In the rolling process of silicon steel strip of the five-stand UCMW tandem cold rolling line, the quality of finished profile is the result of cooperative control of five stands, the exit profiles of the first four stands jointly decide the exit profile of the fifth stand, so it is necessary to accurately control the strip profile in the rolling process. However, the shapemeter is only typically equipped at the exit of fifth stand, making it impossible to obtain the strip profile of the first four stands. A profile prediction model for the whole tandem cold rolling based on PSO-BP algorithm is established, compared with the finite element method, this model can satisfy the demand for fast prediction of strip profile and quickly analyzing the profile change characteristics for five stands according to the adjustment of profile control parameters in the industrial field. Firstly, a 3D elastic-plastic finite element model of rolls and strip for five stands is built, and a large number of profile calculation data are as the training sample sets to build the PSO-BP model. Through the transfer calculation of strip profile between adjacent stands, the PSO-BP model of five stands is established, and the validity is verified by comparing with the actual measured data. Secondly, to improve the quality of product profile, focusing on the unreasonable setting of production parameters, many improvement schemes of WRB and WRS for five stands are designed, and the PSO-BP model is used to quickly calculate the strip profile, then comparing the result of each scheme, the optimum improvement scheme is selected, which is furtherly carried out rolling experiments in the industrial field, and the quality of strip profile is well improved. At present, the new scheme has been successfully applied to industrial production.