Urinary metabolites and handwipe phthalate levels among adults and children in southern China: Implication for dermal exposure

Abstract

Paired handwipe and urine samples were collected from adult (n = 130) and child (n = 82) residents of a typical urban community in southern China to examine relationships between external and internal exposure as well as the contribution of dermal absorption to the exposure of phthalates. The concentrations and composition profiles of phthalates were similar in handwipes from both adults and children, and contained mainly di-2-ethylhexyl phthalate (DEHP), di-n-butyl phthalate (DnBP) and di-iso-butyl phthalate (DiBP), consistent with profiles of phthalates in air and dust. The major metabolites of these phthalates, i.e., mono-n-butyl phthalate (mnBP) from DnBP, mono-iso-butyl phthalate (miBP) from DiBP and three metabolites of DEHP (namely mEHP, mEHHP and mEOHP) were widely detected in paired urine samples. Positive correlations were found between contamination levels of DiBP and DnBP in handwipes and their corresponding urinary metabolites, whereas no significant correlation was observed for DEHP. This suggests that dermal absorption might be an important exposure pathway particularly for low molecular weight phthalates. Our study shows that dermal absorption is a non-negligible exposure pathway for phthalates, to which children are particularly sensitive since the contribution of dermal uptake to the internal exposure of phthalates was higher in children than adults.