Abstract
Background and Aim: Diabetes mellitus (DM) is a systemic disease with complications in the cardiovascular system, nerves, eyes, and kidneys. The potential targeting of the lung as an organ in diabetes is suggested by the rich pulmonary microvascular circulation and ample connective tissue present. This study aims to assess the relationship between pulmonary function tests and diabetic peripheral neuropathy in patients with type 2 DM. Materials and Methods: One hundred patients were included in the study. Michigan neuropathy screening instrument (MNSI) was used to evaluate diabetic peripheral neuropathy in all patients. Based on the results of the MNSI, patients were divided into two groups, 50 diabetic subjects without neuropathy and 50 subjects with neuropathy. Also, a flow-sensitive spirometer was used to evaluate the pulmonary function test (PFT) for all subjects. All the pulmonary function parameters were measured as a percentage of predicted value. In addition, according to hemoglobin A1c (HbA1c) level, patients were divided to three groups (group 1≤7%, group 2=7%-9%, group 3≥9%). Results: No significant difference was observed between the two groups with and without diabetic neuropathy in terms of PFTs, but in subjects with diabetic peripheral neuropathy, a significant reduction of forced vital capacity (FVC) and forced expiratory volume in one second (FEV1) was observed in group 3 (HbA1c >9) compared to groups 1 (HbA1c <7). Conclusion: This study does not show a significant reduction in pulmonary function in patients with type-2 DM with neuropathy compared to those without neuropathy. However, a significant difference was observed in FVC, FEV1, and forced expiratory flow (FEF)25-75 based on HBA1C level in subjects with neuropathy.
Published Version
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