What is the definition of long non-coding RNA?
Answer from top 10 papers
Long non-coding RNAs (lncRNAs) are a class of RNA molecules that are more than 200 nucleotides in length and are not translated into proteins (Fang, 2018; Gao et al., 2011; Guo & Luo, 2017; Shi, 2018; Xin et al., 2016; Xu et al., 2014; Y & Dw, 2016; Zhang, 2018; Zheng et al., 2017). These RNAs are involved in a variety of biological processes, including epigenetic regulation, transcriptional regulation, and post-transcriptional regulation (Gao et al., 2011; Guo & Luo, 2017; Shi, 2018; Xu et al., 2014; Y & Dw, 2016; Zhang, 2018). They play significant roles in cellular functions such as proliferation, differentiation, migration, apoptosis, and wound healing (Guo & Luo, 2017), and have been implicated in the pathogenesis of various diseases, including cancer (Fang, 2018; Gao et al., 2011; He et al., 2018; Xin et al., 2016; Xu et al., 2014; Zhang, 2018; Zheng et al., 2017).
Interestingly, while lncRNAs are crucial in gene regulation, their specific functions and mechanisms of action in many physiological and pathological contexts remain to be fully elucidated (Y & Dw, 2016). Moreover, certain lncRNAs have been identified as potential biomarkers for the diagnosis and prognosis of diseases, particularly in cancers, and may serve as targets for therapeutic intervention (Fang, 2018; Gao et al., 2011; He et al., 2018; Xin et al., 2016; Zhang, 2018).
In summary, lncRNAs are non-protein-coding RNA molecules with regulatory functions across various biological processes and disease states. Their potential as biomarkers and therapeutic targets highlights the importance of ongoing research to unravel their complex roles in gene expression and disease pathogenesis.
Source Papers
Jan 8, 2014
Yue Xu + 2
Open Access