Abstract
The draft genome sequence of Vibrio cholerae O1 strain I-1263, isolated from a patient in the imported focus in Siberia, was determined. The established structural features of the mobile genetic elements indicate stage-by-stage formation of a highly pathogenic V. cholerae clone and promote understanding of the mechanisms of evolutionary pathogen transformations.
Highlights
Atypical variants of Vibrio cholerae El Tor appeared in the beginning of the 1990s and contained a cholera toxin subunit B gene of the classical type (1) that caused all of the epidemic cholera complications registered during that period in Siberia and the Far East (2)
Analysis of the genetic structure of atypical V. cholerae El Tor variants isolated in Siberia and the Far East in the 1990s demonstrated its differentiation to some genotypes (3)
The V. cholerae El Tor O1 I-1263 strain isolated in the imported focus in Irkutsk city in 1997 from a patient followed from Uzbekistan was attributed to one of these genotypes (III b)
Summary
Atypical variants of Vibrio cholerae El Tor appeared in the beginning of the 1990s and contained a cholera toxin subunit B gene of the classical type (ctxB1) (1) that caused all of the epidemic cholera complications registered during that period in Siberia and the Far East (2). Analysis of the genetic structure of atypical V. cholerae El Tor variants isolated in Siberia and the Far East in the 1990s demonstrated its differentiation to some genotypes (3). The V. cholerae El Tor O1 I-1263 strain isolated in the imported focus in Irkutsk city in 1997 from a patient followed from Uzbekistan was attributed to one of these genotypes (III b).
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