Whole-Genome Sequences of Multidrug-Resistant Escherichia coli Strains Sharing the Same Sequence Type (ST410) and Isolated from Human and Avian Sources in Italy.

Maria Giufré,Luca Busani,Marisa Accogli,Marina Cerquetti,Caterina Graziani

doi:10.1128/genomea.00757-15

Abstract

Extraintestinal pathogenic Escherichia coli (ExPEC) is involved in a wide spectrum of human diseases. Chickens have been suggested as reservoirs for fluoroquinolone (FQ)-resistant ExPEC strains. Here, we report the whole-genome sequences of 4 E. coli strains sharing the same sequence type (ST) (ST410) and that were isolated from human and avian sources in Italy.

Highlights

Extraintestinal pathogenic Escherichia coli (ExPEC) is involved in a wide spectrum of human diseases
We found that a subgroup of E. coli strains belonging to phylogenetic group A are potentially exchangeable between poultry and humans and may constitute a potential zoonotic risk [5, 6]
We identified some closely related multilocus sequence type (ST) clones belonging to specific clonal complexes (CC) (CC10 and CC23, both belonging to phylogenetic group A) that were associated with FQ resistance and multidrug resistance and were shared among strains isolated from urinary tract infections (UTIs), sepsis, and avian species [5]

Summary

Introduction

Extraintestinal pathogenic Escherichia coli (ExPEC) is involved in a wide spectrum of human diseases, including urinary tract infections (UTIs), septicemia, and neonatal meningitis [1]. Chicken and chicken products have been suggested to be a source for FQ (often multidrug [MDR])-resistant ExPEC strains causing infections in humans as a result of the massive use of these antimicrobial agents in poultry farming practice [3, 4]. We found that a subgroup of E. coli strains belonging to phylogenetic group A are potentially exchangeable between poultry and humans and may constitute a potential zoonotic risk [5, 6].

Results

Conclusion