Under conditions of maximum seasonal and daily activity of blood-sucking diptera insects of the Ararat region of the Republic of Armenia, the repellent effectiveness of Bars® veterinary drugs was studied. The experiments involved 26 clinically healthy dogs aged 1 to 10 years, of both sexes. As a result of clinical studies of the repellent effectiveness of veterinary drugs Bars ® insectoacaricidal spray and Bars ® insecticidal drops applied to dogs individually, once, during the prevention of bites of diptera flying insects, according to the presented doses, rules and application techniques, the drugs showed a high effectiveness of the repellent effect in the conditions of farms of the Ararat marz for 5 days. During the physical examination, no side effects were detected from the use of Bars® insecticide spray and Bars® insecticide drops.

Tests of drugs Florfenicol 40% LLC «AVZ SP » and Florox LLC «NITA PHARM» from the group of fenicols for bacterial respiratory and intestinal infections were carried out on 43 calves 1.5- 3.5 months old in a large dairy complex in the Central District of the Russian Federation.Based on the results of bacteriological studies before the use of antibiotics Florfenicol 40% and Florox, in lavages from the upper respiratory tract and intestines of calves of experimental and control groups, Corynebacterium spp., Staphylococcus spp., Staphylococcus aureus, Streptococcus spp., Enterococcus spp., Micrococcus spp., Moraxella bovis, Pseudomonas spp., Proteus spp., Bordetella bronchiseptica, Neisseria spp., Clostridium spp., Escherichia spp., Enterobacter spp., Citrobacter spp., Serratia spp., Edvardsiella spp., Providencia spp., Salmonella spp., including pathogenic serotypes and bacterial strains.The results of bacteriological studies of isolated cultures from calves of experimental and control groups after specific therapy showed the absence of pathogenic serotypes and strains of Escherichia coli, Staphylococcus aureus, Bordetella bronchiseptica, Pseudomonas spp., Salmonella spp. in swabs from the nasal cavity and rectum, but the presence of non-fermentative forms of Escherichia spp. and other opportunistic bacteria.Based on the results obtained, it was found that the drug Florfenicol 40% in doses of 1 ml per 20 kg of body weight intramuscularly twice with an interval of 48 hours and 2 ml per 20 kg subcutaneously once has a pronounced activity against aerobic and facultative anaerobic bacteria. According to the results of hematological and biochemical studies, the antibiotic Florfenicol 40% does not have a negative effect on homeostasis with a positive effect on metabolic processes and a decrease in the activity of acute and chronic inflammation in tissues and organs

Due to the ability of ixodid ticks to transmit pathogens transovarially and transphasically, natural foci of dangerous diseases are formed, which is important for preventive measures. Of particular danger are foci of diseases that have formed on the territory of settlements. The aim of our study was to determine the therapeutic efficacy of the insectoacaricidal drug for veterinary use "OKVET Tabs Express for dogs". In the period from June 24 to August 27, 2022, the study drug was tested on 28 dogs of both sexes with a confirmed diagnosis of ixodidosis aged from 10 months to 10 years in the farms of the Meghri district of the Syunik region of the Republic of Armenia. The species affiliation of ticks found in the studied dogs was determined jointly with the specialists of the Laboratory of Molecular Parasitology of the Scientific Center of Zoology and Hydroecology of the National Academy of Sciences of the Republic of Armenia using determinants. According to the results of the experiment, it was found that 40% of all ixodid ticks found on dogs were R. turanicus Pomerantsev 1936, and ticks R. sanguineus Latreille, 1806 and H. scupense Schulze, 1919 were found in 30% of cases. After a single oral administration of the drug, we did not observe the presence of ticks in animals during daily examination for 65 days. In animals during the entire experiment, no deviations from physiological norms and anxiety were found, signs of allergic and other visible side effects were not detected

Mosquitoes are one of the most common dipteran insects and are carriers of dangerous vector-borne diseases. An important role of reservoirs of ectoparasites belongs to dogs. The domestic dog is close to the person. The problem of maintaining the health of the dog and reducing the risk of human infection in conditions of high density of blood-sucking insects can be solved by the use of repellent sprays for animals. Recently, synthetic pyrethroids have been used as effective insecticides. We have conducted clinical studies to study the effectiveness of the repellent action of the new veterinary drug "Okvet" insect-acaricidal spray on dogs. The use of the spray was carried out during the period of mosquito activity, depending on the time of day in the Republic of Armenia. The study involved 22 clinically healthy dogs aged 1.5 to 9 years of both sexes. According to the results of clinical studies, it was found that the repellent effect of the veterinary drug "Okvet" applied to dogs individually, once, while preventing bites of dipterous flying insects according to the presented doses, rules and application techniques, the drug "Okvet" showed a high efficiency of the repellent effect in the conditions of farms in Ararat area within 3 days. During the physical examination, no side effects from the use of the drug "Okvet" were revealed.

Relevance. In modern conditions of industrial poultry farming, technological methods in many respects do not correspond to the biological needs of the bird's body. A high concentration of poultry in limited areas, year-round stay in enclosed spaces in cages leads to negative consequences. Under the influence of unfavorable factors, nonspecific resistance and immunobiological reactivity of the organism decrease. Therefore, at present, the issues of implementing the reproductive qualities and productivity of poultry through the directed impact of biologically active substances are of particular relevance.Methods. The methodology of the work was to study the effectiveness of the use of immunostimulating drugs PS-7 and Prevention-N-C for actualization of the productive and reproductive qualities of hens of the parent flock of the Hubbard F-15 cross. The objects of research were hens of the parent flock of broilers of the French cross Hubbard F-15. In the scientific and economic experiment, according to the principle of analogue groups, three groups of birds were formed with 150 heads each: one control and two experimental groups. Chickens of the 1st experimental group at the age of 21–23 weeks were fed with water three times with an interval of 7 days the biopreparation PS-7 at a dose of 0.1 ml/kg of body weight, chickens of the 2nd experimental group — Prevention-N-C at the same dose and timing.Results. It was found that the use of tested preparations based on the polysaccharide complex of Saccharomyces cerevisiae cells and benzimedazole contributed to an earlier peak of egg production (by 2.0 and 3.0 weeks), increased egg yield on the initial laying hen (by 5.1 and 6.6%) and the average laying hen (by 2.8 and 2.0%), gross egg production (by 1,365 and 1,770 eggs) and livability (by 2.0 and 4.0%). The use of the tested preparations contributed to the improvement of the morphological parameters of eggs and, as a result, the withdrawal of chickens by 0.8 and 2.0%.

Relevance. Against the background of stress and high physiological load, cows experience a lack of energy, the need for which increases many times over in comparison with the dry period, in connection with this, their body is forced to use the reserves of adipose tissue. It is important to timely prevent and monitor the status of cows during the transition period.Methods. The methodology of the work was to study the effectiveness of the use of immunostimulating drugs PS-2, Prevention-N-E and PDE + E-selen. For scientific research, 4 groups of down-calving cows of the Holsteinized Black-and-White breed were selected, 10 animals each. Dry cows of the 1st and 2nd experimental groups received PS-2 and Prevention-N-E intramuscularly at a dose of 10.0 ml three times (40, 20 and 10 days before calving), animals of the 3rd experimental group were injected subcutaneously with tissue preparation PDE (denatured emulsified placenta) at a dose of 20.0 ml and intramuscularly — with a complex mineral and vitamin preparation E-selen at a dose of 10.0 ml 20 days before calving. Biological preparations were not used in animals of the control group.Results. An analysis was made of the prevalence of postpartum metabolic disorders: clinically pronounced hypocalcemia was observed in 5.9% of the newly-calved cows, ketosis — in 11.6%, subclinical hypocalcemia — in 17.7%, and a latent form of ketosis — in 22.7%. Biological preparations PS-2 and Prevention-N-E have a corrective effect on the synthesis of aminotransferases, mineral and carbohydrate metabolism, digestibility of macronutrients, against which background the number of newly-calved cows with subclinical forms of ketosis and hypocalcemia is reduced by 2 times.

The purpose of the research is the analysis of the range of antiparasitic drugs for pig breeding as registered in the Russian Federation and included in the State Register of Medicinal Products for Veterinary Use.The control of parasitic diseases is an essential element of veterinary support for animal husbandry, and its constituent part is the use of antiparasitic drugs. The State Register contains more than three hundred drugs to control parasitic infections of animals of various species. Forty-eight drugs are allowed for use in pig breeding. The analysis of drug compositions found that they contained a limited list of compounds as active substances. For example, 17 antiparasitic drugs contained compounds of the avermectin class as active substances (12 of them had ivermectin as the active substance); 8 drugs against endoparasites contained albendazole in their composition. At the same time, the composition of combined drugs lack distinction and is a combination of two or more active substances produced in mono-preparations. To prevent the resistance in parasites, it is advisable to use a minimum required list of drugs which allows the availability of a reserve for drug rotation in the future. Simultaneous or sequential use of different drugs (including insectoacaricides based on neonicotinoids or synthetic pyrethroids to treat premises in the presence of animals) complicates the assessment of the individual drug effect on animal health and can induce immunological stress, which creates favorable conditions for infectious diseases including opportunistic infections.

The paper presents the results of a method based on RIDA®COUNT test systems for evaluating the microbial contamination in animal products. These test systems are used to demonstrate the possibility of evaluating bacterial contamination (total microbial contamination, the presence of fungi and yeast, E. Coli, S. Aureus, Salmonella bacteria) in artificially contaminated meat and fish products. The methods were developed and updated for evaluating microbial contamination and fungi based on the RIDA®COUNT test systems.

In terms of natural and climatic conditions, the Stavropol Territory is favorable for the development of a number of ectoparasites on animals, which cause significant damage to the development of productive animal husbandry. One of the most common diseases in sheep breeding in the south of Russia is wohlfahrtiosis. This disease is caused by parasitizing of the Wohlfahrtia magnifica larvae, which can lay larvae on the scratches and wounds of the animal. In June 2021, a production experiment was conducted in Filimonovskaya stanitsa, Stavropol Territory, to test a drug Delcid® 7.5 for veterinary use during wohlfahrtiosis in sheep. All experimental animals (30 sheep) had skin damage after shearing and were invaded by W. magnifica. Three groups of 10 sheep each were formed. All sheep of the experimental group No. 1 with skin damage had one-time treatment with Delcid® 7.5 by applying it to the skin of the back, from the head to tail base along the spine, at a dose of 10 ml per animal. It was determined that the insecticidal effect occurred after 3 days, and the duration of the protective effect of the drug Delcid® 7.5 (serial number 040421O) against the W. magnifica, in which the COP was higher than 70%, lasted 35 days. The treatment of sheep from experimental group No. 2 was carried out by local application of the drug Delcid® 7.5 to the affected by W. magnifica larvae areas of the animal body with a cotton pad with an application rate of 0.2 ml/cm2. It was determined that the death of W. magnifica larvae occurred 60 minutes after the drug was used. The sheep of the control group No. 3 were infested during the entire experiment – 42 days.

For the first time, based on complex research, a zoo technical justification for the use of PS-2 and PS-4 biostimulators in the technology of calf raising in individual boxes and pavilions is given to activate the body's adaptogenesis to cold and implement the productive qualities of young stock during rearing and fattening in typical premises. Intramuscular injection of PS-2 (polysaccharide complex of yeast cells immobilized in an agar gel by adding a benzimidazole derivative) and PS-4 (similar to PS-2 plus antibiotic of the cephalosporin) to calves in a dose of 3 ml at 2-3 and 7-9 days of life stimulates their growth and development during the raising, rearing, and fattening periods, thereby reducing the incidence of diseases. By the end of the growing, rearing, and fattening periods, the animals of the 1st and 2nd experimental groups outnumbered their control peers by 7.2 and 8.2 kg; 11.4 and 13.6 kg; as well as 13.8 and 16.8 kg, respectively (P<0.05-0.01). A similar pattern occurred in the nature of changes in exterior measurements and growth coefficient of animals of the compared groups. At the same time, in the calves of the 1st and 2nd experimental groups, respiratory and digestive diseases were reduced by 2.0 and 4.0 times, the recovery time was decreased by 3.47 and 5.12 days, and the Mellenberg coefficient was reduced by 3.7 and 12.1 times, compared to the control group (P<0.05). It was found that PS-2 and PS-4 increased the pre-slaughter weight of the young stock by 14.6 and 18.0 kg, the weight of the hot carcass by 12.8 and 15.8 kg, and the slaughter weight by 13.7 and 16.5 kg (P<0.05-0.01). Moreover, the weight of the half-carcasses of the young stock of the experimental groups, compared to the control group, was higher by 6.7 and 8.7 kg, the yield of meat by 5.4 and 6.9 kg, and of bones by 0.6 and 1.0 kg (P<0.05-0.001). With an increase in the weight of half-carcasses of the experimental animals, the specific weight of the meat increased, and the bones, on the contrary, decreased. Furthermore, the yield of meat of the highest and first grades in the animals of the experimental groups increased on the background of intramuscular injection of biostimulators when using PS-2 (by 0.6 and 0.3%; P<0.01) and PS-4 (by 0.9 and 1.1%; P<0.01). However, the second grade decreased by 0.9 and 2.0% (P>0.05), compared to the control group.