TORCH serologic screening in fertile women and infants and its clinical values from 2008 to 2015

Abstract

Objective To retrospectively study the serum IgG and IgM antibodies against toxoplasma, rubella virus, cytomegalovirus and herpes simplex virus type 1& 2 in various populations, and analyze the clinical values. Methods From 2008 to 2015, 2 661 pregnant women, 324 infertile women, 2 492 women with abnormal pregnancy history, 623 women with recent abnormal pregnancy, 261 infants with intrauterine growth retardation and other diseases, 170 women for preconceptual examination, and 702 women for physical examination in Beijing were included . Commercial EIA kits were used to detect serum IgG and IgM antibodies to toxoplasma, rubella virus, cytomegalovirus and herpes simplex virus type 1& 2. Positive reactions of IgM antibodies to any pathogens were re-tested with another kind of commercial EIA kit. PEMS3.1 software was used for statistical analysis. Results The prevalence of serum IgG or IgM antibodies against toxoplasma, rubella virus, cytomegalovirus and herpes simplex virus type 1& 2 were found within 0.7%-1.6%(0-1.2%), 85.3%-92.0% (0.4%-2.7%), 89.1%-94.9% (0.7%-1.7%), 74.8%-86.0% (0-0.7%), 8.1%-17.4% (0-4.1%) respectively in the studied population groups.The prevalence of TORCH IgG and IgM antibodies were not found to be higher in both populations with past suspicious exposure (infertile women and women with abnormal pregnancy history) and recent suspicious exposure (women with recent abnormal pregnancy and infants with intrauterine growth retardation and other diseases) than that in pregnant women and women for preconceptual and physical examination. Conclusion No associations between TORCH infections and the suspicious exposure were found in the populations above.(Chin J Lab Med, 2016, 39: 281-285) Key words: Toxoplasma; Rubella virus; Cytomegalovirus; Simplexvirus; Retrospective studies