Abstract
The development of breast cancer therapy has now reached the utilization of complementary alternative medicine (CAM) as an adjuvant to breast cancer therapy. One of the natural ingredients that has the potential for further research is white turmeric (Curcuma zedoaria). The purpose of the research is to determine the effects of white turmeric extract on breast cancer cell line 4T1. The research involved extraction by maceration and evaporation methods. White turmeric extract with acetone solvent was tested at 15.625, 31.25, 62.5, 125, 250, 500, and 1000 μg/ml compared to the control to see the most potent concentration in providing therapeutic effects. The results of the test analysis of water content and ash content of acetone extract of white turmeric meet the standards as standardized herbal ingredients with a percentage of 15.935% and 5.523%. Higher concentrations specifically showed a better breast cancer proliferation inhibition effect (mean cell absorbance proportion of 0.096 ± 0.0008). White turmeric extract has the potential to be developed as an alternative therapy for 4T1 breast cancer. Higher concentrations showed a better breast cancer proliferation inhibition effect. White turmeric extract has the potential to be developed as an alternative therapy for 4T1 breast cancer. Keywords: acetone extract, breast cancer, cell proliferation, white turmeric
Published Version
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