions, the underground areas are also exposed to the risk of earthquakes. The devastating 1995 Kobe-Japan, 1999 Chi-Chi-Taiwan and 1999 Kocaeli-Turkey earthquakes are known to have caused major damage to existing underground structures. In this study, numerical models based on finite differences in FLAC 2D were established to evaluate the displacements of the ground around the tunnels located in liquefiable soils. In order to represent the liquefaction condition in the models, soils in the Adapazarı region, which have alluvial characteristics, were used. Soil deformations were examined in models with varying tunnel depths and diameters, for both liquefiable and non-liquefiable soils within the same layers. As a result of this study, it is stated that more stability losses are observed in analyzes where liquefaction can be defined - that is, changes in pore water pressures can be modeled - compared to analyzes without liquefaction. The layout of the ground layers is important for the positioning of the tunnel. The placement of the tunnel towards the solid layers caused the deformations to decrease.

Assessing lava flow susceptibility at neighbouring volcanoes: Nyamulagira and Nyiragongo volcanoes, Virunga Volcanic Province

Assessing volcanic hazards in locations exposed to multiple central volcanoes requires to consider multiple potential eruption sources and their respective characteristics. While this is common practice in ashfall hazard assessment, this is generally not considered for topography-controlled volcanic flow processes. Yet, in volcanic areas with closely spaced volcanic systems, eruptions fed from several contrasted volcanic systems might threaten one given area. Considering the case of the Nyiragongo and Nyamulagira volcanoes in the Virunga Volcanic Province (D.R.Congo), we present a method to produce a combined lava flow inundation susceptibility map that integrates both volcanoes. The spatial distribution of the probability of vent opening for the next eruption is separately constrained for both volcanoes based on the mapping of historical and pre-historical eruptive vents and fissures. The Q-LavHa lava flow probability model is then calibrated separately for each volcano, considering several historical lava flows of Nyamulagira (2004, 2006, 2010) and Nyiragongo (2002). The maps for the two volcanoes are thereafter integrated based on a weighted sum of both individual lava flow inundation probability maps, assuming historically-based relative eruption frequency of the two volcanoes. The accuracy of this probabilistic susceptibility map for the most active volcanic region in Africa was unfortunately validated by the May 2021 lava flow produced by Nyiragongo. This map was discussed and validated in 2019 with local scientists, as well as representatives of disaster management and urban planning institutions, but was not included in the regional contingency plan ahead of the 2021 eruption crisis. Updating the volcanic crisis and evacuation management plans with this lava flow probability map could contribute to reinforce risk awareness among the population and inform the future development of the city of Goma.

TEAD2 initiates ground-state pluripotency by mediating chromatin looping

The transition of mouse embryonic stem cells (ESCs) between serum/LIF and 2i(MEK and GSK3 kinase inhibitor)/LIF culture conditions serves as a valuable model for exploring the mechanisms underlying ground and confused pluripotent states. Regulatory networks comprising core and ancillary pluripotency factors drive the gene expression programs defining stable naïve pluripotency. In our study, we systematically screened factors essential for ESC pluripotency, identifying TEAD2 as an ancillary factor maintaining ground-state pluripotency in 2i/LIF ESCs and facilitating the transition from serum/LIF to 2i/LIF ESCs. TEAD2 exhibits increased binding to chromatin in 2i/LIF ESCs, targeting active chromatin regions to regulate the expression of 2i-specific genes. In addition, TEAD2 facilitates the expression of 2i-specific genes by mediating enhancer-promoter interactions during the serum/LIF to 2i/LIF transition. Notably, deletion of Tead2 results in reduction of a specific set of enhancer-promoter interactions without significantly affecting binding of chromatin architecture proteins, CCCTC-binding factor (CTCF), and Yin Yang 1 (YY1). In summary, our findings highlight a novel prominent role of TEAD2 in orchestrating higher-order chromatin structures of 2i-specific genes to sustain ground-state pluripotency.

Sedimentological characterization of earthquake-generated turbidites in fault-proximal glacial lakes: a case study from Jenny Lake, Teton range, Wyoming

Lakes in seismically active regions preserve valuable sedimentary archives of paleoseismic activity within their catchment and beyond. A series of glacially-excavated lakes positioned directly along the surface trace of the Teton normal fault at the base of the Teton Range, WY, are ideally situated to record past fault activity since their formation approximately 15,000 years ago. Here, we focus on the sediment fill contained in Jenny Lake (5 km2; approximately 73 m max depth) located at the bottom of Cascade Canyon, in the central Tetons, where postglacial slip rates are greatest. Past earthquakes that generated slope failures in and around Jenny Lake are expressed stratigraphically as coseismic turbidite deposits. These deposits were previously identified and dated in sub-bottom profiles and in sediment cores taken from multiple locations around the basin. In this study, we focus on the six thickest turbidites (ranging from 6 to 34 cm thick) present in multiple cores recovered from the central depositional basin and analyze them at sub-centimeter resolution for changes in physical, biological, and geochemical parameters, including sediment density, magnetic susceptibility, grain size distributions, organic content, and elemental composition. Results reveal each deposit contains a well-defined, three-component sedimentary sequence composed of a relatively homogenous and thick basal sandy unit with a sharp bottom contact, a similarly thick silt-rich middle unit, and a thin top unit of very fine-grained sediments. The characteristics of these components and their similarity between individual deposits suggest consistent sediment sources and transport pathways during successive earthquake events. Based on our analyses and the unique local geomorphic setting, we create a mechanistic model of coseismic turbidite formation in Jenny Lake, which may provide an improved framework for identifying, characterizing, and correlating earthquake-generated disturbance deposits in other Teton lakes and lakes in similar tectonic-geomorphological settings, for example, in the Basin and Range Province, USA or beyond.

Surfactant-assisted synthesis of NiCo alloy with specific nanopore architecture as a bifunctional electrocatalyst for rechargeable zinc-air batteries

Designing the effective active sites and reaction areas of catalytic materials is important for the development of bifunctional electrocatalysts for zinc-air batteries (ZABs). In this paper, a catalyst with a uniform nanopore structure (noted as NiCo-PS) was one-pot synthesized by using transition metals nickel and cobalt as catalytic active components, sucrose as a carbon source, and triblock copolymers as a soft template. The N2 absorption and desorption isotherms curves show that the pore size distribution of NiCo-PS modified by surfactant is mainly in 3.6 nm range. NiCo-PS exhibits exceptional bifunctional electrocatalysis due to its effective triple-phase reaction interface from its mesoporous structure, with a positive half-wave potential of 0.758 V for ORR and a low overpotential of 390 mV at 10 mA ⋅ [Formula: see text] for OER. Furthermore, the rechargeable ZABs with the NiCo-PS catalyst exhibit a high open-circuit voltage of 1.31 V, a significant peak power density of 105 mA ⋅ [Formula: see text] at 0.56 V, and good stability throughout 270 h testing. This result offers valuable insights for designing catalysts that enhance the active region of the reaction within the cathodes of ZABs and hold significant promise for practical applications.

High-efficiency and high-brightness broad area laser diodes with buried implantation current blocking

Buried-regrown-implant-structure (BRIS) technology combines two-step epitaxial regrowth with an intermediate ion implantation step in order to realise a buried current aperture close to the active region of a laser diode. In this paper we carry out a systematic performance comparison demonstrating the benefit of BRIS technology in single emitter broad-area lasers (BALs). We investigate stripe width W = 100 μ m and resonator length L = 4 mm single emitter lasers emitting at wavelength λ = 915 nm, comparing the performance of BRIS devices with different implantation depths with reference devices with only contact layer implantation. We show that using BRIS technology we achieve a continuous wave output power of 20 W at 57% efficiency, with a peak efficiency of 68%, and maintain a lateral brightness of 3.4 mm · mrad up to 19 W, improved over the reference devices due to reduced lateral current spreading in the BRIS devices. Further, we show results of ongoing aging experiments, which has shown no device degradation up to 5000 hours from BRIS devices.

Long-period oscillations in the lower solar atmosphere prior to flare events

Multiple studies have identified a range of oscillation periods in active regions, from 3-5 minutes to long-period oscillations that last from tens of minutes to several hours. Recently, it was also suggested that these periods are connected with eruptive activity in the active regions. Thus, it is essential to understand the relation between oscillations in solar active regions and their solar eruption activity. We investigate the long-period oscillations of NOAA12353 prior to a series of C-class flares and correlate the findings with the 3- to 5-minute oscillations that were previously studied in the same active region. The objective of this work is to elucidate the presence of various oscillations with long periods in the lower solar atmosphere both before and after the flare events. To detect long-period oscillations, we assessed the emergence, shearing, and total magnetic helicity flux components from the photosphere to the top of the chromosphere. To analyze the magnetic helicity flux in the lower solar atmosphere, we used linear force-free field extrapolation to construct a model of the magnetic field structure of the active region. Subsequently, the location of long-period oscillations in the active region was probed by examining the spectral energy density of the measured intensity signal in the 1700\,AA , 1600\,AA , and 304\,AA channels of the Atmospheric Imaging Assembly (AIA) of the Solar Dynamics Observatory (SDO). Significant oscillation periods were determined by means of a wavelet analysis. Based on the evolution of the three magnetic helicity flux components, 3- to 8-hour periods were found both before and after the flare events, spanning from the photosphere to the chromosphere. These 3- to 8-hour periods were also evident throughout the active region in the photosphere in the 1700\,AA channel. Observations of AIA 1600\,AA and 304\,AA channels, which cover the chromosphere to the transition region, revealed oscillations of 3-8 hours near the region in which the flare occurred. The spatial distribution of the measured long-period oscillations mirror the previously reported distribution of 3- to 5-minute oscillations in NOAA12353 that were seen both before and after the flares. This case study suggest that the varying oscillation properties in a solar active region could be indicative of future flaring activity.

Constructing eRNA-mediated gene regulatory networks to explore the genetic basis of muscle and fat-relevant traits in pigs

BackgroundEnhancer RNAs (eRNAs) play a crucial role in transcriptional regulation. While significant progress has been made in understanding epigenetic regulation mediated by eRNAs, research on the construction of eRNA-mediated gene regulatory networks (eGRN) and the identification of critical network components that influence complex traits is lacking.ResultsHere, employing the pig as a model, we conducted a comprehensive study using H3K27ac histone ChIP-seq and RNA-seq data to construct eRNA expression profiles from multiple tissues of two distinct pig breeds, namely Enshi Black (ES) and Duroc. In addition to revealing the regulatory landscape of eRNAs at the tissue level, we developed an innovative network construction and refinement method by integrating RNA-seq, ChIP-seq, genome-wide association study (GWAS) signals and enhancer-modulating effects of single nucleotide polymorphisms (SNPs) measured by self-transcribing active regulatory region sequencing (STARR-seq) experiments. Using this approach, we unraveled eGRN that significantly influence the growth and development of muscle and fat tissues, and identified several novel genes that affect adipocyte differentiation in a cell line model.ConclusionsOur work not only provides novel insights into the genetic basis of economic pig traits, but also offers a generalizable approach to elucidate the eRNA-mediated transcriptional regulation underlying a wide spectrum of complex traits for diverse organisms.

Adjusting an active shallow crustal ground motion model to regions with scarce data: application to France

AbstractThe objective of this work is to test whether an empirical Ground Motion Model (GMM) developed for high-seismicity regions can be effectively adapted to a neighbouring region with lower seismic activity. We select the ITA18 suite of GMMs (Lanzano et al. in Bull Seismol Soc Am 109(2): 525-540, 2019a), developed for Italy, which is a region dominated by moderate-to-strong shallow crustal earthquakes, and assess their applicability to Continental France, where the seismic activity is less frequent and characterised by lower magnitudes. Based on a dataset of more than 2300 records of events with 3.0 ≤ MW ≤ 5.2, occurred in France in the time interval 1996–2019 (named FR20), we perform a residual analysis and calibrate an adjustment factor for both horizontal and vertical-to-horizontal (VH) components of Peak Ground Acceleration, Peak Ground Velocity, and 5% damped Spectral Acceleration (SA). Apart from the median correction, no modification of the scaling with magnitude, focal mechanism, and VS,30 is introduced, while the distance scaling is adjusted to capture the lower anelastic attenuation of the French data. In addition, to overcome the underestimation of the ITA18 model for the short period VH spectral amplitudes in the near-source region (Repi < 15 km), an additional empirical corrective factor is introduced. In spite of the good agreement of the adjusted model with respect to the median trends of the FR20 dataset, a regionalization of the source effects is introduced to reduce the relatively high between-event variability of the proposed model. The proposed model provides predictions similar to ITA18 in the most seismically active regions (Alps or Pyrenees), while, in the other zones, the predicted amplitudes are richer at high frequencies. Given the paucity of seismic records in these zones, this behavior should be confirmed on the basis of additional data (e.g. physics-based simulations, geologic and tectonic features). The use of the proposed model for hazard applications is recommended within the validity limits of the data (3.0 ≤ MW ≤ 5.2). However, the similarity of the ground motion in the Alps and Pyrenees with the predictions of ITA18 suggests that the adjusted model could be also employed for higher magnitudes, upon suitable checks.

A model for heating the super-hot corona in solar active regions

A model for heating the super-hot corona in solar active regions

A solar cycle clock for extreme space weather

The variable solar cycle of activity is a long-standing problem in physics. It modulates the overall level of space weather activity at earth, which in turn can have significant societal impact. The Hilbert transform of the sunspot number is used to map the variable length, approximately 11 year Schwabe cycle onto a uniform clock. The clock is used to correlate extreme space weather seen in the aa index, the longest continuous geomagnetic record at earth, with the record of solar active region areas and latitudes since 1874. This shows that a clear switch-off of the most extreme space weather events occurs when >90\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$>90$$\\end{document}% of solar active region areas have moved to within about 15° of the solar equator, from regions of high gradient in solar differential rotation which can power coronal mass ejections, to a region where solar differential rotation is almost constant with latitude. More moderate space weather events which coincide with 27 day solar rotation recurrences in the aa index, consistent with stable, persistent source regions of high speed streams, commence when the centroid of solar active region areas moves to within 15° of the solar equator. This offers a physical explanation for the longstanding identification of a two component cycle of activity in the aa index.

Linear to circular conversion in the polarized radio emission of a magnetar

AbstractRadio emission from magnetars provides a unique probe of the relativistic, magnetized plasma within the near-field environment of these ultra-magnetic neutron stars. The transmitted waves can undergo birefringent and dispersive propagation effects that result in frequency-dependent conversions of linear to circularly polarized radiation and vice versa, thus necessitating classification when relating the measured polarization to the intrinsic properties of neutron star and fast radio burst emission sites. We report the detection of such behaviour in 0.7–4 GHz observations of the P = 5.54 s radio magnetar XTE J1810−197 following its 2018 outburst. The phenomenon is restricted to a narrow range of pulse phase centred around the magnetic meridian. Its temporal evolution is closely coupled to large-scale variations in magnetic topology that originate from either plastic motion of an active region on the magnetar surface or free precession of the neutron star crust. Our model of the effect deviates from simple theoretical expectations for radio waves propagating through a magnetized plasma. Birefringent self-coupling between the transmitted wave modes, line-of-sight variations in the magnetic field direction and differences in particle charge or energy distributions above the magnetic pole are explored as possible explanations. We discuss potential links between the immediate magneto-ionic environments of magnetars and those of fast radio burst progenitors.

Sulfur and nitrogen co-doping of peanut shell-derived biochar for sustainable supercapacitor applications

To enhance the biochar produced from biomass and utilize it in the development of electrodes for applications in supercapacitors, doping the biochar with multiple or double heteroatom elements could be more beneficial than single-element doping. The search for the right heteroatom doping sources and synthesis techniques is difficult but necessary. This study exhibited the synthesis of peanut shell-derived biochar doped with sulfur (S) and nitrogen (N) through carbonization, activation, and ex-situ doping with affordable melamine and thiourea as S and S/N sources. Characterizations such as XPS, XRD, TEM, Raman, EDS mapping revealed that the S and N co-doped biochar has multilayered nanosheet-like morphology, uniform heteroatom doping, and hierarchical pore structure. Electrochemical characterization showed that the S and N co-doped electrode material has a specific capacitance of 224 F/g, higher than those of 200 F/g and 178.94 F/g of N-doped and pristine biochar at 1 A/g, respectively. The supercapacitor fabricated by the developed electrodes at 1 A/g has a specific capacitance of 80.25 F/g with a density of energy of 11.15 Wh/Kg. It is considered that S and N co-doping can enhance the active regions and pore arrangement of peanut shell-derived biochar to improve the passage of ions of the electrolyte and transfer of charge to the electrode surface in supercapacitor applications.

Low-power-consumption modulation of short-cavity DBR laser on SiO2/Si substrate

We developed short-active-length distributed Bragg reflector (DBR) lasers to reduce the power consumption of chip-to-chip optical interconnects. These lasers have buried bulk InGaAsP waveguides to increase the coupling efficiency between the active region and DBR to 99.79% from the 98.14% of our previous DBR lasers that had InP channel waveguides. We achieved continuous wave operation of 5- to 80-µm active-length DBR lasers and the 5-µm-long laser consumed 24 fJ/bit with a 10-Gbps NRZ signal. The threshold current of the 5-µm laser was 51 µA, which compares favorably to our previous 10-µm DBR lasers with a threshold current of 170 µA.

Abstract LB011: Landscape of promoter centric chromatin interactions and co-regulated gene network provide insights for transcriptional regulation in prostate cancer

Abstract Eukaryotic genomes are organized into hierarchical three-dimensional (3D) structure inside the nucleus, forming topological associating domains (TADs) and providing insulated neighborhoods for the highly interacting genome regions. These regions are established by potential chromatin bridging proteins, such as the cohesin complex and CTCF, forming loops. Within the framework of these TADs lie the loops defined by the transcriptional machinery, or RNA polymerase II (RNAPol II). Changes to this 3D genome structure are associated with the development of human diseases, including cancers. Prostate cancer (PCa), associated with transcriptional dysregulation, serves as an optimal model to understand the molecular mechanism behind the formation of dynamic loops between distant regulatory elements and their target genes in 3D space to regulate gene expression and cancer progression. This study integrates two protein-centric ChIA-PET data (RNAPol II and cohesin) with multiple ChIP-Seq data (CTCF, H3K27ac, AR and FOXA1), and RNA-Seq data of PCa cell lines (LNCaP, VCaP, DU145, and RWPE1) to perform promoter (P) centered analysis. Firstly, we investigated the proportions of RNAPol II loops with co-occupancy of cohesin peaks and vice versa to quantify and understand the involvement of these proteins in transcription regulation and validate them using simulations. The results supported the hypothesis that most RNAPol II loops were significantly enriched with cohesin peaks. However, the reverse was not true since inner RNAPol II loops enriched with cohesin regulate transcription, while most of the cohesin loops form long-range interactions, TADs. Further, we compared the correlation between the promoter centric RNAPol II-associated and cohesin-mediated interactions with gene expression. In the case of RNA Pol II mediated interactions, we found a quantitative increase in the strength of interaction between loci, this trend was not observed in cohesin mediated interactions, which were relatively stable. The only exception was in the cell line VCaP, possibly due to its genetic complexity, as the strength of interactions associated with Cohesin as well as RNA Pol II increased. We next examined if the strength of interactions between cohesin loops remains unaffected in the VCaP cell line when treated with dBET inhibitor. However, there was no significant difference observed. This explained that RNAPol II loops are more dynamic, whereas cohesin loops are more stable. However, whether the cohesin loops (internal and TAD boundary) stay stable in the active and inactive regions of the genome remains unexplored. Next, the study inspects how the cluster of regulated genes is organized, preferentially forming multi-gene complexes in PCa for efficient and potential cooperative transcription. We expect a significant role of super-enhancers in identifying interactions between key oncogenes in PCa, owing to cell-type specific biology. Highly co-regulated single- and multi-valent loops will be validated in the patient cohorts to establish significant correlations. Overall, this study enhances the knowledge of promoter-centric molecular mechanisms involved in multi-gene complex formation and coregulated transcription in PCa cell lines. Citation Format: Khyati Raghunath Chandratre, Susmita Ramanad, Ahmed abbas Elmahdi, Yunpeng Gao, Ram Shankar Mani, Michael Zhang. Landscape of promoter centric chromatin interactions and co-regulated gene network provide insights for transcriptional regulation in prostate cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 2 (Late-Breaking, Clinical Trial, and Invited Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(7_Suppl):Abstract nr LB011.