Abstract
Medicinal plants used in folk medicine contain a wide range of substances that can prevent and treat many diseases. The Antiulcer Activities effects of myrrh or Commiphora molmol extract (CME) were assessed in rats. In this experiment, thirty rats were divided into 6 groups as follows: G1) normal control (vehicle); G2) received aspirin without any treatment; G3) pretreated with Omeprazole (antiulcer drug) and groups (4), (5) and (6) were pretreated with CME at 125, 250 and 500 mg/kg b.wt, respective-ly for 2 weeks. At the end of experiment the volume, pH and total acidity of gastric juices; mucus content and ulcer lengths were measured and protection percentages were calculated. Gross and histopathological examinations of stomachs were also performed. CME induced an antiulcer effect manifested by decreased volume and total acidity of gastric juice and increased mucus content and percentages of protec-tion from ulcer as well as partial amelioration of gross and histopathological lesions seen in stomach of ulcerated rats. In conclusion, the results denote that Commiphora molmol extract possess antiulcer effects in rats. These results affirm the traditional use of Myrrh extract for the treatment of gastric ulcer.
Highlights
Peptic ulcer is the most common gastrointestinal disorder in clinical practice and it arises due to imbalance between aggressive and protective factors in the stomach
Commiphora molmol extract (CME) induced an antiulcer effect manifested by decreased volume and total acidity of gastric juice and increased mucus content and percentages of protection from ulcer as well as partial amelioration of gross and histopathological lesions seen in stomach of ulcerated rats
The results denote that Commiphora molmol extract possess antiulcer effects in rats
Summary
Peptic (gastric) ulcer is the most common gastrointestinal disorder in clinical practice and it arises due to imbalance between aggressive and protective factors in the stomach. Several factors are involved in the etiology of gastric ulcers such as imbalance between. There is an urgent need to identify more effective and safe antiulcer agents from medicinal plants [3]. Previous studies showed that Commiphora species produced anti-inflammatory [12]; analgesic [12] [13]; antiulcer [6] [14] [15]; antioxidant [16] and hypolipidemic [17] [18] effects. The present study was designed to investigate (CME) extract on healing of peptic ulcer in rats inflicted with aspirin-induced gastric ulcer
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