The ratio of 2nd to 4th digit length and reproductive function of infertile male patients.

Abstract

To investigate the relationship between the ratio of index to ring finger lengths (2D:4D ratio), reflecting androgen exposure in utero, and reproductive function among men. Male patients (N=180) who consulted for fertility issues participated in the study. The palms of both hands were scanned, and the 2D:4D ratio was calculated. Data on semen volume, sperm concentration and total motility, total and motile sperm counts, and serum hormone concentrations were obtained. Spearman correlation coefficients between the 2D:4D ratio and hormone and semen quality parameters were calculated. The total sperm count was significantly negatively correlated with the 2D:4D ratio of the left hand (r=-0.154, p =0.039) but not with that of the right hand (r=-0.045, p =0.548). Testosterone showed weak negative correlations with the 2D:4D ratio in the left (r=-0.142, p =0.058) and right (r=- 0.149, p =0.046) hands. Follicle-stimulating hormone levels were negatively correlated with the 2D:4D ratios of the left (r=-0.173, p =0.020) and right (r=-0.164, p =0.027) hands. Other semen quality parameters or luteinizing hormone levels showed no significant correlation with the 2D:4D ratios. No clear associations were observed between the 2D:4D ratios and reproductive function.