Zespół rozsianego wykrzepiania wewnątrznaczyniowego w ostrych białaczkach – patofizjologia, obraz kliniczny, diagnostyka oraz leczenie

Abstract

Disseminated intravascular coagulation syndrome (DIC) is a syndrome characterized by generalized intravascular activation of the coagulation system. This syndrome is not an isolated clinical syndrome, but is always secondary to other diseases. It is particularly often observed in neoplastic diseases, and in particular in haematopoietic malignancies such as acute leukemia. The risk of DIC depends on the type and subtype of acute leukemia. DIC is most often observed in the course of acute myeloid leukaemia with particular emphasis on the subtype M3 and M5 according to FAB. The basic treatment for DIC remains the treatment of the underlying disease and substitution treatment. Depending on the disease underlying the development of DIC, the substitution procedure may differ significantly. Knowledge of the pathomechanism of disorders occurring in DIC is the key to early diagnosis and rapid implementation of treatment.