Objective During the 11th national five-year plan period, the information management system for infectious disease surveillance platform was established to provide information support for infectious disease surveillance. However, the system can not meet the new needs of information management after the operation for years, facing a series of challenges, such as the high sensitivity of data collection and complexity of users. Methods This paper expounds the design and implementation of infectious disease syndromes and pathogen surveillance information analysis platform from the aspects of business requirements, structure design, system deployment, etc. and evaluate the application of the platform. Results China CDC has established the cloud platform of infectious disease syndromes and pathogen surveillance information for the integration of existing system, newly established infectious disease syndromes and pathogen surveillance information analysis platform and pathogen genomics information platform to provide visualized statistical analysis results, which can improve the application value of the data. Conclusion The platform can control the access to resources effectively, ensure the authenticity and credibility of user's identity and improve the integration of resources to support scientific decision making.