Abstract
Objective To investigate the mechanism of Glutathione in the prevention of ventilator-associated lung injury. Methods 30 mechanical ventilation patients who were healthy before were selected and randomly divided into the two groups. Group A was the high tidal volume group:10mL/kg;group B was used the tidal volume plus the injection of Glutathione(2.4g/d). After 48 hours,we collected lavage fluid and use Coomassie brilliant blue to detect the protein content of alveolar lavage fluid of the two groups. Results There was a significant difference(P<0.01) between the two groups. The protein content in group A[(9.90±2.25)g/L]was higher than that of group B[(4.17± 0.39)g/L],and there was statistically significant(P<0.01). Conclusion Glutathione can reduce the incidence of ventilator-associated lung injury and prevent the occurrence of ventilator-associated lung injury. Key words: Glutathione; Ventilator-associated lung injury; Mechanical ventilation
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