Therapeutic effect of combination of traditional Chinese medicine and western medicine on chronic obstructive pulmonary disease complicated with respiratory muscle fatigue and its effects on serum IL-6 and IL-8

Abstract

Objective To investigate the clinical effect of integrated traditional Chinese and western medicine in the treatment of chronic obstructive pulmonary disease (COPD) complicated with respiratory muscle fatigue, and to analyze its effects on serum levels of interleukin-6(IL-6) and interleukin-8(IL-8). Methods A total of 92 COPD patients complicated with respiratory muscle fatigue in the Traditional Chinese Medicine Hospital of Keqiao District were selected and randomly divided into observation group and control group according to the digital table, with 46 cases in each group.The control group received routine treatment, the observation group was given Liujunzi Decoction on the basis of the control group.The arterial blood pH values, blood carbon dioxide partial pressure(PaCO2), partial pressure of oxygen(PaO2) and the changes of serum IL-6 and IL-8 levels were compared between the two groups. Results Before treatment, the arterial blood pH, PaCO2, PaO2 between the two groups had no statistically significant differences(t=0.274, 0.108, 0.233, all P>0.05). After treatment, the arterial blood PaCO2 of the observation group [(37.18±3.06)mmHg] was significantly lower than that of the control group [(40.23±2.97)mmHg](t=7.004, P 0.05). Before treatment, the serum IL-6, IL-8 levels between the two groups had no statistically significant differences(t=0.506, 0.412, all P>0.05). After treatment, the levels of serum IL-6, IL-8 in the observation group were (14.27±1.05)pg/mL, (41.26±3.97)pg/mL, respectively, which were significantly lower than those in the control group [(18.38±1.76)pg/mL, (60.54±4.31)pg/mL](t=6.358, 7.138, all P<0.05). The total effective rate of the observation group was 97.8%, which was higher than 73.9% of the control group (χ2=8.617, P<0.05). Conclusion The combination of traditional Chinese medicine and western medicine in the treatment of COPD complicated with respiratory muscle fatigue has significant effect, it can effectively alleviate respiratory muscle fatigue, improve blood gas index, reduce serum IL-6 and IL-8 levels, it is worthy of application. Key words: Pulmonary disease, chronic obstructive; Respiratory muscles; Six gentlemen decoction; Interleukin-6; Interleukin-8