Type Of Acne Research Articles

Evaluation of topical remedies in the treatment of acne available in the Republic of Moldova

Introduction. A lot of research and studies are currently being carried out in the field of elaboration and optimization of topical pharmaceutical forms used in the treatment of various types of acne. Acne vulgaris is a disease with a complex etiopathogenesis with potential negative psychosocial effects on the quality of life of patients, and its prevention is based on the successful management of risk factors. There are currently many topical and systemic treatment options available, so the choice of therapy depends on the form and severity of the condition. The advantage of topical pharmaceutical forms is the ability to target early stages of acne lesions. Material and methods. Statistical, systemic, informational and sociological analysis were used as methods of analysis. Documentation with the State Drug Nomenclature and Classification, evaluation of topical prescription for acne treatment, dispensed in the Vasile Procopisin University Pharmaceutical Center (UPhC), the study of active pharmaceutical ingredients (API) and technological characteristics of topical pharmaceutical forms. Results. Topical treatment for acne should be based on its type and severity. The basic therapy for the treatment of mild acne refers to external applications, due to their action to prevent lesions. Treatment should be maintained over time to prevent recurrence. For domestic patients are accessible drugs with keratolytic, bacteriostatic and anti-inflammatory properties for topical treatments as benzoyl peroxide, salicylic acid, sulfur, azelaic acid, zinc oxide and antibiotic. The analysis of the use of anti-acne medications, in treating mild to moderate acne, by the age group, identified that for adolescents treatment is being focused on combating the causative agent of sebum production using salicylic acid in 32.5% cases and with age increase, the aim is to suppress inflammatory processes requiring retinoids, and in case of absence, can be substituted by benzoyl peroxide. Conclusions. The therapeutic approach in clinical practice must be done individually, considering the severity and shape of acne lesions.

Phytoconstituents-loaded nanomedicines for the management of acne.

According to epidemiological data, a large percentage (80-90%) of adolescents suffer from acne vulgaris and approximately 30% of them need treatment. Possible outcomes of the inflammatory acne lesions are acne scars which, although they can be treated in several ways, may have a negative psychological impact on social life and relationships. There are three levels of acne: mild, moderate, and severe. The main types of acne scars are atrophic and hypertrophic scars. The pathogenesis of acne scarring is still not fully understood, but several hypotheses have been proposed. The aim of this review is phytoconstituents-loaded nanomedicines for the management of acne. An online literature assessment was steered for the acne, phytochemical composition, and nanomedicines, types of acne, types of nanotechnology. Appropriate information were taken from different electronic scientific databases such as Web of Science, Elsevier, Science Direct, Springer, PubMed, Google Scholar, etc., Additional data was summarized from textbooks, local prints, and scripts. Nanotechnology-based nanomedicines provide a great coincidence for the enhancement in the efficacy and safety of pharmaco-therapeutic agents for acne. In this review, we discuss the phytoconstituent that are natural compounds present in plants extensively used for the anti-acne activity. Phytochemicals target cytokine signaling pathways and thus exhibit their anti-acne activity. We further outline the advantages of loading phytoconstituents as a drug in nanocarriers such as emulsion, niosomes, SLN, and nanocrystal for better and improved topical treatment. This review is mainly focused on the usage of herbal nanomedicines in acne, nano delivery carriers used in the delivery of phytoconstituents with an improved therapeutic profile and reduced toxicity. In recent years, phytoconstituents showing their anti-acne potential, and phytoconstituents-loaded nanomedicines have high treatment potential in the management of acne.

Isotretinoin Versus Weekly Pulse Dose Azithromycin In The Treatment Of Acne

Introduction: Acne vulgaris is one of the most common skin disorders. It mainly affects adolescent, though may present at any age. It differs from patient to patient. Thus, the treatment should be differing from individual patients. Methods: The comparative study between the efficacy of isotretinoin and pulse dose azithromycin was carried for one year. Sixty patients of moderate to severe acne were enrolled among 15 – 30 years’ group divided into two equal groups. Isotretinoin 0.5-1mg/kg body weight given to Group A and azithromycin 500mg was given to Group B three days a week for 3 months according to severity of the disease. The severity of acne was done according to Global Acne Grading Score, GAGS. Results: Maximum number of patients were having moderate type of acne i.e., 20 (66.7%) in group A and 25 (83.3%) in group B. In group A, all cases responded and the clinical response was rated as excellent in 24 (80%), good in 5 (16.67%) and fair in 1 (3.33%) case. In group B, 24 (80%) cases responded and the response was categorized as excellent in 6 (20%), good in 9 (30%), fair in 3 (10%) and poor in 6 (20%) cases. There was no response in 6 (20%) cases. The response of isotretinoin in Group A is better than azithromycin in group B [p<0.01]. Conclusions: Isotretinoin appears to be the superior than to weekly pulse dose of azithromycin in moderate to severe case of acne.

The association between acne care provision and quality of life: A cross-sectional survey.

Background and AimsIt has been suggested that professional acne care can be effective not only in reducing clinical signs but also in improving quality of life (QOL). This study aims to reach a better understanding of the association between QOL and professional acne care. The study also investigates other factors that might influence QOL such as age, gender, and acne severity.MethodsBetween 2019 and 2020, a cross‐sectional survey‐based study was conducted among 362 acne patients. Data were collected by the Cardiff Acne Disability Index (CADI) and a Global QOL scale. Analysis of covariance (ANCOVA) and post hoc comparisons were conducted to analyze the association between professional acne care and health‐related QOL.ResultsNo statistically significant differences were found in QOL measured by CADI among patients visiting the four investigated acne caregivers (mean CADI score: dermatologist, 4.49; GPs, 4.42; dermal therapist, 4.07; beautician, 4.20, P = .24). However, the impact of the treatment on the QOL, which was measured by the level of Global QOL improvement before and after care, demonstrated a statistically significant improvement when attending a dermatologist, compared to the care provided by beauticians (Global QOL improvement: dermatologist, 1.50; GP, 1.01; dermal therapist, 1.10; beautician, 0.54, P = .05). Females experienced a more impaired acne‐related QOL than males (P = .05), and increased acne severity was associated with a more impaired QOL (P < .05).ConclusionsThis study delineated factors that influence QOL in acne patients. As the QOL was not associated with the type of caregiver, the greatest QOL improvement before and after care was achieved after medical treatment by the dermatologist. Females and individuals dealing with more severe types of acne experienced a more impaired acne‐related QOL. It is recommended to take these factors into account in acne management to optimize professional treatment in line with patient needs.

INTENSE PULSED LIGHT AS MONOTHERAPY IN THE MANAGEMENT OF ACNE

Acne vulgaris commonly affects adolescents and adults causing disgurement or scarring having psychological impact and reduces quality of life. This study conducted to study impact of Intense Pulsed Light (IPL) over the lesion. An interventional study carried out over 81 (M: F - 37:44) acne patients attending dermatology OPD, 3 setting of Intense Pulsed Light (IPL) therapy (430 -1200 nm wavelength) were given to patients. Mean age of 81 acne patient was 23.56 + 4.47 years and most of patients were having papular type of acne (81%) followed by pustules (71%) &amp; comedones (45%). There was signicant decrease (p&lt;0.05) in average lesion count in third setting (23.44 + 15.6) as compared to rst setting (36.65 + 18.2). Erythema (16.05%) followed by Itching (6.17%) and burning (3.70%) were most common side effect of therapy. IPL is safe, short duration and non-invasive method for inammatory acne lesions with good compliance from patient.

Single‐center, assessor‐blind study to evaluate the efficacy and safety of DA‐5520 topical gel in patients with acne scars: A pilot study

Unlike various topical treatment options for acne vulgaris, options for acne scars mostly involve invasive interventions. So far, only a few clinical trials have investigated the effects of topical treatment for acne scars. We evaluated the safety and efficacy of DA-5520, a recently developed topical gel for the treatment of different types of acne scars. A 12-week prospective, randomized, active-controlled, evaluator-blind, single-center study involving 36 participants with acne scars was performed. Participants were randomized into four different groups at a 1:1:1:1 ratio: laser resurfacing with DA-5520 application (test 1); laser resurfacing without DA-5520 application (control 1); comedone extraction with DA-5520 application (test 2); and comedone extraction without DA-5520 application (control 2). For 12weeks, participants in the two test groups applied DA-5520 twice daily, while participants in the control groups applied moisturizers alone. Participants in the test 1 and control 1groups received a single session of laser resurfacing at visit 1 (week 0). All participants were followed up at 1, 4, 8, and 12weeks, and objective scar evaluation using the échelle d'évaluation clinique des cicatrices d'acné (ECCA) score was performed at each visit. Clinical improvement of acne scars, confirmed by the ECCA grading scale (1 for atrophic scar and 2 for hypertrophic scar), was observed after using DA-5520 when combined with laser resurfacing or individually, and no associated adverse reactions were noted. Preliminary results of this study revealed that DA-5520may be a promising new formulation for treating all type of acne scars.

An Observational Study of Clinical, Metabolic and Hormonal Profile of Pediatric Acne.

To study the biochemical, metabolic and hormonal profile among children presenting with acne and to determine the correlation of these parameters with acne grading. The observational cross-sectional study was conducted for a duration of 18 months on a total of 50 children between 1 and 12 years of age with clinical features of acne. The detailed information regarding the type of acne, biochemical profile (lipid profile, blood sugar levels), hormonal profile and associated illnesses were recorded. Spearman's rank correlation coefficient was used to find out the correlation of acne grading with hormonal and metabolic changes. The mean age of the children was 11.4 years. Among the various lesions, comedones were seen in 98% cases, papules in 94.00% cases, a scar in 14.00% and pustule in 4.00% cases. As compared to children of age 1-7 years, those in age group 8-12 years had significantly more comedones (48 vs 1, P = 0.04), significantly fewer pustules (0.00% vs 100.00%, P = 0.001), and a comparable number of papules and scars. Most of the children (88.00%) had acne vulgaris grade 1. There was a significant negative correlation of Blood sugar-fasting (r = -0.312, P = 0.0275) and a significant positive correlation of HDL (r = 0.28, P = 0.0491) with acne grading. Comedones and papules are the commonest and the earliest forms of pediatric acne. Severe forms of acne are rarely seen below 12 years, age group. Preadolescent acne is commoner than mid-childhood acne, with no difference between male and females. Blood sugar levels and lipid profile derangements have a weak correlation with acne grading.

Izotretinoin - 40 godina iskustva

Isotretinoin is a derivative of vitamin A (13-cis retinoic acid) and represents the first generation of retinoids. It affects all the key factors in the pathogenesis of acne and all current guidelines agree that it is still the most effective therapeutic option in the treatment of acne. In addition to conventional treatment, the modern concept of treatment allows various other protocols, so proper selection of patients and adjustment of isotretinoin treatment modality to the type and severity of acne is necessary to obtain optimal results. Although it was introduced into dermatological practice 40 years ago, this drug is still accompanied by certain controversies and doubts among doctors and patients. The main source of doubt is potential side effects such as teratogenicity, depression, suicide, and inflammatory bowel diseases. Decades of experience have shown that side effects (apart from teratogenicity) are mostly mild, reversible and rare. This paper presents modern approach regarding dosage, monitoring of patients during the treatment, as well as the identification and management of side effects.

Role of Jalukaavcharanain Mukh Dushika(Acne Vulgaris)

More than 90% of the world's population has experienced acne at some point in their lives, making it a fairly prevalent medical disease. Acne vulgaris is the most prevalent type of acne, accounting for 99 percent of all instances. Mukhdushika, which is produced by vitiated Kapha, Vata, and Rakta,is described in Ayurvedic scriptures in a way that is similar to acne vulgaris in modern medicine. Ayurvedic texts mention raktmokshana(bloodletting) as the primary method of treatment for raktajaand dermatological conditions. Jalaukawacharanais the preferred method of bloodletting in Sukumara,according to Acharya Susruta (tender nature person). As a bio-purifying technique, jalaukawacharanaeliminates deeply ingrained pollutants by releasing blood, removing Srotasa,and calming vitiated Doha. Jalaukawacharana is highly effective in terms of its purifying and therapeutic effects. Important components of leech secretions include Destabilase, Bdellin, Histamine, Hyaluronidase, Fibrinases, and Collagenase, which have been shown to normalize and improve capillary as well as collateral blood circulation, express an anti-inflammatory effect, produce analgesia and anesthesia through saliva, and have an immunostimulant and immuno-modulating effect. An effort has been undertaken in this review to examine the potentials of leech therapy in treating Mukhdushikaw.s.r to acne vulgaris.

Adult female acne: Clinical and therapeutic particularities (Review).

Acne is a chronic inflammatory condition affecting the pilosebaceous unit that was traditionally viewed as a disease of the adolescence. However, over the past several years, an increasing number of adult women have been reported to suffer from this condition. The prevalence of adult female acne ranges between 12 and 54%. Two clinical types can be distinguished in this population, a ‘retentional’ and an ‘inflammatory’ type, which usually tend to overlap. In terms of evolution, three main subtypes can be identified: Persistent acne, which is the most frequent subtype, late-onset acne and recurrent acne. This type of acne is mainly mild-to-moderate in severity and may be refractory to conventional treatment. The etiopathogenesis is complex and has yet to be fully elucidated. It appears to involve an interaction among genetic predisposition, hormonal factors, and chronic activation of the innate immune system overlapping with external factors, such as daily stress, Western-type diet, use of tobacco and cosmetics. The treatment may be challenging and a holistic approach is required, with special attention to the individual needs and particularities of adult women. Both topical and systemic treatments are available, with hormonal therapies being of special value in this population. The aim of the present article was to provide up-to-date, evidence-based information on the clinical presentation, etiopathogenesis and treatment of adult female acne.

PATCHES FOR ACNE TREATMENT: AN UPDATE ON THE FORMULATION AND STABILITY TEST

The purpose of this article review was to find out more about acne patch formulations and test stability. The method used is searching data from various articles based on Google Scholar, Elsevier, and Molecules with the keywords "Acne vulgaris, acne treatment, acne patches, and types of acne patches” and with a range of years between 2011 and 2021. Based on the type of acne, acne patches are divided into several types, namely microneedle patches, acne medicine patches, and hydrocolloid patches. The results obtained in this review show that the most commonly used acne patch is the medicated acne patch (hydrogel patches), because of its waterproof property to protect acne from secondary infection, it can absorb liquid inside and flatten acne and is cheaper compared to microneedles. The hydrogel patch is also stable at a temperature of 40±2 °C and a relative humidity (RH) of 75±5% for 6 mo of storage.

Acne prevalence and characterization in adolescents.

Background. Acne vulgaris is a very common chronic disease that affects mainly adolescents and has a negative effect on their quality of life. Objective and methods. The aim of this study was to determine the prevalence of acne in adolescents, to characterize this condition and estimate its impact on adolescents’ quality of life. For this purpose, a questionnaire was distributed in 4 schools to teenagers aged 14 to 17 years in 2021. Results. A sample of 237 adolescents was analyzed. The overall prevalence of acne was 71.3%. The median age was 16 years, acne evolution was favorable in 53.3% of cases, 44.4% had permanent lesions and 75.7% experienced flare ups. Comedonal acne lesions were reported by 74.0% of adolescents and inflammatory acne was reported by 69.2%. As for severity, 27.8% had mild lesions and 12.4% had moderate lesions. We found that female gender, topical and systemic treatment, and acne duration had a statistically significant association with acne severity. There was also an association between female gender, relapses, and acne severity in the last 12 months and worse quality of life scores. Discussion. In our study, the prevalence of acne was high, comedonal and inflammatory lesions were the more frequent type of acne, and severe forms were not frequent. Several adolescents reported relapses and the quality of life was undoubtedly affected. These findings were in accordance with recent literature and strengthen the available data. The extensive characterization of this population along with the risk factors that we found to be associated with acne severity, should be taken into account when treating these adolescents.

P29 A case of paediatric ocular Behcet’s

Abstract Case report - Introduction Bechet’s is a rare chronic inflammatory multisystem disease of unknown cause. It is characterised by recurrent oral ulcerations, genital ulcerations, ocular inflammation and skin involvement. Bechet’s disease is rarely observed during childhood and the clinical picture can be incomplete, thus making the diagnosis challenging. Ocular involvement represents 10—20% of the initial presenting feature. Ocular involvement typically involves anterior and/or posterior uveitis and retinal vasculitis. Severe vision loss can be seen in patients. Prognosis is improving due to enhanced therapeutic options. The use of biologics, particularly anti-TNF drugs, are a positive advance, though more evidence in paediatrics is required. Case report - Case description This young man presented in 2014 at 12 years old to paediatric ophthalmology with a right panuveitis. He was treated with a weaning dose of oral steroids. His right eye became quiet. He reported some oral ulceration, not recurrent, and no genital ulcers. He did not fulfil Bechet’s criteria. Pathergy test and HLA B51 were negative. In 2017 he presented with right macular retinal infiltrate. Vision was reduced to counting fingers. Mycophenolate mofetil (MMF) was started with weaning prednisolone. Despite this, activity was ongoing with inflammation in the anterior chamber and vitreous. Humira was started in August 2017. There was resolution of the inflammation in the right eye but central vision remained poor due to irreversible macular damage. Left eye was normal. Oral steroids were weaned. In 2018, he developed acne and folliculitis type lesions. He reported sore joints and fatigue. He was felt to have probable Behcet’s. Quaternary review by the Bechet’s centre, Liverpool, agreed. A switch from MMF to azathoprine (AZA) was advised. Interferon alpha would have been suitable, but was no longer available. Skin lesions returned when switched to AZA; patient requested switch back to MMF. Over the next 2 years steroids were weaned. MMF and 2-weekly Humira continued. In November 2020 he presented with peripheral retinitis in his left, better-seeing eye, haemorrhaging, with patchy vision. MMF was increased and oral steroids recommenced. In December 2020 visual acuity was hand movements in his right eye and 6/7.5 in his left eye with ongoing inflammation. Adalimumab was increased to weekly. In January 21 there were 3 + of cells in his anterior chamber, extensive haemorrhages and retinal infiltrates in keeping with Behcet’s. He was admitted for pulsed IV methylprednisolone and switched from Humira to infliximab. Eyes are currently quiescent and prednisolone is weaning. Case report - Discussion Bechet’s disease is a multiorgan disease typified by an immune-mediated occlusive vasculitis. The aetiology of Bechet’s remains unclear. HLA-B51 is a major predisposing genetic factor. There is involvement of the innate immune system, propagated by the adaptive immune system. Ophthalmic involvement can be the presenting feature of Bechet’s. Eye disease in Bechet’s is most commonly a non-granulomatous uveitis with necrotising obliterative retinal vasculitis. This can be found in either the anterior or posterior segment or both. Recurrent inflammation in the posterior segment can lead to severe sight loss. Young males typically have the worst ocular prognosis. The treatment of ocular Bechet’s can be challenging as our case emphasises. Treatment follows a step-wise approach. Therapy consists of topical steroid, followed by intravenous or oral steroid. Maintenance therapy of either AZA 2mg/kg/day, MMF (max3 g daily) or ciclosporin max 5mg/kg/day should be commenced. The next step will typically be a TNF inhibitor; in our patient we used adalimumab initially. Infliximab is becoming a popular first choice anti-TNF. Certainly since January 2021 our patient’s eyes have remained quiescent on Infliximab. The alternative to infliximab is interferon alpha but unfortunately this is no longer commercially available. A further treatment that could be offered is rituximab – initially to be given as a one-off cycle. Optimum treatment of ocular Bechet’s involves good multidisciplinary team working between ophthalmology and rheumatology. By early initiation of systemic treatment and regular reviews secondary complications may be avoided/lessened. Case report - Key learning points

Guidance for the pharmacological management of acne vulgaris

ABSTRACT Introduction Many international guidelines and expert consensuses are available to help the clinician diagnose and treat acne vulgaris; however, a simplified practical guidance that integrates current existing published recommendations is still lacking. This article aims to give practical and simplified insight into the treatment of acne. Areas covered Herein, the author discusses the treatment of comedonal, papulopustular, and nodular/cystic/conglobate acne. The author also proposes a simplified treatment escalation strategy that is based on disease severity and extension, starting with topical treatments for mild cases and progressing over to systemic therapies in more severe cases. Expert opinion The ideal acne treatment would simultaneously and safely target all the pathogenic factors implicated in the appearance of acne lesions with minimal side effects. Since no such treatment currently exists, combination therapies are usually recommended for most types of acne. A major limitation in choosing an appropriate treatment plan is the discrepant use of classification systems across the published literature making it difficult to draw clear and succinct conclusions about the recommendations given. Acne is not a traditional infectious disease and so while antibiotics may improve symptoms, they do not reliably resolve the condition. Thus, there is currently a tendency to opt for antibiotic-sparing treatment strategies whenever possible.

In Vitro Assessment of Herbal Topical Ethosomal Gel Formulation for the Treatment of Acne vulgaris

Anti-acne herbal formulations are utilized for the treatment of acne vulgaris with the additional benefit of not creating adverse effects, unlike synthetic drugs. Phytoconstituents present in methanolic extracts of Glycyrrhiza glabra have antibacterial and antioxidant properties. An approved UV spectrophotometer confirmed the presence of glycyrrhizin in these extracts. Extracts loaded with Carbopol 940 were utilized for the preparation of herbal drug-loaded ethosomal gel formulations (EF1, EF2, and EF3) at various times and followed the assessment of ethosomal gel formulation. The evaluation of ethosomal gel formulation done by pH, viscosity, spreadability, texture analysis, differential scanning calorimetry, FT-IR spectral analysis, in vitro drug release study, and antioxidant activity against Propionibacterium acnes. Herbal ethosomal gel formulation demonstrated antibacterial potential and was additionally assessed for skin permeation by gamma scintigraphy utilizing hydrophilic radiotracer 99mTc-DTPA and lipophilic radiotracer 99mTc-MIBI. Significant permeation (1.3 μg/mg) was seen with a hydrophilic radiotracer named 99mTc-DTPA-PHF and this proposed that the formulation was equipped with sustained drug delivery for the treatment of moderate to an extreme type of acne.

Assessment of Calprotectin in blood and tissue of Acne Vulgaris patients of different clinical severities

Abstract Background Acne vulgaris is a multifactorial inflammatory skin disease of the pilosebaceous unit with complex pathogenesis. Calprotectin is a heterodimer of two calcium-binding proteins S100A8 and S100A9, which are members of the S100 protein family, and which play a role in various inflammatory processes, it is mainly present in the cytoplasm of neutrophils and expressed on the membrane of monocytes. Objective to assess the level of Calprotectin in blood and in tissue of AV patients and compare it with healthy controls. Beside correlate it with the degrees of severity of acne in order to further understand the role of Calprotectin in the pathogenesis of AV. Subjects and Methods This case-control study included 28 subjects who have AV, divided into four groups according to Global Acne Grading System: the first group included 7 patients with mild acne, the second group included 7 patients with moderate acne, the third group included 7 patients with severe acne, and the fourth group included 7 patients with very severe AV. In addition to a control group which included 28 apparently healthy individuals of matched age, sex and with no previous history of acne or active acne. All the patients were recruited from the outpatient clinic of Al Haud Al Marsoud hospital from September 2019 till January 2020. After taking the approval of research ethics committee (FMASU M S 22/2019) all subjects gave an informed consent to participate in this work. Results Our study showed that the increase in AV severity was not affected by the difference in gender, type of acne, nor disease duration. However, there was a significant correlation between plasma calprotectin level and AV severity. In addition to, There was a significant statistical correlation between the increase in the age of patients and the decrease in the severity of acne, which indicates that AV is more severe in younger patients than older ones. The correlation between the Plasma Calprotectin level in patients group and Tissue Calprotectin level in inflammatory lesions (papules) was non-significant. However, the correlation between the Plasma Calprotectin level in patients’ group and Tissue Calprotectin level in non-inflammatory lesions (comedones) was highly significant. Conclusion Plasma Calprotectin level showed significant relation with AV severity and presence of scar. The correlation between plasma Calprotectin level and tissue Calprotectin level in noninflammatory lesions (comedones) was highly significant.

Association of Acne with Face Mask in Healthcare Workers Amidst the COVID-19 Outbreak in Karachi, Pakistan.

BackgroundIn the wake of coronavirus (COVID-19) global alert, people have begun to practice safety measures in order to reduce the exposure to life-threatening disease. The largest at risk population is undoubtedly the frontline healthcare workers (HCWs) who are using personal protective equipment (PPE), essentially face masks, to battle against this deadly virus. This study was conducted with the prime intention to reveal an association between face mask and acne and measure the prevalence of acne amongst HCWs amidst COVID-19 outbreak in Karachi. Furthermore, this study aimed to identify the type of mask generating acne, locate the common sites, assess the severity and establish an association of mask use with the skin type.MethodsThis cross-sectional study was carried out at Medicare Cardiac and General Hospital, Jinnah Medical College Hospital, Jinnah Postgraduate Medical Centre and Jamal Noor Hospital located in Karachi, Pakistan. A total of 348 HCWs were interviewed, of which only 193 met the inclusion criteria. All information was recorded on a predesigned proforma and analyzed using SPSS 25.0.ResultsAmong 193 participants, acne was prevalent in 103 (53.4%) participants with maximum cases reported in female HCWs, and in doctors (p<0.05). Out of 73 HCWs using N-95 masks, 46 (44.7%) developed acne, with a p-value of 0.036. Skin type and past history of acne also yielded statistically significant results. Among all the skin types, HCWs with oily skin (64, 62.1%) were prone to face resurgence of acne or new-onset acne. The most common sites of eruption of acne were along the cheeks (45.1%) followed by the nose (40.9%). Majority of the population suffered from mild acne. Moderate and severe acne eruption was particularly observed in those wearing N-95 and surgical masks.ConclusionThe use of face masks is associated with high rates of acne eruption. Disseminating the guidelines and indications of World Health Organization (WHO) regarding proper use of mask, encouraging awareness among HCWs and following proper doffing and donning protocol as endorsed by Centers for Disease Control and Prevention (CDC) will possibly minimize the adverse reactions.

Evaluation of facemask associated acne/ “Maskne” among health care workers and non-health care workers of India during COVID-19 pandemic-A cross-sectional study

“MASK-NE”-Mask associated Acne, is a common form of acne during COVID-19 pandemic. It is type of acne mechanica seen when external factor occludes the skin, leads to irritation, inflammation and starts/aggravates all grades of acne.We conducted a cross-sectional study among 773 participants, using a Self-administered, aim oriented, questionnaire which includes demographic data, acne related history, type and duration of wearing mask &amp; other mask related skin problems in COVID-19 pandemic during 15 October to 15December,2020.: Among 773 participants, age ranged 18-45 years with mean 30.69 (SD: 61.30) and M:F was 1:1.78. After starting of Pandemic, occurrence of new development of mask associated Acne/ Maskne was higher among Health Care Workers (HCW) (34.98%) as compared to non- Health Care Workers (non-HCWs) (17.36%). Moreover, more number of HCWs had aggravation of their pre-existing acne and/or development of new of acne during pandemic (81.2%) than non-HCWs (61%). Wearing N95 type of mask showed the highest aggravation (82%) of Maskne as compare to wearing Surgical mask (75.5%) and wearing cloth (cotton) mask (65.6%).Wearing a face mask for 4 to 8 hours/day and &amp;#62;8 hours/day showed increase in the aggravation of Maskne as compared to wearing a facemask &amp;#60;4 hrs/day.Though wearing face masks can be the best strategy against COVID-19 infection, HAZARD OF THIS SAFETY is not negligible especially in front-line workers-doctors, nurses, pharmacist, policemen, hospital staff who are at higher risk due to several factors including type of mask use, duration of mask use etc.

An Investigation of Makeup Ingredients and their Effects on Acne Cosmetica with Dermatologic Practice Recommendations

Acne cosmetica, a type of acne linked to cosmetic usage, is characterized by persistent mild breakouts and occurs due to the interplay between sebum and trapped comedogenic products in makeup products. Regular cosmetic usage may cause acne since it has been determined that a reduction in makeup application can help reduce its severity. There is a pressing need for dermatologists and patients to select appropriate, well-tolerated, and non-comedogenic makeup products containing active ingredients that help to eradicate acne. This literature review will thus examine common ingredients found in makeup products that act as comedogenic irritants, acnefriendly ingredients, and explore dermatologic recommendations to address beauty product use in acne-prone patients. Both PubMed and Google Scholar were searched using keywords skincare and makeup ingredients combined with acne cosmetica in adolescents and dermatology. This literature review has indicated that patients suffering from acne should be recommended to avoid using comedogenic products and switch to acne-friendly ingredients that are safe for skin. Dermatologists should recommend the use of prescription topical medications containing ingredients such as retinol and salicylic acid to yield visible and noticeable results. These findings help to strengthen the dermatologists' understanding of common active ingredients found in beauty products and helps guide recommendations for patients suffering from acne

EFFECTIVENESS OF APPLICATION OF BINAHONG LEAF (ANREDERA CORDIFOLIA) BOILED WATER AS A THERAPY FOR ACNE VULGARIS

Traditional medicine has been used by various aspects of society from the upper to lower economic levels, one of the medicinal plants that is widely known by the Indonesian people but has prospects as a source of medicinal ingredients is binahong with the scientific name Anredera cordifolia. The binahong leaves are boiled and then applied to respondents who have moderate acne, aged 17-24 years. The purpose of this study was to determine the effect of the application of boiled water from the leaves of binahong (Anredera cordifolia) as a treatment for acne vulgaris. This research method is experimental. How to collect data with questionnaires, documentation and observation. Data analysis using T-test. The sample in this study were students of the Faculty of Health Sciences, University of Ibrahimy, aged 17-24 years who had moderate acne types, with a total of 30 respondents. The variable in this study was the boiled water of binahong leaves packaged in a spray bottle. The average value before treatment is while the value after being given treatment. Based on research that boiled water from binahong leaves has a significant effect on respondents to reduce the number of acne lesions. Based on the hypothesis test, it is known that the correlation coefficient value is 0.796 with p value (sig) 0.000 &lt;0.05, then H0 is rejected and Ha is accepted.