Agriculture in India is facing several challenges which together are manifested into the sustainability issues. The broad contours of the agricultural production system in the country have been defined by the need to achieve food security which calls for close attention to rice–wheat (Triticum aestivum L.) cropping system of the Indo Gangetic Plains (IGP) whose sustainability is under threat. Degradation of natural resources, severe biotic and abi otic stresses specially drought, floods, pest infestations with accompanying impacts on biodiversity and agricultural productivity are the major constraints to agricultural development. Further, climate change has gained significant global attention over the past decade due to concerns of deleterious long-term impacts on agriculture, water sup ply, human welfare, regional and political stability. All the related issues need to be addressed on priority, with par ticular emphasis on soil-carbon through a holistic approach. As the strategy brings focus on income of farmers, the agricultural technology needs to move from “Production oriented-Green Revolution” to “Farmer’s Income oriented Revolution” and environmentally sustainable farming. Therefore, for long-term sustainability in agriculture, 4 pil lars/ components (good agricultural practices, climate-change mitigation and adaptation, diversification of high value crops and biodiversity management) needs to be addressed properly, more importantly good agricultural practices (GAP). The GAPs are based on the principles of risk prevention, risk analysis, sustainable agriculture, and integrated crop management (ICM), which are of utmost importance in present time. The GAPs for agricultural sustainability are reduced tillage, conservation agriculture, resource-conservation technologies (RCTs), erosion control measures, diversified cropping system, micro-irrigation, balanced fertilization, manuring, watershed man agement, organic farming, and integrated farming systems etc. Now that the vision is to impart income security to the farmers of the country, diversification of the system across all the sub-sectors of agriculture assumes impor tance which is, indeed a de-risking mechanism capable of negotiating both endogenous and exogenous risks as sociated with the system. The effective and efficient management of agro-biodiversity is also essential through management of genebanks, science-led innovations; livelihood, food and nutrition security though crop diversifica tion, use of lesser-known crops and wild relatives in crop improvement; dealing appropriately with quarantine, bio safety and bio-security.