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Abstract
Macrophages bearing MHC class II antigens (Ia antigens) play an important role in presenting antigen to specifically primed T lymphocytes(1). Since populations of macrophages are heterogeneous in the expression of detectable Ia antigen (2,3), the presence of the determinant marks the macrophage subpopulation responsible for this important immunoregulatory function. It has been shown that also dendritic cells (4) play a crucial role in antigen presentation to immunocompetent T lymphocytes. In this study we have investigated the expression and function of Ia antigen on different populations of macrophages and dendritic cells from inbred ACI/Mal rats, which are genetically defined high responders for the copolymer GT (glutamine tyrosine, 5). The expression of Ia antigen was detected by EA rosetting on both vital and paraformaldehyde fixed cells and by immunocytochemistry (immunoperoxidase).
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