Abstract
A closely related series of B cell leukemias of inbred strain 2 guinea pigs are available for study. There is strong evidence that these variants all arose from a single cell since all the variants, although having slightly different karyotypes have the same marker chromosome and all share the same surface IgM idiotype. Four of the 5 lines of leukemia have a strong TSTA as measured by immunization tests in syngeneic animals. One line lacks a TSTA and also lacks surface Ia antigens (a part of the MHC of the guinea pig). Criss cross immunization protection tests demonstrate that the TSTA of the Ia negative variant is present but not immunogenic. These studies demonstrate a close functional relationship between Ia antigens and TSTA's. An immunogenic KC1 extract from the L 2 C has been prepared; studies are now in progress to characterize the molecular species in the KC1 extract which acts as the TSTA.
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