Academy Of Sciences Research Articles

Imaging characteristics and diagnosis of primary middle mediastinal tumors

Objectives: To investigate the proportion of different histological types and CT enhanced imaging features of primary middle mediastinal lesions in order to improve the understanding of these tumors and the accuracy of preoperative diagnosis. Methods: Retrospective analysis was conducted on 84 patients with primary middle mediastinal lesions and clear histological classifications diagnosed and treated at the Cancer Hospital, Chinese Academy of Medical Sciences from January 2012 to December 2022. Clinical, imaging, and pathological data were collected and classified according to tumor histological classifications. CT imaging manifestations such as tumor location, size, morphology, edge, boundary, internal components, enhancement characteristics, and surrounding tissue invasion were evaluated and recorded. Results: The histological types of the primary middle mediastinal lesions from the 84 patients included mesenchymal tumors, anterior intestinal cysts, giant lymph node hyperplasia, substernal goiter, neuroendocrine carcinoma, lymphohematopoietic system tumors, and mesothelioma, accounting for 28.6%, 27.4%, 14.3%, 3.6%, 11.9%, 9.5%, and 4.8%, respectively. Mesenchymal tumors included peripheral nerve sheath tumors, vascular tumors, adipogenic tumors, solitary fibrous tumors, and synovial sarcoma, accounting for 54.2%, 20.8%, 12.5%, 8.3%, and 4.2%, respectively. The above tumors had diverse imaging manifestations and specific imaging features. Mature fat were found in 3 cases of liposarcoma; Calcification was observed in 2 cases of thyroid nodules and 7 cases of giant lymph node hyperplasia; Enhanced scanning showed significant enhancement in 2 cases of solitary fibrous tumors, 3 cases of thyroid nodules, and 11 cases of giant lymph node hyperplasia; Mediastinal large lymph nodes was observed in 6 cases of lymphoma and 3 cases of mesothelioma; High invasiveness was observed in 4 cases of mesothelioma and 9 cases of neuroendocrine carcinoma. Conclusion: Mediastinal tumors have low incidence rate and rich histological types, and their imaging manifestations are diverse. Preoperative differential diagnosis can be made according to their specific imaging characteristics.

Correction coil and magnet feeder lessons learned

China has contributed to the manufacturing of the Error Field Correction Coils (CC) and the Magnet Feeders for ITER (International Thermonuclear Experimental Reactor). The manufacturing projects have been carried by ASIPP (Institute of Plasma Physics Chinese Academy of Sciences). In this paper, the lessons learned from these two manufacturing projects will be described with special focus on some key manufacturing processes. These experiences gained from the work carried so far in CC and magnet feeder manufacturing and testing are very valuable not only for the remaining manufacturing tasks of these two projects, but also for similar systems of other Tokamak fusion device.

Assessing the Evidence Base for School-Based Promotion and Prevention Interventions: Introduction to the Series.

Schools are an important component in the mental health system of care for youths. Teachers and other school staff have unique opportunities to promote emotional wellness and prevent mental health conditions. Although numerous programs are available, identifying evidence-based and effective options is a significant challenge. This introduction lays out the rationale and methodology of the Assessing the Evidence Base (AEB) Series, a collection of systematic reviews of school-based mental health promotion and prevention approaches recommended by the National Academies of Sciences, Engineering, and Medicine for students in kindergarten through grade 12. Authors of the current AEB Series used the rating criteria derived from the 2014 AEB Series, which provided systematic reviews of a wide spectrum of interventions for mental and substance use disorders. Like its predecessor, the current series upholds a high standard of scientific rigor while ensuring that the information is easily accessible to various stakeholders in education, behavioral health, and communities. It describes the universal features included in each systematic review, such as a rating of the level of evidence for interventions, intervention program components, identification of interventions that have yielded positive outcomes for students from underserved populations, and a review of cost data. The AEB systematic reviews will serve as an important tool for decision makers involved in managing limited resources for various programs in school-based mental health services by synthesizing large bodies of research for use by leaders in education and behavioral health.

A Bibliometric Analysis of the Outdoor Thermal Environment Based on CiteSpace

The outdoor thermal environment (OTE) is closely related to sustainable urban development and human living, and related research has attracted widespread attention. The research hotspots and research frontiers were obtained using CiteSpace to analyze 4473 relevant studies published in English from the Web of Science (WOS) core database from 1998 to 2023. The results show that (1) Hong Kong Polytechnic University, National University of Singapore, Chinese Academy of Sciences, Tsinghua University, and Harbin Institute of Technology are important in OTE research. China has the largest number of publications in the field of OTE, but the United States has the greatest centrality and significant influence. (2) The focus of OTE keyword clustering research is divided into four main categories: thermal environment perception, the thermal environment index, thermal environment quality, and thermal environment optimization. (3) The frontiers of OTE research have changed from focusing on environmental quality, thermal perception, numerical simulation, urban space, and thermal adaptation to thermal mitigation, energy conservation, energy consumption, and optimization strategies. Visualization research in the field of OTE helps to provide references for the direction of future research on improving climate change, human thermal comfort, urban planning, and pre-planning.

METHODOLOGICAL CHALLENGES OF RESEARCH ON PROBLEMS OF SOCIALIZATION OF PERSONALITY IN THE CONTEXT OF THE RUSSIAN-UKRAINIAN WAR

Relevance. Despite being traditional and important for psychological and sociological sciences, the problem of socialization remains vulnerable to criticism due to the apologetic nature of its theoretical and methodological foundations. Within the limits of traditional approaches, the success or failure of the process and results of socialization are considered, in fact, in the interests of the officially recognized state ideology with a corresponding set of ideals and values. This may be acceptable for countries with established democratic regimes, but it generates many insidious questions in the conditions of confrontation between societies with different civilizational reference points. This is the situation we have today in the context of the russian-Ukrainian war. Methodology is based on the discursive approach, which does not deprive the researcher of the right to evaluate socialization from his or her ideological position, but excludes the extrapolation of these evaluations to the psychological (procedural) content of socialization. According to this approach, the discourses in which socialization takes place, rather than its psychological content itself, can be evaluated from a moral or ideological perspective. This allows for a more realistic evaluation of the socialization experience of different societies, different countries and peoples, for comparison, etc. People’s participation in the reproduction and development of discourse can be traced by the results of monitoring all-Ukrainian representative surveys conducted by the Institute of Social and Political Psychology of the National Academy of Sciences of Ukraine since the early 1990s. Results. During this time, the territorial-state discourse has gradually formed as a leading one in Ukrainian society. Its value imperative is the attitude of state independence. About 80% of citizens believe that although there are many obstacles in the way of our statehood, Ukraine should still be independent.

“Everyone Can Master the Correct Use of Mathematical Methods”: The Relevance of L.D. Kudryavtsev’s Ideas for Modern Mathematics Education

The article discusses the ideas, devoted to mathematics education, of Lev D. Kudryavtsev, corresponding member of the USSR Academy of Sciences, professor-mathematician. These ideas are based on more than half a century of practical experience of L. D. Kudryavtsev at the Moscow Institute of Physics and Technology – he presented his vision of the problems of educating students, the unity of mathematics, as well as methods of teaching it in the collection of articles. The thoughts and ideas of L. D. Kudryavtsev are still relevant today, in the age of digital transformation of the education system and of the entire life of society.

High performance of an innovative cable-in-conduit conductor with CWS cable pattern

Abstract Cable-in-conduit conductors, known as CICCs, were developed for constructing superconducting coils in tokamak fusion reactors. To achieve large currents in high magnetic field, CICCs were utilized with a short-twist-pitch (STP) cable pattern to prevent irreversible performance degradation, but also inducing higher AC losses. Institute Of Plasma Physics Chinese Academy Of Sciences (ASIPP) designed and manufactured three innovative CICCs, all featuring CWS (copper wire with a short-twist-pitch wound around superconducting strands with a long-twist-pitch) structure to increase both the current density and structure stiffness of CICC cable. These CICCs had the same new CWS cable pattern but the Nb3Sn superconducting strands were from different suppliers. All samples were subsequently tested under electromagnetic cycling tests in SULTAN. For similar electromagnetic performance degradation, the Lorentz load threshold of the CWS cable pattern exhibited to be higher than that of STP cable pattern. Moreover, the AC losses of CWS were 15% lower than that of STP cable pattern for low frequencies of the applied alternating magnetic field. Both results indicated that the CWS cable pattern has a higher margin of engineering safety and lower AC losses than STP cable pattern under the target operating conditions. This provides new insights in finding solutions for optimizing the CICCs’ cable pattern and preventing its electromagnetic performance degradation.

„The Black Box" by George Stocking

Three years before his death on July 13, 2013, George William Stocking, widely regarded as the discipline's "greatest historian of anthropology," wrote an autobiography and memoir entitled Glimpses into My Own Black Box: An Exercise in Self-Deconstruction(2010). The book was published as part of the famous History of Anthropology (HOA) edition, which Stocking started at The University of Wisconsin Press (1983) and edited for two decades. This paper is based on the understanding of the American theoretician of autobiography, William Howarth, who posited that autobiography in literary (and scientific) writing is akin to what self-portrait is in painting. In the introductory chapter of the work, biographical data are presented that bring the character and work of George William Stocking closer to the domestic, Serbian readership (his second marriage to the sociologist Carol Bowman; their stays in Yugoslavia). This is followed by a description of the two main phases in Stocking's life and work: the formative period in his intellectual development and the mature age, known as the "Chicago years", spent in the Departments of History and Anthropology. Bearing in mind the main elements of the autobiographical strategy – character/self-portrait, technique (rhetoric and writing style), and the theme presented by the author's work-text – Stocking's book thematizes the life story, professional and scientific history (history of anthropology) from the position of both a witness and the one of the creators of written histories of the discipline and biographies of its practitioners and theorists. His writing technique is characterized by self-reflection and scientifically argued discussions on anthropological, historical and political topics and problems. Despite the significant influence his writing and edition of the HOA has had in anthropology, social sciences and humanities, the autobiographer problematizes his relationship to the two disciplines that shaped him as a scientist, highlighting his ambivalent position within them. In spite of the objective indicators of professional success, such as prestigious recognitions, awards, a secure position at the University and the Academy of Arts and Sciences, and a comfortable civic life filled with trips, conferences and guest appearances at important American and British scientific research institutions, the subjective experience of "double non-belonging" or rather, liminality, is the leitmotif that colors his self-portrait and the meaning of the text as a whole. The main features of the work, such as its discursive style of narration and description, striving for objectivity and honesty (self-disclosure and „self-deconstruction“), anxiety regarding one's own place, role and importance in science, as well as, at times, a resigned or elegiac tone, especially at the end of the book, i.e. towards the end of his life, provide the basis to include Stocking's strategy in a hybrid type with elements of those two categories that Howarth calls "rhetorical" and "poetic" confession.

One Hundred and Thirty-Five Years of Ornithology in Bulgaria: The Role of the National Museum of Natural History at the Bulgarian Academy of Sciences in the Development of Ornithology in Bulgaria—Representatives, Collections and Achievements

For the first time, an attempt has been made to present, chronologically and in a systematized form, the development of ornithological studies at the National Museum of Natural History in Sofia (Bulgaria) from its foundation in the last decades of the 19th century to the present day. This 135-year period (1889–2024) includes the work of 12 curators of the ornithological collections. Their major contributions and most-significant ornithological publications are also presented.

Study on Ecological Water Demand Pressure of Forest and Grass Vegetation Construction in Northwest Loess Plateau Based on Fitting Verification

In this paper, the minimum ecological water requirement of forest and grass vegetation in different types and regions and small basins in Pingliang City was analyzed and evaluated by using the quota of water consumption for ecological construction. The actual evapotranspiration water consumption of different types of vegetation was used as the quota to calculate the appropriate ecological water demand of vegetation, and the actual evapotranspiration water consumption of vegetation was used as the quota to calculate the appropriate ecological water consumption of vegetation in this region. At the same time, in order to make the calculation result more accurate, the water consumption per unit area after the actual evapotranspiration of different regions and different types of vegetation is used as the calculation quota. In addition, according to the principles of similar vegetation types, similar site conditions and similar climate environment, the research results of He Wentao et al., Institute of Geographical Sciences and Natural Resources Research, Chinese Academy of Sciences, on the ecological water requirement of forest in the whole Jinghe River basin (He Wentao et al. Determination and calculation of ecological water requirement of forest vegetation, Journal of Soil and Water Conservation, 2004, 18(6)) were selected and compared with this study. This study verifies the reliability of the calculation results of evapotranspiration water consumption of vegetation in this area. It should be noted that He Wentao et al. also evaluated the ecological water requirement of vegetation in the whole Jinghe River basin by calculating the evapotranspiration water consumption of vegetation, and analyzed the vegetation ecological water requirement deficit in 2020 by comparing the calculated minimum ecological water requirement of vegetation in the region, so as to reflect the ecological water demand pressure faced by vegetation construction in the region. It provides a basic basis for coordinating the relationship between vegetation construction and water resources in this region.

Spatio-Temporal Changes of Arable Land and Their Impacts on Grain Output in the Yangtze River Economic Belt from 1980 to 2020

The “Yangtze River Economic Belt Development Strategy” is one of China’s three major national development strategies. Enhancing the protection and quality of arable land in the Yangtze River Economic Belt (YEB) is pivotal for fostering regional growth. In this study, land use data spanning the years 1980 to 2020 in the YEB were extracted from the national land use database maintained by the Resource and Environment Data Center of the Chinese Academy of Sciences. Employing Geographic Information System (GIS) spatial analysis techniques and arable land change metrics, the study delineated the spatiotemporal characteristics of arable land alterations across the YEB for the period. Additionally, using grain output data at the prefecture level from 2011 to 2020, the paper calculated provincial grain output to analyze the impact of arable land changes over the last four decades on grain output. The findings revealed that: (1) From 1980 to 2020, the total arable land area in the YEB decreased by approximately 41,775 square kilometers, with the most significant decrease occurring in the downstream region. (2) From 1980 to 1990, the primary factor contributing to the decrease in arable land area was the expansion of water bodies, while from 1990 to 2020, the principal reason for the reduction in arable land area was the expansion of construction land. (3) From 1980 to 2020, the decrease in arable land area resulted in a net reduction of approximately 25.12 million tons in total grain output, with the largest decline observed in the downstream regions and the smallest decline in the upstream regions. (4) Consistent with the trends in arable land area reduction, the main reason for the decline in grain output from 1980 to 1990 was the expansion of water bodies encroaching upon arable land, whereas from 2000 to 2010, the primary cause of arable land reduction was the expansion of construction land areas. In conclusion, the research suggested that over the past four decades, the primary driver behind the reduction in arable land within the YEB has been the expansion of construction land areas. Particularly noteworthy was the period from 2000 to 2010, during which the impact of arable land reduction on grain output was most pronounced. This period coincided with the rapid economic development and accelerated urbanization process within the YEB.

New productive pear variety Favoritka

The results of the selection and variety study of pears in the conditions of the Southern Urals are considered. At the South Ural Research Institute of Horticulture and Potato Growing, a branch of the Federal State Budgetary Institution Urfanits Ural Branch of the Russian Academy of Sciences, breeding work was carried out to improve the assortment of pears for the Ural region. As a result of many years of breeding work, the range of fruit and berry plants was replenished with a new pear variety, Favoritka, which in 2022 was included in the State Register of Breeding Achievements approved for use. In the process of breeding work, the winter hardiness of pear varieties in the harsh climatic conditions of the Chelyabinsk region was studied, as a result it was noted that infield conditions when the temperature dropped to -40 ° C, freezing of trees of local varieties did not exceed 1 point. An assessment was made of the yield of local varieties, among which the following varieties stand out: Vekovaya, Myth, Favoritka, and Zolotoy Shar, with an average yield of 24 - 28 kg per tree. The economic indicators of the Favoritka pear variety (profitability level of 253.5%) indicate its suitability for cultivation in both industrial and amateur gardening in the Ural region. A pomological description and assessment of the economic usefulness of the new Favoritka pear variety are presented, which combines large fruit (fruit weight can reach 340 g), high winter hardiness, productivity, resistance to abiotic and biotic stressors (not affected by scab, resistant to pear gall mite), has fruits of excellent taste, suitable for fresh consumption, as well as for processing (preparing jams, preserves, compotes, etc.). The variety is in demand among the population and is of interest as a source of giant fruit in further breeding work.

ARTURO ISSEL (1842–1922): THE MAN FROM GENOA BEHIND THE TYRRHENIAN STAGE OF THE PLEISTOCENE

ABSTRACT Arturo Issel (1842–1922) introduced the regional Tyrrhenian stage of the late Pleistocene in 1914. This still stands within modern stratigraphic classification as an Italian Marine Stage for the Mediterranean Sea marking the base of the Late Pleistocene underlining the scientific importance of Issel's research within the geological sciences. This paper provides a short overview of the career and the wide-ranging interests of this Italian geologist and naturalistic traveller in order to provide a context to the knowledge and research experience behind his stratigraphic work. As university professor in Genovese society during the late nineteenth and early twentieth centuries, he played an important role in scientific instruction, exploration and research contributing to the popularization of science through museum collections and publications and in the application of such knowledge within public office both in Liguria and within Italy. He formed part of the Italian delegation at International Geological Congresses and held membership of the most outstanding geological societies and scientific academies of the time.

Study on the inhibitory and pro-apoptotic effects of different concentrations of total tanshinone alone and in combination with tyrosine kinase inhibitors on human myeloid leukemia cell lines

Objective: To explore the effect and investigate the molecular mechanism of different concentrations of total tanshinones alone and in combination with tyrosine kinase inhibitors (TKIs) on the proliferation inhibition and apoptosis of human myeloid leukemia cell lines. Methods: K562 and Kasumi-1 cell lines were purchased from the Shanghai Cell Bank of the Chinese Academy of Sciences, and the TKIs-resistant strain K562/T315I cell line was constructed in Molecular Medicine Research Center, Beijing Lu Daopei Institute of Hematology. Logarithmic growth phase cells were taken and divided into intervention groups with total tanshinone of 0, 2.19, 4.38, 8.75, 17.50 and 35.00 μg/ml intervention groups, which were inoculated in 96-well plates at a density of 1×104 cells/well and exposed to the drug for 24 h, and a control group treated with dimethyl sulfoxide was also set up simultaneously. All experiments were repeated independently 3-5 times. The proliferative activity of the cells was assessed using the CCK-8 assay, the apoptotic rates were measured by flow cytometry, and the expression levels of apoptosis-regulating proteins Bcl-2 and Bax were analyzed by Western blotting. The cell lines treated and untreated with total tanshinone were subjected to transcriptome sequencing and gene set enrichment analysis to identify differentially expressed genes. Results: The half-inhibitory concentration (IC50) values of 8.75 μg/ml total tanshinone at 24 h for K562, K562/T315I and Kasumi-1 cells were (4.11±0.02), (4.95±0.04) and (3.98±0.01) μg/ml, respectively. When combined with 0.25 μmol/L imatinib, 8.75 μg/ml total tanshinone could enhance the induction of apoptosis effects on K562 and K562/T315I cell lines. After being treated with 4.38, 8.75, and 17.50 μg/ml of total tanshinone for 24 h, compared with the control group, total tanshinone upregulated the expression level of Bax protein, downregulated the expression level of Bcl-2 protein, and decreased the Bcl-2/Bax ratio (all P<0.05). Total tanshinone inhibited the proliferation-related signaling pathway and DNA damage repair pathway of myeloid leukemia cell lines, and activated the signaling pathway that induces apoptosis in leukemia cells. Conclusion: Different concentrations of total tanshinoneinhibites proliferation and promote apoptosis in K562, Kasumi-1 and TKIs-resistant K562/T315I cell lines, and further enhance the anti-leukemic effect when combined with TKIs.

Optical-spectroscopic and isotope-geochemical characteristics of zircons from diamond-bearing placers in Yakutia as indicators of diamond ore bodies

Research subject. Zircon grains from diamond placers of the Molodo and Ebelyakh rivers of the Yakut Arctic. Aim. To study the indicator characteristics of zircon to determine sources of diamonds and ways of their transfer to placers; to analyze optical-spectroscopic and isotope-geochemical parameters of zircon grains, their microelemental, U-Pb, and Lu-Hf isotope composition. Materials and methods. A LA-ICP-MS analysis of the U-Pb isotopic and trace element composition of zircon was carried out using a NexION 300S mass spectrometer with an NWR 213 attachment. An analysis of the Lu-Hf isotope system was carried out using a Neptune Plus mass spectrometer with an NWR 213 attachment, located in a room of cleanliness class 7 ISO at the Geoanalitik Center for Collective Use (IGG Ural Branch of the Russian Academy of Sciences, Ekaterinburg). Raman spectra were obtained using a LabRAM HR800 Evolution confocal spectrometer. CL spectra were obtained using a Jeol JSM6390LV scanning electron microscope equipped with a Horiba H-CLUE iHR500 attachment. Results. The local optical spectroscopic characteristics (Raman spectra and catholuminescence) of zircon grains were established, which made it possible to substantiate the conclusion about their high crystallinity and homogeneity (monochrony), as well as to select international zircon standards with similar characteristics for use in LA-ICP-MS analysis to ensure similar conditions for evaporation of the substance and fractionation parameters of the U and Pb elements. LA-ICPMS data on the microimpurity, U-Pb and Lu-Hf isotopic composition of zircon grains from diamond placers, as well as the dose values of their self-irradiation, are presented. Conclusions. The obtained U-Pb dating contributes to reconstructing a more precise history, character, and sequence of manifestation of kimberlite magmatism, tectonic processes, and migration routes of kimberlite material and diamonds across the Siberian craton, within the Yakut kimberlite province.

LAJOS FEKETE, HUNGARIAN ROYAL MINISTER COUNCELLAR, DIRECTOR OF THE HUNGARIAN ROYAL ACADEMY OF MINING AND FORESTRY

Lajos Fekete, Hungarian Royal Minister Counsellor, Forestry Academy professor is a leading figure in higher forestry education, who achieved indefeasible results in creating Hungarian language education and the Hungarian forestry language. Between 1872 and 1891, he headed the Department of Phytology and Silviculture at the Royal Hungarian Academy of Mining and Forestry in Selmecbánya, and from 1891 until his retirement he headed the Department of Forest Management. He played an important role in the organisation of the Academy campus, the construction of new educational buildings and the development and furnishing of the botanical gardens, as well as in the compilation and development of collections related to the subjects he taught (zoology, entomology, botany, climatology and soil science). Hungarian experiments in forestry began to take institutional form in 1897/98, and Lajos Fekete was responsible for this, as well as for the idea of establishing forestry education on a secondary level. Although he had already exceeded the possible age of retirement in 1894, his tireless work ethic kept him in the Academy. He enjoyed the confidence of the Academy's teaching staff and served as vice-principal in the academic year 1892/93, then as director in the academic years 1897/98, 1898/1899 and 1899/1900, and was also head of the forestry department. At the age of 69, on 1 October 1906, he was retired at his own request, because of his failing eyesight towards the end of his life. Thus, the last serving teacher of the first faculty of the Forestry Academy left the academy chair. On this occasion, he was awarded the title of Minister Counsellor in recognition of his services. In 1910, six years before his death, he received the highest recognition for his work, being accepted as a corresponding member of the Hungarian Academy of Sciences. There is no branch of forestry science in which his work has not left a lasting mark. Despite this extremely productive and diversified career, which produced outstanding achievements in all fields, posterity has treated and still treats Lajos Fekete, whose work and human behaviour can stand as an example to us all, rather cruel.

François Gros, Permanent Secretary of the French Academy of Sciences

François Gros, Permanent Secretary of the French Academy of Sciences

The Influence of the Teacher’s Psycho-Physiological States on the Development of Professional Competencies in the Course of the Military Aggression

The aim of the article is to determine the specifics of the impact of the correctional programme of psycho-physiological conditions on the development of the professional competence of general secondary school teachers. The Diagnostics of Mental States of the National Academy of Sciences and the Impact of Event Scale - Revised (IES-R) were used to obtain reliable data on the psycho-physiological state of the individual. A specialized online test for teachers was used to obtain data on the teachers’ competence aimed at determining informational competence, testing to determine the teacher’s subject methodical competence, observation of communicative competence. A formative experiment was planned and conducted. It was established that average indicators of psycho-physiological state prevail among teachers. The positive impact of the developed corrective programme on the teachers’ activity and mood was proved. It was concluded that the change in the psycho-physiological states of “invasion” and “avoidance” significantly depends on current social conditions, in particular, on the stability of the safety component. It was found that the correctional programme levelled the connections between the teachers’ subject methodical competence and the current psycho-physiological state. It was established that the teachers’ communicative competence continues to correlate after the completion of the programme with psycho-physiological comfort and general emotional background. In general, we can talk about the relative effectiveness of the developed corrective programme. The obtained results can be used to optimize programmes of continuous postgraduate education in the context of the development of resistance to the stresses of wartime. The prospects for further research are expanding the arsenal of methods for studying the teachers’ psycho-physiological state and clarifying gender differences in the teachers’ experience of stress. Received: 2 February 2024 / Accepted: 25 April 2024 / Published: 5 May 2024

224 Influence of gender on animal science research funding from the National Institute of Food and Agriculture

Abstract According to the National Academies of Sciences, Engineering, and Medicine, females and males in science disciplines obtain bachelor of science degrees at or near parity, yet females are not equally represented in academic faculty positions. This is true for agricultural field including the animal sciences. The National Institute of Food and Agriculture (NIFA) administers the Agriculture and Food Research Initiative (AFRI) at USDA, a flagship competitive grants program that fund research, education, and extension efforts with a total appropriation of $455 million in 2023. Our objective was to determine the difference between genders for submission rates (i.e., number of standard and seed grant applications submitted), success rates (i.e., number of grant award/number of applications submitted), and peer reviewers of grant applications in the main animal related AFRI program area priorities. All applications submitted to AFRI programs in animal genomics, reproduction, health, nutrition and growth, and welfare during 2013 to 2022 were evaluated. Gender was assigned to Project Directors (PD) and peer reviewers using first names as input into Gender API software (Gender-API.com; Passau, Germany) with ≥ 95% accuracy and ≥ 20 database occurrences used as quality filters and binary outcomes only (i.e., male or female). Effect of gender on submission rates, success rates, and peer review panel compositions were then analyzed using Pearson’s Chi-squared tests with P ≤ 0.05 considered significant. A total of 3,392 applications were submitted, of which 2,579 (76%) PD genders were assigned and analyzed further. Overall, the proportional submission rate for females was 28% and for males was 72%. Submission rates for females increased (P = 0.0497) over time ranging from 22% in 2013 to 33% in 2021. Submission rates differed by gender across programs (P &amp;lt; 0.0001) and ranged from 22% female in animal reproduction to 48% female in animal welfare. Overall, the funding success rate was 22% and did not differ between genders (P = 0.9826). Success rates did not differ between genders over time (P = 0.4691), but differences among programs approached significance (P = 0.0670). Across 53 panels, 42% of panelists were female; no differences were identified for the proportion of female panelists over time (P = 0.9762) or by program (P = 0.7028). Females submitted less than one-half as many applications as males, but the proportion of submissions by females increased over time. This trend remained consistent despite challenges of relocation of NIFA and COVID-19 during this time. Funding success rates did not differ by gender, but some variation was observed across programs. Overall, the proportion of NIFA panelists who were female exceeded the proportion of applications submitted by females. These results indicate that although differences in gender existed for application submission rate and panel composition, these differences did not impact funding success rate of applications in animal science programs at NIFA, which did not differ between genders.

Electrocardiographic abnormalities in patients with microtia

The main objective of this study was to investigate the incidence and characteristics of electrocardiographic abnormalities in patients with microtia, and to explore cardiac maldevelopment associated with microtia. This retrospective study analyzed a large cohort of microtia patients admitted to Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, from September 2017 to August 2022. The routine electrocardiographic reports of these patients were reviewed to assess the incidence and characteristics of abnormalities. The study included a total of 10,151 patients (5598 in the microtia group and 4553 in the control group) who were admitted to the Plastic Surgery Hospital of Peking Union Medical College. The microtia group had a significantly higher incidence of abnormal electrocardiographies compared to the control group (18.3% vs. 13.6%, P < 0.01), even when excluding sinus irregularity (6.1% vs. 4.4%, P < 0.01). Among the 1025 cases of abnormal electrocardiographies in the microtia group, 686 cases were reported with simple sinus irregularity. After excluding sinus irregularity as abnormal, the most prevalent abnormalities was right bundle branch block (37.5%), followed by sinus bradycardia (17.4%), ST-T wave abnormalities (13.3%), atrial rhythm (9.1%), sinus tachycardia (8.3%), and ventricular high voltage (4.7%). Less common ECG abnormalities included atrial tachycardia (2.1%), ventricular premature contraction (2.4%), and ectopic atrial rhythm (1.8%). atrioventricular block and junctional rhythm were present in 1.2% and 0.9% of the cases, respectively. Wolff Parkinson White syndrome and dextrocardia had a lower prevalence, at 0.6% and 0.9%, respectively. The occurrence of electrocardiographic abnormalities in microtia patients was found to be higher compared to the control group. These findings highlight the potential congenital defect in cardiac electrophysiology beyond the presence of congenital heart defect that coincide with microtia.