The relationship between cervical lesions in patients with high-risk human papilloma virus infection and serum interleukin-1 beta, interleukin-2, interleukin-10

Abstract

Objective To explore the relationship between cervical lesions in patients with high-risk human papilloma virus(HPV) infection and serum interleukin-1 beta(IL-1 ), interleukin 2(IL-2), interleukin 10(IL-10). Methods 180 cases of cervical lesions were treated in our hospital from August 2013 to August 2015.Among them, 105 cases were infected with HPV, and 75 cases were not infected by HPV.The serum levels of IL-2, IL-10 and IL-1β were observed in two groups, and compared the levels of serum IL-2, IL-10 and IL-1β in patients with different DNA hr-HPV load, the correlation between DNA hr-HPV load and IL-1β, IL-2 and IL-10 levels was analyzed. Results The levels of IL-1β, IL-10, IL-2 were (0.85±0.23)ng/L, (182.35±10.02)ng/L, (38.97±5.23)ng/L in patients with HPV infection, the levels of IL-1β, IL-10, IL-2 in patients without HPV infection were (0.62±0.18)ng/L, (305.42±11.13)ng/L, (25.18±3.16)ng/L.The levels of IL-1β, IL-10 were significantly higher in HPV group than in without HPV infection group, the level of IL-2 in HPV group was significantly lower than that of uninfected HPV group, and the differences were statistically significant(t=7.222, 20.328, -7.558, all P 1 000, 100-1 000 and 1 000.DNA hr-HPV load was positively correlated with serum IL-1β and IL-10 levels in patients with cervical lesions and HPV infection(r=0.452, 0.422, P=0.035, 0.019), and negatively correlated with IL-2 level(r=-0.398, P=0.027). Conclusion hr-HPV infection is closely correlated with serum IL-1β, IL-2, IL-10 levels in cervical lesions patients, IL-1, IL-2 and IL-10 can be used as important index for clinical monitoring. Key words: Uterine cervical diseases; Human papillomavirus; Cytokines