Ratio 2D Research Articles

High digit ratio (2D:4D) is associated with attack frequency and severity in hereditary angioedema patients

BackgroundHereditary angioedema (HAE) caused by a deficiency or dysfunction of the plasma protease C1-inhibitor is a rare autosomal-dominant disorder. We explored a possible correlation between the ratio of the second and fourth finger lengths (2D:4D) and the frequency of HEA attacks, and whether the ratio might predict laryngeal attack. MethodWe evaluated 35 HEA patients aged 19 to 66 years; 3 were subsequently excluded. The 2D:4D ratio was calculated by dividing the length of the second finger by that of the fourth finger of both hands. A structured clinical questionnaire exploring HAE course and treatment over the prior year was administered. ResultsOf the 32 participants, 56.25 % (n = 18) were female. Of them, those with high 2D:4D ratios suffered significantly more laryngeal attacks than others; 93.3% of patients with high 2D:4D ratios experienced ≥5 attacks annually, significantly more than those with low ratios. Among type 2 HEA patients, 75 % of those experiencing ≥5 attacks annually had high 2D:4D ratios; all patients with low 2D:4D ratios reported <5 attacks annually. These significant effects were found for right-hand 2D:4D ratios and not left-hand 2D:4D ratios. ConclusionThe data suggest that intrauterine sex hormone exposure, which affects the 2D:4D ratio, is significantly associated with HEA attack frequency and severity, and laryngeal edema.

Relationship between 2d:4d ratio, handgrip strength, and hamstring muscle length in different sports: a study of volleyball, football and basketball branches

Background and Study Aim. The relationship between the 2nd digit (2D) and the 4th digit (4D) provides much preliminary information about the physiological, psychological, and psychomotor characteristics of individuals. Although there are many studies on the 2D:4D ratio, the number of studies investigating the ratio in different sports is limited. Therefore, the purpose of this study is to determine the relationship between the 2D:4D ratio, posterior thigh muscle length, and handgrip strength in different sports.&#x0D; Material and Methods. 63 athletes aged 18-29 years from football, volleyball and basketball participated in this study (nFutbol=20, nVoleybol=21, nBasketbol=22). Right and left hand width and length, 2D, 4D, 2D:4D ratio, grip strength, and hamstring muscle length of the participants were determined. When examining the relationship between the parameters, hand grip strength and hamstring muscle length, Pearson correlation analysis was performed.&#x0D; Results. In the study, there was a high correlation between right and left hand width, length, 2D, and 4D measurements and handgrip strength of volleyball and basketball players (p&lt;.05). There was also a high correlation between left 2D:4D ratio in basketball players and handgrip strength (p&lt;.05). There was a moderate correlation between football players’ 2D length of the football players and the length of the hamstring muscle (p&lt;.05). In volleyball and basketball branches, no parameter was associated with hamstring muscle length in volleyball and basketball players. Sport age and right hand 2D:4D ratio were associated in football (p&lt;.05). For volleyball, athletic age was associated with left hand width and length and 2D and 4D measures (p&lt;.05). In basketball, athletic age was associated with left hand width and length.&#x0D; Conclusions. The results of the study suggest that some of the right and left hand measurements can be used to predict performance indicators such as hand grip and hamstring muscle length in the sports of football, volleyball, and basketball.

An Exploratory Analysis on the 2D:4D Digit Ratio and Its Relationship with Social Responsiveness in Adults with Prader-Willi Syndrome.

Prader-Willi syndrome (PWS) is a genetic disorder produced by a lack of expression of paternally derived genes in the 15q11-13 region. Research has generally focused on its genetic and behavioral expression, but only a few studies have examined epigenetic influences. Prenatal testosterone or the maternal testosterone-to-estradiol ratio (MaTtEr) has been suggested to play an important role in the development of the 'social brain' during pregnancy. Some studies propose the 2D:4D digit ratio of the hand as an indirect MaTtEr measure. The relationship between social performance and MaTtEr has been studied in other neurodevelopmental conditions such as Autism Spectrum Disorder (ASD), but to our best knowledge, it has never been studied in PWS. Therefore, our study aims to clarify the possible existence of a relationship between social performance-as measured using the Social Responsiveness Scale (SRS)-and MaTtEr levels using the 2D:4D ratio. We found that, as a group, PWS individuals have shorter index and ring fingers than the control group, but no significant difference in the 2D:4D ratios. The 2D:4D ratio showed a correlation only with Restricted Interests and Repetitive Behavior Subscale, where a positive correlation only for male individuals with PWS was found. Considering only PWS with previous GH treatment during childhood/adolescence (PWS-GH), index and ring fingers did not show differences in length with the control group, but the 2D:4D ratio was significantly higher in the right or dominant hand compared to controls.

No association between developmental instability as a general measure of stress and 2D:4D digit ratios in a non-western sample.

Random deviation from perfect symmetry of organisms is defined as fluctuating asymmetry. Fluctuating asymmetry is widely considered to be a marker of developmental instability, developmental noise and phenotypic quality at the population level. In this study, we investigated hypothesized relationship between 2D:4D digit ratios as a proxy measure of prenatal sex hormones and developmental instability levels in young adult humans. In the study, seven bilateral traits were measured for fluctuating asymmetry, as well as second and fourth digit lengths on both hands of 185 individuals, 87 men (mean age: 22.42 ± 3.37) and 97 women (mean age: 22.88 ± 3.87). The second digit length was divided by the fourth digit length and the resulting value was used as the digit ratio (2D:4D). Composite fluctuating asymmetry was calculated using five bilateral traits displaying fluctuating asymmetry. Only the right hand 2D:4D ratio is lower in men than in women. However, this difference disappears when the effect of digit lengths is controlled. Composite fluctuating asymmetry results reveal that men are more asymmetrical than women. There was no significant relationship between digit ratios and composite fluctuating asymmetry. In this study, the 2D:4D digit ratios appear to be influenced (at least in humans) by different digit lengths. This study also confirms previous studies that digit ratios as a proxy measure of exposure to either high testosterone or estrogen levels during early development does not appear to affect levels of developmental instability.

The ratio of 2nd to 4th digit length and reproductive function of infertile male patients.

To investigate the relationship between the ratio of index to ring finger lengths (2D:4D ratio), reflecting androgen exposure in utero, and reproductive function among men. Male patients (N=180) who consulted for fertility issues participated in the study. The palms of both hands were scanned, and the 2D:4D ratio was calculated. Data on semen volume, sperm concentration and total motility, total and motile sperm counts, and serum hormone concentrations were obtained. Spearman correlation coefficients between the 2D:4D ratio and hormone and semen quality parameters were calculated. The total sperm count was significantly negatively correlated with the 2D:4D ratio of the left hand (r=-0.154, p =0.039) but not with that of the right hand (r=-0.045, p =0.548). Testosterone showed weak negative correlations with the 2D:4D ratio in the left (r=-0.142, p =0.058) and right (r=- 0.149, p =0.046) hands. Follicle-stimulating hormone levels were negatively correlated with the 2D:4D ratios of the left (r=-0.173, p =0.020) and right (r=-0.164, p =0.027) hands. Other semen quality parameters or luteinizing hormone levels showed no significant correlation with the 2D:4D ratios. No clear associations were observed between the 2D:4D ratios and reproductive function.

Digit ratio (2D:4D) and performance in non-elite male badminton players

Background: The second to fourth digit ratio (2D:4D ratio) is derived by dividing the length of the index finger (2D) by the length of the ring finger (4D). It has been considered as an index of how much the fetus is exposed to testosterone in utero. Research has suggested that high levels of testosterone are associated with low 2D:4D ratio. The relationship between 2D:4D ratio and physical performance is still an unexplored field in badminton players. Aims and Objectives: This study intends to assess the digit ratio 2D:4D in non-elite male badminton players in comparison to their sedentary controls. Materials and Methods: The study included 30 male badminton players in the age group of 19–23 years who were practicing badminton for more than 3 years and 30 age, body mass index-matched sedentary controls. The second and fourth finger measurements were taken from scanned printouts using Vernier calipers. Results: The 2D:4D ratio was significantly lower in the left hand of badminton players when compared to their controls (P = 0.0001). There was no significant difference in 2D:4D ratios of the right hand and 2D:4D (Δ r–l) between badminton players and controls. Conclusion: The findings in our study partly support the concept that 2D:4D ratio in an important parameter in selection of athletes. The reason for no difference in 2D:4D ratio and controls in the right hand could be due to the fact that badminton is a moderate intensity sport, and also, the study participants were non-elite players.

Sex-moderated relationship between the 2D:4D ratio and circulating hormones in an adult Ghanaian population.

The second-to-fourth digit ratio (2D:4D) is the putative marker of prenatal hormone exposure. The 2D:4D ratio or the right-left difference (Dr-l) are said to be negative and positive correlates, respectively, of circulating testosterone and estrogen in both adult males and females. However, previous studies on the subject have reported mixed results. This study aimed to determine the sex-moderated relationship between the 2D:4D ratio and adult circulating testosterone, estradiol, testosterone-to-estradiol ratio and the free androgen index. This was a cross-sectional study from January to June 2021 at the University for Development Studies, Ghana. The study involved 62 participants (Female=28; Male=34), aged between 20 and 26 years. The right (2D:4DR), the left (2D:4DL), and their difference (Dr-l) were measured by computer-assisted analysis. Fasting venous samples were assayed for total testosterone (T), estradiol (E2 ), and sex hormone-binding globulin (SHBG) using ELISA. The free androgen index (FAI) was then calculated (T/SHBG) and the data were analyzed using moderated and/or weighted regression. Males had significantly higher T and FAI than females while females had significantly higher E2 than males, which were independent of age and body mass index (p < 0.001). There was a significant SEX*Dr-l interaction on FAI (p=0.007). The Dr-l correlated negatively with FAI in males but positively in females and accounted for about 94.0% of the variability of FAI in males (adjR2 =0.940) and only 0.2% in females (adjR2 =0.002). The 2D:4D ratio, a putative marker of prenatal hormone exposure, may have an impact on sex differences in adult free androgen index.

Investigation of the relationship between 2D:4D finger ratios and internet and smartphone addiction in middle school children

In humans, prenatal testosterone exposure affects a sexually dimorphic feature called the second-to-fourth digit ratio (2D:4D). Our research sought to better understand the connections among 2D:4D, Internet addiction (IA), and smartphone addiction (SPA) among middle school students. The study included 104 students aged between 10 and 14 years (mean age for girls: 11.3, the mean age for boys: 11.6), with 48 male and 56 female participants. Measurements of 2D:4D, hand length, and hand width were taken from the participants' hands. IA was assessed using the Young Internet Addiction Scale (YIAS), and SPA was assessed using the Smartphone Addiction Scale-Short Form (SAS-SF). In male participants, a negative correlation was found between the 2D:4D ratio and IA, while no correlation was observed in female participants. Both male and female participants showed a high correlation between IA and SPA. The study concludes that 2D:4D is an easily measurable and reliable marker for gender differentiation. It was found that male participants had higher levels of IA compared to female participants and that IA and SPA are strongly correlated in both genders.

Second-to-fourth digit ratio and age predicting the severity of androgenetic alopecia: a cross-sectional study

Purpose: Androgenetic alopecia (AGA) is a common type of hair loss. Previous studies indicated that the relative length of the index and ring finger (2D:4D ratio) of AGA patients was lower than control. However, the correlation between 2D:4D ratio and disease severity is unclear. In this study, we sought to evaluate the relationship between digit ratio of the right hand and AGA severity in male patients. Materials and methods: The cross-sectional study was performed. Hamilton–Norwood scale was used to assess severity. The finger lengths of the right hand were measured using a digital caliper. Results: Our study found that the lower the right-handed 2D:4D ratio, the greater the risk of developing AGA and that the severity of AGA increases with age. Patients with moderate and severe AGA (grade 3 and above) had lower 2D:4D ratios and higher average age compared with patients with mild AGA (Norwood grade 2). Patients aged ≥37.5 with a 2D:4D ratio <0.947 were six times more likely to have moderate-to-severe androgenetic alopecia compared with the reference group (OR: 6.11; 95% CI: 1.96–19.04). Conclusions: Combining 2D:4D ratio and older age may help predict the severity risk of AGA, and offer a clinically accessible, non-invasive approach for patients to easily predict their future severity.

Effects of caste, birth season, and family income on digit ratios.

The contributions of latitude and ethnicity in the determination of cross-society differences in digit ratios are unclear. In India, different castes (endogamous groups) have been living in the same areas (villages or towns) for the last 1500 years and, therefore, these groups may have different gene pools without a latitude-related difference component. Thus, in the present study, we studied the effect of caste on digit ratios. We also studied the effects of sex, birth season, and family income on digit ratios. We selected a sample of 301 college students (age: M=19.9 years, SD=2.63) in Muzaffarnagar city of western Uttar Pradesh, India, and asked participants for information regarding their birth month, religion, caste, and monthly family income. We measured participants' dorsal and palmar digit lengths (of all fingers, except the thumb, in both hands) using vernier calipers of 0.01 mm accuracy. Other backward castes (intermediate castes) had longer digit lengths than general castes (upper castes), scheduled castes (lower castes), and Muslims. However, there was no difference in digit ratios of caste groups (scheduled castes vs. other backward castes vs. general castes vs. Muslims) or specific castes (Chamar-Jatav vs. Jat vs. Pandit-Tyagi). Winter-born women had lower left dorsal 2D:4D and 3D:4D ratios than summer-born women. Family income was related to higher dorsal 2D:4D and 3D:4D ratios among women. Moreover, in dorsal digit ratios, sex difference (men < women) occurred in digit ratios constituting digit 5, whereas, in palmar digit ratios, sex difference occurred in digit ratios constituting digit 2. The present study suggests that endogamy-led genetic difference in ethnic/caste groups is not a determinant, whereas birth season (i.e., the exposure to sunlight) and family income might be determinants of digit ratios. In addition, compared to palmar digit ratios, dorsal digit ratios are better markers of sexual dimorphism.

The association between the 2D:4D ratio and psychopathic characteristics

Prior research has identified relations between prenatal testosterone exposure and various antisocial and criminal behaviors. However, less is known about the association between prenatal testosterone exposure and personality traits, such as psychopathy. This study used self-report and biometric data from a sample of undergraduates (n = 491) at a large southwestern university to examine the association between prenatal testosterone exposure (measured by the 2D:4D ratio) and three dimensions of psychopathy (i.e., callousness, egocentricity, and antisocial behavior). Analyses were stratified by sex to explore sex-specific biological underpinnings of psychopathy in young adulthood. Results showed that males scored significantly higher in psychopathic traits and reported significantly lower 2D:4D ratios, compared to females. Additionally, 2D:4D ratios were negatively associated with egocentricity in males, but not females. These findings contribute to a growing literature on the organizational effects that prenatal testosterone exposure may have on the development of different dimensions of psychopathy.

The Ratio of Second and Fourth Digit Length: A Biomarker for Methamphetamine Dependence?

The ratio of 2nd and 4th digit length (2D:4D) is considered to be a sexually dimorphic trait. Low 2D:4D is implicated in alcohol dependence and heroin dependence and correlated with psychological traits such as aggression, physical aggression, and sensation. The purpose of this study is to compare the 2D:4D between methamphetamine (METH) dependence and controls and the 2D:4D ratio that is a potential biomarker for METH dependence. In this study, 40 patients diagnosed with METH dependence in Eulji University Gangnam Eulji Hospital and 50 healthy volunteers were all employees in the same hospital. Images of participants' hands were created using a scanning device. The images contained both the right and left hands; computer software was used to measure the 2D:4D ratio for both hands. We compared the ratios, analyzed by t test, between the METH dependence group and the control group. The mean 2D:4D values were 0.941 (right hand) and 0.943 (left hand) for the patients with METH dependence; in contrast, they were 0.961 (right hand) and 0.961 (left hand) for the control group. These values were significantly smaller than the control in patients' right hands (p = 0.003) and left hands (p = 0.012). Patients with METH dependence had smaller 2D:4D ratios than those in the control group, which is similar to the results from the previous substance use disorder studies. Thus, elevated prenatal testosterone levels during the gonadal period could be related to future METH problems. Furthermore, the 2D:4D ratio is a potential marker for the prediction of METH dependence.

Does sex interact with the 2D:4D ratio or adult circulating hormones on the estimated glomerular filtration rate? A cross-sectional study in Ghana.

The 2D:4D ratio is the putative marker of prenatal hormone exposure and has been suggested as a correlate of adult circulating testosterone and estrogen. The study aimed to determine whether sexual dimorphism in the estimated glomerular filtration rate (eGFR) can be partly explained by the 2D:4D ratio or adult circulating testosterone or estrogen. The study was cross-sectional from June to December 2021 at the University for Development Studies. The study involved 206 healthy adults (Female=93, Male=113) between 18 and 30 years. The 2D:4D ratio was measured using computer-assisted analysis. Venous blood samples were collected and analyzed for testosterone, estradiol and creatinine using the ELISA technique and routine biochemical analysis. The adjusted eGFR was calculated using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) creatinine equation (2021). The eGFR and the testosterone-to-estradiol ratio (TT:E2 ) were significantly higher in males than in females (p < 0.001). There was a significant interaction between sex and the TT:E2 on the eGFR (p < 0.001). Although the relationship between the eGFR and the TT:E2 was negative in both males and females, a unit change in the TT:E2 had a greater impact on the eGFR in females (B=-1.38) than in males (B=-0.01). Sexual dimorphism in the eGFR is influenced by both testosterone and estradiol. Although the sex difference in the eGFR may be influenced by the TT:E2 , estrogen seems to account for more variability in the eGFR than testosterone.

SUBCAPITAL- CLINICAL CORRELATION OF 2ND (INDEX) TO 4TH (RING) DIGIT RATIO WITH HIGH BLOOD PRESSURE AND ITS IMPLICATION FOR CORONARY HEART DISEASE IN WEST U.P. MALES

BACKGROUND - The aim of our research work was to estimate the association with high blood pressure and the 2D : 4D ratio, and the intimation of this association with the cardiovascular problem in males living in the west of the Uttar Pradesh. As a result of exposure to prenatal sex steroids the ratio of the index nger to the ring nger of the hand is changed. Three METHOD - hundred adult male human subjects from the west up region served as participants in the study. The total number of subjects was divided into two groups: one group consisted of 150 west U.P males with high blood pressure (also known as hypertension), while the other group consisted of 150 west U.P. males with normal blood pressure (also known as normotensive) and served as the control group. The length of the index and ring ngers (2D:4D) was measured, and then we estimated the mean value, the standard deviation, and the p-value. According to the RESULT – measurements that we were taken, the results exhibit that there is a great distinction of of 2D:4D ratio with the control category and the hypertensive category, and the ratio is greater in both hands for the hypertensive group than it is for the control category. In counting to this, the ratio was found to be greater in the left hand of the hypertension group. If the p-value is &lt; 0.05, then there is a statistically distinction positive association. The ndings of the recent work indicate that there is a stat CONCLUSION - istically great direct correlation with 2D:4D ratio and hypertension in adult males. This connection may serve as a predictor for coronary heart disorders that are connected to prenatal sex hormones. Nevertheless, additional research is required to validate these preliminary ndings.

THE RATIO BETWEEN THE LENGTH OF THE SECOND AND FOURTH DIGIT (2D:4D RATIO) AS A BIOMARKER OF OVARIAN RESERVE IN INFERTILE PATIENTS

Ovarian reserve is established during intrauterine life, with a peak at 20 weeks of gestation. The 2D:4D ratio, which is also established during prenatal life, has been proposed as a non-invasive biomarker of the prenatal hormonal environment. It has been suggested that an intrauterine environment rich in androgens induces a development of the 2D:4D ratio < 1 while estrogen exposure during prenatal life leads to a higher 2D:4D ratio. However, whether 2D:4D ratio can be used to could predict ovarian reserve needs further investigation.

Association of 2D:4D Ratio (Hormonal Fingerprints) with Dental Caries and Malocclusion among 18–25-year-old Dental Students

Association of 2D:4D Ratio (Hormonal Fingerprints) with Dental Caries and Malocclusion among 18–25-year-old Dental Students

Use of crowdsourced images for determining 2D:4D and relationship to pro-environmental variables.

The primary purpose of this study was to examine whether 2D:4D ratios (a putative measure of prenatal androgen exposure) could be determined using participant-submitted hand images. The secondary purpose was to examine whether 2D:4D ratio was associated with pro-environmental behaviors, attitudes, and empathy, given the recent literature linking sex to environmental attitudes and actions. Participants (N = 1065) were asked via an online survey to submit a clear photograph of their right hand, palm side up. Participants also completed a questionnaire to assess (a) demographics, (b) dispositional empathy, and (c) environmental attitudes and behavior. A 2D:4D ratio was calculated for each participant, and the quality of each image was classified as poor, moderate, or good. We then examined the reliability of the 2D:4D image measurements, and the relationship between 2D:4D and our environmental measures. 2D:4D ratios fell somewhat outside of previously reported ranges, but the measurements did show acceptable intra-rater consistency. Although we did not find a sex difference in 2D:4D, we did find a sex by ratio interaction for both empathy and the number of pro-environmental behaviors in which individuals had engaged. Specifically, as 2D:4D ratio increased, males reported lower empathy and less engagement in pro-environmental behaviors, whereas females reported more engagement in pro-environmental behaviors (but no differences in empathy). These findings were contrary to expectations, as we anticipated that greater digit ratios (i.e., feminized) would be associated with greater empathy and pro-environmental behaviors. Overall, the findings of this study present a preliminary examination of the utility of measuring digit ratio with online samples. Furthermore, our results provide information regarding the complex relationship between sex and pro-environmental behaviors.Supplementary InformationThe online version contains supplementary material available at 10.1007/s10211-022-00401-5.

2D:4D digit ratio and its relationship to BMI, sporting choices and physiological predispositions among women

The 2D:4D digit ratio has been established as a biomarker of the level of exposure to prenatal sex hormones’ balancebetween prenatal testosterone (PT) and estrogenne levels. Higher 2D:4D indicates lower PT exposure and vice versa. Data suggests that PT exposure is linked to a risk-taking attitude and physical aggressiveness, both of which are requirements in contact sport. A possible correlation between 2D:4D and human body mass index has also been identified. The aim of the study was to examine the relation between 2D:4D ratio and choice of sport. It was assumed that female soccer players who choose a contact sport would have a lower 2D:4D ratio (thus experiencing higher exposure to PT) than female volleyball players (selecting non-contact sport). The analysis was also aimed at identifying whether a correlation between prenatal testosterone level and BMI exists. The participant sample consisted of 103 women – 36 volleyball players, 33 soccer players and a control group (N=34). Measurements were collected in 2019–2020. The results suggest that 2D:4D was significantly different in women practicing various sports (contact and non-contact sports). Women engaged in contact sports had lower 2D:4D than women engaged in non-contact sports, and vice versa (p&lt;0.05). 2D:4D correlated positively with BMI and body weight – the higher the 2D:4D ratio, the higher the BMI and body weight (and vice versa) (p&lt;0.05). Low 2D:4D (high PT exposure) may predict the choice of more risky, aggressive contact sports, and vice versa. High 2D:4D may predict a higher BMI and body weight, and vice versa.

Second to fourth digit ratio (2D:4D), impulsivity and aggression levels in patients with opiate use disorder and alcohol use disorder

ABSTRACT Objective To compare the ratio of the right and left second and fourth digits (2D:4D), aggression, and impulsivity levels in opiate use disorder (OUD), alcohol use disorder (AUD), and healthy controls. Methods Eighty-four patients diagnosed with OUD, 58 patients diagnosed with AUD, and 58 healthy volunteers were included. Participants administered the sociodemographic data form, Barratt Impulsivity Scale (BIS-11), and Buss-Perry Aggression Questionnaire (BPAQ). Results Healthy controls’ right-hand 2D:4D ratio was higher than the OUD and AUD groups (respectively; p < .001, p < .001). The right-hand 2D:4D ratio was similar between OUD and AUD (p = .542). Left-hand 2D:4D ratio of healthy controls was higher than OUD and AUD groups (respectively; p < .001, p < .001). The left-hand 2D:4D ratio was similar between OUD and AUD (p = .429). The BIS-11 scores of the healthy controls were lower than OUD and AUD groups (respectively; p < .001, p < .001). It was found similar in the AUD and OUD groups (p = .264). The BPAQ scores of the healthy controls were lower than the OUD group and the AUD group (respectively; p < .001, p < .001). It was found similar in the AUD and OUD groups (p = .973). Conclusion It was found that the 2D:4D ratio of both hands in OUD and AUD patients is lower than that of healthy volunteers. The 2D:4D ratio can be an indicator of addiction, regardless of the type of substance used.

Early Prediction of Dental Caries using Hormonal Fingerprint in 6-12 Years Old Children: A Cross-sectional Study.

BackgroundThe ratio between second and fourth digit lengths (2D:4D ratio) is termed as hormonal fingerprint. Second and fourth digit lengths ratio is used as a biological marker for predicting and diagnosis of many metabolic disorders mainly coronary heart disease and autism, whereas, in dentistry, this method is still in blooming stage. The aim of the study was to assess the relationship between the new biological marker–hormonal fingerprints in the early detection of caries in children.MethodologyA total of 250 children were randomly selected from both sexes of the age group 6–16 years. Caries assessment was done using standard mouth mirrors and community periodontal index probes. Caries status (deft and DMFT) was recorded and subjects with a total DMFT/deft score of >5 were considered to have a high caries rate. The hormonal fingerprint was made by measuring the length ratio of the index and ring finger with the help of vernier caliper. The entire study population was divided into children with 2D:4D ratio less than 1 and ≥1 based on the calculations of 2D:4D.ResultsThe results showed that 79.67% males and 29.92% females have 2D:4D ratio <1 and 70.07% females and 20.32% males have 2D:4D ≥1. There is negative correlation between caries incidence and 2D:4D ratio. Children with low 2D:4D ratio have high caries index (54.4%) and high 2D:4D ratio have low caries index (45.6%), which is statistically significant.ConclusionThe study confirms a positive correlation between low 2D:4D ratio and high caries, which could be used as an early biological predictor of dental caries.How to cite this articleBeegum F, Khan N, George S, et al. Early Prediction of Dental Caries using Hormonal Fingerprint in 6–12 Years Old Children: A Cross-sectional Study. Int J Clin Pediatr Dent 2022;15(3):247-250.