Abstract
A unique porcine circovirus type 2 capsid protein (ORF2) sequence was detected in swine samples submitted to the Iowa State University Veterinary Diagnostic Laboratory. The complete genome sequences of four viruses, one from Mexico and three from the United States, were determined to further characterize this novel PCV2 genotype.
Highlights
A unique porcine circovirus type 2 capsid protein (ORF2) sequence was detected in swine samples submitted to the Iowa State University Veterinary Diagnostic Laboratory
Porcine circovirus type 2 (PCV2) is a small, nonenveloped, single-stranded DNA virus belonging to the family Circoviridae and genus Circovirus [1]
Porcine circovirus type 2 is the cause of several syndromes in swine known en masse as porcine circovirus-associated disease (PCVAD) or porcine multisystemic wasting syndrome [2,3,4]
Summary
A unique porcine circovirus type 2 capsid protein (ORF2) sequence was detected in swine samples submitted to the Iowa State University Veterinary Diagnostic Laboratory. Four global PCV2 genotypes have been described in swine based on the ORF2 capsid protein sequence and designated PCV2a, PCV2b, PCV2c, and PCV2d (formerly mutant PCV2b) [5]. Over the course of approximately 1 year, four different cases submitted to the Iowa State University Veterinary Diagnostic Laboratory (ISU VDL) were tested for PCV2 by PCR and demonstrated atypical nucleotide and amino acid sequences of the ORF2 (Cap) protein.
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