Abstract
Male Sprague-Dawley rats were exposed, by inhalation, to n-hexane (900 ppm), xylene (600 ppm), methylethylketone (800 ppm) and methylchloroform (800 ppm) for four weeks and to toluene and dichloromethane (500, 1500, 3000 ppm) for three days. The in vitro liver microsomal metabolism of biphenyl and benzo(a)pyrene and SDS-polyacrylamide gel electrophoresis showed that xylene is a phenobarbital-like inducer of rat liver microsomal cytochrome P-450. Exposure to toluene and dichloromethane caused a dose-dependent increase in the in vitro metabolism of biphenyl and benzo(a)pyrene.
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