Abstract
Long non-coding RNA small nucleolar RNA host gene 20 (SNHG20) has been demonstrated to play crucial regulatory roles in many types of cancer. However, the biological function of long ncRNA (lncRNA) SNHG20 in ovarian cancer is still unclear. In the present study, we found that lncRNA SNHG20 was significantly increased in ovarian cancer. In addition, lncRNA SNHG20 knockdown suppressed the ovarian cancer progression, whereas overexpression of SNHG20 showed the opposite effects. Moreover, our results also revealed that lncRNA SNHG20 knockdown inhibited Wnt/β-catenin signaling activity by suppressing β-catenin expression and reversing the downstream target gene expression. Taken together, lncRNA SNHG20 plays an pivotal role in ovarian cancer progression by regulating Wnt/β-catenin signaling.
Highlights
Ovarian cancer is the sixth most frequently diagnosed cancer amongst women worldwide, the second most common gynecologic malignancy in females, and the most fatal tumor in female reproductive system [1]
The expression of Small nucleolar RNA host gene 20 (SNHG20) was significantly correlated with tumor metastasis (Figure 1B). These results revealed that long ncRNA (lncRNA) SNHG20 might play a vital role in ovarian cancer progression
It has been reported that lncRNA SNHG20 is significantly increased in hepatocellular carcinoma (HCC) and promoted cell invasion by regulating the epithelial-to-mesenchymal transition (EMT) in HCC [13,12]
Summary
Ovarian cancer is the sixth most frequently diagnosed cancer amongst women worldwide, the second most common gynecologic malignancy in females, and the most fatal tumor in female reproductive system [1]. Several lncRNAs have elicited the interest of scientists and clinicians because of their specific roles in ovarian cancer [9,10,11]. They were shown to be associated with various biological activities in ovarian cancer, including cell growth, metastasis, cell senescence, cell apoptosis, and multidrug resistance. All these studies indicate that lncRNAs may play critical roles in the development and progression of ovarian cancer. Its potential prognostic value and biological function in ovarian cancer have not yet been explored
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