Abstract
We examined the effect of 1-benzylimadazole on the induction of cytochrome P-450 1A1/2 ( P-450 1A1/2) and cytochrome P-450 2B1/2 ( P-450 2B1/2) in normal, castrated, ovariectomized and hypophysectomized male rats, and in castrated rats treated with testosterone. 1-Benzylimadazole markedly increased P-450 content in male and female rats. Parallell to the dose-dependent increase in P-450 content, 1-benzylimidazole produced a significant increase in P-450 2B1/2 in male rats, but not in female rats. 1-Benzylimidazole failed to induce P-450 2B1/2 in castrated male and ovariectomized female rats. Treatment of castrated male rats with testosterone restored the induction of P-450 2B1/2 by 1-benzylimidazole. Treatment of ovariectomized female rats with 1-benzylimidazole or phenobarbital led to the increase in P-450 content, accompanying by the inductino of P-450 2B1/2 by the latter treatment, but not ther former. In hypophysectomized male rats, 1-benzilimidazole was able to induce P-450 2B1/2 in contrast to castrated male rats. Neonatal male and female rats responded well to the induction of P-450 2B1/2 by 1-benzylimidazole. The present findings suggest that P-450 2B1/2 induction by 1-benzylimidazole would be coupled with circulating testosterone regulated by hypophysis-testis axis. 1-Benzylimidazole produced sex-differentiated induction of P-450 2B1/2 in pubertal rats, but not in neonatal animals. The present findings would be provide information on a unique effect ot 1-benzylimidazole on P-450 2B1/2 induction in rats.
Published Version
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