The prospective randomized controlled study of primary pterygium surgery

Abstract

Objective To study two different methods in treatment of primary pterygium surgery on corneal epithelial wound repair and the influence on the recurrence rate. Methods Used prospective controlled study, according to a number table 128 patients with 128 eyes were randomly divided into control group (64 cases), and observation group (64 cases). The two groups of patients underwent pterygium excision and limbal stem cell transplantation.The observation group (64 eyes) received 0.2 mg/mL mitomycin C of mitomycin-C(MMC) adjuvant therapy.Corneal epithelial wound repair speed was observed.The patients were followed up for 6-12 months, average 8.5months, the recurrence rate of pterygium was observed in the two groups. Results The grafts were smooth, and the conjunctival flap healed well in the two groups.The postoperative corneal epithelial healing time of the control group and the observation group were (2.13±0.37)d, (2.87±0.41)d, there was statistically significant difference (t=4.91, P 0.05). Conclusion There was no difference in recurrence rate between two kinds of pterygium surgical method, but the combined MMC can cause corneal epithelial healing delay. Key words: Pterygium; Limbal stem cell; Transplantation; Mitomycin C