Introduction: The ulcer gastroduodenal (UGD) is a frequent affection. There are several types of ulcers, one of most common is the one that affects the gastro-intestinal system which can be gastric, duodenal or both at the same time. In the majority of the cases, the bacterium Helicobacter pylori contributes to the genesis of this disease. The UGD averagely affects 50% of the world population, both in France and in Madagascar, one respectively note 0,2% and 82% of the cases per annum. In Madagascar, the use of the plants is very current in traditional medicine because those are less expensive than the pharmaceutical drugs. In this context, decoction of the sheets of Borreria verticillata (Rubiacea plant family) is used by the population of the Antsinanana (Eastern) area of the large island to treat the gastric ulcer by relieving the epigastric burn and stopping the bloody vomiting. Methods: Taking these facts into account, pharmacological studies were undertaken in order to evaluate the anti-ulcer activity of this plant. For this fact, tests in vivo on Rats Wistar old males and females from 12 to 14 weeks were carried out while using them like dopes reference, the cimetidine (100 mg/kg). Results: The results obtained show that the cimetidine decreases the acidity of the rough gastric juice to a value of pH= 6,12 vs pH= 1,5 with distilled water. The administration of the hydro-alcoholic extract of Borreria verticillata to amounts of 100, 200 and 400 mg/kg gives values, respectively, of pH = 1,70; 1,82 and 2,18 indicating as well as the studied plant does not have the capacity to inhibit the secretion of acid caused by the binding of pylor. In parallel, the cimetidine decreases by 81,20 ± 1,65% the lesions caused by the ulcer of constraint whereas, the extract of the plant causes reductions of about 89,84 ± 1,65%, 79,51 ± 1,65% and 81,67 ± 1,65%, respectively, indicating thus that Borreria verticillata protects the mucous membrane from the stomach. Conclusion: These results show meets that the extract of the sheets of Borreria verticillata has a gastric mucoprotector effect. However, several pharmacological tests are still necessary to confirm this anti-ulcer activity.