Two different surgical procedures for treatment of pterygium

Abstract

Objective To observe the effect of autologous corneal limbal stem cell transplantation (LCAT) with or without MMC for pterygium. Methods One hundred and twenty eyes of 120 cases of pterygium were selected in this study. The cases were numbered by the hospital case number and were divided into two groups according to the random number table. Patients in the control group were given LCAT treatment, and patients in the observation group were treated with LCAT+ MMC. The corneal epithelial healing time, recurrence rate and the effect on neovascuarization was observed. And the treatment effects between the two groups were compared. Results The total effective rates of observation group was 95.00%, which is better than that in control group (60.00%); the recurrence rates in observation group was 5.00%, which is better than that in control group (40.00%) (χ2=21.075, P=0.000). The eye irritation disappearance time, corneal epithelial healing time, and hospitalization time in observation group were (3.71±2.63) d, (4.12±1.31) d, and (13.61±2.43) d. That were not different form control group statistically (P>0.05). Infection occurred in 2 cases and sclera thinning occurred only 1 case of sclera thinning in control group and only 1 case of sclera thinning in observation group (t=17.905, P=0.000). Conclusion LCAT+ MMC in the treatment of pterygium can reduce the possibility of recurrence and tissue proliferation. Key words: Pterygium; Transplantation, stem cell, limbus; Mitomycin C