The main aspects of the clinical course of acute pancreatitis in obese patients

Abstract

Obesity is a problem of the third millennium. It is known that obesity is the main factor in the development of various diseases, including acute pancreatitis. The aim is to study the clinical course of acute pancreatitis in obese patients. Patients with acute pancreatitis and obesity have a statistically higher percentage of the severe course of the disease (р=0.01; α=0.05), a positive relationship between the body mass index and the level of leukocytes (r=0.128; p=0.038) was found, and also with the level of C-reactive protein (r=0.18; p=0.003). It should also be noted that in obese patients, the level of interleukin-1 increases by 2.3 times (p=0.01; α=0.05), and the level of interleukin-6 by 2.4 times (p=0.01; α=0.05). A statistically significant difference in increased cytokine levels in obese patients suggests an enhanced protease response and a “cytokine storm” that is the starting point of a non-reversible chain reaction. In patients with third-degree obesity, a strong correlation with the severity of acute pancreatitis was established (r=0.85, p=0.001; α=0.05).