Abstract
Objective To investigate the relationship between congenital heart dieases (CHD) and toxoplasma (TOX), rubella virus (RV), cytomegalovirus (HCMV) and herpes virus (HSV), human parvovirus B19 (HPVBIg) infections. Methods Five pathogenic genes of heart tissue were tested in ca-ses of CHD and cases of controls coming from rheumatic heart disease and death foetus by using fluores-cence quantity polymerase chain reaction (PCR). The positive ratio was compared. At the same time, the quantity of five pathogenic genes was detected. Results The positive ratio of TOX, RV, HCMV, HSV and HPVB19 in heart tissue of CHD was 16. 2%, 18. 8%, 28. 8%, 7. 5%, and 17. 5%, respectively, and that in controls was 0, 0, 18. 8%, 6. 2%, 0, respectively. There was significant difference in the positive ratio of TOX, RV and HPVB19 between CHD group and control group (P 0.05). Conclusion There is close relation between pathogen infection and CHD. Key words: Congenital heart disease; Pathogen; Polymerase chain reaction
Published Version
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