Abstract
This chapter discusses the metabolism and irreversible binding of phencyclidine (PCP) by rabbit lung and liver microsomes. The animal tranquilizer, that is, phencyclidine, is being self-administered by man with increasing frequency through smoke inhalation. PCP is metabolized by animals to monohydroxylated and dihydroxylated metabolites. Samples of PCP frequently contain piperidinocyclohexane carbonitrile (PCC), a synthetic intermediate of PCP. The chapter discusses the in vitro metabolism of PCP, and PCC by rabbit lung and liver microsomes. It has been suggested that PCP is oxidized by rabbit lung and liver microsomes at the phenyl, cyclohexyl, or piperidinyl ring of the molecule. Hydroxylation of PCP at the cyclohexyl or piperidinyl ring is consistent with the metabolites in animal urine. The conversion of PCP to a reactive metabolite that irreversibly binds to microsomal proteins may be important in elucidating the mechanisms of PCP toxicity.
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