Abstract
The genetic restrictions of macrophage-T cell interactions in response to antigen were examined by an in vitro primary technique in which non-immune guinea pig T cells were primed and challenged in tissue culture with TNP-modified macrophages. The results show that the genetic restriction on the T cell proliferative response is imposed by the histocompatibility type of the macrophage used for initial sensitization and that T cells can be specifically sensitized to antigen associated with allogeneic macrophages. In addition, the genetic restriction on T cell-macrophage interactions depends on Ia antigen expression solely by the stimulator macrophages and there is no requirement for Ia antigen expression by responder T cells for efficient collaboration with macrophages. These results are discussed with respect to the role of macrophage I-region gene products in the antigenic complex recognized by T cells and the significance of Ia-negative T cell collaboration with antigen-treated macrophages.
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